Post-viral research digest - Open Source Medicine Foundation

Post-viral research digest, week 41 2026: 1 new study

Wed, 07 Oct 2026 08:00:00 +0000

Between 24 September 2026 and 7 October 2026 the tracker indexed 1 new peer-reviewed study and 17 clinical-trial updates across 8 post-viral and post-infectious conditions.

Note: fewer than 3 new studies were indexed in the 7 days to 7 October 2026, so this issue covers the 14 days from 24 September 2026. Some items may therefore also appear in the previous issue.

By the numbers

1new studies this issue

17trial updates this issue

540studies currently in the feeds

629clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-10-07); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

Post-Acute COVID-19 Vaccination Syndrome (PACVS) 1 new

Full feed: PACVS research tracker

Hospital Readmissions in Patients with Severe Acute Respiratory Syndrome: A Retrospective Study in Northeastern Brazil.

Diseases (Basel, Switzerland) · 24 September 2026 · Wanderley, Raphael Omena, Dos Santos, Carmina Silva, Agra, Karine Ferreira, Gonçalves et al. PubMed 42783201

Severe acute respiratory syndrome (SARS) remains an important cause of hospitalization and mortality, particularly among vulnerable populations. Understanding the factors associated with previous hospitalization may support more effective prevention and vaccination strategies.

No new studies this window for: Long COVID, ME/CFS, Lyme / PTLDS, Gulf War Illness, POTS, MCAS, Other post-viral.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 24 September 2026 and 7 October 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT07388550	Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Long COVID	Not Yet Recruiting	Phase 1	Keytruda	2026-10-07
NCT05874037	Fluvoxamine for Long COVID-19 Long COVID	Completed	Phase 2	Fluvoxamine	2026-10-07
NCT07661862	PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID Long COVID	Recruiting	Not applicable	Perceive-Outreach Disease Management Program	2026-10-06
NCT06928272	Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study Long COVID	Recruiting	Phase 3	Pirfenidone, Upadacitinib	2026-10-06
NCT06404073	RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM)) Long COVID	Completed	Not applicable	Structured Pacing	2026-10-06
NCT07398508	NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease Other post-viral	Recruiting	Phase 1	Droxidopa Oral Product	2026-10-05
NCT05493605	Cardiac Involvement in Wilson's Disease Other post-viral	Recruiting	Not applicable	Delivery Of A Long-Term Holter 21 Days Or Placement Of An Implantable Holter From The Outset So Syncope	2026-10-01
NCT07621588	Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID Long COVID	Completed	Not applicable	Diaphragmatic Electrostimulation Using Kots Currents, Diaphragmatic Breathing Exercises	2026-09-29
NCT07468604	Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition Other post-viral	Recruiting	Phase 4	5 Ml Of 0.25% Bupivacaine With Epinephrine	2026-09-29
NCT07021794	SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID) Long COVID	Recruiting	Phase 2	Sipavibart	2026-09-29
NCT06928116	Heat thErapy And mobiLity in COVID-19 Survivors Long COVID	Recruiting	Not applicable	Heat Therapy, Walking	2026-09-28
NCT07842302	Fighting Fatigue in Multiple Sclerosis: TMS vs. tDCS Efficacy. Other post-viral	Not Yet Recruiting	Not applicable	Tms, Tdcs	2026-09-25
NCT07005921	QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG Long COVID	Completed	Not applicable	Qeeg-Neurofeedback	2026-09-25
NCT06631287	Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID Long COVID	Recruiting	Phase 3	Baricitinib	2026-09-25
NCT07837804	RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome POTS, Other post-viral	Not Yet Recruiting	Not applicable	Bilateral Sequential Stellate Ganglion Block	2026-09-24
NCT07123727	A Study to Examine Anktiva for the Treatment of COVID-19. Long COVID	Recruiting	Phase 2	Anktiva	2026-09-24
NCT04137757	fMRI in Postural Tachycardia Syndrome Other post-viral	Active Not Recruiting	Not applicable	Lower Body Negative Pressure	2026-09-24

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 28 2026: 33 new studies

Sun, 12 Jul 2026 08:00:00 +0000

Between 6 July 2026 and 12 July 2026 the tracker indexed 33 new peer-reviewed studies and 0 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

33new studies this issue

0trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

Long COVID (PASC) 10 new

Full feed: Long COVID research tracker

Temelimab versus placebo in patients with post-COVID condition.

Brain, behavior, and immunity · 7 July 2026 · Nehme, Mayssam, Hund-Georgiadis, Margret, Corral Beamonte, Esther Del, Bridevaux, Pierre-Olivier et al. PubMed 42409185

More than 400 million individuals are estimated to have been affected by post-COVID condition or long COVID. This condition can lead to significantly decreased quality of life and increased individual and societal costs.

Post-acute sequelae of COVID in children: Pulmonary assessment using impulse oscillometry and the effect of vaccination.

Pediatrics and neonatology · 7 July 2026 · Chen, Chieh-Ho, Chen, Pei-Chi, Liu, Xiao-Ling, Wei, Chi-Hung et al. PubMed 42409655

Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID syndrome (LCS), is characterized by persistent symptoms following SARS-CoV-2 infection and poses significant health challenges, particularly impacting pulmonary function in children. This study aims to evaluate the effect of COVID-19 vaccination on pulmonary function in children with PASC using standardized spirometry and impulse...

Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo.

The Journal of biological chemistry · 7 July 2026 · Natarajan, Niranjana, Ahmed, Thaybah, Govindaswamy, Balaji, Manickam, Devika S et al. PubMed 42409265

Macrophages are versatile immune cells, with the ability to respond to varied intrinsic and extrinsic cues, and transition between inflammatory and pro-reparative phenotypes. A complex network of epigenetic processes, such as DNA methylation, and histone methylation and acetylation, plays key roles in modulating macrophage polarization and inflammatory gene expression.

Time to Recovery from Long COVID: A Longitudinal Analysis of Symptom Duration and Risk Factors Using Accelerated Failure Time Models.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 6 July 2026 · Jo, Youngji, Hu, Zeyu, Joo, Hyejin, Jung, Jaehun et al. PubMed 42402260

Long COVID comprises heterogeneous symptoms that may persist for months to years after acute SARS-CoV-2 infection. While prevalence is well described, less is known about symptom duration and determinants of recovery.

Regional Disparities in Functional and Socioeconomic Impacts of Long COVID in Brazil: A Cross-Sectional Observational Study.

Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 6 July 2026 · Dos Santos, Ana Cleides Pereira, Goulart, Cássia da Luz, Neves, Victor Ribeiro, Milani, Mauricio et al. PubMed 42403350

In low- and middle-income countries such as Brazil, regional inequalities in healthcare access and socioeconomic conditions may exacerbate the functional and occupational consequences of Long COVID. This study explored between-center differences in functional and socioeconomic outcomes among individuals with Long COVID from three Brazilian centers in Brazil, while examining how these findings may have been...

Postacute COVID-19 Symptoms and Health Care Utilization and Spending Among Traditional Medicare Beneficiaries.

JAMA network open · 6 July 2026 · Ghosh, Kaushik, Zuckerman, Rachael, Feyman, Yevgeniy, Orav, E John et al. PubMed 42406399

Postacute sequelae of SARS-CoV-2 infection include fatigue, respiratory symptoms, and cognitive dysfunction. However, the extent to which these symptoms contribute to increased health care utilization and spending among Medicare beneficiaries remains unclear.

Post-COVID paediatric dysautonomia: never the heart, always the brain-myth or maxim?also POTS

Cardiology in the young · 6 July 2026 · Das, Bibhuti, Moodley, Manikum PubMed 42403377

Paediatric dysautonomia has become increasingly recognised in children and adolescents, particularly in the post-COVID era. Affected patients commonly present with dizziness, palpitations, exercise intolerance, fatigue, and syncope, although reported prevalence varies widely because of evolving definitions and heterogeneous referral patterns.

Mechanisms and impact of long COVID: pathophysiology, neuropsychiatric effects and vaccination.

Frontiers in immunology · 6 July 2026 · Ponnachan, Pretty, Dhawlarker, Anam, Yasmin, Hadida, Shah, Akash et al. PubMed 42404887

Long COVID or post-acute sequelae of COVID-19 is defined as an after-effect of acute COVID-19 infection. Its broad clinical symptoms include brain fog, shortness of breath, fatigue, joint, chest, or muscle pain, dysautonomia and neuropsychiatric symptoms such as anxiety, depression and post-traumatic stress disorder.

Jianpi Huayu decoction alleviates hepatic fibrosis involving coordinated modulation of PPARα-mediated lipid metabolic reprogramming and the ROCK pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology · 6 July 2026 · Luo, Rui, Lai, Yongheng, Zhang, Sijia, Yao, Ruiwei et al. PubMed 42407187

Hepatic fibrosis is a critical stage in the progression from chronic liver injury to hepatocellular carcinoma (HCC), yet effective therapeutic options remain limited. Jianpi Huayu Decoction (JPHY) has been used clinically in patients with HCC accompanied by hepatic fibrosis, but its anti-fibrotic mechanisms remain unclear.

Evaluation of nirmatrelvir/ritonavir treatment for COVID-19 on health-related outcomes: a global economic value systematic literature review.

Journal of medical economics · 6 July 2026 · Mugwagwa, Tendai, Marcano Belisario, José, Hartley, Louise, Phan, Nguyen Thi Nhan et al. PubMed 42406565

Nirmatrelvir/ritonavir (NMV/r) A systematic search of Embase, PubMed, Cochrane, and EconLit and of conference and health technology assessment agency websites was performed to identify economic analyses published between January 2022 and October 2025. Of the 33 included economic evaluations, most were cost-utility analyses ( Most studies were conducted in high-income countries, were based on different COVID-19...

ME/CFS 2 new

Full feed: ME/CFS research tracker

Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS.

Frontiers in neuroscience · 6 July 2026 · Thapaliya, Kiran, Marshall-Gradisnik, Sonya, Inderyas, Maira, Barnden, Leighton PubMed 42403482

The glymphatic system is a recently discovered brain waste clearance system that is mostly active during sleep and disengaged during wakefulness. Impaired glymphatic function leads to the deposition of metabolic waste products in the brain potentially causing inflammation leading to various symptoms in ME/CFS.

Cognitive impairment and prefrontal TGF-β1 elevation in a rat model of fatigue.

Frontiers in psychiatry · 6 July 2026 · Wu, Yingru, Wen, Xuan, Fang, Zeman, Zhang, Jinling et al. PubMed 42404713

Chronic fatigue syndrome (CFS) is a complex disorder of unknown etiology, characterized by persistent fatigue unrelieved by rest and accompanied by cognitive dysfunction. While dysregulated cytokines are implicated in CFS pathogenesis, the role of anti-inflammatory transforming growth factor β1 (TGF-β1) remains poorly defined.

Postural Orthostatic Tachycardia Syndrome (POTS) 4 new

Full feed: POTS research tracker

Author Response to "Dysautonomia in Long COVID: Why Sex Differences Matter in Cardiovascular Risk Assessment".

Clinical medicine & research · 9 July 2026 · Tamariz, Leonardo, Palacio, Ana PubMed 42419817

No abstract available.

Safety monitoring of bivalent, quadrivalent, and 9-valent human papillomavirus vaccination in Japan: The vaccine effectiveness, networking, and universal safety (VENUS) study.

Human vaccines & immunotherapeutics · 8 July 2026 · Ishiguro, Chieko, Morita, Hiroya, Mimura, Wataru, Tsuzuki, Shinya et al. PubMed 42415471

Safety data on human papillomavirus (HPV) vaccination in the Japanese population remain limited owing to the lack of healthcare databases available for vaccine safety assessment. In this study, we assessed the risk of adverse events of special interest (AESIs) following HPV vaccination among females aged 12-26 y using medical claims data linked to routine or catch-up vaccination records provided by municipalities.

Prolonged rhythmic mid-temporal theta of drowsiness in a patient with postural orthostatic tachycardia syndrome: A diagnostic challenge.

Epileptic disorders : international epilepsy journal with videotape · 7 July 2026 · Sun, Ruiqing L, Valaparla, Vijaya, Reiley, Luz Elena PubMed 42412583

No abstract available.

Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Journal of cardiovascular pharmacology · 7 July 2026 · Qadri, Syeda Hafsa, Nardelli da Silva, Ana Beatriz, Malaj, Andela, Ahmed, Rohma et al. PubMed 42411507

Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated.

Mast Cell Activation Syndrome (MCAS) 17 new

Full feed: MCAS research tracker

Targeting IL-33 in Precision Neuroimmunology: Cellular Mechanisms and Therapeutic Strategies for CNS Disorders.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 10 July 2026 · Li, Lili, Wang, Shuting, Duan, Lian, Zhang, Luyu et al. PubMed 42430077

Interleukin-33 (IL-33), an alarmin cytokine of the IL-1 family, has emerged as a pivotal regulator of neuroimmune interactions in the central nervous system (CNS). Acting through its receptor ST2, IL-33 orchestrates diverse immune responses by modulating microglial polarization, shaping T cell differentiation, activating type 2 innate lymphoid cells (ILC2s), and engaging mast cell-macrophage regulatory circuits.

Phenotype-specific associations of mosaic chromosomal alterations in systemic sclerosis.

Annals of the rheumatic diseases · 10 July 2026 · Nishio, Yuki, Ishikawa, Yuki, Uchiyama, Shunsuke, Liu, Xiaoxi et al. PubMed 42425799

Mosaic chromosomal alterations (mCAs) increase with age and are associated with many diseases, including autoimmune diseases. The associations between mCAs and systemic sclerosis (SSc) and its clinical subtypes have not been explored.

Pharmacological modulation of TRPV2 enhances migration and induces Immunoglobulin E (IgE)-independent degranulation of mast cells.

Cell calcium · 10 July 2026 · Leipe, Andrea, Raudszus, Rick, Urban, Nicole, Schaefer, Michael et al. PubMed 42424794

Transient receptor potential vanilloid 2 (TRPV2) is highly expressed in immune cells, including mast cells, yet its functional role in mast cell physiology remains incompletely understood. Given the increasing global prevalence of immune disorders, elucidating TRPV2-mediated mechanisms may uncover novel therapeutic approaches.

Hematopoietic mosaic chromosomal alterations are pleiotropic drivers of inflammaging, multimorbidity, and mortality.

medRxiv : the preprint server for health sciences · 10 July 2026 · Vincelette, Nicole D, Mo, Qianxing, Cheng, Chia-Ho, Park, Junyoung et al. PubMed 42428085

Mosaic chromosomal alterations (mCAs) are a prevalent but poorly understood form of clonal hematopoiesis (CH). Whether mCAs contribute to disease independently of CHIP, and whether their large-scale genomic effects can be resolved to actionable targets, remain unknown.

Topical Trichosanthis Radix Water Extract Attenuates Atopic Dermatitis-Like Skin Inflammation: Marker Standardization, Network Pharmacology, and Preclinical Validation.

Mediators of inflammation · 9 July 2026 · Kim, Hye-Min, Kim, Geun-Lip, Gil, Tae-Young, Sim, Ha-Yeon et al. PubMed 42423275

Trichosanthis Radix (TR) is a pharmacopeial crude drug traditionally used to clear heat, reduce swelling, expel pus, and generate fluids, suggesting potential relevance to inflammatory skin disorders such as atopic dermatitis (AD). In this study, we evaluated the AD-related activity of a TR water extract using an integrated workflow combining network-based target analysis, marker compound analysis, and experimental...

Origami Metamaterials Based on Low-Melting-Point Alloy Phase Transition: Breaking the Trade-Off Between Reusability and Energy Absorption Quality.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 9 July 2026 · Liu, Yupeng, Zhao, Wei, Zeng, Chengjun, Fan, Jiuming et al. PubMed 42423558

Mechanical metamaterials provide a promising platform for designing energy-absorbing materials. However, the trade-off between reusability and energy absorption quality limits the overall performance of existing energy-absorbing metamaterials.

New-onset allergic diseases after SARS-CoV-2 infection: mechanistic hypotheses and emerging strategies for risk stratification.

Frontiers in immunology · 9 July 2026 · Li, Encheng, Shi, Manying, Huang, Shixiang PubMed 42421939

Multinational cohort studies consistently associate SARS-CoV-2 infection with elevated incidence of allergic diseases, with hazard ratios of 2.25 for asthma and 1.23 for allergic rhinitis persisting beyond six months post-infection; whether this excess risk reflects

Dual-Site-Binding Ligand-Driven (100) Orientation for Efficient and Stable Perovskite Solar Cells.

Advanced materials (Deerfield Beach, Fla.) · 9 July 2026 · Lv, Dongyang, Wang, Cheng, Li, Luyao, Chu, Weicun et al. PubMed 42424102

Regulating crystal orientation is a powerful strategy for enhancing the optoelectronic performance of perovskite solar cells (PSCs). However, most existing approaches rely on single-site ligand binding, which not only forms insulating layers that hinder charge transport but also involves weak coordination that limits orientation control.

Caffeic acid attenuates stress-induced colon inflammation and barrier disruption in Sprague-Dawley rats.

Cytokine · 9 July 2026 · Mazumder, Sangita, Dubey, Itishree, Gupta, Arushi, Bhardwaj, Shivani et al. PubMed 42419153

Chronic stress promotes colonic inflammation by sustaining activation of the hypothalamic-pituitary-adrenal (HPA) axis, inducing oxidative stress, and disrupting barrier integrity, thereby exacerbating inflammatory bowel disease and irritable bowel syndrome. Therefore, there is a need for therapeutic compounds that can ameliorate stress-induced colonic inflammation.

Revisiting pharmacological actions of disodium cromoglycate in light of GPR35: New therapeutic contexts for classical drugs.

Biochemical pharmacology · 8 July 2026 · Tanaka, Satoshi PubMed 42413736

Mast cell stabilizers such as disodium cromoglycate have been used for decades as prophylactic anti-allergic agents, yet their molecular targets remained unknown, and their intracellular mechanisms were long debated. Identification of GPR35 as a receptor engaged by multiple mast cell stabilizers provided a new framework to reinterpret classical pharmacology.

Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.

Nature communications · 8 July 2026 · Tearle, Jacqueline LE, Sviriaeva, Ekaterina, Zhang, Fan, Jackson, Katherine Jl et al. PubMed 42414303

Primary sclerosing cholangitis (PSC) is a chronic, progressing cholestatic disease that often co-occurs with inflammatory bowel disease (PSC-IBD). PSC-IBD affecting the colon (PSC-ulcerative colitis or PSC-UC) resembles clinical UC, but is characterised by less severe disease flares, right-colon predominance, and a greater lifetime risk of colorectal cancer than UC alone.

Mast cell-derived IL-13 as a driver of Crohn disease-associated intestinal fibrosis.

Inflammatory bowel diseases · 8 July 2026 · Safari, Kwestan, Ma, Wei Jen, Sekhon, Prabhreet, Rai, Priya et al. PubMed 42418669

Crohn disease is a chronic, immune-mediated disease that can lead to intestinal fibrosis, strictures, and bowel obstruction. The Src homology 2 domain-containing inositol polyphosphate 5'-phosphatase-deficient (SHIP-/-) mouse develops spontaneous Crohn disease-like ileal inflammation and fibrosis.

Activation of GABA

Biochemical pharmacology · 8 July 2026 · Xie, Haoxian, Liu, Huilin, Xiu, Yixin, Lao, Rongkang et al. PubMed 42413737

Although the metabotropic GABA type B receptor (GABA

The scaffolding protein AKAP79/150 shapes innate immune responses to allergen.

Journal of immunology (Baltimore, Md. : 1950) · 6 July 2026 · Kaur, Suneet, Lin, Yu-Ping, Nakano, Hideki, Brown, Paula et al. PubMed 42406837

Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the lung.

Mast cell activation disorders: mechanisms, comorbidities and look alike.

Expert review of clinical immunology · 6 July 2026 · Theoharides, Theoharis C, Kempuraj, Duraisamy, Maitland, Anne PubMed 42405823

Mast Cells (MCs) are unique tissue immune cells found perivascularly close to nerves at interfaces with the external environment. Upon detection of danger signals, MCs act as master responders aiming to restore homeostasis.

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Allergy · 6 July 2026 · Tharakan, Anuj, Qu, Xufeng, Camarena, Carmen, Abaidoo-Myles, Araba et al. PubMed 42403014

Initiation of allergic responses requires activation of specialized subsets of T follicular helper (Tfh) cells called Tfh13 cells. Differentiation of these cells from naïve CD4

Cpg boosts peptide-based oral immunotherapy in mice with peanut allergy.

Frontiers in allergy · 6 July 2026 · Liu, Fang, Yang, Jun-Hui, Han, Lei, Liu, Qiao et al. PubMed 42404753

Effective therapies for peanut allergy (PA) remain limited. Cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) have emerged as promising adjuvants for allergen-specific immunotherapy (AIT).

No new studies this window for: PACVS, Lyme / PTLDS, Gulf War Illness, Other post-viral.

Trial activity

No ClinicalTrials.gov records in the tracker were updated during this window.

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 27 2026: 90 new studies

Sun, 05 Jul 2026 08:00:00 +0000

Between 29 June 2026 and 5 July 2026 the tracker indexed 90 new peer-reviewed studies and 0 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

90new studies this issue

0trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

Long COVID (PASC) 58 new

Full feed: Long COVID research tracker

[Long-COVID syndrome and lung-specific abnormalities following COVID-19].

Orvosi hetilap · 5 July 2026 · Fésü, Dorottya, Horváth, Gábor, Müller, Veronika PubMed 42402140

Following the acute phase of a SARS-CoV-2 infection, post-COVID - or long-COVID - syndrome may develop. This condition is characterized by unpleasant, persistent or new-onset symptoms following the acute phase of the infection.

Long COVID: Lived Experiences, Diagnosis, Treatment and Care.

Health expectations : an international journal of public participation in health care and health policy · 5 July 2026 · Mullard, Jordan PubMed 42402067

No abstract available.

Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice.

Neuroscience · 5 July 2026 · Lkhagvasuren, Battuvshin, Suematsu, Takafumi, Xiangyu, Liu, Hata, Tomokazu et al. PubMed 42401313

This study examined the long-term effects of polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA and Toll-like receptor 3 (TLR3) agonist, on behavioral and immune outcomes in chronically stressed mice. Male C57BL/6J mice were exposed to 21 days of wet bedding stress followed by a poly I:C injection.

Association Between Air Pollution and Post Acute Sequelae of SARS-CoV-2 (PASC).

American journal of respiratory and critical care medicine · 5 July 2026 · Jerrett, Michael, Nau, Claudia L, Young, Deborah R, Butler, Rebecca K et al. PubMed 42402207

No abstract available.

Understanding heterogeneity in paediatric long COVID research: an overview of reviews and recommendations for future pandemics.

BMC pediatrics · 4 July 2026 · Appel, Simone, Coughtrey, Anna E, Kyrdalen, Anika, Takeda, Andrea et al. PubMed 42399828

Studies of Long COVID or Post-COVID-19 condition in children and young people have varied considerably in their reported prevalences. We aimed to examine the methodological heterogeneity underlying this variability and explore whether methodological characteristics were correlated with reported Long COVID outcome prevalence, in order to inform recommendations to improve reporting in future pandemic-related...

Perceptions, acceptability and experiences of yoga to support long-COVID: a survey of people living with long-COVID.

BMC complementary medicine and therapies · 4 July 2026 · Cheshire, Anna, Cartwright, Tina PubMed 42399853

The impact of long-COVID can be substantial for individuals, health systems and the economy, nevertheless, treatment and support options are limited. Yoga offers a potential solution to reduce the burden of long-COVID, demonstrating positive impacts on the biological mechanisms implicated in long-COVID, key long-COVID symptoms and associated mental health challenges.

Coronary artery dilatation in neonates: A novel case series.

Journal of neonatal-perinatal medicine · 4 July 2026 · Bhat, Irfan Bashir, Rahul, Aswathy, Kn, Harikrishnan, Charulatha, Binsi et al. PubMed 42400138

BackgroundCoronary artery dilatation (CAD) in neonates is an uncommon but clinically important finding on echocardiography. Reported associations include multisystem inflammatory syndrome in the newborn (MIS-N) following COVID-19 infection, congenital cardiac malformations, and perinatal inflammatory states.

Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study.also ME/CFS

Journal of translational medicine · 4 July 2026 · Cambras, Trinitat, Domingo, Joan Carles, Sanmartín-Sentañes, Ramon, Alegre-Martín, José et al. PubMed 42399727

Light is a major environmental factor regulating circadian rhythms, sleep- wake cycles, and mood-related behaviors. Patients with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often experience circadian disruption and poor sleep quality, which severely compromise their quality of life; however, the relationship between light exposure and illness severity remains largely unknown.

[Status analysis of clinical outcome for treatment of long COVID with traditional Chinese and western medicines].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 3 July 2026 · Yan, Xing, Tang, Xiang, Zhang, Ya-Zi, Liu, Yao-Yuan et al. PubMed 42392788

This study sorted out the clinical outcome of traditional Chinese and western medicines in the treatment of long COVID to lay the foundation for the construction of a core indicator set. Search was made on some databases and platforms from their inception to December 2024, which included eight databases of CNKI, Wanfang, SinoMed, VIP, PubMed, Cochrane Library, EMbase, and Web of Science and three clinical research...

Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.also ME/CFSalso Lyme / PTLDS

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 3 July 2026 · Kaplan, Gary PubMed 42391726

Post-infectious syndromes including post-treatment Lyme disease syndrome (PTLDS), long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and pediatric acute-onset neuropsychiatric syndrome (PANS)/pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) share overlapping clinical phenotypes characterized by fatigue, cognitive dysfunction, sleep disturbance...

Symptom, functional, and medication overlap between long COVID and fibromyalgia.

Clinics (Sao Paulo, Brazil) · 3 July 2026 · Hackshaw, Kevin V, Osuna-Diaz, Michelle M, Sebastian, Katherine R, Nuguri, Shreya Madhav et al. PubMed 42398146

Long COVID (LC/PASC) and Fibromyalgia (FM) share prominent pain, fatigue, and cognitive symptoms and are often difficult to distinguish clinically. The authors compared LC/PASC and FM using harmonized questionnaires assessing symptoms, function, and medication burden to quantify phenotype overlap and inform biomarker development.

Spatial Immune Model of Alveolar Lung Infection (SIMALI) Identifies Structural Determinants of Lung Inflammation.

Research square · 3 July 2026 · Tasnim, Humayra, Forrest, Stephanie, Hofmeyr, Steven, Friedman, Alan et al. PubMed 42396494

Inflammation and lung damage in response to respiratory viral infection is a major cause of morbidity and mortality. How specialized lung alveolar structures contribute to variation in inflammatory lung damage observed in patients is a gap in current knowledge.

Self-management of long COVID symptoms with over-the-counter medicines and other non-prescribed therapies: a cross-sectional survey.

BMC public health · 3 July 2026 · Guan, Naijie, Turner, Grace, Hotham, Richard, Lange, Daniel et al. PubMed 42393618

The high prevalence of long COVID globally necessitates investigation into its self-management, especially given the absence of definitive and effective treatments and uneven access to healthcare services. This study surveyed the use of over-the-counter (OTC) medicines, supplements, remedies, and other non-prescription therapies for managing long COVID symptoms in the UK.

Post-COVID-19 Autonomic Dysfunction in an Adolescent: Ogilvie Syndrome With Acute Urinary Retention.

Journal of paediatrics and child health · 3 July 2026 · Musielak, Anna, Stachecka-Zyk, Alicja, Frankowicz, Magdalena, Noskiewcz, Jakub et al. PubMed 42394349

No abstract available.

Post-COVID neuropsychiatric symptoms in India: Prevalence, risk factors, and persistence.

Indian journal of psychiatry · 3 July 2026 · Laha, Poulami, Gowda, Guru S, Moirangthem, Sydney, Veenakumari, H B et al. PubMed 42396417

The global research has actively investigated the post-COVID neuropsychiatric symptoms (PCNS). There is a paucity of studies from India that explore long-term PCNS.

Perception of body donation among the Phase-1 medical students, a questionnaire-based study.

F1000Research · 3 July 2026 · Murlimanju, B V, Shenoy, M Praveen, Ullal, Sheetal D, Vadgaonkar, Rajanigandha PubMed 42396378

This study aimed to examine the knowledge, attitude, and perception of body donation among Phase-1 medical students at our institution. The objectives were to assist teachers in providing insight into the perception of this among students.

PNPLA3 I148M Variant Activates Hepatic Stellate Cells via AMIGO2 Upregulation Using iPSC-Derived Model.

Liver international : official journal of the International Association for the Study of the Liver · 3 July 2026 · Toshida, Katsuya, Takeishi, Kazuki, Itoh, Shinji, Kurihara, Takeshi et al. PubMed 42394201

A variant in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) was reported to be related to metabolic-associated fatty liver disease. However, the mechanism by which this variant leads to liver fibrosis has not been unveiled yet.

Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome.

Brain, behavior, & immunity - health · 3 July 2026 · Martins, Daniel, Cai, Ziyuan, Mariani, Nicole, Borsini, Alessandra et al. PubMed 42395031

Post-COVID-19 syndrome encompasses persistent cognitive, neurological, and psychiatric symptoms following SARS-CoV-2 infection, profoundly affecting global quality of life. Clarifying the neurobiological basis of these symptoms is vital for effective therapeutic interventions.

Long COVID and health-related quality of life: a systematic review of immune, inflammatory, and metabolic markers.

Frontiers in public health · 3 July 2026 · Turebekova, Dinara, Kosherova, Bakhyt, Dauletkaliyeva, Zhaniya, Shayakhmetova, Yelena et al. PubMed 42395315

Long COVID is known to be associated with prolonged multiple organ symptoms and decreased health-related quality of life (HRQoL), but the pathogenesis and relationship between immune, inflammatory, and metabolic biomarkers and HRQoL remains poorly understood. This systematic review aims to synthesize the evidence on the health-related quality of life of patients with Long COVID and to summarize the reported...

FGFR Inhibitor AZD4547 Disrupts Inflammatory CAF Crosstalk With Cancer Cells and Macrophages and Attenuates Metastasis in Pancreatic Cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 3 July 2026 · Mostafa, Ahmed M R H, Hemdan, Ahmed G, Assayag, Franck, Prakash, Jai PubMed 42394340

Cancer-associated fibroblasts (CAFs) are key cell types within the tumor microenvironment (TME), responsible for their pro-tumorigenic effects and metastasis. Specifically, inflammatory CAFs (iCAFs), a CAF subtype, are known to induce tumor cell progression, migration, and immunosuppression.

Exploring surgical patients' health literacy following the use of a patient safety checklist - A qualitative study.

Patient education and counseling · 3 July 2026 · Austarheim, Ann Kristin Sandsbakk, Wæhle, Hilde Valen, Harris, Kristin, Haugen, Arvid Steinar PubMed 42391984

Low health literacy is common among surgical patients, with few interventions addressing this problem. A patient safety checklist (PASC) was developed to involve elective surgical patients in optimising health and safety before and after surgery.

Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

European journal of pharmacology · 3 July 2026 · Zhu, Mengqi, Yang, Xi, Xie, Jingmin, Shi, Xiaojing et al. PubMed 42392250

Liver fibrosis constitutes a central pathological hallmark of advanced chronic liver diseases. However, effective therapeutic targets and pharmacological interventions remain insufficiently defined.

Challenges in Preprocessing Routine Laboratory Data for Machine Learning.

Studies in health technology and informatics · 3 July 2026 · Wendt, Katharina, Marschollek, Michael, Illig, Thomas, Wolff, Dominik et al. PubMed 42394025

Post-Covid syndrome remains a major clinical challenge due to the lack of specific biomarkers and reliance on exclusion criteria. Routine laboratory data offers potential for identifying biological signatures, but their use in machine learning is hampered by data quality issues.

Engineering

Frontiers in bioengineering and biotechnology · 2 July 2026 · Štravs, Petra, Fierobe, Henri-Pierre, Perret, Stéphanie, Berlec, Aleš PubMed 42389466

Lactic acid bacteria are commonly used to convert carbohydrates into valuable products like lactic acid, but they currently rely on carbon sources from food crops, raising sustainability and cost concerns. Lignocellulosic waste is a more sustainable alternative, yet these bacteria cannot naturally break down cellulose to grow on it.

Distinctive Endoscopic Ultrasound Features of Pancreatic Adenosquamous Carcinoma: A Propensity Score-Matched Analysis.

Digestive diseases and sciences · 2 July 2026 · Ke, Chen, Yini, Dang, Qiang, Zheng, Ming, He et al. PubMed 42390720

Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive malignancy with poorer prognosis than pancreatic ductal adenocarcinoma (PDAC). This study aimed to identify distinctive endoscopic ultrasound (EUS) features for pre-operative differentiation between PASC and PDAC.

Autoantibody-mediated pain in long COVID: evidence from multiple lines.

Frontiers in immunology · 2 July 2026 · Nicaise, Charles, Bulpa, Pierre, Jamoulle, Marc PubMed 42389520

No abstract available.

Voice Outcomes of Patients Intubated for Critical COVID Illness: A Multicenter Study.

OTO open · 1 July 2026 · Caruana, Francesco F, Gelbard, Alexander, Francis, David, Pitman, Michael J et al. PubMed 42381644

Characterize the long-term vocal outcomes of patients who required ICU care for COVID-19 infection. Prospective cohort study.

SARS-CoV-2 reinfection: a possible contributing factor to long COVID in children and adolescents.

Frontiers in pediatrics · 1 July 2026 · Chipol-Ceja, Rosela Lucero, Morales-Romero, Jaime, Rivero-López, Carlos Alonso, Pérez-Callejas et al. PubMed 42382648

Following the end of the COVID-19 pandemic, attention shifted towards patients who developed sequelae, persistent symptoms, or relapsing or remitting symptoms of new conditions after a prior history of acute SARS-CoV-2 infection. The objective of the present study was to identify the prevalence, clinical characteristics, and potential associated factors of long COVID in children treated during the pandemic in a...

SARS-CoV-2 inhibitory, anti-inflammatory, antibacterial activity of black chokeberry (Aronia melanocarpa (Michx.) Elliott) branches' extracts and proanthocyanidins, and their synergistic interaction with antibiotics.

Scientific reports · 1 July 2026 · Andersone, Anna, Ramata-Stunda, Anna, Nikolajeva, Vizma, Truhins, Marks et al. PubMed 42380577

Bacteria and viruses' potential collaboration has been reported to result in enhanced infection pathogenesis. New antimicrobial agents are necessary, but stronger synthetic antibiotics cause more severe side effects.

Psychological and medical outcomes of post-COVID-19 patients: A longitudinal study.

Journal of psychosomatic research · 1 July 2026 · Benfante, Agata, Di Tella, Marialaura, Chiappero, Chiara, Nocera, Claudia et al. PubMed 42385306

The coronavirus disease (COVID-19) pandemic affected different populations from a physical and psychological point of view. Psychological characteristics can have an impact on adjustment to illness conditions and increase the risk of persistence of physical symptoms and psychopathology.

Prolonged return to work and hampered work ability: insights from a scoping review on the impact of long COVID on healthcare workers job performance.

BMC health services research · 1 July 2026 · Delano, Pia, Serra-Suton, Vicky, Benavides, Fernando G, Utzet, Mireia PubMed 42380995

Healthcare workers (HCWs) may have a higher risk of developing long COVID due to greater exposure to COVID-19, with symptoms extending beyond the acute phase impacting their daily living activities and job performance. To systematically map the existing literature on the impact of long COVID on HCWs' job performance, focusing on their time to return to work and work ability.

Multimorbidity patterns and phenotype transitions in patients with clinician-coded long COVID: a multicenter US electronic health record cohort study.

BMC infectious diseases · 1 July 2026 · Wang, Xiaofeng F, Huang, Shuaiqi, Xu, Yaomin, Zou, Yan et al. PubMed 42380873

Long COVID is clinically heterogeneous, but longitudinal changes in documented chronic disease burden and transitions in multimorbidity phenotypes after infection are not well characterized in routine care. We considered 425,614 patients with clinician-coded long COVID (ICD-10-CM U09.9) and a definable COVID-19 index date between October 1, 2021 and September 16, 2024 using deidentified electronic health record data...

Influence of inflammatory and reninangiotensin system gene polymorphisms ACE2 rs2285666, IL1A rs1800587, and TNF rs1800629 on COVID-19 severity and the persistence of symptoms in the post-COVID-19 phase: a cross-sectional study.

Einstein (Sao Paulo, Brazil) · 1 July 2026 · Daudt-Lemos, Matheus, Oliveira, Evelyn Maciel de, Ramos-Silva, Alice, Rosário, Natalia Fonseca et al. PubMed 42384984

We evaluated the influence of single-nucleotide polymorphisms in cytokine, renin-angiotensin-aldosterone system, and uromodulin genes on COVID-19 severity and the persistence of symptoms in the post-COVID phase. Two cross-sectional cohort studies were conducted: a retrospective cohort (cohort 1) from early phase of the pandemic and a prospective cohort (cohort 2) including patients with symptoms in the post-COVID...

Hybrid deep learning framework for cardiovascular risk prediction in post-COVID-19 patients.

Scientific reports · 1 July 2026 · Diana Juliet, S, Banumathi, J, Anix Joel Singh, J PubMed 42380347

Cardiovascular complications associated with Post-COVID-19 Patients remain difficult to identify at early stages due to heterogeneous physiological manifestations and the limited integration of imaging and clinical indicators in conventional diagnostic frameworks. To address this challenge, this work proposes a multimodal deep learning framework for cardiovascular disease (CVD) risk prediction by integrating cardiac...

Exploring the mechanisms of acupuncture in improving cognitive function in post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome: study protocol for a randomized controlled trial using multimodal MRI.also ME/CFS

Frontiers in neurology · 1 July 2026 · Luo, Tingting, Luo, Yang, Huang, Liang, Jin, Hongjiao et al. PubMed 42383026

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common sequela following COVID-19. Although cognitive dysfunction is one of the most debilitating symptoms in ME/CFS, effective therapies are limited.

Cognitive Rehabilitation and Functional Outcomes in Long COVID-Related Cognitive Impairment: A Randomized Clinical Trial.

JAMA network open · 1 July 2026 · Vanova, Martina, Patel, Aysha Mohamed Rafik, Scott, Iona, Gilpin, Gina et al. PubMed 42384384

Cognitive impairment is common in long COVID and severely affects daily life, with no proven treatments to date. To evaluate the ability of cognitive rehabilitation (CR) to improve goal attainment, cognitive, and clinical outcomes in individuals with cognitive impairment as part of long COVID.

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Biochemical pharmacology · 1 July 2026 · Tang, Chao, Song, Huanhuan, Zhu, Qian, Han, Pengzhe et al. PubMed 42379475

Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular injury, inflammation, and progressive fibrosis, yet current non-invasive tests do not directly assess the cellular drivers of fibrogenesis. Platelet-derived growth factor receptor beta (PDGFRβ) is highly expressed on activated hepatic stellate cells (aHSC), a major effector cell population in MASH.

Young People Navigating the Looping Effects of Long Covid: Exhausting Agency and the 'Ongoing After' of Pandemic.

Sociology of health & illness · 30 June 2026 · Rhodes, Tim, Cowan, Hannah, Clarke, Zaira, Fernes, Praveena et al. PubMed 42376966

Seeing beyond the COVID-19 pandemic as an extraordinary spectacle situated in the past, we draw on qualitative research with young people to trace experiences of Long Covid as 'looping effects' of entangling physical and social impacts which intersect with, and extend, those of pandemic. Navigating the capacity to do ordinary things becomes highly contingent, and exhausting work, in the face of Long Covid.

The Silent Crisis: Loneliness in Older Adults-A Critical Review of Impacts, Strategies and Path Forward.

Scandinavian journal of caring sciences · 30 June 2026 · Abdul Rahman, Hanif, Zahari, Nurrabiatul Haziqah PubMed 42376726

Loneliness, distinct from social isolation, is a subjective sense of social disconnection exacerbating a public health crisis among older adults. Affecting ~33% of community-dwelling individuals aged 50-80 years post-COVID-19, it rivals smoking in mortality risk and drives cognitive, cardiovascular, and mental health declines.

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle-Mediated Crosstalk in Pancreatic Cancer.

Journal of extracellular vesicles · 30 June 2026 · Chang, Jiawei, Alenizi, Shafi, Milioli, Heloisa Zaccaron, Lay, Winston et al. PubMed 42377994

Pancreatic cancer (PaC) remains one of the deadliest cancers, with 5-year survival rates of 13%. A major driver of its aggressiveness is the tumour microenvironment (TME), which fuels tumour growth, metastasis, and therapeutic resistance through dynamic, bi-directional communication between cancer cells, fibroblasts, and immune cells.

Post-hospitalized Health Conditions of Covid-19 patients: A Cross-sectional study in Bangladesh.

Mymensingh medical journal : MMJ · 30 June 2026 · Sharif, M M, Jabed, M A, Mahanta, J, Bari, M S et al. PubMed 42375052

The objective of this research is to examine comorbidity status of hospitalized Covid-19 patients and its association with post-Covid-19 health complications. Data were collected from 1207 Covid-19 patients who were hospitalized at Dhaka Medical College Hospital (DMCH), Bangladesh from May 2020 to April 2021.

Genetic association between LONG COVID and TMPRSS2 polymorphisms (rs12329760 and rs2070788) in Brazilian healthcare professionals.

Frontiers in cellular and infection microbiology · 30 June 2026 · Telles, Alysson Fellipe Costa, Menezes Junior, Bearli Souza, Dos Santos, Cliomar Alves, Sena et al. PubMed 42376321

Long COVID syndrome has a multifactorial cause that is not fully understood and may be influenced by both external and intrinsic factors. In this context, a Genome-Wide Association Study (GWAS) was proposed to evaluate the association between Single Nucleotide Polymorphisms (SNPs) in TMPRSS2 (rs12329760 and rs2070788) and the occurrence of Long COVID in 363 Brazilian healthcare professionals, recruited using a...

Factors affecting exercise performance at the 6-min walk test in long-COVID: a multicenter study from Italy.

Internal and emergency medicine · 30 June 2026 · Floridia, Marco, Weimer, Liliana Elena, Palange, Paolo, Ciardi, Maria Rosa et al. PubMed 42377750

The cofactors potentially affecting exercise performance after COVID-19 are still incompletely investigated. The contribution of several clinical and demographic variables to the exercise capacity measured with the 6-min walk test was assessed in multivariable analyses that used the absolute distance walked in 6 min (6MWD) and an impaired performance (6MWD < 60% of the predicted value) as study outcomes.

Characterization of a lytic polysaccharide monooxygenase important for utilization of chitin in Chitinibacter mangrovi FCG-7.

International journal of biological macromolecules · 30 June 2026 · Huang, Liju, Fang, Hongliang, Yang, Dengfeng, Yang, Liyan et al. PubMed 42372895

Lytic polysaccharide monooxygenases (LPMOs) are crucial for recalcitrant biomass degradation. We characterized CmLPMO10, an AA10 LPMO from Chitinibacter mangrovi FCG-7, and demonstrated its essential role in α-chitin utilization through transcriptomics and gene deletion.

Case Report: Metastatic right ventricular tumor and pulmonary embolism from cervical cancer post COVID-19 infection.

Frontiers in immunology · 30 June 2026 · Yang, Yuemei, Zhu, Xiaohui, Hu, Danli PubMed 42375366

The intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix combined with pulmonary embolism is extremely rare, with mean survival less than six months. We report a case of a 52-year-old female with stage IVB cervical squamous cell carcinoma (SCC) and cardiac metastasis presented with exertional dyspnea and chest pain concerning pulmonary embolism (PE) post COVID-19 infection.

Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes.

The Journal of clinical endocrinology and metabolism · 30 June 2026 · Lee, Ju Hee, Kim, Ha Young, Park, Min Jeong, Hong, A Ram et al. PubMed 42375012

The 2025 clinical guideline for primary aldosteronism (PA) recommends a diagnostic and therapeutic pathway stratified by lateralization risk. The PA severity classification (PASC) integrates biochemical and clinical features and is intended to inform graded recommendations for adrenal venous sampling (AVS).

A randomised, placebo-controlled, triple-blind clinical trial to investigate the efficacy of

Frontiers in human neuroscience · 30 June 2026 · Matias-Guiu, Jordi A, Arelin, Katrin, Serrano, Paula Jiménez, Wacker, Anna et al. PubMed 42376237

Cognitive impairment is frequent in post-COVID-19 syndrome (PCS). The understanding of the pathogenesis is still limited.

The Time Course of Serum Iron and Serum Ferritin Concentrations Post-COVID-19 and Influenza Vaccinations.

Case reports in infectious diseases · 29 June 2026 · Lodemann, Peter, Tsuprykov, Oleg, Lawaczeck, Rüdiger PubMed 42371502

Temporal responses of serum iron and ferritin in COVID-19 infection and vaccination remain insufficiently characterized. This case report presents their timeline after SARS-CoV-2 and influenza vaccinations and may serve as a model for future studies.

Progressive Supranuclear Palsy Unmasked After Post-COVID-19 Functional Decline in an Elderly Patient: A Diagnostic Challenge.

Cureus · 29 June 2026 · Fulco, Enrico PubMed 42367505

Progressive supranuclear palsy (PSP) is a rare neurodegenerative tauopathy characterized by early postural instability, vertical supranuclear gaze palsy, axial rigidity, and poor response to levodopa therapy. Diagnosis remains challenging, particularly in the early stages, because of overlap with other Parkinsonian syndromes.

Post-COVID: a specific neuropsychological profile in performance deficits.

Journal of neural transmission (Vienna, Austria : 1996) · 29 June 2026 · Müller, Britta, Balz, Ulrike, Bartels, Katharina, Eggers, Farina et al. PubMed 42371051

SARS-CoV-2 is frequently associated with cognitive impairment. When symptoms persist for more than four weeks after acute infection, a Long-COVID condition is diagnosed.

Microthrombi targeted nano-micelle synchronizing endothelial gap opening and matrix decompression for augmenting drug perfusion within pancreatic cancer.

Acta pharmaceutica Sinica. B · 29 June 2026 · Yang, Mengnan, Tong, Yuqing, Yin, Shaoping, Zhang, Hengchuan et al. PubMed 42368558

Local inhibition of the "patching" function of tumor-associated platelets against neutrophil infiltration-caused vascular breaches has been used as an "enhanced permeability and retention (EPR) amplification" strategy. Nevertheless, the vascular leakage-resulted elevation of interstitial fluid pressure (IFP) could impact tumoral perfusion and convection of nanodrugs.

Mapping the occupational therapy process in response to COVID-19 and long COVID: A scoping review.

The British journal of occupational therapy · 29 June 2026 · Cezar da Cruz, Daniel, Haertl, Kristine, Tomlin, George S, Yu, Chih-Huang et al. PubMed 42371512

COVID-19 and long COVID have had an impact worldwide on people's participation in occupations. Occupational therapists play a role in supporting individuals' recovery and participation in daily life.

Longitudinal trajectories of hematological indices and serum metalloproteinases-2 and 9 over 1 year after moderate and severe COVID-19.

Frontiers in medicine · 29 June 2026 · Salomão, Rebecca, Pasquarelli-do-Nascimento, Gabriel, Ananias, Mayara, Assis, Victoria et al. PubMed 42369154

The long-term clinical burden of Coronavirus disease (COVID-19) remains substantial, yet one-year cohort evidence linking blood-based biomarkers to persistent sequelae is limited. We conducted a longitudinal study in adults aged 18-80 years who were classified as moderate or severe COVID-19 or non-COVID-19 controls.

Impact of COVID-19 Infection and Vaccination on Abdominal-based Microvascular Breast Reconstruction Outcomes.

Plastic and reconstructive surgery. Global open · 29 June 2026 · Tobias, Finn, Fazzalari, Amanda, Malapati, Sri Harshini, Hyland, Colby et al. PubMed 42367705

SARS-CoV-2 (COVID-19) infection increases thrombotic risk; however, its impact on microsurgical breast reconstruction outcomes remains unclear. This study examines postoperative complications in patients following abdominal-based microvascular breast reconstruction relative to (1) timing relative to the COVID-19 pandemic, (2) history of COVID-19 infection, and (3) time since COVID-19 vaccination/booster.

Idiopathic anaphylaxis and histamine dysregulation: Revisiting pathophysiologic assumptions.also MCAS

The Nurse practitioner · 29 June 2026 · Applewhite, Tneecia L PubMed 42370768

Idiopathic anaphylaxis (IA) is a diagnosis of exclusion, and the etiology remains elusive. Research on immunoglobulin E (IgE)-mediated anaphylaxis has identified histamine as the immune system mediator, but dietary histamine's potential role in IA is often overlooked.

Dissociation Between Peripheral Muscle Strength and Exercise Capacity in Symptomatic Post-COVID-19 Individuals: Implications for Musculoskeletal Rehabilitation.

Musculoskeletal care · 29 June 2026 · Silva, Kaique Fernando Macedo da, Sczepanski, Felipe, Júnior, Vagner Pires de Campos, Brunnquell, Claudia PubMed 42366452

Infection with SARS-CoV-2 may result in persistent functional impairment after the acute phase of the disease. Emerging evidence suggests that the presence and intensity of COVID-19-related symptoms may be associated with deficits in muscle strength and physical performance during the post-infection period.

Associated thromboembolic events to the post COVID syndrome: a systematic review and meta-analysis.

Frontiers in cardiovascular medicine · 29 June 2026 · Endara-Mina, Jesús, Escudero, Cristopher-Josue, Intriago, Cesar, Coloma-Ramirez, Lisseth et al. PubMed 42368852

The COVID-19 pandemic has imposed a substantial worldwide health burden; a fraction of people develops post-COVID syndrome, in which symptoms persist long after the initial phase of infection. Although these individuals may be more susceptible to developing thromboembolic events, the extent and significance of this link remain uncertain.

"That's not my silo": Navigating fragmented long COVID care in the mid-Atlantic United States.

SSM. Qualitative research in health · 29 June 2026 · Tan, Heang-Lee, Rosser, Erica, Hernandez, Angélica Lopez, Fei, Y Christine et al. PubMed 42367370

Long COVID is a chronic illness affecting multiple organ systems, which can be at odds with a highly specialized and siloed U.S. healthcare system. Patients frequently see multiple specialists for diverse symptoms, creating substantial coordination challenges.

ME/CFS 2 new

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Higher-order brain processes, rather than early processing, underlie sensory problems in ME/CFS: evidence from ERPs.

Frontiers in medicine · 3 July 2026 · Kumar, Sanjay, Veldhuis, Alfred, Yazdani, Farzaneh PubMed 42396162

Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) experience significant sensory problems that affect their personal, social and occupational life. However, there is no clear understanding of how the sensory problems manifest in ME/CFS.

Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.

Biochemistry and biophysics reports · 30 June 2026 · Rydland, Anne, Yran, Elena Støvring, Nyman, Tuula A, Strand, Elin Bolle et al. PubMed 42375682

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood.

Chronic Lyme / Post-Treatment Lyme Disease Syndrome 2 new

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Antiphospholipid antibodies in acute and post-treatment Lyme disease.

Infection and immunity · 5 July 2026 · Shrestha, Muskan, Hickman, Anna F, Zhong, Yuelin, Zvinys, Audre et al. PubMed 42402029

Acute Lyme disease is caused by a

Assessment of the frequency of IgM and IgG antibodies against

Annals of agricultural and environmental medicine : AAEM · 30 June 2026 · Koczanowicz, Sylwia, Nowak-Chmura, Magdalena, Hudy, Dorota, Baranowska, Karolina et al. PubMed 42374672

Borreliosis, also known as Lyme disease, is a chronic, multi-organ illness that is very difficult to diagnose. It is caused by the spirochete Serum for the study was obtained from 99 randomly selected patients who reported for routine testing at the medical diagnostic laboratory in Krynica-Zdrój.

Postural Orthostatic Tachycardia Syndrome (POTS) 8 new

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The co-existence of Ehlers-Danlos syndrome and postural orthostatic tachycardia syndrome: A systematic review of the literature.

Autonomic neuroscience : basic & clinical · 4 July 2026 · Kwok, Chun Shing, Hagger, Georgia, Gillespie, David, Hall, Mark et al. PubMed 42398445

There is a growing body of literature evaluating both postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS). We conducted a systematic review to evaluate what is currently known about the co-existence of both conditions.

Multimodule Human-Artificial Intelligence Collaboration Pipeline for Large Language Model-Assisted Thematic Analysis Across Digital Health Interview Studies: Comparative Evaluation Study.

JMIR medical informatics · 4 July 2026 · Bai, Yunbing, Finkelstein, Joseph PubMed 42398927

Qualitative thematic analysis is widely used in health research to examine patient experiences and inform the refinement of digital health interventions, but it is time- and labor-intensive. Large language models (LLMs) may help accelerate this process, yet their performance may depend not only on the model itself but also on how the analytic workflow is structured.

Distinct sensory and autonomic involvement in hypermobile Ehlers-Danlos syndrome compared with idiopathic small fiber neuropathy: a multimodal study.

Scientific reports · 4 July 2026 · Dell'Aversana, Domenico, Provitera, Vincenzo, Trinchillo, Assunta, Masciarelli, Francesca et al. PubMed 42399338

Hypermobile Ehlers-Danlos syndrome (hEDS), frequently presents with pain and autonomic symptoms suggestive of small fiber neuropathy (SFN). However, systematic comparisons between hEDS and idiopathic SFN (iSFN) using combined clinical, functional, and morphological approaches are lacking.

Feasibility and Preliminary Outcomes of a Brain/Body Intervention for Postural Tachycardia Syndrome (POTS): Pilot Trial of POts Reprocessing Therapy (PORT).

Research square · 3 July 2026 · Crouch, Taylor B, Chase, Spencer Owen, Redman, Tammy, Wells, Mary et al. PubMed 42396528

Postural tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by orthostatic intolerance and frequently accompanied by a broad constellation of debilitating symptoms. Emerging evidence suggests that dysregulation within central-autonomic regulatory networks may contribute to symptom persistence.

Holter-Based Heart Rate Variability Distinguishes Adolescent Postural Orthostatic Tachycardia Syndrome from Healthy Controls.

Pediatric cardiology · 1 July 2026 · Kakavand, Bahram, Ebadi, Ameneh, Kakavand, Arman A, Rueda-De-Leon, Elena PubMed 42380672

Postural orthostatic tachycardia syndrome (POTS) is associated with autonomic dysregulation, but ambulatory markers that capture autonomic phenotype remain incompletely defined. To compare Holter-derived heart rate variability (HRV) metrics between adolescents with POTS and healthy controls and to derive candidate discriminatory thresholds.

Autonomic Assessment and Management in Sports-Related Concussion.

Neurologic clinics · 1 July 2026 · Vanood, Aimen, Arca, Karissa N PubMed 42379671

Autonomic dysfunction, or dysautonomia, is increasingly being recognized as a complication of concussion. While the symptoms can overlap with other postconcussion sequelae, it is important to distinguish the patient suffering from postconcussion dysautonomia in order to provide proper symptomatic management and aid in recovery.

The body and the brain keep the score: a data-driven conceptual model linking trauma and postural tachycardia syndrome.

Frontiers in psychology · 29 June 2026 · Crouch, Taylor B, Chelimsky, Gisela, Boylan, Laura, Maxwell, Madison et al. PubMed 42369281

Postural tachycardia syndrome (POTS) is a common, often disabling disorder of autonomic nervous system regulation without a unifying etiological account. Converging evidence suggests infectious, physical, and emotional threats frequently precede onset.

Pelvic venous disorders and orthostatic intolerance: A systematic review of diagnostic associations and treatment outcomes.

Autonomic neuroscience : basic & clinical · 29 June 2026 · Imami, Maliha R, Galdino, Vandilson Dos Santos, Harvey, Paula, Selke, Moira Sarah et al. PubMed 42372331

Pelvic venous disorders (PeVD) are recognised causes of chronic pelvic pain; emerging evidence suggests that venous outflow obstruction or reflux can also provoke orthostatic intolerance (OI) by infra-diaphragmatic pooling and reduced preload. Diagnostic and therapeutic frameworks for this overlap remain poorly defined.

Mast Cell Activation Syndrome (MCAS) 20 new

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Lactiplantibacillus plantarum SLpl116 attenuates OVA-induced food allergy with ecological restoration of the gut microbiota and immune rebalancing.

NPJ science of food · 5 July 2026 · Jin, Soyeon, Kim, You-Tae, Yang, Jihye, Lee, Ju-Hoon PubMed 42401599

Gut dysbiosis is increasingly recognized as a key contributor to food allergy, yet probiotic strains capable of restoring allergic microbiota and rebalancing host immunity remain limited. Here, we identified Lactiplantibacillus plantarum SLpl116 through a multi-criteria screening pipeline integrating anti-allergic activity, safety, and processing stability, and evaluated its efficacy in a prophylactic ovalbumin...

Exercise remodels the skeletal muscle immune microenvironment to ameliorate type 2 diabetes mellitus-induced muscle atrophy: From immunometabolism to organ crosstalk.

Reviews in endocrine & metabolic disorders · 5 July 2026 · Pengyu, Fu, Huiyun, Xu, Lijing, Gong PubMed 42400735

Type 2 diabetes mellitus (T2DM) complicated by muscle atrophy (diabetic sarcopenia) significantly increases mortality risk, with immunometabolic imbalance-driven disruption of the skeletal muscle microenvironment as a core mechanism. This review focuses on the immune cell-myocyte crosstalk network to elucidate the pathological mechanisms of T2DM-induced muscle atrophy, the local remodeling effects of exercise, and...

Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.

Digestive diseases and sciences · 5 July 2026 · He, Xinlei, Lv, Mingyue, Chen, Jiamin, Zhu, Qiancheng et al. PubMed 42400718

Cholangiocarcinoma (CCA) is a common and highly refractory malignancy; however, biomarkers and therapeutic targets associated with its progression remain incompletely understood. Crotonylation is an emerging lysine acylation modification that has been implicated in multiple diseases.

Unveiling the pharmacological basis of Rhodiola crenulata for atopic dermatitis: A multi-model approach combining zebrafish, mouse studies, and intelligent computational analysis.

Phytomedicine : international journal of phytotherapy and phytopharmacology · 4 July 2026 · Zhang, Xiongyi, Wang, Yanfu, Zhao, Dongyang, Yin, Cong et al. PubMed 42398206

Atopic dermatitis (AD) is a complex inflammatory skin disorder. Rhodiola crenulata extract (RC) contains bioactive compounds with potential benefits for AD, but its mechanisms are not fully elucidated.

A Real-World Cross-Sectional Study on Suspected Mast Cell Activation Syndrome: Multiple Heterogeneous Symptoms Identified.

Clinical and translational allergy · 4 July 2026 · Gutsche, Annika, Buttgereit, Thomas, Buchkremer, Rüdiger, Panse, Jens et al. PubMed 42399206

A variety of clinical signs and symptoms have been described in patients suspected of having mast cell activation syndrome (MCAS), however, symptom patterns and linked organ systems were not yet described. This cross-sectional online survey included adults with physician-diagnosed self-assessed or suspected MCAS between June and September 2021.

Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.

Clinical reviews in allergy & immunology · 3 July 2026 · Riedl, Marc A, Cohn, Danny M, Magerl, Markus, Farkas, Henriette et al. PubMed 42397484

Bradykinin is a nonapeptide of the kinin family with vasoactive and proinflammatory activities. While generation of kinins is mainly driven by activation of the contact system and plasma or tissue kallikreins, additional independent cascades contribute to their formation.

From acute mast cell activation to a structured immunothrombotic and autoimmune niche in chronic spontaneous urticaria.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 3 July 2026 · Criado, Paulo Ricardo, Fachini Jardim Criado, Roberta, Martinez Zugaib Abdalla, Beatrice PubMed 42393364

Chronic spontaneous urticaria (CSU) presents recurrent wheals and/or angioedema for more than six weeks without an identifiable trigger. Although mast cell activation and histamine release are well-established effector mechanisms, this model does not explain disease persistence, immune dysregulation, or treatment refractoriness.

Dirhamnolipids from

ACS omega · 3 July 2026 · Sawoniuk, Isadora Caroline, Pinto, Ingrid Caroline, Saito, Priscila, Ratko, Jonathan et al. PubMed 42395949

Frequent and excessive skin exposure to ultraviolet radiation induces oxidative stress and inflammation, raising skin diseases. Therapeutic strategies targeting both oxidative stress and inflammation may reduce skin disorders.

Correction to: IL-27 signaling negatively regulates FcɛRI-mediated mast cell activation and allergic response.

Journal of leukocyte biology · 3 July 2026 · Authors not listed PubMed 42394590

No abstract available.

Clinical significance and effects of miR-431-5p in children with asthma.

The Journal of asthma : official journal of the Association for the Care of Asthma · 3 July 2026 · Hou, Yafei, Ji, Luping, Gao, Jielin PubMed 42394180

This study investigated the clinical significance of miR-431-5p in childhood asthma and its cell function in house dust mite (HDM)-induced cell models. Differential miRNA expression was analyzed in the GSE263408 dataset using bioinformatics tools (Limma package).

Antitumor effects of acupuncture and moxibustion: from immune modulation to tumor microenvironment remodeling.

Frontiers in immunology · 3 July 2026 · Li, Yinan, Gao, Xia, He, Tian, Ma, Benxu et al. PubMed 42396432

Acupuncture and moxibustion are evidence - based modalities derived from traditional Chinese medicine. They employ strategic needle insertion or moxa - derived thermal stimulation at specific acupoints to ameliorate pathological conditions.

Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS.

Frontiers in neurology · 2 July 2026 · Zhu, Yidi, Wang, Luoyu, Zhang, Liqing, Tang, Xue et al. PubMed 42388713

Middle cerebral artery stenosis (MCA-S) impairs cerebral perfusion and vascular pulsatility, potentially disrupting cerebrospinal fluid dynamics. We evaluated perivascular diffusivity in MCA-S using diffusion tensor image analysis along the perivascular space (DTI-ALPS) index and the redirected ALPS (ro-ALPS) index, and assessed their clinical correlations.

Using new approach methodologies (NAMs) to investigate ZnONPs and UVR induced skin sensitization.

Scientific reports · 1 July 2026 · Chen, Yu-Ying, Wang, Bour-Jr, Cheng, Yung-Hsuan, Cheng, Hsien-Jen et al. PubMed 42380427

Zinc oxide nanoparticles (ZnONPs) are widely used in sunscreens and cosmetics; however, increasing evidence suggests their potential to induce skin toxicity, particularly under conditions of skin function disruption. Here, we investigated the mechanisms underlying allergic skin inflammation triggered by repeated ZnONPs exposure following UVR damage using an in vivo hairless mouse model and in vitro Adverse Outcome...

Electroacupuncture as an eosinophil-targeting treatment in ovalbumin-induced allergic rhinitis involving β

Frontiers in immunology · 1 July 2026 · Quach, Tran Van Bao, Nguyen, Thanh-Hien Vu, Nguyen, Ngoc Chi Lan, Lin, Che-Hsuan et al. PubMed 42382776

Eosinophils amplify type-2 (Th2) inflammation and tissue injury in allergic rhinitis (AR), and eosinophilic burden correlates with disease severity and future asthma risk. Current AR therapies have limitations, motivating interest in non-pharmacologic neuromodulatory approaches.

Selective Elimination of Mast Cells via Siglec-6-Targeted Nanodelivery of Drug Payload.

The Journal of allergy and clinical immunology · 30 June 2026 · Thames, Ariel Helms, Rische, Clayton H, Krier-Burris, Rebecca A, Cao, Yun et al. PubMed 42372830

Mast cell elimination through Siglec-6 is a minimally explored strategy for diseases characterized by mast cell overactivity or overproduction. Here, we combine nanotechnology with cell-free protein synthesis to develop a therapeutic strategy (anti-Sig6-NPmidoFab) for selectively eliminating mast cells.

Protective role of rosmarinic acid against radiation-induced dermatitis: focus on oxidative stress and inflammation.

BMC complementary medicine and therapies · 30 June 2026 · Karip, Betül Zehra, Çikler, Esra, Beyaztaş, Hakan, Güler, Eray Metin et al. PubMed 42374349

This study investigated the potential protective role of rosmarinic acid (RA) against oxidative stress, inflammation, and fibrosis induced by ionizing radiation in an experimental rat model. A total of 42 male Sprague-Dawley rats were randomly divided into seven groups (n = 6): G0, G1(14), G1(28), G2(14), G2(28), G3(14), and G3(28).

The Rare Trio: Concomitant Bone Marrow Involvement by Smoldering Myeloma and Systemic Mastocytosis with an Associated Hematologic Neoplasm and ALECT-2 Renal Amyloidosis - A Case Report and Literature Review.

Case reports in oncology · 29 June 2026 · Soliman, Dina, Alqatati, Fadel, Mudawi, Deena, Al-Mashdali, Abdulrahman F et al. PubMed 42368884

Systemic mastocytosis (SM) is a clonal disorder characterized by abnormal accumulation of mast cells in various tissues and is categorized into distinct subtypes per the World Health Organization (WHO) 2022 classification. When SM is associated with another hematologic neoplasm, typically of myeloid lineage, it is classified as systemic mastocytosis with an associated hematologic neoplasm (SM-AHN).

Targeting Bruton tyrosine kinase with acalabrutinib attenuates murine sclerodermatous chronic graft versus host disease.

Frontiers in immunology · 29 June 2026 · Raguraman, Vasantharaja, Mysinger, Miranda, Verma, Mohit, Mohiyuddin, Shanid et al. PubMed 42367798

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the only curative option for certain malignant hematopoietic disorders, yet its benefits are limited by the development of graft-versus-host disease (GVHD). Chronic GVHD (cGVHD) is often characterized by chronic inflammation and fibrosis, propagated by alloreactive donor B- and T-cell involvement.

Pregnancy-associated telangiectasia macularis eruptiva perstans: a case suggesting mast cell-mediated modulation.

International journal of women's dermatology · 29 June 2026 · Arellano, Javier, Oyarzún, Sebastián, Oyarzún, Alejandro, Corredoira, Yamile PubMed 42369844

No abstract available.

Flow cytometry-based basophil and mast cell activation tests for IgE-mediated food and drug allergy: have we crossed the Rubicon?

Expert review of clinical immunology · 29 June 2026 · Peeters, Laura, Elst, Jessy, Ebo, Didier G PubMed 42366757

No abstract available.

No new studies this window for: PACVS, Gulf War Illness, Other post-viral.

Trial activity

No ClinicalTrials.gov records in the tracker were updated during this window.

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 26 2026: 45 new studies

Sun, 28 Jun 2026 08:00:00 +0000

Between 22 June 2026 and 28 June 2026 the tracker indexed 45 new peer-reviewed studies and 9 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

45new studies this issue

9trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

Long COVID (PASC) 7 new

Full feed: Long COVID research tracker

Systemic atopy and upper-airway disease define susceptibility to incident asthma after COVID-19 in Korea.

Nature communications · 28 June 2026 · Choi, You-Jung, Kim, Young-Chan, Bea, Sungho, Shin, Ju-Young et al. PubMed 42364998

Incident asthma is an important respiratory sequela after COVID-19, but it is unclear which allergic phenotypes amplify risk. Using a linked nationwide Korean database of 3,987,182 individuals with confirmed severe acute respiratory syndrome coronavirus 2 infection, we compare claims-based incident asthma in those with pre-existing systemic atopy and/or upper-airway disease (allergic rhinitis, chronic...

Artificial intelligence-enhanced nurse navigation for monitoring and care of long COVID.

International journal of medical informatics · 28 June 2026 · Bandeira Barboza, Ana Paula, Monteiro, Renata Luciria, Muschi, Alessandra Luna, Dos Santos Silva et al. PubMed 42364466

Long COVID is a multisystem condition with challenging diagnosis. Nurse-navigation, a patient-centered intervention, can enhance education and care access.

The efficacy of conventional chest physiotherapy in managing acute hypoxaemic respiratory failure.

BMJ case reports · 27 June 2026 · Deshmukh, Mayura, Vishwakarma, Janvi Chandrasen, Chitale, Neha, Palekar, Tushar PubMed 42362344

A man in his 60s presented with acute hypoxaemic respiratory failure secondary to post-COVID-19 fibrotic pneumonia, requiring 3 L/min oxygen therapy (peripheral oxygen saturation (SpO

SARS-CoV-2 and diabetes: a post-pandemic reappraisal.

Diabetologia · 27 June 2026 · Said, Noora, Jones, Ian, Anderson-Baucum, Emily K, Evans-Molina, Carmella PubMed 42362970

The COVID-19 pandemic was a dynamic and often confusing period for clinical and biomedical research. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread globally, knowledge accumulated rapidly through publications that were frequently based on preliminary or sometimes conflicting evidence, yet these papers played a critical role in shaping evolving medical, research and societal responses.

Genetic evidence that advanced COVID-19 accelerates longitudinal brain atrophy: A Mendelian randomization study.

Medicine · 27 June 2026 · Wen, Jie, Chen, Yuyao, Zhang, Jingwei, Tan, Zeming et al. PubMed 42363551

Coronavirus disease 2019 (COVID-19) was reported to persist long-term in the brain and leave several long-term neurologic sequelae. However, the causal relationship between COVID-19 and brain aging is still unknown.

Bronchovascular texture pattern on quantitative CT reveals airway and vascular remodeling in post-COVID-19 Lungs.

Respiratory research · 27 June 2026 · Zhang, Xuan, Rajaraman, Prathish K, Comellas, Alejandro P, Hoffman, Eric A et al. PubMed 42363216

The long-term consequences of COVID-19 remain poorly understood. To assess CT image-based biomarkers and clinical symptoms in COVID-19 survivors approximately 3-4 years after infection.

A qualitative study of the impact of the COVID-19 pandemic on healthcare access and service delivery for people living with chronic obstructive pulmonary disease and asthma.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 27 June 2026 · Brehon, Katelyn, Choi, Mirsol, Hung, Pam, Miciak, Maxi et al. PubMed 42363213

Incidence of chronic obstructive pulmonary disease and asthma diagnosis were lower during and after the Coronavirus disease 2019 pandemic in Alberta, Canada. However, it is unknown whether incidences were actually lower or if the pandemic created circumstances where patients did not seek care.

ME/CFS 10 new

Full feed: ME/CFS research tracker

Effect of "Tongdu Yupi Tiaoshen" electroacupuncture on behavioral performance and hippocampal structure and function in chronic fatigue syndrome rats.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 28 June 2026 · Yuanyuan, Q U, Chuwen, Feng, Weibo, Sun, Yuying, Shao et al. PubMed 42365408

To investigate the effects of electroacupuncture intervention on behavioral performance, hippocampal structure, and function in chronic fatigue syndrome (CFS) rats and to explore the underlying mechanisms. Specific pathogen free-grade male Sprague-Dawley rats were randomly allocated into a control group (Con group, Behavioral assessments demonstrated that electroacupuncture intervention significantly improved rat...

Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis.

Journal of neurochemistry · 27 June 2026 · Sabetta, Eleonora, Rallmann, Karin, Taba, Pille, Pfaff, Abigail L et al. PubMed 42360043

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non-motor symptoms. Approximately 85% of ALS cases are sporadic (sALS), while the remaining 10%-15% are familial (fALS).

Redefining pandemic resilience: a roadmap for post-infectious syndrome preparedness and health system transformation.

Frontiers in health services · 26 June 2026 · Schieffer, Bernhard PubMed 42358486

Post-infectious syndromes like Long COVID and ME/CFS lead to disability and economic losses globally, especially in lower-income countries. These involve complex multisystem issues such as immune disturbances, inflammation, autonomic dysregulation, vascular problems, altered metabolism, and tissue damage.

Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.

Journal of clinical medicine · 26 June 2026 · d'Incau, Emmanuel, Kaplan, Chelsea Marie, Micoulaud-Franchi, Jean-Arthur, Veasley, Christin et al. PubMed 42356003

Chronic overlapping pain conditions (COPCs) refer to a set of chronic pain disorders that frequently co-occur and may involve partially overlapping mechanisms. The U.S.

Long-Term Follow-Up of Women with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A 16-Year Longitudinal Study.

Medicina (Kaunas, Lithuania) · 26 June 2026 · Tomić, Slavica, Pastornački, Aleksandra, Drljača, Maja, Glogovac, Jelena et al. PubMed 42356126

No abstract available.

Human Herpesvirus-6A and -6B (HHV-6A and HHV-6B): The Role of Roseoloviruses in Neurological Dysfunction and the Mechanisms of Viral-Induced Epileptogenesis.

Viruses · 26 June 2026 · Bahramian, Elham, Bajpai, Ananya, Yang, Xue, Cairns, Dana M et al. PubMed 42357670

Human herpesvirus-6 consists of a pair of viral species, HHV-6A and HHV-6B, which are neurotropic with the ability to invade, persist, and reactivate within the nervous system. Accumulating evidence links HHV-6 to epilepsy and other neuropathologies, including: multiple sclerosis, chronic fatigue syndrome, and neurodegeneration.

Comparative Gut Microbiome Alterations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID-19 Syndrome.

Biomedicines · 26 June 2026 · Donchev, Deyan, Nikolova, Ralitsa, Vaseva, Katya, Taskov, Hristo et al. PubMed 42351611

No abstract available.

Effect of photobiomodulation on pain and quality of life in fibromyalgia syndrome: a systematic review.

Lasers in medical science · 23 June 2026 · G A, Swathi, Maiya, G Arun, Shetty, Shiran, Abrahamse, Heidi et al. PubMed 42334638

Fibromyalgia Syndrome (FMS) is a chronic pain disorder characterized by widespread pain and central sensitization that significantly impacts the quality of life (QoL). For management to be effective, a multidisciplinary approach to care is typically required.

Tryptophan Metabolism and Aryl-Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

MicrobiologyOpen · 22 June 2026 · Esteban, David J, Conrad, Brynn, Cullinan, Autumn, Luong, Sharon et al. PubMed 42325052

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease with unknown biological basis and no cure. Microbiome dysbiosis has been reported in people with ME/CFS but its relevance to pathophysiology is unknown.

Elevated serum levels of interleukin-11 and matrix metalloproteinase-9 in myalgic encephalomyelitis/chronic fatigue syndrome.

Frontiers in immunology · 22 June 2026 · Chinnappan, Baskaran, Kempuraj, Duraisamy, Aenlle, Kristina K, Middleton, Ashley et al. PubMed 42327760

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown etiology associated with chronic severe fatigue and neurological symptoms, including dizziness, sleep disturbances, cognitive impairment and pain. There are no reliable blood biomarkers available for ME/CFS, possibly due to the lack of specific pathogenesis, even though Epstein-Barr Virus (EBV) has been suspected.

Chronic Lyme / Post-Treatment Lyme Disease Syndrome 2 new

Full feed: Lyme / PTLDS research tracker

Patient roadmap and economic burden of chronic tick-borne illness and post-treatment Lyme disease syndrome in Ireland, and public health issues arising.

Frontiers in public health · 26 June 2026 · Avramovic, Gordana, Gilbert, Leona, Kujawski, Sławomir, Blehle, Sigrid et al. PubMed 42359130

Lyme borreliosis (LB), commonly referred to as Lyme disease (LD), is a prominent global health issue, exhibiting a seroprevalence rate of 14.5%. Heightened incidence levels of LD have been recorded in parts of Europe, Poland, Eastern Europe, and the Baltic States.

Anti-

Pathogens (Basel, Switzerland) · 25 June 2026 · Aslan Başbulut, Eşe, Yavuz, Demet, Demir, Tülin PubMed 42347267

Lyme borreliosis is a multisystemic tick-borne infection caused by The study included 45 patients and 45 age and sex matched controls. Serum samples were tested for anti- Overall, anti- IgG seropositivity was numerically higher among patients with CKD of unknown etiology than among healthy controls; however, this difference was not statistically significant.

Gulf War Illness 2 new

Full feed: Gulf War Illness research tracker

The comparative ameliorating effects of an amorphous formula of curcumin and α-glycosyl isoquercitrin on hippocampal dysfunction in a rat gulf war illness model.

Metabolic brain disease · 25 June 2026 · Tang, Qian, Shobudani, Momoka, Sakamaki, Yuri, Ebizuka, Yuri et al. PubMed 42347851

Brain dysfunction is a primary symptom of Gulf War illness (GWI). The present study investigated the effects of an amorphous formula of curcumin (CUR) and α-glycosyl isoquercitrin (AGIQ) on neurobehaviors and adult neurogenesis and following synaptic plasticity of produced neurons in the hippocampal dentate gyrus (DG) in a rat GWI model.

"Treat us Like Human Beings": Messages and Recommendations to U.S. Policymakers and Veterans Health Administration Providers from a Qualitative Inquiry Into the Health Experiences of Gulf War Veterans With Gulf War Illness.

Journal of patient experience · 22 June 2026 · Montague, Kara A, Lafferty, Megan, Graham, Michael, Nugent, Shannon M PubMed 42328091

Gulf War Illness (GWI) affects many U.S. Veterans of the 1990-1991 Persian Gulf War (GWVs), yet recognition of the condition and effective treatments remain limited.

Postural Orthostatic Tachycardia Syndrome (POTS) 3 new

Full feed: POTS research tracker

[Cardiorespiratory functional disorders: A transnosologic approach].

La Revue de medecine interne · 25 June 2026 · Ranque, Brigitte, Cathebras, Pascal PubMed 42342500

Functional disorders affecting the cardiorespiratory system are common. Non-cardiac chest pain affects more than 10% of the population.

Effects of auricular vagal neuromodulation therapy combined with slow-paced diaphragmatic breathing in individuals with postural tachycardia syndrome: a randomised controlled trial protocol.

BMJ open · 25 June 2026 · Brandl, Tobias, Pichler, Florian, Grabovac, Igor, Waldhoer, Thomas et al. PubMed 42342403

Postural orthostatic tachycardia syndrome (POTS) is a multifactorial disorder of the autonomic nervous system characterised by an excessive increase in heart rate (HR) on standing and a wide range of debilitating symptoms, including fatigue, exercise intolerance, cognitive impairment and a high prevalence of depression, anxiety and sleep disturbances. Conventional pharmacological strategies often offer limited...

Assessing autonomic nervous system imbalance in long COVID-19 patients through heart rate variability during tilt testing.

Scientific reports · 25 June 2026 · Camargo, Samuel Minucci, Dos Santos, Ana Leticia Gomes, Maximo, Stella Tassinari, da Silva et al. PubMed 42343084

Long COVID-19 is recognized as a condition associated with autonomic nervous system (ANS) dysfunction. However, quantitative evidence of its impact on heart rate variability (HRV) and blood pressure (BP) regulation during postural changes remains limited.

Mast Cell Activation Syndrome (MCAS) 20 new

Full feed: MCAS research tracker

Role of gamma-aminobutyric acid-ergic neurons in the thalamic reticular nucleus in regulating sleep-wake cycles in mice treated with acupuncture for insomnia.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 28 June 2026 · Xiaoxiao, L U, Yipeng, X U, Minjie, Zhou, Chengshun, Zhang et al. PubMed 42365403

To test whether acupuncture improves sleep by enhancing gamma-aminobutyric acid-ergic (GABA) neuronal activity in the thalamic reticular nucleus (TRN). We established an animal model using p-chlorophenylalanine (PCPA).

Protein-Free Diet Aggravates Food Allergy Response via the Consumption of Glycochenodeoxycholic Acid in a Murine Model.

Journal of agricultural and food chemistry · 27 June 2026 · Shi, Qiang, Chen, Chuang, Bai, Tianliang, Zhang, Shan et al. PubMed 42360286

Amino acid-based formulas (AAFs) are increasingly consumed in infants with food allergy (FA), while the effects of their long-term consumption on FA remain poorly known. This study investigated the effects of the long-term consumption of AAFs on FA by subjecting neonatal mice to an amino acid-based diet (AAD).

Outcomes and prognostic factors in patients with systemic mastocytosis and an associated myeloid neoplasm: an international ECNM registry study.

Journal of hematology & oncology · 27 June 2026 · Hermine, Olivier, Debeaupuis, Orianne, Damaj, Gandhi, Lübke, Johannes et al. PubMed 42363232

Systemic mastocytosis (SM) is a spectrum of hematologic disorders characterized by accumulation of atypical mast cells (MCs) in extracutaneous organs. SM with an associated hematologic neoplasm (SM-AHN), the most frequent subtype of advanced SM, is predominantly associated with myeloid neoplasms, consistent with shared clonal architecture.

Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.

Pharmacological reviews · 27 June 2026 · Derakhshani, Afshin, Mahajan, Leela, Lesack, Kyle, Saranjam, Navid et al. PubMed 42361439

Mast cells (MCs) are versatile, multifunctional immune cells with broad roles in physiological homeostasis and pathogenic processes. MCs are found in most tissues, including skin, lungs, intestines, and peritoneum, and they vary in numbers, types, and biological functions.

Loss of epidermal miR-149 sensitizes to skin inflammation.

The Journal of allergy and clinical immunology · 27 June 2026 · Luo, Longlong, Yuan, Hao, Srivastava, Ankit, Annusver, Karl et al. PubMed 42362092

Keratinocytes play a central role in amplifying skin inflammation in psoriasis and atopic dermatitis (AD). However, the epithelial-intrinsic regulators involved in responsiveness to inflammatory cues remain poorly defined.

Innovative diagnostic techniques and their clinical implications in food allergy: current clinical practice and future perspectives.

Frontiers in allergy · 26 June 2026 · Rossi, Carlo Maria, Merli, Stefania, Borgonovo, Linda, Giardina, Michelle et al. PubMed 42358594

Food allergy (FA) is an immune-mediated adverse reaction to food components (mainly proteins) and represents an increasing global health problem, affecting millions of individuals and imposing substantial clinical, psychosocial, and economic burdens. Accurate diagnosis is essential to prevent life-threatening reactions while avoiding unnecessary dietary restrictions and impaired quality of life.

Benzo(a)pyrene aggregating lung inflammation via inducing IL1R1 expression in asthma: Insights from network toxicology, single-cell transcriptomics, and Mendelian randomization.

Ecotoxicology and environmental safety · 26 June 2026 · Lu, Xi, Ji, Siqin, Liu, Jinyu, Sun, Yipeng et al. PubMed 42349175

Exposure to benzo(a)pyrene (BaP) negatively affects lung inflammation in patients with asthma. However, there is a lack of systematic research on the key mechanisms of BaP toxicity in asthma.

A Follow-Up Study of the Supraaortic and Intracranial Vessels, Cerebrovascular Reactivity, Brain Vascular Lesions and Atrophy in Patients with Rheumatoid Arthritis.

Journal of clinical medicine · 26 June 2026 · Sas, Attila, Jónyer, Dávid, Valikovics, Attila, Kostyál, László et al. PubMed 42355859

No abstract available.

Treatment Approaches for Omalizumab-Refractory Chronic Spontaneous Urticaria.

Journal of inflammation research · 25 June 2026 · Ensina, Luis Felipe, Ferrer, Marta, Al-Ahmad, Mona, Fomina, Daria et al. PubMed 42345003

Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that impairs health-related quality of life. Although omalizumab is a cornerstone treatment for patients uncontrolled with up-dosed second-generation H1-antihistamines, some patients remain partially responsive or refractory.

Therapeutic effects of jaceosidin on atopic dermatitis via ubiquitin-mediated JAK1 degradation.

Phytomedicine : international journal of phytotherapy and phytopharmacology · 25 June 2026 · Wei, Ruoqu, Cheng, Wenjie, Zhang, Jie, Zou, Quan et al. PubMed 42341525

Atopic dermatitis (AD) is a prevalent inflammatory skin disease with substantial clinical burden. Jaceosidin (JAC), a trihydroxy-dimethoxy flavone primarily isolated from Artemisia genus and several other plants, possesses potent immunomodulatory and anti-inflammatory activities with therapeutic potential for inflammatory skin diseases.

P2 Receptors as Therapeutic Targets in Allergic Rhinitis: Insights From the Use of Natural Products and Preclinical Studies.

Journal of immunology research · 25 June 2026 · Pereira, Thalita Calvet, Rocha, Leandro, Faria, Robson Xavier PubMed 42345616

Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways that is mediated by immunoglobulin E (IgE) and triggered by environmental allergens. Current pharmacological therapies, including antihistamines, corticosteroids, and immunotherapy, offer symptomatic relief but are limited by their incomplete disease-modulating effects and potential adverse side effects.

Nasal Cytology as a Local Biomarker of Airway Inflammation: A Paradigm Shift in Precision Medicine.

Pathophysiology : the official journal of the International Society for Pathophysiology · 25 June 2026 · Gelardi, Matteo PubMed 42347019

Biomarker-driven approaches have markedly improved the stratification and management of airway inflammatory diseases. However, in everyday clinical practice, these strategies still rely mainly on systemic indicators, which often provide only an indirect view of the inflammatory processes occurring within the airway mucosa.

INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice.

Frontiers in medicine · 25 June 2026 · Sharma, Sameer, Chen, Lixian, Zhou, Tianhao, Chawla, Meenakshi et al. PubMed 42344483

Mast cells (MCs) play a significant role in autoimmune diseases by mediating inflammatory responses, innate and adaptive responses, angiogenesis, and various pathological processes. In chronic liver diseases, MC numbers are significantly increased, and their degranulation leads to release of mediators, including chymase, which increases inflammation, activates hepatic stellate cells (HSCs), leading to fibrosis.

Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models.

Journal of Zhejiang University. Science. B · 25 June 2026 · Gonul, Ayca Nur, Torun, Ibrahim Ethem, Kilinc, Yasemin Baranoglu, Kilinc, Erkan PubMed 42343635

Growing evidence suggests that esculetin, a 5-lipoxygenase inhibitor, has pharmacotherapeutic potential due to its various pharmacological properties, such as potent anti-inflammatory, anti-nociceptive, and γ-aminobutyric acid type A (GABA 越来越多的证据表明，秦皮乙素作为一种5-脂氧合酶抑制剂，因其具有强效抗炎、抗伤害感受及γ-氨基丁酸A型（GABA

Differential Regulation of Granule Release in Platelets and Immune Cells.

TH open : companion journal to thrombosis and haemostasis · 25 June 2026 · Xia, Qing, Hu, Jiandao, Sun, Hongcun, Zhu, Zhixiang et al. PubMed 42343980

Platelets and certain immune cells contain releasable granules that play essential roles in hemostasis and immune regulation. However, the regulatory mechanisms governing degranulation of platelets versus immune cells remain incompletely understood.

Melittin in AllergoOncology: From Honey Bee Venom to Anti-Cancer Therapeutic Innovation-An EAACI Position Paper.

Allergy · 24 June 2026 · Jimenez-Rodriguez, Teodorikez-Wilfox, Ahmetaj, Luljeta, Alfaya Arias, Teresa, Boni, Elisa et al. PubMed 42337945

Honey bee venom (HBV) represents a unique interface between allergy and oncology, exemplifying how allergen-derived molecules can be repurposed as anti-cancer agents. Melittin, the principal component of HBV, accounts for 40%-50% of its dry weight and is responsible for most of its biological activity.

The association between atopic dermatitis and rosacea: a comprehensive review from comorbidities to pathogenic mechanisms.

Frontiers in immunology · 22 June 2026 · Zeng, Yuewei, Feng, Yanyan PubMed 42327780

Atopic dermatitis (AD) and rosacea have traditionally been regarded as two distinct inflammatory skin disorders with divergent pathophysiology. However, emerging evidence has progressively revealed unexpected convergences between these conditions in clinical manifestations, comorbidity profiles and pathogenic mechanisms-raising the question of whether the apparent mechanistic overlaps represent true...

Identification of circadian rhythm-associated key genes in metabolic dysfunction-associated fatty liver disease.

Clinical and experimental medicine · 22 June 2026 · Luo, Jinbo, Ma, Xiuying, Wang, Quanyu, Zhang, Ruyi et al. PubMed 42329455

As of now, current studies have confirmed that circadian rhythm genes (CRGs) can modulate the onset and development of metabolic dysfunction-associated fatty liver disease (MAFLD). Leveraging computational biology methodologies, systematic and thorough investigations into MAFLD and CRGs enhance our capacity to gain deeper insights into the disease's pathogenic mechanisms.

Early life stress and the pathogenesis of visceral hypersensitivity: mechanisms and implications for disorders of gut-brain interaction.

Frontiers in cell and developmental biology · 22 June 2026 · Tao, Enfu PubMed 42326011

Early life stress (ELS) is a major risk factor for disorders of gut-brain interaction (DGBIs), particularly irritable bowel syndrome (IBS), through the induction of persistent visceral hypersensitivity. This review synthesizes evidence from epidemiological studies, clinical observations, and preclinical models to establish ELS-induced visceral hypersensitivity as a core pathophysiological axis.

Chronic spontaneous cholinergic urticaria: advances in immunological mechanisms focusing on neuro-immune crosstalk and novel targeted therapeutic strategies.

Frontiers in immunology · 22 June 2026 · Yang, Meilv, Lin, Suxian, Lu, Yang, Jin, Huanzhi et al. PubMed 42327770

Chronic spontaneous cholinergic urticaria (CSU-Chol) is a chronic inflammatory skin disorder characterized by intense pruritus and small wheals triggered by a rise in core body temperature. This review aims to systematically elucidate its complex pathogenesis, with a particular focus on the pivotal role of neuro-immune crosstalk in disease initiation and progression.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 22 June 2026 and 28 June 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT07388550	Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Long COVID	Not Yet Recruiting	Phase 1	Keytruda	2026-06-26
NCT05874037	Fluvoxamine for Long COVID-19 Long COVID	Completed	Phase 2	Fluvoxamine	2026-06-25
NCT07546539	Photobiomodulation in Chronic Fatigue Syndrome ME/CFS	Recruiting	Not applicable	Photobiomodulation	2026-06-24
NCT04827992	Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain Other post-viral	Completed	Not applicable	Cannabis, Prescription Opioid Taper Support	2026-06-24
NCT05977179	Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome Long COVID	Recruiting	Not applicable	Dietary Intervention To Mitigate Post-Acute Covid-19 Syndrome	2026-06-23
NCT07661862	PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID Long COVID	Recruiting	Not applicable	Perceive-Outreach Intervention	2026-06-22
NCT07655375	Study Evaluating the Effect of UCB8600 on Mast Cell Activation in the Human Gut MCAS, Other post-viral	Not Yet Recruiting	Not applicable	Sample Collection	2026-06-22
NCT06231238	Balance Acceptance and Commitment Therapy for Long COVID Long COVID	Active Not Recruiting	Not applicable	Balance Acceptance And Commitment Therapy	2026-06-22
NCT04542161	Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS	Active Not Recruiting	Phase 2	N-Acetylcysteine (NAC)	2026-06-22

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 25 2026: 33 new studies

Sun, 21 Jun 2026 08:00:00 +0000

Between 15 June 2026 and 21 June 2026 the tracker indexed 33 new peer-reviewed studies and 5 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

33new studies this issue

5trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

ME/CFS 8 new

Full feed: ME/CFS research tracker

Study on Sijunzi decoction regulating intestinal microbiota structure and metabolic profile for improving chronic fatigue syndrome.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 21 June 2026 · Shan, Yi, Jin, Jin, Wu, Yiduo, Yu, Runsheng et al. PubMed 42322758

Chronic fatigue syndrome (CFS) is a syndrome encompassing several systemic diseases. Sijunzi Decoction (SJZD) is a classic formula in traditional Chinese medicine (TCM) for the treatment of spleen deficiency syndrome.

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research.

Frontiers in neuroendocrinology · 20 June 2026 · Thomas, Natalie, Huang, Katherine, Schneider-Futschik, Elena K, Pollack, Beth et al. PubMed 42320559

Hormonal dysregulation is increasingly reported in ME/CFS and Long COVID, yet the broader role of neuroendocrine disruption in these conditions remains underexplored. While changes in steroid, peptide, and neuropeptide hormones have been identified, these findings are often considered in isolation and without attention to their timing or integration within broader physiological systems.

Gastrointestinal symptoms correlate with core clinical features and systemic inflammation in myalgic encephalomyelitis/chronic fatigue syndrome.

Journal of translational medicine · 20 June 2026 · Brown, Mikayla, Vernon, Suzanne D, Indart, Alyssa C, Green, Peter H et al. PubMed 42321833

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem illness marked by fatigue, cognitive impairment, and post-exertional malaise. Gastrointestinal (GI) symptoms are frequently reported, yet their relationship to central features of the illness and biological correlates remains poorly understood.

[Not Available].

Der Nervenarzt · 18 June 2026 · Erbguth, F, Tegenthoff, M, Böwering-Möllenkamp, C, Schain, H et al. PubMed 42313182

No abstract available.

Effectiveness of adapted physical activity and therapeutic exercise programme in improving chronic fatigue syndrome in long COVID, delivered via hospital-based rehabilitation versus telerehabilitation.

Trials · 18 June 2026 · Kabir, Feroz, Yin, Khin Nyein, Jeffree, Mohammad Saffree, Ahmedy, Fatimah Binti et al. PubMed 42310705

Long COVID is a prevalent condition characterised by pain, fatigue, disability, and a multitude of health issues. There are various treatment options for managing long COVID symptoms, including non-pharmacological interventions like physiotherapy and rehabilitation, which can be effectively delivered either in institutional care settings or via telerehabilitation.

Self-management support needs for individuals with Myalgic Encephalomyelitis and their next of kin - a qualitative study.

BMC health services research · 16 June 2026 · Grønning, Kjersti, Lysfjord, Liv Eli, Røstad, Ann Katrin Hagen PubMed 42298601

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, disabling condition with limited evidence-based treatment options. Self-management support is recommended to improve people's coping and quality of life, yet little is known about whether the provided self-management support meet individuals with ME/CFS and their next of kins needs.

Fatigue-associated gut bacteria in Japanese healthy adults characterized by metagenomic analysis.

Scientific reports · 15 June 2026 · Masuoka, Hiroaki, Miyatake, Takumi, Park, Jonguk, Negishi, Hiroki et al. PubMed 42289444

Emerging evidence suggests that fatigue caused by accumulated stress may serve as a prodromal symptom of psychiatric disorders, and gut microbiome dysbiosis has been reported in many such conditions. However, little is known about microbial and metabolic signatures associated with fatigue in otherwise healthy individuals.

Approach to Fatigue in Primary Care: A Practical Diagnostic Framework for General Practitioners.

Cureus · 15 June 2026 · Elbaroumi, Omar PubMed 42291861

Fatigue is one of the most common presenting complaints in primary care and poses a significant diagnostic challenge due to its multifactorial aetiology. While the majority of cases are benign and self-limiting, fatigue may also represent an early manifestation of serious underlying pathology.

Gulf War Illness 1 new

Full feed: Gulf War Illness research tracker

Association between deployment and Gulf War Illness and adverse COVID outcomes in a nationwide cohort of 1990-1991 Gulf Era war veterans in the VA's Million Veteran Program.

PloS one · 15 June 2026 · White, Donna L, NonoDjotsa, Alice B S, Ahmed, Sarah T, Boyle, Stephen H et al. PubMed 42296096

U.S. military veterans deployed to the Persian Gulf to serve in the 1990-1991 Gulf War (GWVs) have expressed concerns about potential increased risk of experiencing adverse COVID-related health outcomes given broad near-unique exposure to multiple diverse toxic agents during deployment and ongoing ~30% prevalence of Gulf War Illness (GWI+), a chronic, medically unexplained multi-symptom disorder associated with...

Postural Orthostatic Tachycardia Syndrome (POTS) 6 new

Full feed: POTS research tracker

Robotic management of superior mesenteric artery syndrome after weight loss: a case report.

Journal of surgical case reports · 17 June 2026 · Kontogiannis, Cristina, Asif, Sami, Kharod, Amit PubMed 42305393

Superior mesenteric artery (SMA) syndrome is a rare cause of proximal intestinal obstruction resulting from compression of the third portion of the duodenum between the aorta and the SMA. It most commonly occurs in slender individuals or those experiencing rapid weight loss, but presentations can be atypical and diagnostically challenging.

Adverse events following HPV vaccine reported to the Vaccine Adverse Event Reporting System.

PloS one · 17 June 2026 · Zhang, Siqi, Li, Yu, Liu, Miaomiao, Yang, Jiajia et al. PubMed 42308205

Vaccination against high-risk HPV types is a key preventive measure. However, concerns regarding vaccine safety may hinder vaccination efforts.

Unusual presentation of scleroderma: case report.

AME case reports · 16 June 2026 · Finsterer, Josef PubMed 42299385

The combination of neurological, cardiac, and pulmonary disease in patients with systemic sclerosis (SS) is rare. The aim of the study was to report a patient with SS who manifested with migraine without aura, Raynaud's phenomenon, pulmonary hypertension, and postural tachycardia syndrome (POTS), a combination which has not been previously reported.

Hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome: patient experiences, disability and implications for rehabilitation.also MCAS

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation · 16 June 2026 · Brandt, Lindsay, Kondratek, Melodie, Kim, Limmy, Ohanian, Hailey et al. PubMed 42298945

The diagnosis and management of hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome (HSD/hEDS) are a healthcare challenge because of the wide array of symptoms, lack of diagnostic biomarkers, and evolving management guidelines. This study aimed to describe patient experiences, disability, and self-perceived success managing HSD/hEDS, with or without comorbid postural orthostatic tachycardia...

How does postural orthostatic tachycardia syndrome (POTS) affect pediatric patients?

Nursing · 16 June 2026 · Gerik, Daniella J, Cadet, Myriam J PubMed 42299763

Postural orthostatic tachycardia syndrome (POTS) is a disorder characterized by a sudden onset of orthostatic intolerance upon standing, which may be relieved when lying down. The most common complications associated with POTS are trauma or injury from falling or fainting.

Dysautonomia and Postural Orthostatic Tachycardia Syndrome (POTS) in the ENT Clinic: Differentiating Orthostatic Dizziness From Vestibular Migraine and Persistent Postural-Perceptual Dizziness (PPPD).

Cureus · 16 June 2026 · Zitser, Philip, Kolomiyets, Ilana, Imran, Maheen, Kulkarni, Aashi et al. PubMed 42299168

One of the most common complaints in ENT clinics is dizziness. Although most cases are caused by vestibular neuritis and benign paroxysmal positional vertigo (BPPV), a significant number of patients experience non-vestibular dizziness.

Mast Cell Activation Syndrome (MCAS) 16 new

Full feed: MCAS research tracker

Next-generation heparin antidotes: "Exosomes as a biocompatible alternative to protamine sulfate".

Molecular biology reports · 19 June 2026 · Bahar, Leyla, Tüysüz, Mehmet Erin, Omay, Pınar Hüner, Kınay, Vehbi et al. PubMed 42319568

Controlling bleeding is one of the most fundamental challenges in cardiac surgery. Bleeding is controlled by neutralising heparin with protamine.

Mast Cells and Cardiovascular Disorders.

Current vascular pharmacology · 19 June 2026 · Manolis, Antonis A, Manolis, Theodora A, Vouliotis, Apostolos, Manolis, Antonis S PubMed 42316564

Mastocytosis is a neoplasm characterised by clonal proliferation of mast cells (MCs) in the skin and other organs, including the heart, and symptoms produced by MC-derived mediators. MC activation syndrome (MCAS) relates to increased and inappropriate activation of MCs without clonal proliferation.

Ethnopharmacological investigation of Elaeocarpus sylvestris leaf extract in mitigating atopic dermatitis-like lesions via inflammatory signaling modulation.

Journal of ethnopharmacology · 19 June 2026 · Kim, So-Yeon, Do, Young-Ju, Lee, Su-Jung, Cho, Ye Eun et al. PubMed 42314808

Historically, Elaeocarpus sylvestris has served as a traditional medicinal agent for inflammatory disorders across East Asia. Recent studies have reported its antioxidant and anti-inflammatory activities, supporting its potential as a natural therapeutic resource for inflammatory skin diseases such as atopic dermatitis (AD).

Epithelial Duox2 Drives Chronic Colitis-Associated Fibrosis via the NLRP3-IL-33-Mast Cell Axis.

Combinatorial chemistry & high throughput screening · 19 June 2026 · Chen, Zhixiong, Yang, Juanmin, He, Zhigang PubMed 42316559

Intestinal fibrosis is a common and serious complication of chronic inflammatory bowel disease (IBD) associated with stricture and obstruction. Although oxidative stress has been associated with IBD, how Duox2, the major source of ROS in gut epithelium, promotes fibrosis remains unknown.

Critical evaluation of the key mediators causing life-threatening symptoms during human anaphylaxis.

Drug discovery today · 19 June 2026 · Boehm, Thomas, Jilma, Bernd PubMed 42314830

Most pathophysiologically oriented anaphylaxis reviews list a plethora of mediators purportedly involved in symptom development during severe anaphylaxis. However, how many mediators are responsible for life-threatening anaphylaxis symptoms?

Association of the endosomal TLR4 pathway with dorsolateral prostatic remodeling induced by perinatal phthalate mixture exposure in rats.

Reproductive toxicology (Elmsford, N.Y.) · 19 June 2026 · Maria, Vinícius Luís Rocha da Silva, Santana, Ana Clara Pacheco de, Souza, Patrick Vieira, Rocha et al. PubMed 42315046

Phthalates are endocrine disruptors that alter the homeostasis of hormone-dependent organs. Perinatal exposure to endocrine disruptors can program different organs and promote morphological and metabolic alterations, increasing susceptibility to diseases later in life, as proposed by the Developmental Origins of Health and Disease (DOHaD) hypothesis.

Acalabrutinib for long-term prevention of recurrent idiopathic anaphylaxis.

The journal of allergy and clinical immunology. In practice · 19 June 2026 · Tucker, James R, Wanandy, Troy, Lau, Wun Yee, Mulcahy, Emily M et al. PubMed 42314929

No abstract available.

Abluminal plasma induces vasoconstriction meditated by serotonin and counterbalanced by endothelial nitric oxide synthase in healthy and malarial mouse arteries.

American journal of physiology. Heart and circulatory physiology · 19 June 2026 · Sanches, Guilherme S, Hakim, Md Abdul, Brooks, Steven D, Marins, Thais da Silva Barenco et al. PubMed 42315097

No abstract available.

Systemic Mastocytosis in Adults: 2026 Update on Diagnosis, Risk Stratification and Management.

American journal of hematology · 18 June 2026 · Pardanani, Animesh PubMed 42310859

Systemic mastocytosis (SM) results from clonal proliferation of mast cells (MC) in extra-cutaneous organs. The major criterion is the presence of multifocal MC clusters in the bone marrow and/or extracutaneous organs.

Kounis Syndrome Triggered by Hymenoptera Stings and Exacerbated by Streptokinase.

JACC. Case reports · 18 June 2026 · Chai, Siew Yap, Liew, Kai Soon, Soh, Kok Ming, Subramanian, Seetha Devi et al. PubMed 42313027

Kounis syndrome (KS) is an allergy-mediated acute coronary syndrome that is frequently under-recognized and potentially life threatening. A 52-year-old man developed an inferior ST-segment elevation myocardial infarction following a bee swarm attack.

Any role for respiratory allergens in IBS symptoms? From pathogenetic hypothesis to therapeutic implications.

Frontiers in allergy · 18 June 2026 · Rossi, Carlo Maria, Lenti, Marco Vincenzo, Di Sabatino, Antonio PubMed 42311633

Irritable bowel syndrome is a common disorder associated with substantial impairment in quality of life and remains challenging to manage due to its heterogeneous and incompletely understood pathophysiology leading to high rates of treatment failure. Recent evidence supports the existence of distinct IBS endotypes, including an emerging atopic variant characterised by allergic comorbidities, type 2 inflammation, and...

Rolling Up Transition Metal Chalcogenides/Oxide Heterostructures Enables Polarity-Tunable and High-Switchable Memristors.

Advanced materials (Deerfield Beach, Fla.) · 16 June 2026 · Wang, Xiaofan, Chen, Xiaokai, Qiao, Ruixi, Xu, Jing et al. PubMed 42299106

Harnessing transition metal dichalcogenides (TMDCs) for memristors provides a promising pathway toward high-density data storage and neuromorphic functionalities. Yet the single operation mode and insufficient on/off ratio extremely restrict the ultimate device performance.

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria.

Journal of the European Academy of Dermatology and Venereology : JEADV · 16 June 2026 · Bizjak-Suran, Mojca, Fležar, Matjaž, Pereira, Manuel Pedro PubMed 42299718

Chronic inducible urticarias (CIndUs), including symptomatic dermographism (SD), cholinergic urticaria (CholU) and cold urticaria (ColdU), are mast cell (MC)-driven conditions triggered by subtype-specific, definite and reproducible stimuli. Although often considered self-limiting, these diseases can persist for years and significantly impair quality of life.

Anaphylaxis during hemodialysis associated with a polysulfone membrane: evidence from basophil activation testing.

Kidney research and clinical practice · 16 June 2026 · Jung, Ji Yong, Moon, Da-Hye, Kim, Hyunsook, Chang, Jae Hyun et al. PubMed 42299450

Dialyzer-associated anaphylaxis is an uncommon but serious complication of hemodialysis. Although severe anaphylaxis is rare, milder hypersensitivity reactions are likely underrecognized and frequently misattributed to cardiopulmonary or volume-related causes.

Integrative machine learning and network toxicology framework for assessing environmental pollutant TCDD-induced osteoarthritis risk: a computational cheminformatics approach.

Frontiers in pharmacology · 15 June 2026 · Li, Lei, Zhang, Yihong, Qiu, Wenkui, Li, Xiaolong et al. PubMed 42292825

Osteoarthritis (OA) is a prevalent degenerative joint disease influenced by both genetic susceptibility and environmental factors. Increasing evidence suggests that exposure to persistent environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), may contribute to OA progression; however, the molecular mechanisms underlying these effects remain unclear.

Characterization of a mouse model to study mechanisms of hemophilia A pain.

Blood advances · 15 June 2026 · Fouda, Raghda T, Argueta, Donovan Alexander, Goel, Yugal, Velasco, Graham J et al. PubMed 42295153

Pain is a debilitating feature of hemophilia A (HA), yet it remains understudied. We developed models of chronic and acute pain in factor VIII knock-out (FVIIIKO; B6;129S-FVIIItm1Kaz/J), demonstrating characteristic features of hemarthrosis pain and gait.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 15 June 2026 and 21 June 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT06974084	A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID Long COVID	Not Yet Recruiting	Phase 2	Maraviroc, Atorvastatin, 10Mg, 20Mg, 40Mg	2026-06-18
NCT06142253	Water-based Activity to Enhance Recovery in Long COVID-19 Long COVID	Recruiting	Not applicable	Water+Ct	2026-06-18
NCT06593600	Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS) POTS, Other post-viral	Active Not Recruiting	Phase 2	Regn7544	2026-06-17
NCT05967052	Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation ME/CFS	Terminated	Phase 2	Pregabalin, Independent Walking Training, Gradual Movement Therapy In The Ward	2026-06-17
NCT07651371	Effects of a Physical Rehabilitation Program on Long COVID Long COVID	Completed	Not applicable	Physical Rehabilitation, Treadmill Ergometer, Pulley	2026-06-16

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 24 2026: 25 new studies

Sun, 14 Jun 2026 08:00:00 +0000

Between 8 June 2026 and 14 June 2026 the tracker indexed 25 new peer-reviewed studies and 7 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

25new studies this issue

7trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

ME/CFS 11 new

Full feed: ME/CFS research tracker

UHPLC-Q-Exactive Orbitrap MS-based brain-gut metabolomics implicates multi-pathway modulation by Ginseng stem-leaf saponins in chronic fatigue syndrome mice.

Journal of pharmaceutical and biomedical analysis · 13 June 2026 · Wu, Wei, Aishan, Saibire, Zhang, Meng, Chen, Xue et al. PubMed 42284918

Ginseng stem-leaf saponins (GSLS) were evaluated as potential bioactive food ingredients by characterizing brain-gut metabolic disturbances in a chronic fatigue syndrome (CFS) mouse model and assessing the regulatory effects of GSLS using ultra-high-performance liquid chromatography-Q-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive Orbitrap MS). Male C57BL/6 mice were assigned to control, model, positive...

Two-timepoint multidomain follow-up of post-COVID condition and ME/CFS: overlapping autonomic, small-fiber, and cognitive changes.

Journal of translational medicine · 13 June 2026 · Azcue, N, Barranco, C, Tijero-Merino, B, Acera, M et al. PubMed 42286686

Post-COVID condition (PCC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) show marked clinical overlap, suggesting a shared post-infectious pathophysiology. This study aims to characterize the longitudinal change of autonomic function, small-fiber integrity, cognitive performance, and clinical symptoms in PCC and ME/CFS, and to determine whether trajectories differ between diagnostic groups.

Combatting ventilator induced diaphragm dysfunction with human bone marrow mesenchymal stromal cell-derived extracellular vesicles.

Skeletal muscle · 13 June 2026 · Wen, Ya, Zhang, Xiang, Hedström, Yvette, Cacciani, Nicola et al. PubMed 42286685

Prolonged mechanical ventilation is closely associated with ventilator-induced lung injury (VILI) and ventilator-induced diaphragm dysfunction (VIDD). These two conditions occur in parallel and contribute to delayed weaning, prolonged intensive care unit (ICU) stay, and poor clinical outcomes.

[Pain in post-acute infection syndromes: clinical classification and practical management].

MMW Fortschritte der Medizin · 12 June 2026 · Luchting, Benjamin PubMed 42277526

No abstract available.

The Potential Role of Camel Milk in Alleviating Chronic Fatigue Syndrome in Mice: A Network Pharmacology and In Vivo Validation Study.

Foods (Basel, Switzerland) · 12 June 2026 · Li, Hongman, Osman, Henigul, Zhang, Hongyan, Chen, He et al. PubMed 42279648

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex and debilitating disorder with limited treatment options. Camel milk (CM), known for its rich nutrients and anti-fatigue properties, may offer multi-target benefits for managing this condition.

Significant aggravation of pre-existing myalgic encephalomyelitis/chronic fatigue syndrome following proton beam therapy for sphenoid wing meningioma: case report.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 12 June 2026 · Fischer, Christian, Seidlitz, Annekatrin, Krause, Mechthild PubMed 42277311

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder characterized by profound fatigue, post-exertional malaise (PEM), immune dysregulation, and mitochondrial dysfunction. While radiation exposure has been linked to fatigue syndromes with overlapping pathophysiology, no previous reports have described the effects of therapeutic radiation, including proton beam...

Raman Spectroscopy Combined with Machine Learning Reveals Myalgic Encephalomyelitis-Associated Biomolecular Signatures at Rest and After Standardized Stress.

International journal of molecular sciences · 12 June 2026 · Heidarifard, Maryam, Moezzi, Atefeh, Dallaire, Frédérick, Ember, Katherine et al. PubMed 42278463

Myalgic encephalomyelitis (ME) is characterized by profound fatigue, post-exertional malaise (PEM), and cognitive dysfunction. Despite its clinical significance, the pathophysiology of PEM and disease heterogeneity remain unclear, and no validated biomarkers are available for rapid diagnosis or monitoring.

Irisin Signaling Resistance in Myalgic Encephalomyelitis: A Proposed Mechanistic Framework for Post-Exertional Malaise Involving the TSP-1-HSP90α-αvβ5 Axis.

International journal of molecular sciences · 12 June 2026 · Souma, Bernard, Elremaly, Wesam, Akoume, Marie-Yvonne, Elbakry, Mohamed et al. PubMed 42278300

Myalgic Encephalomyelitis (ME) is a chronic, multisystem disease characterized by systemic metabolic dysfunction and post-exertional malaise (PEM). In this study, we investigated the dysregulation of irisin, an exercise-induced myokine, and its potential antagonism by thrombospondin-1 (TSP-1).

Benchmarking large language models for cell-free RNA diagnostic biomarker discovery.

Nature communications · 12 June 2026 · Gaudio, Hunter A, Bliss, Andrew, Loy, Conor J, Eweis-LaBolle, Daniel et al. PubMed 42276999

Large language models can synthesize biomedical knowledge, parse vast amounts of data, and generate code, positioning them as promising tools for biomarker discovery from high-throughput omics data. Here, we benchmark six models from OpenAI, Anthropic, and Google on plasma cell-free RNA datasets spanning three clinical cohorts: Kawasaki disease versus multisystem inflammatory syndrome in children, active...

Dynamic microclot profiling: thromboelastography advances precision management in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 11 June 2026 · Saleem, Shafaq, Hussain, Ahmad, Haroon, Muhammad, Raza, Ahmad et al. PubMed 42274123

Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share overlapping symptoms, and emerging evidence implicates persistent fibrinoid microclots in their pathophysiology, contributing to impaired microcirculation. This review explores the role of microclots and evaluates thromboelastography (TEG) as a potential diagnostic tool.

A new patient-led approach to building research infrastructure and evidence generation.

Oxford open immunology · 9 June 2026 · Cousins, Oonagh, Leeming, Harry, Putrino, David, Gordon, Janna PubMed 42261335

Over recent decades, patient and public involvement (PPI) has become a more established element of health research policy, although its implementation is often criticized for tokenism and for underrepresenting marginalized groups. In fields such as complex chronic illness (CCI), where formal research activity has historically been limited, conventional PPI frameworks have had little scope for meaningful application.

Post-Acute COVID-19 Vaccination Syndrome (PACVS) 2 new

Full feed: PACVS research tracker

Clinical predictors of SARS-CoV-2 vaccine immunogenicity in kidney transplant recipients at a rural center.

World journal of transplantation · 12 June 2026 · Basuli, Debargha, Ross, Bonnie, Rebellato, Lorita M PubMed 42281871

Kidney transplant recipients (KTR) have impaired immune responses to vaccination and remain at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection despite mRNA coronavirus disease 2019 (COVID-19) vaccination. Data from rural and medically underserved transplant populations remain limited.

Acute and chronic kidney injury following COVID-19 infection and vaccination: a narrative review.

European journal of translational myology · 12 June 2026 · Saadat, Seyed Hassan, Javanbakht, Mohammad, Amini, Hossein, Rouhollahei, Mahboubeh et al. PubMed 42283396

This narrative review examines acute and chronic kidney injury following COVID-19 infection and vaccination, discussing the mechanism of SARS-CoV-2 entry into host cells through the ACE2 receptor - highly expressed in renal tissues - facilitating the viral invasion. Viral RNA has been detected in the urine of patients infected with SARS-CoV-2, suggesting direct renal involvement.

Chronic Lyme / Post-Treatment Lyme Disease Syndrome 1 new

Full feed: Lyme / PTLDS research tracker

Risk factors for EBV reactivation and impact of graft composition following GVHD prophylaxis with rabbit ATG or PTCy.

Bone marrow transplantation · 10 June 2026 · Thiant, Stéphanie, Dufresne, Simon, Ahmad, Imran, Cohen, Sandra et al. PubMed 42265463

EBV reactivation is frequent after allogeneic HCT and can lead to post-transplant lymphoproliferative disorder (PTLD). While ATG and PTCy are established strategies to prevent GVHD, their comparative impact on EBV reactivation remains insufficiently characterized.

Gulf War Illness 1 new

Full feed: Gulf War Illness research tracker

Observational and genetically-informed characterization of Gulf War Illness symptoms in 1990-1991 Gulf War deployed Veterans and non-deployed Gulf War Era Veterans.

Environmental health : a global access science source · 12 June 2026 · He, Jun, Pathak, Gita A, Cabrera-Mendoza, Brenda, Qiu, Dan et al. PubMed 42277823

Gulf War Illness (GWI) has been identified in more than 20% of Veterans following military service in the 1990-1991 Gulf War (GW). Unfortunately, after several decades, GWI pathogenesis remains unclear and the patterns of GWI symptom co-occurrence are still poorly understood.

Postural Orthostatic Tachycardia Syndrome (POTS) 7 new

Full feed: POTS research tracker

Dysautonomia and joint hypermobility reflect a distinct subtype in eosinophilic esophagitis.

The Journal of allergy and clinical immunology · 13 June 2026 · Patel, Ritam H, Peraza, Jose Roberto, Keeley, Kaitlin, Dehghani, Zeinab et al. PubMed 42285365

Joint hypermobility (JH) and autonomic symptoms commonly coexist and are associated with gastrointestinal symptoms and poor quality of life. Gastric and duodenal mast cells (MCs) may be increased in these patients; however, their relevance to eosinophilic esophagitis (EoE) is unclear.

Clinical and Immunovirological Characteristics Associated with Cardiovascular Dysautonomia in Long COVID.

Journal of clinical medicine · 12 June 2026 · Renaudineau, Yves, Teillaud, Selena, Chaves, Sébastien De Almeida, Alvarez, Muriel et al. PubMed 42279051

No abstract available.

Trends in antidepressant and antianxiety medication use in patients evaluated for postural orthostatic tachycardia syndrome.

Heart rhythm · 11 June 2026 · Shrestha, Yash, de Souza, Russell J, Rabbi, Fazle, Mian, Owais et al. PubMed 42270000

No abstract available.

No association of complex regional pain syndrome and other neurological disorders with human papillomavirus vaccination in a large-scale real-world database.

Neuroepidemiology · 11 June 2026 · Kitano, Taito, Yoshida, Sayaka PubMed 42275267

Establishing evidence of vaccine safety is critical for optimizing vaccine coverage. This study aimed to assess the risk of developing neurological disorders following human papillomavirus (HPV) vaccination.

Maximizing treatment response in patients with neuropathic-subtype postural orthostatic tachycardia syndrome.

Frontiers in neurology · 11 June 2026 · Rilinger, Ryan G, Chin, Adeline Y, Cantrell, Christopher, Levine, Mackaleigh et al. PubMed 42273028

Postural Orthostatic Tachycardia Syndrome (POTS) is notoriously difficult to diagnose and successfully treat. POTS encompasses several different subtypes, but little research attention has focused on optimizing the diagnosis and treatment of specific subtypes.

Treatment of Headache in Children and Adolescents with POTS.

Current pain and headache reports · 8 June 2026 · Nayak, Katrina, Rahman, Shaoon, Oakley, Christopher PubMed 42257809

This review provides an overview of POTS in children and adolescents with headaches, with a focus on the pharmacologic and non-pharmacologic treatment approaches. Current research in headache and POTS focuses on an individualized management that includes a multi-tiered patient-centric approach that selects treatments to match specific phenotypes.

Diet and environment: unexplored influences on sleep quality in postural orthostatic tachycardia syndrome (POTS).

Annals of medicine and surgery (2012) · 8 June 2026 · Fatima, Syeda Samia, Ayaz, Syeda Nashrah, Raza, Ahmed Asad, Samadi, Abedin PubMed 42254140

Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by an excessive increase in heart rate upon standing, accompanied by symptoms such as dizziness, fatigue, palpitations, cognitive impairment, and sleep disturbances. Sleep dysfunction is increasingly recognized as a significant contributor to symptom burden and reduced quality of life among individuals with POTS.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 8 June 2026 and 14 June 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT05350774	Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 Other post-viral	Enrolling By Invitation	Phase 2	Iv Normal Saline, Iv Immunoglobulin	2026-06-12
NCT05947136	PASCA-MM Study. Impact of the PASCA (PArcours de Santé au Cours du CAncer) Program on Complications Associated With Multiple Myeloma and/or Its Treatments in the Context of a First Hematopoietic Stem Cell Autograft, in Adults Aged 18 to 70. Other post-viral	Recruiting	Not applicable	Interpretation Of The Results From The Detection Visit, Explaining Detection Results And Referrals To The Patient, Early Medical Care Through The Network	2026-06-11
NCT07359482	sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19 Long COVID	Recruiting	Phase 3	Fluvoxamine	2026-06-09
NCT05618067	The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity Other post-viral	Not Yet Recruiting	Not applicable	Breathing Exercise Training	2026-06-09
NCT07523113	ME/CFS Brain Fog: Cognitive Rehabilitation Trial ME/CFS	Not Yet Recruiting	Not applicable	Processing Speed Training, In-Session Instrumental Activities Of Daily Living Training, Transfer Package	2026-06-08
NCT07491315	Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test. ME/CFS	Recruiting	Not applicable	Exercise Test On Ergocycle, Near Infrared Spectroscopy	2026-06-08
NCT07468604	Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition Other post-viral	Recruiting	Phase 4	5 Ml Of 0.25% Bupivacaine With Epinephrine	2026-06-08

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 23 2026: 21 new studies

Sun, 07 Jun 2026 08:00:00 +0000

Between 1 June 2026 and 7 June 2026 the tracker indexed 21 new peer-reviewed studies and 10 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

21new studies this issue

10trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

ME/CFS 8 new

Full feed: ME/CFS research tracker

Novel activity and participation scales for children, adolescents, and young adults with postacute infection and vaccination syndromes and/or ME/CFS.

European journal of pediatrics · 6 June 2026 · Weidmann, Carola, Grabbe, Annika, Eberhartinger, Maria, Kircher, Alissa et al. PubMed 42249231

Children, adolescents, and young adults (CYP) with postacute infection and vaccination syndromes (PAIVS), and/or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), experience profound loss in activity and participation. We introduce and psychometrically validate two new brief, age-adapted, and domain-specific questionnaires for clinical use assessing activity and participation in this vulnerable patient...

Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study.

Journal of translational medicine · 6 June 2026 · Kim, Laura, Cammà, Guido, Peters, Claudia Kedor, Mantwill, Maron et al. PubMed 42249466

Hyperbaric oxygen therapy (HBOT) has been proposed as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but evidence remains limited. This study evaluated its clinical effectiveness and feasibility, as well as associated functional brain changes.

The expanding potential of low-dose naltrexone in clinical practice with a focus on long COVID.

The mental health clinician · 4 June 2026 · Pucci, Sara L, Veide, Allison, Pierce, Haley, Kaminski, Dana PubMed 42239825

No abstract available.

Correction to "Evidence of White Matter Neuroinflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Diffusion-Based Neuroinflammation Imaging Study".

Human brain mapping · 2 June 2026 · Authors not listed PubMed 42227214

No abstract available.

[Transdisciplinary Expert Statement: care guide for people severely affected by ME/CFS in home-based care].

Wiener medizinische Wochenschrift (1946) · 1 June 2026 · Hermisson, Joachim, Schreiner, Claudia, Weichselbaumer, Stefanie, Werner, Marlene et al. PubMed 42223876

Many of those affected by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have significant care needs. However, post-exertional malaise, the defining feature of ME/CFS, means that even minor physical, orthostatic, cognitive, or sensory stressors can trigger a disproportionate worsening of health status, condition and symptoms.

Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Leading to Assisted Suicide in a Patient in Her Late 30s: A Case Report.

Cureus · 1 June 2026 · Opala, Dominika, Villiger, Erich, Levenfus, Ian PubMed 42222634

A patient in her late 30s developed severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) following an Epstein-Barr virus infection. No distinct autoimmune or autoinflammatory disorder could be identified as the underlying cause of her symptoms, as the observed constellation of cytokine elevations (IL-2, IL-6, and IFN-γ) was not consistent with any known or established disease entity.

Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation.

Frontiers in immunology · 1 June 2026 · Hu, Zekai, Wang, Jinyan, Ma, Sicong, Zhuang, Jie et al. PubMed 42220511

Inflammation-driven fatigue is a clinically significant feature of several chronic inflammatory conditions, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), post-COVID condition, autoimmune disease, and cancer-related fatigue. Across these conditions, partially overlapping disturbances in immune regulation, cellular metabolism, and neuroimmune signaling may contribute to persistent fatigue...

Components and Delivery Formats of Cognitive Behavioral Therapy for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Systematic Review and Component Network Meta-Analysis.

Brain and behavior · 1 June 2026 · Wang, Shoujian, Ren, Jun, Fang, Sitong, Hao, Qiukui et al. PubMed 42219745

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating condition characterized by persistent fatigue, impaired functioning, and substantial societal burden. Although cognitive behavioral therapy (CBT) is commonly used for CFS/ME, the effective components and delivery formats remain unclear.

Post-Acute COVID-19 Vaccination Syndrome (PACVS) 1 new

Full feed: PACVS research tracker

A narrative review of COVID-19 epidemiology and mRNA vaccine impact in children <12 years during the omicron era (November 2021 - December 2025).

Expert review of vaccines · 5 June 2026 · Zheng, Zhe, Yousefi, Mitra, Marks, Morgan, Dixit, Avika et al. PubMed 42246405

COVID-19 continues to pose a burden in children under 12 years of age during the Omicron era (November 2021 - December 2025). Following Omicron's emergence, SARS-CoV-2 seroprevalence increased rapidly, with most children infected by ages 2-4 years.

Gulf War Illness 1 new

Full feed: Gulf War Illness research tracker

Mitochondrial Bioenergetic Approach to Restore Veteran Vitality: A Feasibility Pilot.

Integrative medicine (Encinitas, Calif.) · 1 June 2026 · Osinubi, Omowunmi, Greer, Steven, McManus, Pauline, Carlson, Carrie J et al. PubMed 42222193

No abstract available.

Postural Orthostatic Tachycardia Syndrome (POTS) 9 new

Full feed: POTS research tracker

What are we treating? The need for broader provider understanding of POTS, its nature, and care.

The American journal of medicine · 6 June 2026 · Reyes, Jorge L, Fedorowski, Artur, Deering, Thomas, Grubb, Blair et al. PubMed 42248496

Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically > 3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lightheadedness, and near-syncope) in the absence of orthostatic hypotension (ie, absence of a sustained systolic blood pressure drop > 20mmHg with upright posture). More recently, however, the :landscape...

Postural tachycardia during active standing: diagnostic criteria in adolescents.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 5 June 2026 · Jarjour, Imad T, Aras, Sukru, Jarjour, Laila K PubMed 42247198

No abstract available.

Patient-reported perspectives of a temporal relationship between autonomic dysfunction and mental health symptoms in a pediatric population.

Autonomic neuroscience : basic & clinical · 5 June 2026 · Frye, William S, Ward, Sydney R, Johnston, Julia D PubMed 42241931

Autonomic dysfunction, characterized by orthostatic intolerance and presyncope, is understudied in youth. Mental health comorbidities are commonly reported and sometimes blamed for the onset of autonomic dysfunction; however, no studies have yet examined this relationship.

Monocyte Oxidative Stress Underlies Persistent Immune Activation in Long COVID Postural Orthostatic Tachycardia Syndrome.

medRxiv : the preprint server for health sciences · 5 June 2026 · Abd-Eldayem, Marwa A, Vinayagam, Meenakshi, Vance, Yuliya A, Paranjape, Sachin Y et al. PubMed 42245008

Long COVID Postural Orthostatic Tachycardia Syndrome (LCPOTS) is characterized by persistent orthostatic tachycardia and systemic symptoms following SARS-CoV-2 infection. Many features of LCPOTS suggest ongoing immune activation, but the mechanisms driving this response remain unclear.

Integrating psychological care into atrial fibrillation management: insights from HOPE-AF.

European journal of cardiovascular nursing · 5 June 2026 · Wilson, Gemma, Tully, Phillip J, Gallagher, Celine PubMed 42246770

No abstract available.

To tilt or not? Role of the active stand test in the evaluation of postural orthostatic tachycardia syndrome (POTS).

Autonomic neuroscience : basic & clinical · 4 June 2026 · Uppal, Jaiden, Sheldon, Robert S, Raj, Satish R PubMed 42235469

No abstract available.

Comorbidities in Ehlers-Danlos syndromes and hypermobile spectrum disorders.

Acta ortopedica mexicana · 3 June 2026 · Wang, T J, Serrano-Ardila, A M PubMed 42229474

hypermobile spectrum disorders (HSD) and Ehlers-Danlos syndromes (EDS) are connective tissue disorders often associated with systemic manifestations such as mast cell activation syndrome (MCAS), postural orthostatic tachycardia syndrome (POTS), irritable bowel syndrome (IBS), and autoimmune conditions, including spondyloarthritis (SpA). The overlap of these conditions complicates diagnosis and treatment.

The long and winding road of postural orthostatic tachycardia syndrome.

Journal of internal medicine · 1 June 2026 · Fedorowski, Artur PubMed 42222895

No abstract available.

Research progress on the prediction of heart rate and blood pressure in the diagnosis and prognosis of pediatric postural orthostatic tachycardia syndrome.

Cardiology in the young · 1 June 2026 · Wang, Shuo, Zou, Runmei, Cai, Hong, Wang, Cheng PubMed 42219912

Pediatric postural orthostatic tachycardia syndrome is one of the main haemodynamic types of neurally mediated syncope and is commonly seen in school-aged children. Heart rate and blood pressure are important physiological indicators in the human cardiovascular system.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 1 June 2026 and 7 June 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT06614309	Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog Long COVID	Recruiting	Not applicable	Acute Progressive Carbon Dioxide, Acute Intermittent Hypoxia, Training: Progressive Carbon Dioxide Ramping	2026-06-05
NCT07627815	Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID Long COVID	Recruiting	Phase 2	Paragon Novel Metabolic Regulator, Dietary And Lifestyle Recommendations	2026-06-04
NCT07621588	Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID Long COVID	Not Yet Recruiting	Not applicable	Diaphragmatic Electrostimulation Using Kots Currents, Diaphragmatic Breathing Exercises	2026-06-04
NCT06560554	Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID Long COVID	Enrolling By Invitation	Not applicable	Fermented Foods	2026-06-03
NCT06404112	RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD) Long COVID	Completed	Phase 2	Melatonin, Tailored Lighting (Tl) Active	2026-06-03
NCT06404099	RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia) Long COVID	Completed	Phase 2	Modafinil, Solriamfetol	2026-06-03
NCT06305793	RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG) Long COVID	Active Not Recruiting	Phase 2	IVIG (Intravenous Immunoglobulin), Coordinated Care	2026-06-03
NCT07621068	Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS) ME/CFS	Not Yet Recruiting	Not applicable	Hyperbaric Oxygen Therapy (HBOT)	2026-06-02
NCT03807973	Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes. ME/CFS	Suspended	Phase 1	[Zr-89]Oxine-Labeled Leukocytes Pet/Mri	2026-06-02
NCT03759522	Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714. ME/CFS	Recruiting	Phase 1	Dpa-714 Pet/Mri	2026-06-02

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 22 2026: 11 new studies

Sun, 31 May 2026 08:00:00 +0000

Between 25 May 2026 and 31 May 2026 the tracker indexed 11 new peer-reviewed studies and 5 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

11new studies this issue

5trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

ME/CFS 6 new

Full feed: ME/CFS research tracker

Cardiopulmonary exercise test results do not change over two sequential days in patients with chronic fatigue syndrome.

Frontiers in physiology · 29 May 2026 · Mancini, Donna M, Cook, Dane B, Brunjes, Danielle L, Soto, Tiffany et al. PubMed 42212259

Two consecutive cardiopulmonary exercise tests (CPETs) performed 24 hours apart are increasingly used to determine post-exertional malaise (PEM) and disability in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Declines in functional capacity on Day 2 reflect impaired recovery and PEM.

Central noradrenergic deficiency in post-infectious chronic fatigue: neurobehavioral correlates.

Brain communications · 28 May 2026 · Aregawi, Lillian, Walitt, Brian, Sullivan, Patti, Norato, Gina et al. PubMed 42205163

Fatigue, brain fog and post-exertional malaise are major features of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of severe acute respiratory syndrome coronavirus 2. To date, no specific neurotransmitter abnormalities have been found in either condition.

Toward a Molecular Reclassification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Integrating Multi-Omics, Machine Learning, and Precision Medicine.

International journal of molecular sciences · 27 May 2026 · Frank, Joshua, Nesterovitch, Nicole, Movva, Chetana, Klimas, Nancy G et al. PubMed 42196410

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease characterized by a multitude of symptoms across various organ systems. Diagnosis has relied heavily on heterogeneous clinical symptom presentation and evolving case definitions, with treatment focused on addressing presenting symptoms due to the paucity of validated biomarkers.

Shared genetic risk between functional somatic syndromes, internalizing disorders, and immune-mediated diseases: a twin-sibling study.

Brain, behavior, and immunity · 27 May 2026 · Steen, Olivier D, Ohlsson, Henrik, van Ockenburg, Sonja L, Kendler, Kenneth S et al. PubMed 42190845

Functional somatic syndromes frequently co-occur with internalizing disorders such as anxiety disorders and major depressive disorder. Both show familial associations with immune-mediated diseases.

Human Endogenous Retroviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Emerging Roles in Pathogenesis, Immunity, Biomarkers and Therapeutics.also Other post-viral

International journal of molecular sciences · 27 May 2026 · Perera, Krishani Dinali, Oltra, Elisa, Carding, Simon R PubMed 42196290

Human endogenous retroviruses (HERVs) are potential driving forces of the pathophysiology of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), linking post-infectious immune dysfunction to chronic inflammation and immune and neurocognitive dysfunction that are hallmark features of ME/CFS. Accumulating evidence from related autoimmune diseases and cancers has shown that reactivated HERVs can contribute to...

Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in Chronic Fatigue Syndrome and Long COVID.

International journal of molecular sciences · 27 May 2026 · Petrov, Steliyan, Bozhkova, Martina, Ivanovska, Mariya, Kalfova, Teodora et al. PubMed 42196466

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long Coronavirus Disease 2019 (long COVID) are complex chronic conditions that often follow infectious triggers with overlapping clinical features but poorly defined pathophysiological relationships. This study aimed to identify disease-specific immune signatures through multiparameter immunophenotyping of monocytes, dendritic cells, and T cell subsets.

Postural Orthostatic Tachycardia Syndrome (POTS) 4 new

Full feed: POTS research tracker

[Post-COVID postural orthostatic tachycardia syndrome: Documentation of a hyperadrenergic phenotype by comprehensive autonomic testing].

Annales de cardiologie et d'angeiologie · 27 May 2026 · Rahali, Z, El Boussaadani, B, Raissuni, Z PubMed 42191437

Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia characterized by an excessive increase in heart rate upon standing, in the absence of orthostatic hypotension. Post-infectious forms, particularly following SARS-CoV-2 infection, have been increasingly reported.

Physiological and clinical comparison of active stand and head-up tilt tests in Postural Orthostatic Tachycardia Syndrome (POTS).

Autonomic neuroscience : basic & clinical · 27 May 2026 · Robbins, N M PubMed 42191429

No abstract available.

Eye pain and ocular surface characteristics in Postural Orthostatic Tachycardia Syndrome (POTS): The role of autonomic dysfunction.

The ocular surface · 25 May 2026 · Karakus, Sezen, Huang, Jane Jin, Yashar, Meltem, Haile, Meron et al. PubMed 42183595

Postural Orthostatic Tachycardia Syndrome (POTS), an autonomic nervous system dysfunction, is frequently associated with ocular symptoms including pain and dryness. This study aimed to characterize ocular surface findings in POTS patients to clarify whether these symptoms reflect classic dry eye disease or altered sensory processing related to autonomic dysfunction.

Comparative Analysis of Circulating Cytokines and Adrenergic Autoantibodies in Postural Orthostatic Tachycardia Syndrome, Postacute Sequelae of SARS-CoV-2, and Healthy Controls.

Journal of the American Heart Association · 25 May 2026 · Seeley, Marie-Claire, Gallagher, Celine, Wilson, Gemma, Bailey, Danielle et al. PubMed 42179241

Postural orthostatic tachycardia syndrome (POTS) is increasingly recognized after SARS-CoV-2 infection. We compared autonomic phenotype, functional impact, and circulating immune markers in POTS, postacute sequelae of COVID-19 (PASC), and healthy controls.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 25 May 2026 and 31 May 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT06847191	NE3107 in Adults With Neurological Symptoms of Long COVID Long COVID	Active Not Recruiting	Phase 2	Ne3107	2026-05-29
NCT05676008	A Study of Positive Emotions With Long COVID-19 Long COVID	Active Not Recruiting	Not applicable	Microdosing Of Mindfulness	2026-05-29
NCT07559994	Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain Long COVID	Active Not Recruiting	Not applicable	Coronary Functional Test	2026-05-28
NCT06721949	Taurine Supplementation in Long COVID Long COVID	Recruiting	Phase 2	Taurine	2026-05-27
NCT05705193	Brain-Training Treatment for Long COVID in Older Adults Long COVID	Active Not Recruiting	Not applicable	Neuroflex	2026-05-26

Browse all tracked trials: clinical trials tracker.

Post-viral research digest, week 21 2026: 17 new studies

Sun, 24 May 2026 08:00:00 +0000

Between 18 May 2026 and 24 May 2026 the tracker indexed 17 new peer-reviewed studies and 8 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

17new studies this issue

8trial updates this issue

544studies currently in the feeds

620clinical trials tracked

546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

New studies by condition

ME/CFS 9 new

Full feed: ME/CFS research tracker

Deficient TRPM3-linked mitochondrial Ca

BMC immunology · 24 May 2026 · Magawa, Chandi Tabeth, Eaton-Fitch, Natalie, Muraki, Katsuhiko, Marshall-Gradisnik, Sonya PubMed 42177403

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic illness, commonly associated with dysregulation of the immune system including reduced cytotoxicity of natural killer (NK) cells and post-exertional neuroimmune exhaustion. Previously, transient receptor potential melastatin 3 (TRPM3) ion channel impairment associated with reduced Ca Fluorescence live-cell imaging was used to investigate...

Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.

Journal of translational medicine · 23 May 2026 · Watton, Paul, Prusty, Bhupesh K PubMed 42174604

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem illness marked by post-exertional malaise (PEM), cognitive dysfunction, autonomic disturbance, and impaired physiological resilience. Historically, the absence of validated biomarkers, heterogeneous definitions, and limited investigative capacity have complicated mechanistic interpretation and contributed to the use of psychosocial...

Post COVID-19 treated with AstraZeneca vaccine exacerbates arthritis with susceptibility to herpes in an older woman: A case report.

Medicine · 23 May 2026 · Guzman, David Calderon, Brizuela, Norma Osnaya, Herrera, Maribel Ortiz, Peraza, Armando Valenzuela et al. PubMed 42175450

Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide. This report describes a rare case of herpes infection, secondary to RA, that emerged after coronavirus disease 2019 (COVID-19) infection or vaccination.

A systematic scoping review and conceptual analysis of new-onset fibromyalgia manifestations after non-hospitalized COVID-19: empirics, definitions, methodologies, pathophysiology, mapping of literature, and knowledge gaps.

Journal of translational medicine · 23 May 2026 · Plaut, Shiloh PubMed 42174645

The global coronavirus pandemic has led to a quiet wave of a chronic illness referred to as 'Long/Post Covid-19 syndrome' (LC) which bears a notable resemblance to functional-somatic or 'fibromyalgia-type' syndromes, and whose pathophysiology is undetermined. The lack of effective therapies for LC is straining healthcare systems worldwide and causing widespread public health and socioeconomic concerns.

Longitudinal association of mental-health problems with subsequent diagnosis of persistent somatic symptom disorders: A large-scale registry-based observational study in primary care.

General hospital psychiatry · 22 May 2026 · Kitselaar, Willeke M, Hartmann, Lea, Evers, Andrea W M, Numans, Mattijs E PubMed 42167072

Somatic symptoms of common persistent somatic symptom (PSS) syndromes like irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and fibromyalgia (FM) are not fully attributed to well-established biomedical pathological processes. These syndromes are often under-recognized and diagnosis is often delayed.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS-CoV-2 Infection-A Case Report.

Clinical case reports · 20 May 2026 · Ciobanu, Georgiana, Arn, Norbert PubMed 42158223

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex neuroimmunological disorder characterized by disabling symptoms that are often difficult to manage. More recently, in the context of SARS-CoV-2 infection, potential pathophysiological overlaps and disease modulation have been hypothesized.

Response: Commentary: Cognitive behavioural therapy for the treatment of chronic fatigue syndrome in adults: a short analysis of the meta-analysis.

Frontiers in psychiatry · 18 May 2026 · Kolala, Vivek, La Rosa, Billie, Vangaveti, Venkat, Chen, Kai Yang PubMed 42147023

No abstract available.

Phenotypes of Chronic Overlapping Pain Multimorbidity in Rheumatology: A Population-Based Claims Study.

Arthritis care & research · 18 May 2026 · Lu, Di, Cunanan, Kristen, Cragun, James, Vuong, Lauren et al. PubMed 42148468

This study aims to characterize the burden and distinct patterns of chronic overlapping pain conditions (COPCs) multimorbidity in adults with autoimmune rheumatic diseases (ARDs). We analyzed 2008 to 2021 data from the Merative MarketScan Commercial Claims and Encounters Database, identifying 149,742 patients with ARDs (ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, Sjögren disease, systemic...

Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses.also Lyme / PTLDS

Brain : a journal of neurology · 18 May 2026 · Arnaboldi, Paul M, Becker, Jacqueline, Nath, Avindra, Coyle, Patricia K et al. PubMed 42148664

Infection-associated chronic illnesses (IACIs) encompass a spectrum of poorly understood syndromes often marked by significant neurologic and multisystem symptoms following an infectious event. This review focuses on several diseases representative of the IACI spectrum.

Postural Orthostatic Tachycardia Syndrome (POTS) 4 new

Full feed: POTS research tracker

Presumed Postural Tachycardia Syndrome: 12-Lead Electrocardiograms During Tilt Table Testing Unmask an Atrial Tachycardia.

JACC. Case reports · 21 May 2026 · Ramonfaur, Diego, El-Assaad, Iqbal, Mayuga, Kenneth A PubMed 42165488

Tilt table testing is commonly used to evaluate orthostatic intolerance and syncope and is typically performed with three-lead electrocardiography (ECG) monitoring, which limits P-wave interpretation. A 21-year-old woman with congenitally corrected transposition of the great arteries presented with recurrent tachy-palpitations and near syncope and was presumed to have postural tachycardia syndrome (POTS) after...

Gut hormones in POTS and their relation to hemodynamic parameters and gastrointestinal symptoms.

Scientific reports · 20 May 2026 · Tufvesson, Hanna, Roth, Bodil, Johansson, Madeleine, Hamrefors, Viktor et al. PubMed 42156945

Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS.

Long-term outcomes in patients with postural orthostatic tachycardia syndrome with an average follow-up of over 20 years.

Journal of internal medicine · 19 May 2026 · Bourne, Kate M, Gamboa, Alfredo, Black, Bonnie, Hall, Juliette et al. PubMed 42153984

Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily affects female patients. There are scarce data evaluating the long-term outcomes in POTS.

Do Medications Actually Help in Patients with Postural Orthostatic Tachycardia Syndrome?: A Qualitative Study.

CJC open · 18 May 2026 · Uppal, Jaiden, Deol, Paras, Giri, Priyanshu, Sheldon, Robert S et al. PubMed 42146286

Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder associated with debilitating symptoms. No medications have been approved for treatment, and patients commonly use off-label medications to treat symptoms.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 18 May 2026 and 24 May 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCT	Trial	Status	Phase	Agents	Updated
NCT07317401	Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment ME/CFS	Not Yet Recruiting	Not applicable	Intermittent Hypoxia-Hyperoxia Treatment	2026-05-22
NCT07076862	Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC) Long COVID	Recruiting	Early phase 1	A.1 - [¹⁸F]F-Arag Pet/Ct, A.2 - [¹⁸F]F-Arag Pet/Ct, B.1 - [¹⁸F]F-Arag Pet/Ct	2026-05-22
NCT05747534	AT1001 for the Treatment of Long COVID Long COVID	Active Not Recruiting	Phase 2	Larazotide Acetate	2026-05-22
NCT07600320	Fareon Open Label Device Clinical Trial Other post-viral	Not Yet Recruiting	Not applicable	Fareon Device	2026-05-20
NCT07597902	SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction Long COVID	Not Yet Recruiting	Phase 2	Valacyclovir, Celecoxib, Paxlovid (Nirmatrelvir/Ritonavir)	2026-05-19
NCT07224490	Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease Long COVID	Recruiting	Phase 1	Kisspeptin 112-121	2026-05-19
NCT06960928	Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 Long COVID	Recruiting	Phase 3	Sirolimus (low-dose)	2026-05-18
NCT05699538	Fatigability in Long COVID-19 Long COVID	Completed	Not applicable	Minimal-Dose Home-Based Resistance Exercise	2026-05-18

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