RepurpOS
by OpenSourceMedicine — structured biomarkers, ranked therapeutics, natural products, and clinical evidence for 100 conditions (100-disease database) from Open Targets, HPO, ChEMBL, DGIdb, ClinicalTrials.gov, and OSMF narrative reviews.
Right-to-Try Compendium
30 conditions without FDA-approved disease-modifying therapy where right-to-try legal frameworks apply. Includes 1,250+ investigational agents in Phase 3 trials.
Gene Therapy Mapper
Monogenic diseases suitable for single-gene therapies. Includes approved gene therapies (Casgevy, Roctavian, Trikafta), biomarker stratification, mutation types, and active clinical trials for 5 major genetic diseases.
ADHD
117 biomarkers · 13 clinical · 305 therapeutics · 84 natural products
Updated 2026-07-05
Acne Vulgaris
113 biomarkers · 9 clinical · 538 therapeutics · 89 natural products
Updated 2026-07-06
Age-Related Macular Degeneration (AMD)
153 biomarkers · 6 clinical · 450 therapeutics · 127 natural products
Updated 2026-07-05
Alcohol Use Disorder
116 biomarkers · 14 clinical · 375 therapeutics · 49 natural products
Updated 2026-07-05
Alopecia Areata
126 biomarkers · 13 clinical · 178 therapeutics · 19 natural products
Updated 2026-07-06
Alpha-1 Antitrypsin Deficiency (AATD)
141 biomarkers · 12 clinical · 173 therapeutics · 1 natural products
Updated 2026-07-06
Alzheimer's Disease and Other Dementias
155 biomarkers · 1 clinical · 705 therapeutics · 112 natural products
Updated 2026-07-05
Amyotrophic Lateral Sclerosis (ALS)
168 biomarkers · 7 clinical · 305 therapeutics · 79 natural products
Updated 2026-07-06
Ankylosing Spondylitis / Axial Spondyloarthropathy
115 biomarkers · 8 clinical · 151 therapeutics · 22 natural products
Updated 2026-07-05
Anxiety Disorders
139 biomarkers · 3 clinical · 535 therapeutics · 34 natural products · 9 OSMF review agents
Updated 2026-07-05
Asthma
113 biomarkers · 7 clinical · 642 therapeutics · 128 natural products
Updated 2026-07-05
Atopic Dermatitis (Eczema)
124 biomarkers · 6 clinical · 294 therapeutics · 82 natural products
Updated 2026-07-05
Atrial Fibrillation
140 biomarkers · 6 clinical · 332 therapeutics · 43 natural products
Updated 2026-07-05
Benign Prostatic Hyperplasia (BPH)
112 biomarkers · 9 clinical · 635 therapeutics · 82 natural products
Updated 2026-07-06
Bipolar Disorder
108 biomarkers · 3 clinical · 389 therapeutics · 56 natural products
Updated 2026-07-05
Bladder Cancer
126 biomarkers · 15 clinical · 662 therapeutics · 3 natural products
Updated 2026-07-06
Breast Cancer
106 biomarkers · 5 clinical · 1462 therapeutics · 107 natural products
Updated 2026-07-05
COPD
156 biomarkers · 13 clinical · 505 therapeutics · 101 natural products · 13 OSMF review agents
Updated 2026-07-05
Carpal Tunnel Syndrome
136 biomarkers · 13 clinical · 146 therapeutics · 17 natural products
Updated 2026-07-06
Cervical Cancer
110 biomarkers · 6 clinical · 425 therapeutics · 77 natural products
Updated 2026-07-06
Chronic Kidney Disease
100 biomarkers · 534 therapeutics · 109 natural products
Updated 2026-07-05
Chronic Lymphocytic Leukaemia (CLL)
110 biomarkers · 8 clinical · 807 therapeutics · 41 natural products
Updated 2026-07-06
Chronic Pancreatitis
134 biomarkers · 7 clinical · 215 therapeutics · 9 natural products
Updated 2026-07-06
Chronic Urticaria (CSU)
130 biomarkers · 21 clinical · 431 therapeutics
Updated 2026-07-06
Chronic Venous Insufficiency / Venous Leg Ulcers
117 biomarkers · 20 clinical · 167 therapeutics · 10 natural products
Updated 2026-07-06
Coeliac Disease (Refractory / RCD)
103 biomarkers · 2 clinical · 73 therapeutics · 45 natural products
Updated 2026-07-05
Colorectal Cancer
190 biomarkers · 11 clinical · 1212 therapeutics · 101 natural products
Updated 2026-07-05
Cystic Fibrosis
176 biomarkers · 8 clinical · 332 therapeutics · 64 natural products
Updated 2026-07-06
Deep Vein Thrombosis / Pulmonary Embolism (VTE)
105 biomarkers · 4 clinical · 135 therapeutics · 7 natural products
Updated 2026-07-06
Endometriosis
116 biomarkers · 12 clinical · 477 therapeutics · 81 natural products
Updated 2026-07-06
Epilepsy
203 biomarkers · 8 clinical · 187 therapeutics · 95 natural products
Updated 2026-07-05
Fibromyalgia
107 biomarkers · 1 clinical · 462 therapeutics · 60 natural products
Updated 2026-07-06
GERD (Gastroesophageal Reflux Disease)
111 biomarkers · 5 clinical · 203 therapeutics · 60 natural products
Updated 2026-07-05
Gastroparesis
107 biomarkers · 6 clinical · 202 therapeutics · 10 natural products
Updated 2026-07-06
Glaucoma
169 biomarkers · 7 clinical · 339 therapeutics · 112 natural products
Updated 2026-07-05
Gout
114 biomarkers · 12 clinical · 186 therapeutics · 96 natural products
Updated 2026-07-05
HIV/AIDS
138 biomarkers · 25 clinical · 249 therapeutics · 20 natural products
Updated 2026-07-05
Haemophilia A / B
155 biomarkers · 11 clinical · 181 therapeutics · 1 natural products
Updated 2026-07-06
Heart Failure
124 biomarkers · 7 clinical · 616 therapeutics · 112 natural products
Updated 2026-07-05
Hepatitis B
109 biomarkers · 10 clinical · 363 therapeutics
Updated 2026-07-06
Hepatitis C
107 biomarkers · 7 clinical · 357 therapeutics · 105 natural products
Updated 2026-07-05
Huntington's Disease
177 biomarkers · 2 clinical · 418 therapeutics · 72 natural products
Updated 2026-07-06
Hypertension
114 biomarkers · 14 clinical · 376 therapeutics · 98 natural products · 7 OSMF review agents
Updated 2026-07-05
Hypothyroidism
159 biomarkers · 13 clinical · 81 therapeutics · 67 natural products · 5 OSMF review agents
Updated 2026-07-05
Immune Thrombocytopaenia (ITP)
130 biomarkers · 7 clinical · 551 therapeutics · 16 natural products
Updated 2026-07-06
Inflammatory Bowel Disease (Crohn's / UC)
178 biomarkers · 13 clinical · 200 therapeutics · 85 natural products
Updated 2026-07-05
Inflammatory Myopathies (Dermatomyositis / PM / IBM)
194 biomarkers · 15 clinical · 162 therapeutics · 1 natural products
Updated 2026-07-06
Insomnia / Sleep Disorders
167 biomarkers · 21 clinical · 317 therapeutics · 101 natural products
Updated 2026-07-05
Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS)
123 biomarkers · 4 clinical · 195 therapeutics · 12 natural products
Updated 2026-07-06
Irritable Bowel Syndrome (IBS)
111 biomarkers · 8 clinical · 228 therapeutics · 97 natural products
Updated 2026-07-05
Kidney Stones (Nephrolithiasis)
127 biomarkers · 11 clinical · 268 therapeutics · 69 natural products
Updated 2026-07-06
Long COVID / Post-Acute COVID Sequelae (PACVS)
104 biomarkers · 2 clinical · 675 therapeutics · 10 natural products · 11 OSMF review agents
Updated 2026-07-05
Low Back Pain
130 biomarkers · 20 clinical · 331 therapeutics · 65 natural products
Updated 2026-07-05
Lung Cancer
133 biomarkers · 12 clinical · 465 therapeutics · 108 natural products
Updated 2026-07-05
Lupus Nephritis
110 biomarkers · 10 clinical · 235 therapeutics · 32 natural products
Updated 2026-07-06
Lyme Disease / Post-Treatment Lyme Disease Syndrome (PTLDS)
127 biomarkers · 3 clinical · 113 therapeutics · 38 natural products
Updated 2026-07-06
MCAS (Mast Cell Activation Syndrome)
49 biomarkers · 7 clinical · 24 therapeutics
Updated 2026-07-10
ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome)
107 biomarkers · 3 clinical · 126 therapeutics · 44 natural products
Updated 2026-07-05
Major Depressive Disorder
122 biomarkers · 10 clinical · 580 therapeutics · 141 natural products · 11 OSMF review agents
Updated 2026-07-05
Melanoma
133 biomarkers · 4 clinical · 1068 therapeutics · 80 natural products
Updated 2026-07-06
Migraine
174 biomarkers · 6 clinical · 377 therapeutics · 80 natural products
Updated 2026-07-05
Multiple Myeloma
155 biomarkers · 25 clinical · 764 therapeutics · 1 natural products
Updated 2026-07-06
Multiple Sclerosis
123 biomarkers · 10 clinical · 371 therapeutics · 120 natural products
Updated 2026-07-05
Myasthenia Gravis (MG)
174 biomarkers · 6 clinical · 281 therapeutics · 12 natural products
Updated 2026-07-06
Myelodysplastic Syndromes (MDS)
178 biomarkers · 9 clinical · 576 therapeutics · 21 natural products
Updated 2026-07-06
NAFLD / MASH (Metabolic-Associated Steatohepatitis)
104 biomarkers · 4 clinical · 292 therapeutics · 48 natural products
Updated 2026-07-05
Non-Hodgkin Lymphoma (NHL)
188 biomarkers · 12 clinical · 734 therapeutics · 77 natural products
Updated 2026-07-06
Obesity
130 biomarkers · 27 clinical · 368 therapeutics · 153 natural products
Updated 2026-07-05
Obstructive Sleep Apnoea (OSA)
108 biomarkers · 1 clinical · 237 therapeutics · 11 natural products
Updated 2026-07-06
Opioid Use Disorder
107 biomarkers · 5 clinical · 289 therapeutics · 40 natural products · 10 OSMF review agents
Updated 2026-07-05
Osteoarthritis
128 biomarkers · 9 clinical · 302 therapeutics · 106 natural products
Updated 2026-07-05
Osteoporosis
142 biomarkers · 19 clinical · 221 therapeutics · 100 natural products · 8 OSMF review agents
Updated 2026-07-05
Ovarian Cancer
124 biomarkers · 8 clinical · 1037 therapeutics · 77 natural products
Updated 2026-07-06
Overactive Bladder (OAB)
116 biomarkers · 13 clinical · 516 therapeutics · 33 natural products
Updated 2026-07-06
PCOS (Polycystic Ovary Syndrome)
116 biomarkers · 8 clinical · 177 therapeutics · 111 natural products
Updated 2026-07-05
POTS (Postural Orthostatic Tachycardia Syndrome)
136 biomarkers · 18 clinical · 137 therapeutics
Updated 2026-07-10
Pancreatic Cancer
126 biomarkers · 2 clinical · 672 therapeutics · 1 natural products
Updated 2026-07-06
Parkinson's Disease
165 biomarkers · 9 clinical · 540 therapeutics · 58 natural products
Updated 2026-07-05
Peripheral Artery Disease (PAD)
130 biomarkers · 21 clinical · 292 therapeutics · 57 natural products
Updated 2026-07-05
Peripheral Neuropathy (Diabetic Peripheral Neuropathy)
109 biomarkers · 7 clinical · 186 therapeutics · 94 natural products
Updated 2026-07-05
Polycystic Kidney Disease (ADPKD)
166 biomarkers · 16 clinical · 143 therapeutics · 13 natural products
Updated 2026-07-06
Polycythaemia Vera / Myeloproliferative Neoplasms
144 biomarkers · 1 clinical · 277 therapeutics
Updated 2026-07-06
Primary Sclerosing Cholangitis (PSC)
187 biomarkers · 14 clinical · 127 therapeutics · 2 natural products
Updated 2026-07-06
Prostate Cancer
105 biomarkers · 4 clinical · 1217 therapeutics · 81 natural products
Updated 2026-07-06
Psoriasis (Nail / Palmoplantar)
121 biomarkers · 15 clinical · 242 therapeutics · 104 natural products
Updated 2026-07-05
Psoriatic Arthritis
155 biomarkers · 18 clinical · 211 therapeutics · 15 natural products
Updated 2026-07-06
Pulmonary Arterial Hypertension (PAH)
183 biomarkers · 11 clinical · 421 therapeutics · 77 natural products
Updated 2026-07-06
Restless Legs Syndrome (RLS)
109 biomarkers · 3 clinical · 200 therapeutics · 15 natural products
Updated 2026-07-06
Rheumatoid Arthritis
186 biomarkers · 8 clinical · 544 therapeutics · 87 natural products
Updated 2026-07-05
Schizophrenia
156 biomarkers · 17 clinical · 499 therapeutics · 113 natural products
Updated 2026-07-05
Sepsis
106 biomarkers · 6 clinical · 518 therapeutics · 123 natural products
Updated 2026-07-05
Sickle Cell Disease
168 biomarkers · 22 clinical · 508 therapeutics · 30 natural products
Updated 2026-07-06
Sjögren's Syndrome
10 biomarkers · 4 clinical · 0 therapeutics · 18 natural products
Updated 2026-07-06
Stroke (Ischaemic / Cerebrovascular Disease)
112 biomarkers · 9 clinical · 577 therapeutics · 99 natural products
Updated 2026-07-05
Systemic Lupus Erythematosus (SLE)
189 biomarkers · 13 clinical · 276 therapeutics · 80 natural products
Updated 2026-07-05
Thyroid Cancer (Well-Differentiated)
189 biomarkers · 14 clinical · 321 therapeutics · 82 natural products
Updated 2026-07-06
Tinnitus
118 biomarkers · 4 clinical · 219 therapeutics · 31 natural products
Updated 2026-07-06
Type 1 Diabetes
121 biomarkers · 11 clinical · 324 therapeutics · 110 natural products
Updated 2026-07-05
Type 2 Diabetes
127 biomarkers · 19 clinical · 767 therapeutics · 222 natural products · 8 OSMF review agents
Updated 2026-07-05
Vitiligo
108 biomarkers · 4 clinical · 88 therapeutics · 34 natural products
Updated 2026-07-06