RepurpOS

by OpenSourceMedicine — structured biomarkers, ranked therapeutics, natural products, and clinical evidence for 100 conditions (100-disease database) from Open Targets, HPO, ChEMBL, DGIdb, ClinicalTrials.gov, and OSMF narrative reviews.

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Right-to-Try Compendium

30 conditions without FDA-approved disease-modifying therapy where right-to-try legal frameworks apply. Includes 1,250+ investigational agents in Phase 3 trials.

View the Right-to-Try Compendium →

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Gene Therapy Mapper

Monogenic diseases suitable for single-gene therapies. Includes approved gene therapies (Casgevy, Roctavian, Trikafta), biomarker stratification, mutation types, and active clinical trials for 5 major genetic diseases.

Explore Gene Therapy Candidates →

ADHD

117 biomarkers · 13 clinical · 305 therapeutics · 84 natural products

Updated 2026-07-05

Acne Vulgaris

113 biomarkers · 9 clinical · 538 therapeutics · 89 natural products

Updated 2026-07-06

Age-Related Macular Degeneration (AMD)

153 biomarkers · 6 clinical · 450 therapeutics · 127 natural products

Updated 2026-07-05

Alcohol Use Disorder

116 biomarkers · 14 clinical · 375 therapeutics · 49 natural products

Updated 2026-07-05

Alopecia Areata

126 biomarkers · 13 clinical · 178 therapeutics · 19 natural products

Updated 2026-07-06

Alpha-1 Antitrypsin Deficiency (AATD)

141 biomarkers · 12 clinical · 173 therapeutics · 1 natural products

Updated 2026-07-06

Alzheimer's Disease and Other Dementias

155 biomarkers · 1 clinical · 705 therapeutics · 112 natural products

Updated 2026-07-05

Amyotrophic Lateral Sclerosis (ALS)

168 biomarkers · 7 clinical · 305 therapeutics · 79 natural products

Updated 2026-07-06

Ankylosing Spondylitis / Axial Spondyloarthropathy

115 biomarkers · 8 clinical · 151 therapeutics · 22 natural products

Updated 2026-07-05

Anxiety Disorders

139 biomarkers · 3 clinical · 535 therapeutics · 34 natural products · 9 OSMF review agents

Updated 2026-07-05

Asthma

113 biomarkers · 7 clinical · 642 therapeutics · 128 natural products

Updated 2026-07-05

Atopic Dermatitis (Eczema)

124 biomarkers · 6 clinical · 294 therapeutics · 82 natural products

Updated 2026-07-05

Atrial Fibrillation

140 biomarkers · 6 clinical · 332 therapeutics · 43 natural products

Updated 2026-07-05

Benign Prostatic Hyperplasia (BPH)

112 biomarkers · 9 clinical · 635 therapeutics · 82 natural products

Updated 2026-07-06

Bipolar Disorder

108 biomarkers · 3 clinical · 389 therapeutics · 56 natural products

Updated 2026-07-05

Bladder Cancer

126 biomarkers · 15 clinical · 662 therapeutics · 3 natural products

Updated 2026-07-06

Breast Cancer

106 biomarkers · 5 clinical · 1462 therapeutics · 107 natural products

Updated 2026-07-05

COPD

156 biomarkers · 13 clinical · 505 therapeutics · 101 natural products · 13 OSMF review agents

Updated 2026-07-05

Carpal Tunnel Syndrome

136 biomarkers · 13 clinical · 146 therapeutics · 17 natural products

Updated 2026-07-06

Cervical Cancer

110 biomarkers · 6 clinical · 425 therapeutics · 77 natural products

Updated 2026-07-06

Chronic Kidney Disease

100 biomarkers · 534 therapeutics · 109 natural products

Updated 2026-07-05

Chronic Lymphocytic Leukaemia (CLL)

110 biomarkers · 8 clinical · 807 therapeutics · 41 natural products

Updated 2026-07-06

Chronic Pancreatitis

134 biomarkers · 7 clinical · 215 therapeutics · 9 natural products

Updated 2026-07-06

Chronic Urticaria (CSU)

130 biomarkers · 21 clinical · 431 therapeutics

Updated 2026-07-06

Chronic Venous Insufficiency / Venous Leg Ulcers

117 biomarkers · 20 clinical · 167 therapeutics · 10 natural products

Updated 2026-07-06

Coeliac Disease (Refractory / RCD)

103 biomarkers · 2 clinical · 73 therapeutics · 45 natural products

Updated 2026-07-05

Colorectal Cancer

190 biomarkers · 11 clinical · 1212 therapeutics · 101 natural products

Updated 2026-07-05

Cystic Fibrosis

176 biomarkers · 8 clinical · 332 therapeutics · 64 natural products

Updated 2026-07-06

Deep Vein Thrombosis / Pulmonary Embolism (VTE)

105 biomarkers · 4 clinical · 135 therapeutics · 7 natural products

Updated 2026-07-06

Endometriosis

116 biomarkers · 12 clinical · 477 therapeutics · 81 natural products

Updated 2026-07-06

Epilepsy

203 biomarkers · 8 clinical · 187 therapeutics · 95 natural products

Updated 2026-07-05

Fibromyalgia

107 biomarkers · 1 clinical · 462 therapeutics · 60 natural products

Updated 2026-07-06

GERD (Gastroesophageal Reflux Disease)

111 biomarkers · 5 clinical · 203 therapeutics · 60 natural products

Updated 2026-07-05

Gastroparesis

107 biomarkers · 6 clinical · 202 therapeutics · 10 natural products

Updated 2026-07-06

Glaucoma

169 biomarkers · 7 clinical · 339 therapeutics · 112 natural products

Updated 2026-07-05

Gout

114 biomarkers · 12 clinical · 186 therapeutics · 96 natural products

Updated 2026-07-05

HIV/AIDS

138 biomarkers · 25 clinical · 249 therapeutics · 20 natural products

Updated 2026-07-05

Haemophilia A / B

155 biomarkers · 11 clinical · 181 therapeutics · 1 natural products

Updated 2026-07-06

Heart Failure

124 biomarkers · 7 clinical · 616 therapeutics · 112 natural products

Updated 2026-07-05

Hepatitis B

109 biomarkers · 10 clinical · 363 therapeutics

Updated 2026-07-06

Hepatitis C

107 biomarkers · 7 clinical · 357 therapeutics · 105 natural products

Updated 2026-07-05

Huntington's Disease

177 biomarkers · 2 clinical · 418 therapeutics · 72 natural products

Updated 2026-07-06

Hypertension

114 biomarkers · 14 clinical · 376 therapeutics · 98 natural products · 7 OSMF review agents

Updated 2026-07-05

Hypothyroidism

159 biomarkers · 13 clinical · 81 therapeutics · 67 natural products · 5 OSMF review agents

Updated 2026-07-05

Immune Thrombocytopaenia (ITP)

130 biomarkers · 7 clinical · 551 therapeutics · 16 natural products

Updated 2026-07-06

Inflammatory Bowel Disease (Crohn's / UC)

178 biomarkers · 13 clinical · 200 therapeutics · 85 natural products

Updated 2026-07-05

Inflammatory Myopathies (Dermatomyositis / PM / IBM)

194 biomarkers · 15 clinical · 162 therapeutics · 1 natural products

Updated 2026-07-06

Insomnia / Sleep Disorders

167 biomarkers · 21 clinical · 317 therapeutics · 101 natural products

Updated 2026-07-05

Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS)

123 biomarkers · 4 clinical · 195 therapeutics · 12 natural products

Updated 2026-07-06

Irritable Bowel Syndrome (IBS)

111 biomarkers · 8 clinical · 228 therapeutics · 97 natural products

Updated 2026-07-05

Kidney Stones (Nephrolithiasis)

127 biomarkers · 11 clinical · 268 therapeutics · 69 natural products

Updated 2026-07-06

Long COVID / Post-Acute COVID Sequelae (PACVS)

104 biomarkers · 2 clinical · 675 therapeutics · 10 natural products · 11 OSMF review agents

Updated 2026-07-05

Low Back Pain

130 biomarkers · 20 clinical · 331 therapeutics · 65 natural products

Updated 2026-07-05

Lung Cancer

133 biomarkers · 12 clinical · 465 therapeutics · 108 natural products

Updated 2026-07-05

Lupus Nephritis

110 biomarkers · 10 clinical · 235 therapeutics · 32 natural products

Updated 2026-07-06

Lyme Disease / Post-Treatment Lyme Disease Syndrome (PTLDS)

127 biomarkers · 3 clinical · 113 therapeutics · 38 natural products

Updated 2026-07-06

MCAS (Mast Cell Activation Syndrome)

49 biomarkers · 7 clinical · 24 therapeutics

Updated 2026-07-10

ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome)

107 biomarkers · 3 clinical · 126 therapeutics · 44 natural products

Updated 2026-07-05

Major Depressive Disorder

122 biomarkers · 10 clinical · 580 therapeutics · 141 natural products · 11 OSMF review agents

Updated 2026-07-05

Melanoma

133 biomarkers · 4 clinical · 1068 therapeutics · 80 natural products

Updated 2026-07-06

Migraine

174 biomarkers · 6 clinical · 377 therapeutics · 80 natural products

Updated 2026-07-05

Multiple Myeloma

155 biomarkers · 25 clinical · 764 therapeutics · 1 natural products

Updated 2026-07-06

Multiple Sclerosis

123 biomarkers · 10 clinical · 371 therapeutics · 120 natural products

Updated 2026-07-05

Myasthenia Gravis (MG)

174 biomarkers · 6 clinical · 281 therapeutics · 12 natural products

Updated 2026-07-06

Myelodysplastic Syndromes (MDS)

178 biomarkers · 9 clinical · 576 therapeutics · 21 natural products

Updated 2026-07-06

NAFLD / MASH (Metabolic-Associated Steatohepatitis)

104 biomarkers · 4 clinical · 292 therapeutics · 48 natural products

Updated 2026-07-05

Non-Hodgkin Lymphoma (NHL)

188 biomarkers · 12 clinical · 734 therapeutics · 77 natural products

Updated 2026-07-06

Obesity

130 biomarkers · 27 clinical · 368 therapeutics · 153 natural products

Updated 2026-07-05

Obstructive Sleep Apnoea (OSA)

108 biomarkers · 1 clinical · 237 therapeutics · 11 natural products

Updated 2026-07-06

Opioid Use Disorder

107 biomarkers · 5 clinical · 289 therapeutics · 40 natural products · 10 OSMF review agents

Updated 2026-07-05

Osteoarthritis

128 biomarkers · 9 clinical · 302 therapeutics · 106 natural products

Updated 2026-07-05

Osteoporosis

142 biomarkers · 19 clinical · 221 therapeutics · 100 natural products · 8 OSMF review agents

Updated 2026-07-05

Ovarian Cancer

124 biomarkers · 8 clinical · 1037 therapeutics · 77 natural products

Updated 2026-07-06

Overactive Bladder (OAB)

116 biomarkers · 13 clinical · 516 therapeutics · 33 natural products

Updated 2026-07-06

PCOS (Polycystic Ovary Syndrome)

116 biomarkers · 8 clinical · 177 therapeutics · 111 natural products

Updated 2026-07-05

POTS (Postural Orthostatic Tachycardia Syndrome)

136 biomarkers · 18 clinical · 137 therapeutics

Updated 2026-07-10

Pancreatic Cancer

126 biomarkers · 2 clinical · 672 therapeutics · 1 natural products

Updated 2026-07-06

Parkinson's Disease

165 biomarkers · 9 clinical · 540 therapeutics · 58 natural products

Updated 2026-07-05

Peripheral Artery Disease (PAD)

130 biomarkers · 21 clinical · 292 therapeutics · 57 natural products

Updated 2026-07-05

Peripheral Neuropathy (Diabetic Peripheral Neuropathy)

109 biomarkers · 7 clinical · 186 therapeutics · 94 natural products

Updated 2026-07-05

Polycystic Kidney Disease (ADPKD)

166 biomarkers · 16 clinical · 143 therapeutics · 13 natural products

Updated 2026-07-06

Polycythaemia Vera / Myeloproliferative Neoplasms

144 biomarkers · 1 clinical · 277 therapeutics

Updated 2026-07-06

Primary Sclerosing Cholangitis (PSC)

187 biomarkers · 14 clinical · 127 therapeutics · 2 natural products

Updated 2026-07-06

Prostate Cancer

105 biomarkers · 4 clinical · 1217 therapeutics · 81 natural products

Updated 2026-07-06

Psoriasis (Nail / Palmoplantar)

121 biomarkers · 15 clinical · 242 therapeutics · 104 natural products

Updated 2026-07-05

Psoriatic Arthritis

155 biomarkers · 18 clinical · 211 therapeutics · 15 natural products

Updated 2026-07-06

Pulmonary Arterial Hypertension (PAH)

183 biomarkers · 11 clinical · 421 therapeutics · 77 natural products

Updated 2026-07-06

Restless Legs Syndrome (RLS)

109 biomarkers · 3 clinical · 200 therapeutics · 15 natural products

Updated 2026-07-06

Rheumatoid Arthritis

186 biomarkers · 8 clinical · 544 therapeutics · 87 natural products

Updated 2026-07-05

Schizophrenia

156 biomarkers · 17 clinical · 499 therapeutics · 113 natural products

Updated 2026-07-05

Sepsis

106 biomarkers · 6 clinical · 518 therapeutics · 123 natural products

Updated 2026-07-05

Sickle Cell Disease

168 biomarkers · 22 clinical · 508 therapeutics · 30 natural products

Updated 2026-07-06

Sjögren's Syndrome

10 biomarkers · 4 clinical · 0 therapeutics · 18 natural products

Updated 2026-07-06

Stroke (Ischaemic / Cerebrovascular Disease)

112 biomarkers · 9 clinical · 577 therapeutics · 99 natural products

Updated 2026-07-05

Systemic Lupus Erythematosus (SLE)

189 biomarkers · 13 clinical · 276 therapeutics · 80 natural products

Updated 2026-07-05

Thyroid Cancer (Well-Differentiated)

189 biomarkers · 14 clinical · 321 therapeutics · 82 natural products

Updated 2026-07-06

Tinnitus

118 biomarkers · 4 clinical · 219 therapeutics · 31 natural products

Updated 2026-07-06

Type 1 Diabetes

121 biomarkers · 11 clinical · 324 therapeutics · 110 natural products

Updated 2026-07-05

Type 2 Diabetes

127 biomarkers · 19 clinical · 767 therapeutics · 222 natural products · 8 OSMF review agents

Updated 2026-07-05

Vitiligo

108 biomarkers · 4 clinical · 88 therapeutics · 34 natural products

Updated 2026-07-06

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