Fibromyalgia — RepurpOS | OpenSourceMedicine

Disease overview

Alterations

107

Molecular (A)

100

Clinical (B–E)

Direct drugs

103

Via biomarker

360

Natural agents

Natural products

Merged ranked

462

With trial/literature evidence

Sources: Open Targets, HPO, ClinicalTrials.gov, DGIdb, ChEMBL, PubMed Literature, Seeds, Examine.com · Pipeline phase 7 · Updated 2026-07-06

Remission & chronicity

Spontaneous remission

Partial spontaneous improvement in ~25-30% over 5 years; complete resolution without treatment rare; chronic fluctuating course in majority; central sensitisation often persists

Best-intervention remission

Multimodal approach (aerobic exercise + CBT + sleep optimisation): most effective combination — 50-60% significant improvement; duloxetine: 50% pain response in 43% vs 29% placebo; milnacipran: similar; pregabalin: 50% pain response 38-50%; low-dose naltrexone (LDN): 30% improvement in open-label studies

Drug-free remission

—

Relapse after remission

—

Chronicity

—

Gap size

Large — pharmacotherapy is modestly effective; exercise is the most effective single intervention but chronically underused as 'too painful'; disease is often dismissed

Primary barrier

framing/practice

Barrier detail: Fibromyalgia was dismissed as non-organic by mainstream medicine for decades; this has resulted in: delayed diagnosis (mean 5 years), inappropriate investigations, ineffective treatments (opioids in particular), and under-referral to physiotherapy and psychological therapies; the 2010 ACR criteria removed tender point requirement and improved diagnosis

Last SoC change: 2021 — 2021 update to EULAR fibromyalgia recommendations; milnacipran/duloxetine/pregabalin approvals 2007-2008; these remain the only FDA-approved drugs for fibromyalgia; tricyclics (amitriptyline) off-label since 1980s

Remission data layers: disease_db_100 · source-locked manual data · confidence: high

Identifiers: MONDO: MONDO:0005546

Right to Try Relevance

Eligibility: This disease meets the federal and state right-to-try legal standard (21 U.S.C. § 360bbb-0a and Montana SB 535): it lacks disease-modifying therapy with indication-specific FDA approval. Patients with Fibromyalgia may be eligible to access investigational therapies outside of clinical trials under right-to-try frameworks.

Investigational Agents

Phase 3: 22, Phase 2: 18

Most Advanced Phase

Phase 3

Highest dev. stage

Gene Targets

107

Actionable

Pipeline Compounds (Top 6)

Amitriptyline, Cannabidiol, Cyclobenzaprine, Cyclobenzaprine Hydrochloride, Dolasetron, Duloxetine

Legal Standard: Right-to-try requires the disease lacks "adequate approved therapy for that specific disease" (not symptom-management drugs). This distinction means a disease with antidepressants available still qualifies if no FDA approval exists for THAT disease indication.

View Right-to-Try Compendium

Alterations

Showing 80 of 107 · Types A (molecular) through E (functional)

Name	Type	Subtype	Direction	Frequency	Evidence	Sources	Links
ACHE acetylcholinesterase (Yt blood group)	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRA1A adrenoceptor alpha 1A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRA2A adrenoceptor alpha 2A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRA2B adrenoceptor alpha 2B	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRA2C adrenoceptor alpha 2C	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRB1 adrenoceptor beta 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRB2 adrenoceptor beta 2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
ADRB3 adrenoceptor beta 3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
Beck Depression Inventory	Scales & PROs	Clinical scale	—	—	Emerging	ClinicalTrials.gov	—
Body Image Perception	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
CACNA1A calcium voltage-gated channel subunit alpha1 A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1B calcium voltage-gated channel subunit alpha1 B	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1C calcium voltage-gated channel subunit alpha1 C	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1D calcium voltage-gated channel subunit alpha1 D	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1E calcium voltage-gated channel subunit alpha1 E	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1F calcium voltage-gated channel subunit alpha1 F	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1G calcium voltage-gated channel subunit alpha1 G	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1H calcium voltage-gated channel subunit alpha1 H	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1I calcium voltage-gated channel subunit alpha1 I	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA1S calcium voltage-gated channel subunit alpha1 S	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNA2D4 calcium voltage-gated channel auxiliary subunit alpha2delta 4	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNB1 calcium voltage-gated channel auxiliary subunit beta 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNB2 calcium voltage-gated channel auxiliary subunit beta 2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNB3 calcium voltage-gated channel auxiliary subunit beta 3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNB4 calcium voltage-gated channel auxiliary subunit beta 4	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG3 calcium voltage-gated channel auxiliary subunit gamma 3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG4 calcium voltage-gated channel auxiliary subunit gamma 4	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG5 calcium voltage-gated channel auxiliary subunit gamma 5	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG6 calcium voltage-gated channel auxiliary subunit gamma 6	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG7 calcium voltage-gated channel auxiliary subunit gamma 7	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CALCRL calcitonin receptor like receptor	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CD274 CD274 molecule	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
CNR1 cannabinoid receptor 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
DRD2 dopamine receptor D2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
DRD3 dopamine receptor D3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
DRD4 dopamine receptor D4	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
Fibromyalgia Impact Questionnaire (FIQ)	Scales & PROs	Clinical scale	—	—	Emerging	ClinicalTrials.gov	—
GABBR1 gamma-aminobutyric acid type B receptor subunit 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GABBR2 gamma-aminobutyric acid type B receptor subunit 2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GHR growth hormone receptor	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GHSR growth hormone secretagogue receptor	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN1 glutamate ionotropic receptor NMDA type subunit 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN2A glutamate ionotropic receptor NMDA type subunit 2A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN2B glutamate ionotropic receptor NMDA type subunit 2B	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN2C glutamate ionotropic receptor NMDA type subunit 2C	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN2D glutamate ionotropic receptor NMDA type subunit 2D	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN3A glutamate ionotropic receptor NMDA type subunit 3A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
GRIN3B glutamate ionotropic receptor NMDA type subunit 3B	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HRH1 histamine receptor H1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR2A 5-hydroxytryptamine receptor 2A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR2C 5-hydroxytryptamine receptor 2C	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR3A 5-hydroxytryptamine receptor 3A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR3B 5-hydroxytryptamine receptor 3B	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR3C 5-hydroxytryptamine receptor 3C	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR3D 5-hydroxytryptamine receptor 3D	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
HTR3E 5-hydroxytryptamine receptor 3E	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
IFNAR1 interferon alpha and beta receptor subunit 1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
IFNAR2 interferon alpha and beta receptor subunit 2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
LEP leptin	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
MMP3 matrix metallopeptidase 3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
MTNR1A melatonin receptor 1A	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
MTNR1B melatonin receptor 1B	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFA1 NADH:ubiquinone oxidoreductase subunit A1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFA11 NADH:ubiquinone oxidoreductase subunit A11	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFA3 NADH:ubiquinone oxidoreductase subunit A3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFAB1 NADH:ubiquinone oxidoreductase subunit AB1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFAF4 NADH:ubiquinone oxidoreductase complex assembly factor 4	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFB1 NADH:ubiquinone oxidoreductase subunit B1	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFB2 NADH:ubiquinone oxidoreductase subunit B2	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFB3 NADH:ubiquinone oxidoreductase subunit B3	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets
NDUFB7 NADH:ubiquinone oxidoreductase subunit B7	Molecular	Gene	—	—	Emerging	Open Targets	UniProt Ensembl Open Targets

FDA-Approved Therapies

Phase 4 agents with regulatory approval for this indication

Drug Name	Mechanism	Type
ACEBUTOLOL	inhibitor	Gene-targeted
ACEBUTOLOL HYDROCHLORIDE	inhibitor	Gene-targeted
ACETAZOLAMIDE	None	Gene-targeted
ALBUTEROL SULFATE	agonist	Gene-targeted
ALFUZOSIN	inhibitor	Gene-targeted
ALFUZOSIN HYDROCHLORIDE	agonist	Gene-targeted
AMBENONIUM		Gene-targeted
AMBENONIUM CHLORIDE	inhibitor	Gene-targeted
AMIODARONE HYDROCHLORIDE		Gene-targeted
AMITRIPTYLINE HYDROCHLORIDE	inhibitor	Gene-targeted
AMLODIPINE BENZOATE	blocker	Gene-targeted
AMLODIPINE BESYLATE	blocker	Gene-targeted
AMLODIPINE BESYLATE		Gene-targeted
AMLODIPINE MALEATE	blocker	Gene-targeted
AMPHETAMINE	None	Gene-targeted
APIGENIN	inhibitor	Gene-targeted
APOMORPHINE	inhibitor	Gene-targeted
APRACLONIDINE	agonist	Gene-targeted
APRACLONIDINE HYDROCHLORIDE	agonist	Gene-targeted
ARBUTAMINE		Gene-targeted
ARFORMOTEROL		Gene-targeted
ARFORMOTEROL TARTRATE	agonist	Gene-targeted
ASENAPINE		Gene-targeted
ATENOLOL	inhibitor	Gene-targeted
ATIPAMEZOLE	inhibitor	Gene-targeted
ATROPINE	inhibitor	Gene-targeted
BENZGALANTAMINE GLUCONATE	inhibitor	Gene-targeted
BENZPHETAMINE		Gene-targeted
BEPRIDIL		Gene-targeted
BEPRIDIL HYDROCHLORIDE	blocker	Gene-targeted
BETAMETHASONE		Gene-targeted
BETAXOLOL	inhibitor	Gene-targeted
BETAXOLOL HYDROCHLORIDE	inhibitor	Gene-targeted
BETHANIDINE		Gene-targeted
BICALUTAMIDE	None	Gene-targeted
BISOPROLOL	inhibitor	Gene-targeted
BISOPROLOL FUMARATE	inhibitor	Gene-targeted
BITOLTEROL MESYLATE	agonist	Gene-targeted
BRETYLIUM		Gene-targeted
BRIMONIDINE	agonist	Gene-targeted

Therapeutics

Direct disease associations, biomarker-linked drugs, OSMF narrative-review natural agents, and merged ranking. Only agents with registry trials or published clinical literature are shown by default.

Show agents without direct trial evidence

Drug	Type	Phase	Evidence	Score	Trials & literature	Sources	Links
IMIPRAMINE	Small molecule	Approved	Strong	100	1 trials 1 Meta-analysis View evidence Registry trials NCT04832100 — Bio-significance of LPC16:0 in Fibromyalgia (RECRUITING) Published literature Meta-analysis Are antidepressants effective in fibromyalgia? (Joint bone spine, 2002) CT.gov search · Cochrane · PubMed	Open Targets, ChEMBL	ChEMBL Open Targets
ACEBUTOLOL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ACEBUTOLOL HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
ACETAZOLAMIDE Repurposing	Small molecule	Approved	Strong	95	—	ChEMBL	ChEMBL Open Targets
ALBUTEROL SULFATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
ALFUZOSIN Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ALFUZOSIN HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
AMBENONIUM Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
AMBENONIUM CHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
AMIODARONE HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
AMITRIPTYLINE HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
AMLODIPINE BENZOATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
AMLODIPINE BESYLATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
AMLODIPINE BESYLATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
AMLODIPINE MALEATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
AMPHETAMINE Repurposing	Small molecule	Approved	Strong	95	—	ChEMBL	ChEMBL Open Targets
APIGENIN Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
APOMORPHINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
APRACLONIDINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
APRACLONIDINE HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
ARBUTAMINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ARFORMOTEROL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ARFORMOTEROL TARTRATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
ASENAPINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ATENOLOL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ATIPAMEZOLE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
ATROPINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BENZGALANTAMINE GLUCONATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
BENZPHETAMINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BEPRIDIL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BEPRIDIL HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
BETAMETHASONE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BETAXOLOL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BETAXOLOL HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
BETHANIDINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BICALUTAMIDE Repurposing	Small molecule	Approved	Strong	95	—	ChEMBL	ChEMBL Open Targets
BISOPROLOL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BISOPROLOL FUMARATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
BITOLTEROL MESYLATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
BRETYLIUM Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BRIMONIDINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
BRIMONIDINE TARTRATE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	ChEMBL Open Targets
BROMOCRIPTINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
CABERGOLINE Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
CARBACHOL Repurposing	Small molecule	Approved	Strong	95	—	ChEMBL	ChEMBL Open Targets
CARTEOLOL Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—
CARTEOLOL HYDROCHLORIDE Repurposing	Small molecule	Approved	Strong	95	No indexed hits View evidence CT.gov search · Cochrane · PubMed	DGIdb	ChEMBL Open Targets
CARVEDILOL Repurposing	Small molecule	Approved	Strong	95	No indexed hits View evidence CT.gov search · Cochrane · PubMed	DGIdb	—
CARVEDILOL PHOSPHATE Repurposing	Small molecule	Approved	Strong	95	No indexed hits View evidence CT.gov search · Cochrane · PubMed	DGIdb	ChEMBL Open Targets
CELECOXIB Repurposing	Small molecule	Approved	Strong	95	—	DGIdb	—

Drug	Type	Phase	Evidence	Score	Trials & literature	Sources	Links
AMITRIPTYLINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
CANNABIDIOL	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
CYCLOBENZAPRINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
CYCLOBENZAPRINE HYDROCHLORIDE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
DOLASETRON	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
DULOXETINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
ERENUMAB	Biologic	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
ESREBOXETINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
FERRIC CARBOXYMALTOSE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
FERRIC OXYHYDROXIDE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
FERROUS SULFATE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
GABAPENTIN	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
IRON ISOMALTOSIDE 1000	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
KETOTIFEN	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
LIDOCAINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
MEMANTINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
MILNACIPRAN	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
MIROGABALIN	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
REBOXETINE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
SODIUM OXYBATE	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
SOMATROPIN	Biologic	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
TRAMADOL	Small molecule	Phase III	Moderate	80	—	Open Targets	ChEMBL Open Targets
AMPRELOXETINE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
BCG VACCINE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
CARBIDOPA	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
CYCLOSERINE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
DESVENLAFAXINE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
DESVENLAFAXINE SUCCINATE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
DEXAMETHASONE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
DEXTROMETHORPHAN	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
DRONABINOL	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
DROXIDOPA	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
ESCITALOPRAM	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
ESLICARBAZEPINE ACETATE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
FAMCICLOVIR	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
FAXELADOL	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
FLUPIRTINE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
FREMANEZUMAB	Biologic	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
IBUTAMOREN MESYLATE	Small molecule	Phase II	Emerging	60	—	Open Targets	ChEMBL Open Targets
IMIPRAMINE	Small molecule	Phase II	Emerging	60	1 trials 1 Meta-analysis View evidence Registry trials NCT04832100 — Bio-significance of LPC16:0 in Fibromyalgia (RECRUITING) Published literature Meta-analysis Are antidepressants effective in fibromyalgia? (Joint bone spine, 2002) CT.gov search · Cochrane · PubMed	Open Targets	ChEMBL Open Targets

Drug	Type	Phase	Evidence	Score	Sources	Links
ACEBUTOLOL Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
ACEBUTOLOL HYDROCHLORIDE Repurposing via ADRB1	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
ACETAZOLAMIDE Repurposing via ACHE	Small molecule	Approved	Strong	95	ChEMBL	ChEMBL Open Targets
ALBUTEROL SULFATE Repurposing via ADRB2	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
ALFUZOSIN Repurposing via ADRA1A	Small molecule	Approved	Strong	95	DGIdb	—
ALFUZOSIN HYDROCHLORIDE Repurposing via ADRA1A	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
AMBENONIUM Repurposing via ACHE	Small molecule	Approved	Strong	95	DGIdb	—
AMBENONIUM CHLORIDE Repurposing via ACHE	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
AMIODARONE HYDROCHLORIDE Repurposing via ADRA1A	Small molecule	Approved	Strong	95	DGIdb	—
AMITRIPTYLINE HYDROCHLORIDE Repurposing via ADRA1A	Small molecule	Approved	Strong	95	DGIdb	—
AMLODIPINE BENZOATE Repurposing via CACNA1F	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
AMLODIPINE BESYLATE Repurposing via CACNA1F	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
AMLODIPINE BESYLATE Repurposing via CACNA1C	Small molecule	Approved	Strong	95	DGIdb	—
AMLODIPINE MALEATE Repurposing via CACNA1F	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
AMPHETAMINE Repurposing via ACHE	Small molecule	Approved	Strong	95	ChEMBL	ChEMBL Open Targets
APIGENIN Repurposing via ACHE	Small molecule	Approved	Strong	95	DGIdb	—
APOMORPHINE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
APRACLONIDINE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
APRACLONIDINE HYDROCHLORIDE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
ARBUTAMINE Repurposing via ADRB1	Small molecule	Approved	Strong	95	DGIdb	—
ARFORMOTEROL Repurposing via ADRB2	Small molecule	Approved	Strong	95	DGIdb	—
ARFORMOTEROL TARTRATE Repurposing via ADRB2	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
ASENAPINE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
ATENOLOL Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
ATIPAMEZOLE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
ATROPINE Repurposing via ADRA2A	Small molecule	Approved	Strong	95	DGIdb	—
BENZGALANTAMINE GLUCONATE Repurposing via ACHE	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
BENZPHETAMINE Repurposing via ADRA1A	Small molecule	Approved	Strong	95	DGIdb	—
BEPRIDIL Repurposing via CACNA1A	Small molecule	Approved	Strong	95	DGIdb	—
BEPRIDIL HYDROCHLORIDE Repurposing via CACNA1G	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
BETAMETHASONE Repurposing via ACHE	Small molecule	Approved	Strong	95	DGIdb	—
BETAXOLOL Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
BETAXOLOL HYDROCHLORIDE Repurposing via ADRB1	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
BETHANIDINE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
BICALUTAMIDE Repurposing via ACHE	Small molecule	Approved	Strong	95	ChEMBL	ChEMBL Open Targets
BISOPROLOL Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—
BISOPROLOL FUMARATE Repurposing via ADRB1	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
BITOLTEROL MESYLATE Repurposing via ADRB2	Small molecule	Approved	Strong	95	DGIdb	ChEMBL Open Targets
BRETYLIUM Repurposing via ADRB1	Small molecule	Approved	Strong	95	DGIdb	—
BRIMONIDINE Repurposing via ADRA2C	Small molecule	Approved	Strong	95	DGIdb	—

Natural Products

60 natural products with the same evidence schema as repurposed drugs — registry trials, PubMed literature, and reference links (pipeline-ranked). Only agents with direct clinical evidence are shown by default.

Reference lookups: Examine.com

Show agents without direct trial evidence

Drug	Type	Phase	Evidence	Score	Trials & literature	Sources	Links
Magnesium Natural product Cochrane review Magnesium and malic acid supplement for fibromyalgia Cochrane review Combination pharmacotherapy for the treatment of fibromyalgia in adults Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome	Nutraceutical	Phase II	Moderate	20	8 trials 2 Cochrane 6 RCT View evidence Registry trials NCT06595017 — Lidocaine Versus Magnesium Sulphate in Management of Myofascial Pain Dysfunction Syndrome (NOT_YET_RECRUITING) PHASE2 NCT07390851 — Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG. (RECRUITING) NA NCT07519824 — The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety? (COMPLETED) NCT05389761 — Fibromyalgia Treatment With Enzyme DAO (COMPLETED) NA NCT04158388 — Effects of Nutritional Strategies or Manual Therapies in Women With Fibromyalgia (COMPLETED) NA NCT01460680 — Membrane Polyunsaturated Fatty Acid Content in Fibromyalgia and Systemic Lupus Erythematosus (SLE) (UNKNOWN) NCT06975813 — Magnesium Sulfate and Trigger Points (NOT_YET_RECRUITING) PHASE2 NCT03887000 — Magnesium, Stress and Fibromyalgia (COMPLETED) NA Published literature Cochrane review Magnesium and malic acid supplement for fibromyalgia (Medwave, 2019) Cochrane review Combination pharmacotherapy for the treatment of fibromyalgia in adults (The Cochrane database of systematic reviews, 2018) Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome (Nutrients, 2020) Systematic review Complementary and alternative medicine in fibromyalgia and related syndromes (Best practice & research. Clinical rheumatology, 2003) Randomized controlled trial Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial (Journal of dietary supplements, 2025) Randomized controlled trial High-dose Omega-3 Alters Serum Magnesium and Calcium Levels and Affects Fibromyalgia Symptoms: A Randomized, Double-blind, Placebo-Control Study (Current rheumatology reviews, 2025) Randomized controlled trial Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial (Nutrients, 2022) Randomized controlled trial Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia (International journal of environmental research and public health, 2020) Randomized controlled trial Comparison between Acupuncture and Nutraceutical Treatment with Migratens(®) in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial (Nutrients, 2020) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Vitamin D3 Natural product Human Study A combination of ascorbigen (a food derived form of vitamin c) and broc… Human Study Due to the higher levels of oxidative stress in patients with fibromyal… Human Study Elevated homocysteine levels in the cerebrospinal fluid of patients wit…	Nutraceutical	Approved	Moderate	20	8 trials View evidence Registry trials NCT04301609 — Clinical Trial to Assess the Improvement of Fatigue, Sleep Problems, Anxiety / Depression, Neurovegetatives Alterations and Quality of Life After the Administration of ImmunoVita® in Chronic Fatigue Syndrome Patients (COMPLETED) NA NCT07013305 — Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study (COMPLETED) NCT03369379 — Valuation of Efficacy and Safety of Vitamin D3 Use in 80 Women Diagnosed With Fibromyalgia. Using FIQ Score and VAS. (COMPLETED) PHASE4 NCT07649824 — Isokinetic Muscle Strength, Torque, Ultrasonographic Muscle Thickness in Fibromyalgia Syndrome: A Case-Control Study (COMPLETED) NCT04845737 — Electrophysiological Findings in Fibromyalgia Patients (COMPLETED) NA NCT06111573 — Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial Pain (COMPLETED) PHASE4 NCT06969716 — Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters (COMPLETED) NCT04892602 — Fibromyalgia in Rheumatiod and Psoriatic Patients (COMPLETED) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Vitamin D3 Natural product Human Study A combination of ascorbigen (a food derived form of vitamin c) and broc… Human Study Due to the higher levels of oxidative stress in patients with fibromyal… Human Study Elevated homocysteine levels in the cerebrospinal fluid of patients wit…	Nutraceutical	Approved	Emerging	19	8 trials View evidence Registry trials NCT04301609 — Clinical Trial to Assess the Improvement of Fatigue, Sleep Problems, Anxiety / Depression, Neurovegetatives Alterations and Quality of Life After the Administration of ImmunoVita® in Chronic Fatigue Syndrome Patients (COMPLETED) NA NCT07013305 — Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study (COMPLETED) NCT03369379 — Valuation of Efficacy and Safety of Vitamin D3 Use in 80 Women Diagnosed With Fibromyalgia. Using FIQ Score and VAS. (COMPLETED) PHASE4 NCT07649824 — Isokinetic Muscle Strength, Torque, Ultrasonographic Muscle Thickness in Fibromyalgia Syndrome: A Case-Control Study (COMPLETED) NCT04845737 — Electrophysiological Findings in Fibromyalgia Patients (COMPLETED) NA NCT06111573 — Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial Pain (COMPLETED) PHASE4 NCT06969716 — Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters (COMPLETED) NCT04892602 — Fibromyalgia in Rheumatiod and Psoriatic Patients (COMPLETED) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Magnesium Natural product Cochrane review Magnesium and malic acid supplement for fibromyalgia Cochrane review Combination pharmacotherapy for the treatment of fibromyalgia in adults Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome	Nutraceutical	Phase II	Emerging	19	8 trials 2 Cochrane 6 RCT View evidence Registry trials NCT06595017 — Lidocaine Versus Magnesium Sulphate in Management of Myofascial Pain Dysfunction Syndrome (NOT_YET_RECRUITING) PHASE2 NCT07390851 — Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG. (RECRUITING) NA NCT07519824 — The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety? (COMPLETED) NCT05389761 — Fibromyalgia Treatment With Enzyme DAO (COMPLETED) NA NCT04158388 — Effects of Nutritional Strategies or Manual Therapies in Women With Fibromyalgia (COMPLETED) NA NCT01460680 — Membrane Polyunsaturated Fatty Acid Content in Fibromyalgia and Systemic Lupus Erythematosus (SLE) (UNKNOWN) NCT06975813 — Magnesium Sulfate and Trigger Points (NOT_YET_RECRUITING) PHASE2 NCT03887000 — Magnesium, Stress and Fibromyalgia (COMPLETED) NA Published literature Cochrane review Magnesium and malic acid supplement for fibromyalgia (Medwave, 2019) Cochrane review Combination pharmacotherapy for the treatment of fibromyalgia in adults (The Cochrane database of systematic reviews, 2018) Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome (Nutrients, 2020) Systematic review Complementary and alternative medicine in fibromyalgia and related syndromes (Best practice & research. Clinical rheumatology, 2003) Randomized controlled trial Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial (Journal of dietary supplements, 2025) Randomized controlled trial High-dose Omega-3 Alters Serum Magnesium and Calcium Levels and Affects Fibromyalgia Symptoms: A Randomized, Double-blind, Placebo-Control Study (Current rheumatology reviews, 2025) Randomized controlled trial Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial (Nutrients, 2022) Randomized controlled trial Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia (International journal of environmental research and public health, 2020) Randomized controlled trial Comparison between Acupuncture and Nutraceutical Treatment with Migratens(®) in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial (Nutrients, 2020) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Chlorella Natural product Human Study Chlorella may help to relieve the symptoms of fibromyalgia in some pati…	Nutraceutical	Preclinical	Moderate	17	No indexed hits View evidence CT.gov search · Cochrane · PubMed	Examine.com	Examine.com
Coenzyme Q10 Natural product Systematic review Coenzyme Q10 supplementation in rheumatic diseases: A systematic review Systematic review Dietary Interventions in the Management of Fibromyalgia: A Systematic R… Clinical trial publication Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on F…	Nutraceutical	Preclinical	Moderate	17	1 trials 2 Cochrane 9 Trial pubs 8 RCT View evidence Registry trials NCT04098757 — Fibromyalgia Different Approaches: Acupuncture vs Migratens (UNKNOWN) Published literature Systematic review Coenzyme Q10 supplementation in rheumatic diseases: A systematic review (Clinical nutrition ESPEN, 2024) Systematic review Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis (Nutrients, 2020) Clinical trial publication Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial (Journal of dietary supplements, 2025) Clinical trial publication Comparison between Acupuncture and Nutraceutical Treatment with Migratens(®) in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial (Nutrients, 2020) Clinical trial publication Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction (Free radical research, 2019) Clinical trial publication A randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis (Complementary therapies in medicine, 2015) Clinical trial publication Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial (Journal of clinical psychopharmacology, 2014) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
L-Carnitine Natural product Human Study Acetyl-L-carnitine as an add-on treatment in fibromyalgia syndrome. Human Study Acetyl-L-carnitine significantly improves the condition of patients wit… Human Study Palmitoylethanolamide and acetyl-L-carnitine act synergistically with d…	Amino acid	Preclinical	Moderate	17	1 Cochrane 3 Trial pubs View evidence CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Saffron Natural product Human Study Saffron and duloxetine demonstrated comparable efficacy in treatment of…	Botanical	Preclinical	Moderate	17	1 Cochrane View evidence CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Creatine Natural product Clinical trial publication Clinical and anti-aging effect of mud-bathing therapy for patients with… Clinical trial publication Changes in metabolites after treatment with memantine in fibromyalgia.… Clinical trial publication Creatine supplementation in fibromyalgia: a randomized, double-blind, p…	Amino acid	Preclinical	Moderate	17	2 trials 6 Trial pubs View evidence Registry trials NCT06675708 — Effectiveness of Creatine on Pain, Fatigue, and Muscle Architectural Variables in Patients Witg Fibromyalgia. (ENROLLING_BY_INVITATION) NA NCT00749983 — Effects of Creatine Supplementation in Women With Knee Osteoarthritis and Fibromyalgia (COMPLETED) NA Published literature Clinical trial publication Clinical and anti-aging effect of mud-bathing therapy for patients with fibromyalgia (Molecular and cellular biochemistry, 2018) Clinical trial publication Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up (CNS neuroscience & therapeutics, 2014) Clinical trial publication Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial (Arthritis care & research, 2013) Clinical trial publication An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome (Annals of the New York Academy of Sciences, 2009) Clinical trial publication Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia (Arthritis and rheumatism, 2008) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Iron Natural product Systematic review Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review… Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome Randomized controlled trial Effectiveness of the SYNCHRONIZE + Brief Intervention in Improving Medi…	Nutraceutical	Approved	Moderate	17	6 trials 1 RCT View evidence Registry trials NCT01820052 — A Randomized Trial of Oral Iron Therapy in Fibromyalgia (COMPLETED) PHASE3 NCT07519824 — The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety? (COMPLETED) NCT05067998 — The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature (RECRUITING) NCT06665516 — Frequency and Impact of Iron Deficiency in Pain Clinic Patients (COMPLETED) NCT02409459 — Blinded Randomized Placebo-Controlled Study Efficacy and Safety of Injectafer in ID Patients With Fibromyalgia (COMPLETED) PHASE2 NCT00673608 — Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload (COMPLETED) PHASE4 Published literature Systematic review Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies (Current pain and headache reports, 2024) Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome (Nutrients, 2020) Randomized controlled trial Effectiveness of the SYNCHRONIZE + Brief Intervention in Improving Mediterranean Diet Adherence, Nutritional Quality and Intake Pattern in Persons with Fibromyalgia and Chronic Fatigue Syndrome (Nutrients, 2024) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Iron Natural product Systematic review Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review… Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome Randomized controlled trial Effectiveness of the SYNCHRONIZE + Brief Intervention in Improving Medi…	Nutraceutical	Approved	Emerging	16	6 trials 1 RCT View evidence Registry trials NCT01820052 — A Randomized Trial of Oral Iron Therapy in Fibromyalgia (COMPLETED) PHASE3 NCT07519824 — The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety? (COMPLETED) NCT05067998 — The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature (RECRUITING) NCT06665516 — Frequency and Impact of Iron Deficiency in Pain Clinic Patients (COMPLETED) NCT02409459 — Blinded Randomized Placebo-Controlled Study Efficacy and Safety of Injectafer in ID Patients With Fibromyalgia (COMPLETED) PHASE2 NCT00673608 — Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload (COMPLETED) PHASE4 Published literature Systematic review Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies (Current pain and headache reports, 2024) Systematic review Nutritional Interventions in the Management of Fibromyalgia Syndrome (Nutrients, 2020) Randomized controlled trial Effectiveness of the SYNCHRONIZE + Brief Intervention in Improving Mediterranean Diet Adherence, Nutritional Quality and Intake Pattern in Persons with Fibromyalgia and Chronic Fatigue Syndrome (Nutrients, 2024) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Creatine Natural product Clinical trial publication Clinical and anti-aging effect of mud-bathing therapy for patients with… Clinical trial publication Changes in metabolites after treatment with memantine in fibromyalgia.… Clinical trial publication Creatine supplementation in fibromyalgia: a randomized, double-blind, p…	Amino acid	Phase I	Emerging	13	2 trials 6 Trial pubs View evidence Registry trials NCT06675708 — Effectiveness of Creatine on Pain, Fatigue, and Muscle Architectural Variables in Patients Witg Fibromyalgia. (ENROLLING_BY_INVITATION) NA NCT00749983 — Effects of Creatine Supplementation in Women With Knee Osteoarthritis and Fibromyalgia (COMPLETED) NA Published literature Clinical trial publication Clinical and anti-aging effect of mud-bathing therapy for patients with fibromyalgia (Molecular and cellular biochemistry, 2018) Clinical trial publication Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up (CNS neuroscience & therapeutics, 2014) Clinical trial publication Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial (Arthritis care & research, 2013) Clinical trial publication An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome (Annals of the New York Academy of Sciences, 2009) Clinical trial publication Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia (Arthritis and rheumatism, 2008) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
S-Adenosylmethionine Natural product Randomized controlled trial Evaluation of S-adenosylmethionine in secondary fibromyalgia: a double-…	Nutraceutical	Phase II	Moderate	13	1 trials 1 RCT View evidence Registry trials NCT00528710 — Efficacy of S-Adenosylmethionine in Fibromyalgia (COMPLETED) PHASE2 Published literature Randomized controlled trial Evaluation of S-adenosylmethionine in secondary fibromyalgia: a double-blind study (Clinical and experimental rheumatology, 1998) CT.gov search · Cochrane · PubMed	Examine.com	Examine.com
Coenzyme Q10 Natural product Systematic review Coenzyme Q10 supplementation in rheumatic diseases: A systematic review Systematic review Dietary Interventions in the Management of Fibromyalgia: A Systematic R… Clinical trial publication Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on F…	Nutraceutical	Phase I	Emerging	10	1 trials 2 Cochrane 9 Trial pubs 8 RCT View evidence Registry trials NCT04098757 — Fibromyalgia Different Approaches: Acupuncture vs Migratens (UNKNOWN) Published literature Systematic review Coenzyme Q10 supplementation in rheumatic diseases: A systematic review (Clinical nutrition ESPEN, 2024) Systematic review Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis (Nutrients, 2020) Clinical trial publication Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial (Journal of dietary supplements, 2025) Clinical trial publication Comparison between Acupuncture and Nutraceutical Treatment with Migratens(®) in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial (Nutrients, 2020) Clinical trial publication Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction (Free radical research, 2019) Clinical trial publication A randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis (Complementary therapies in medicine, 2015) Clinical trial publication Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial (Journal of clinical psychopharmacology, 2014) CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Calcium Natural product Meta-analysis Pregabalin in Pregnancy: Major Congenital Malformations, Other Birth Ou… Randomized controlled trial High-dose Omega-3 Alters Serum Magnesium and Calcium Levels and Affects… Randomized controlled trial Association of Alterations in Gray Matter Volume With Reduced Evoked-Pa…	Nutraceutical	Preclinical	Emerging	10	1 trials 1 Meta-analysis 2 RCT View evidence Registry trials NCT05067998 — The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature (RECRUITING) Published literature Meta-analysis Pregabalin in Pregnancy: Major Congenital Malformations, Other Birth Outcomes, and Neurodevelopmental Outcomes (The Journal of clinical psychiatry, 2026) Randomized controlled trial High-dose Omega-3 Alters Serum Magnesium and Calcium Levels and Affects Fibromyalgia Symptoms: A Randomized, Double-blind, Placebo-Control Study (Current rheumatology reviews, 2025) Randomized controlled trial Association of Alterations in Gray Matter Volume With Reduced Evoked-Pain Connectivity Following Short-Term Administration of Pregabalin in Patients With Fibromyalgia (Arthritis & rheumatology (Hoboken, N.J.), 2016) CT.gov search · Cochrane · PubMed		PubChem
Vitamin B12 Natural product Systematic review Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgi… Human Study A combination of ascorbigen (a food derived form of vitamin c) and broc… Human Study Due to the higher levels of oxidative stress in patients with fibromyal…	Nutraceutical	Phase II	Emerging	10	4 trials View evidence Registry trials NCT07013305 — Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study (COMPLETED) NCT05067998 — The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature (RECRUITING) NCT06804460 — Effect of a Vegan Mediterranean Diet on Cardiometabolic Biomarkers, Functional Capacity, and Quality of Life in Patients with Fibromyalgia (NOT_YET_RECRUITING) PHASE1 NCT05008042 — Evaluation of the Efficiacy of Mecobalamine in the Treatment of Long-term Pain in Women Diagnosed With Fibromyalgia (COMPLETED) PHASE1, PHASE2 Published literature Systematic review Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-Analysis (Musculoskeletal care, 2025) CT.gov search · Cochrane · PubMed		PubChem
Vitamin C Natural product Randomized controlled trial Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fib… Human Study A combination of ascorbigen (a food derived form of vitamin c) and broc… Human Study Due to the higher levels of oxidative stress in patients with fibromyal…	Nutraceutical	Preclinical	Emerging	10	1 trials 1 RCT View evidence Registry trials NCT05067998 — The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature (RECRUITING) Published literature Randomized controlled trial Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life (International journal of molecular sciences, 2024) CT.gov search · Cochrane · PubMed		PubChem
D-Ribose Natural product Human Study D-ribose significantly reduces clinical symptoms in patients suffering…	Food compound	Preclinical	Moderate	10	No indexed hits View evidence CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Zinc Natural product Human Study Patients with fibromyalgia appear to have low levels of zinc and magnes…	Nutraceutical	Phase I	Emerging	10	4 trials View evidence Registry trials NCT04301609 — Clinical Trial to Assess the Improvement of Fatigue, Sleep Problems, Anxiety / Depression, Neurovegetatives Alterations and Quality of Life After the Administration of ImmunoVita® in Chronic Fatigue Syndrome Patients (COMPLETED) NA NCT05605886 — Botulinum Toxin A in Patients With Myofascial Pain Syndrome With and Without Zinc Supplementation (UNKNOWN) EARLY_PHASE1 NCT07519824 — The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety? (COMPLETED) NCT01469936 — Effect of PERMEAPROTECT on the Quality of Life of Patients With Fibromyalgia (UNKNOWN) NA CT.gov search · Cochrane · PubMed		PubChem
Folate Natural product Effect of fibromyalgia on demographic, biochemical, metabolic and infla… Do Nutritional Factors Interact with Chronic Musculoskeletal Pain? A Sy… Food intake assessment and quality of life in women with fibromyalgia	Nutraceutical	Preclinical	Emerging	10	5 trials View evidence Registry trials NCT07013305 — Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study (COMPLETED) NCT05067998 — The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature (RECRUITING) NCT06969716 — Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters (COMPLETED) NCT01469936 — Effect of PERMEAPROTECT on the Quality of Life of Patients With Fibromyalgia (UNKNOWN) NA NCT05357157 — Electroacupuncture Pain Treatment, Mechanical Hyperalgesia, Quality of Life & Expression of Mu+ B Cells in Fibromyalgia (RECRUITING) CT.gov search · Cochrane · PubMed		PubChem
Dhea Natural product	Food compound	Preclinical	Moderate	10	—	Examine.com	PubChem Examine.com
Olive Oil Natural product Human Study Olive oil may be a valuable therapeutic support in Fibromyalgia. Human Study Silicone gel breast implant rupture and resultant extracapsular silicon…	Nutraceutical	Preclinical	Emerging	10	—		—
L-Carnitine Natural product Human Study Acetyl-L-carnitine as an add-on treatment in fibromyalgia syndrome. Human Study Acetyl-L-carnitine significantly improves the condition of patients wit… Human Study Palmitoylethanolamide and acetyl-L-carnitine act synergistically with d…	Amino acid	Preclinical	Emerging	7	1 Cochrane 3 Trial pubs View evidence CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Saffron Natural product Human Study Saffron and duloxetine demonstrated comparable efficacy in treatment of…	Botanical	Preclinical	Emerging	7	1 Cochrane View evidence CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Melatonin Natural product Human Study Administration of melatonin, alone or in a combination with fluoxetine… Human Study Amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supple… Human Study Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibr…	Nutraceutical	Preclinical	Emerging	7	—		PubChem
Probiotics Natural product Human Study Probiotics improved impulsivity and decision-making in fibromyalgia pat…	Probiotic	Preclinical	Emerging	7	—		—
Tryptophan Natural product Human Study The dietary supplement was efficacious in improving physical aspects of…	Amino acid	Preclinical	Emerging	7	—		PubChem
Turmeric Natural product Diet Composition's Effect on Chronic Musculoskeletal Pain: A Narrative… Beyond Seasoning-The Role of Herbs and Spices in Rheumatic Diseases Effects of Antioxidants on Pain Perception in Patients with Fibromyalgi…	Botanical	Preclinical	Emerging	7	—		PubChem
SAMe (S-Adenosylmethionine) Natural product Human Study Sam-e improves symptoms in primary fibromyalgia.	Nutraceutical	Phase I	Emerging	3	—		—
Cannabidiol Natural product Human Study Fibromyalgia patients saw many benefits from using CBD across multiple…	Food compound	Preclinical	Emerging	2	—		PubChem
D-Ribose Natural product Human Study D-ribose significantly reduces clinical symptoms in patients suffering…	Food compound	Preclinical	Emerging	0	No indexed hits View evidence CT.gov search · Cochrane · PubMed	Examine.com	PubChem Examine.com
Dhea Natural product Different DHEA-S Levels and Response Patterns in Individuals with Chron… The effects of dehydroepiandrosterone (DHEA) in the treatment of depres… A randomized controlled trial of dehydroepiandrosterone in postmenopaus…	Food compound	Preclinical	Emerging	0	—	Examine.com	PubChem Examine.com
Cannabis Natural product Human Study Cannabis reduces symptoms in patients with fibromyalgia. Human Study Medical cannabis appears to be a safe and effective alternative for the… Human Study Phytocannabinoids can be a low-cost and well-tolerated therapy to reduc…	Nutraceutical	Preclinical	Emerging	0	—		—
Palmitoylethanolamide Natural product Human Study Palmitoylethanolamide and acetyl-L-carnitine act synergistically with d… Human Study Research suggests the efficacy and safety of palmitoylethanolamide in t… Human Study These results suggest that adding LAC and PEA to standard care may prov…	Nutraceutical	Preclinical	Emerging	0	—		—
Homeopathic Medicine: All Natural product Meta Analysis, Review Homeopathy could have some benefit in the treatment of fibromyalgia. Human Study Homeopathic treatment appears to be safe and effective in patients with… Human Study Individualized homeopathic treatment improves clinical status in fibrom…	Nutraceutical	Preclinical	Emerging	0	—		—
5-HTP (5-Hydroxytryptophan) Natural product Human Study 5-HTP improves Fibromyalgia symptoms in a human clinical study.	Nutraceutical	Preclinical	Emerging	0	—		—
Chlorella (Algae) Natural product Human Study Chlorella may help to relieve the symptoms of fibromyalgia in some pati…	Nutraceutical	Preclinical	Emerging	0	—		—
Hydroxytyrosol Natural product Human In Vitro Hydroxytyrosol as a promising ally in the treatment of fibromyalgia.	Nutraceutical	Preclinical	Emerging	0	—		—
Broccoli Natural product Human Study A combination of ascorbigen (a food derived form of vitamin c) and broc…	Nutraceutical	Preclinical	Emerging	0	—		—
Malic Acid Natural product Human Study A combination of malic acid and magnesium is safe and may be beneficial…	Nutraceutical	Preclinical	Emerging	0	—		—
Chocolate Natural product Human Study Antioxidant protection from bioactive compounds present in fruit and ve…	Nutraceutical	Preclinical	Emerging	0	—		—
Fruit: All Natural product Human Study Antioxidant protection from bioactive compounds present in fruit and ve…	Nutraceutical	Preclinical	Emerging	0	—		—
Polyphenols Natural product Human Study Antioxidant protection from bioactive compounds present in fruit and ve…	Nutraceutical	Preclinical	Emerging	0	—		—
Vegetables: All Natural product Human Study Antioxidant protection from bioactive compounds present in fruit and ve…	Nutraceutical	Preclinical	Emerging	0	—		—
Sea Salt: Dead Sea Natural product Human Study Balneotherapy at the Dead Sea area appears to produce a statistically s…	Nutraceutical	Preclinical	Emerging	0	—		—
Cellfood Natural product Human Study Cellfood (deutrosulfazyme) improves fibromyalgia symptoms and health-re…	Nutraceutical	Preclinical	Emerging	0	—		—
Oxygen Therapies Natural product Human Study Cellfood (deutrosulfazyme) improves fibromyalgia symptoms and health-re… Meta Analysis, Review Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia. Meta Analysis Effectiveness of hyperbaric oxygen for fibromyalgia.	Nutraceutical	Preclinical	Emerging	0	—		—
Pycnogenol (Pine Bark) Natural product Human Study Idiopathic myalgic pain (fibromyalgia): supportive management and preve…	Nutraceutical	Preclinical	Emerging	0	—		—
Delta-Tetrahydrocannabinol (THC) Natural product Human Study Phytocannabinoids can be a low-cost and well-tolerated therapy to reduc…	Nutraceutical	Preclinical	Emerging	0	—		—
Homeopathic Medicine: Rhus Toxicodendron Natural product Meta Analysis, Review Homeopathy could have some benefit in the treatment of fibromyalgia. Human Study Homeopathic treatment appears to be safe and effective in patients with… Human Study Individualized homeopathic treatment improves clinical status in fibrom…	Nutraceutical	Preclinical	Emerging	0	—		—
Magnesium: Transdermal Natural product Human Study A combination of malic acid and magnesium is safe and may be beneficial… Human Study Due to the high hair calcium and magnesium levels in patients with Fibr… Human Study Magnesium deficiency is common in patients with chronic fatigue syndrom…	Nutraceutical	Preclinical	Emerging	0	—		—
Astaxanthin Natural product	Food compound	Preclinical	Emerging	0	—		PubChem
Fisetin Natural product Longitudinal Progression of Patients with Long COVID Treated in a Post-… Evaluation of Endothelial Dysfunction and Autophagy in Fibromyalgia-Rel… Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic…	Food compound	Preclinical	Emerging	0	—		PubChem
Diosmetin Natural product Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced…	Nutraceutical	Preclinical	Emerging	0	—		—
Honokiol Natural product Honokiol ameliorates reserpine-induced fibromyalgia through antioxidant…	Nutraceutical	Preclinical	Emerging	0	—		—
Lignans Natural product	Nutraceutical	Preclinical	Emerging	0	—		—
Psychedelics:All Natural product	Nutraceutical	Preclinical	Emerging	0	—		—
Bifidobacterium Infantis Natural product Are probiotic treatments useful on fibromyalgia syndrome or chronic fat…	Nutraceutical	Preclinical	Emerging	0	—		—
Capsaicin Natural product Pharmacotherapy and non-invasive neuromodulation for neuropathic pain:… Short-term efficacy of topical capsaicin therapy in severely affected f… Evidence for the efficacy of complementary and alternative medicines in…	Nutraceutical	Preclinical	Emerging	0	—		—
Mineral Water Natural product Human Study A water-based Ai Chi program may contribute to the improvement of menta… Human Study Baths with mineral-medicinal water from As Burgas can make an improveme… Human Study Effects of thermal therapy combining sauna therapy and underwater exerc…	Nutraceutical	Preclinical	Emerging	0	—		—

Alterations and therapeutics are aggregated from public databases (Open Targets, HPO, ChEMBL, DGIdb, and others). Natural agents are candidates from OSMF narrative reviews on opensourcemed.info/chronic-disease.html — not approved treatments. This page is for research orientation only — not medical advice.