75 studies
An automated collection of peer-reviewed publications on POTS (Postural Orthostatic Tachycardia Syndrome) and related dysautonomia. POTS is a form of autonomic dysfunction characterized by an excessive heart rate increase on standing, often with dizziness, fatigue, brain fog, exercise intolerance, and syncope or pre-syncope. It commonly follows viral infection, including SARS-CoV-2 and COVID-19 vaccination, and frequently overlaps with Long COVID, PACVS, and ME/CFS phenotypes.
Latest research: this page tracks 75 studies on POTS indexed in PubMed, published between Jul 12, 2026 and Nov 5, 2026. The 30 most recent are listed below; the search box filters the full list. Journals with the most studies in this set: Autonomic neuroscience : basic & clinical (7), Clinical autonomic research : official journal of the Clinical Autonomic Research Society (7) and Cureus (3). List refreshed Nov 6, 2026 from PubMed.
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Disclaimer: Automated PubMed feed. Not medical advice. Consult a qualified healthcare provider.
More common than we thought: Hypermobile Ehlers-Danlos Syndrome, comorbidity burden, and long COVID risk in a national cohort.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID. Using data from over 19 million patie...
Experiences of individually tailored physical exercise in COVID-19-induced postural orthostatic tachycardia syndrome: A qualitative content analysis.
Postural Orthostatic Tachycardia Syndrome (POTS) is a phenotype of post-COVID-19 Condition (PCC), characterised by orthostatic intolerance and a range of debilitating symptoms. Exercise is a frequently implemented intervention in the treatment of POTS and PCC. However, patients' experiences with exercise as a therapeutic modality remain largely unexplored. This study aimed...
Gender Diversity in Pediatric Chronic Orthostatic Intolerance: Mental Health and Quality-of-Life Outcomes.
This retrospective medical record review examined the proportion of transgender and gender-diverse (TGD) youth within a multidisciplinary pediatric autonomic dysfunction clinic specializing in chronic orthostatic intolerance, compared quality-of-life (QoL) scores between TGD and cisgender youth, and identified opportunities to improve health equity in nonpharmacological re...
Fibromyalgia and dysautonomia: towards a neurophysiological framework for personalized management.
Fibromyalgia (FM) is a persistent, heterogeneous disorder characterized by widespread pain and multiple non-pain symptoms, including fatigue, cognitive dysfunction, gastrointestinal disturbance, dizziness and balance impairment. Increasing evidence suggests that autonomic dysfunction may contribute to this multisystem presentation, with abnormalities in heart rate variabil...
Evaluation and Management of Syncope in Pregnancy and Postpartum.
Syncope and presyncope symptoms occur commonly in pregnancy. Evaluation of syncope should include careful history and physical examination to determine underlying etiology. Patients with concerns for cardiogenic syncope require cardiology evaluation and multidisciplinary management. Orthostatic hypotension, vasovagal syncope and orthostatic intolerance carry favorable prog...
Orthostatic and exercise intolerance in post-acute sequelae of COVID-19 occur with intact sympathetic neural control and preserved cardiac reserve.
No abstract available.
Overlapping Post-COVID Conditions: A Case of Myalgic Encephalomyelitis and Postural Orthostatic Tachycardia Syndrome Triggered by Sequential Epstein-Barr Virus (EBV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections.
The rise in post-infectious syndromes following COVID-19, such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Postural Orthostatic Tachycardia Syndrome (POTS), has become increasingly common in clinical practice, representing an emerging clinical challenge. This case highlights a possible clinical scenario involving the interaction between sequential vi...
Editorial: Hereditary alpha-tryptasemia: 10 years on.
Hereditary alpha-tryptasemia (H
Hypermobility spectrum disorder/hypermobile Ehlers-Danlos syndrome, mast cell activation syndrome, and dysautonomia as risk factors for adverse events and complications.
Hypermobility spectrum disorder/hypermobile Ehlers-Danlos syndrome (HSD/hEDS), mast cell activation syndrome (MCAS), and dysautonomia, including postural orthostatic tachycardia syndrome (POTS), are comorbid conditions encountered in clinical practice with possible overlapping immunologic, autonomic, and connective tissue abnormalities. Clinicians frequently observe that i...
Small Fiber Neuropathy is Present in Nonpainful Conditions.
No abstract available.
Heart Rate-Lowering Therapies for Tachycardia in Postural Orthostatic Tachycardia Syndrome: A Systematic Review.
Postural orthostatic tachycardia syndrome (POTS) is defined by a sustained increase in heart rate of ≥30 beats/min within 10 minutes of standing, accompanied by symptoms of orthostatic intolerance persisting for at least 3 months. Prior research has focused on determinants of tachycardia, raising the question of whether the tachycardia represents a compensatory mechanism o...
Nutritional strategies to manage postural orthostatic tachycardia syndrome (POTS) and its comorbidities: A narrative review.
BackgroundPostural orthostatic tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system characterized by orthostatic intolerance and involvement of multiple organ systems. It commonly coexists with conditions such as hypermobile Ehlers-Danlos syndrome (hEDS), mast cell activation syndrome (MCAS), and a spectrum of gastrointestinal (GI) disord...
Exogenous testosterone use in cisgender heterosexual females with postural orthostatic tachycardia syndrome: A dual case report.
Exogenous testosterone has been previously reported to have given clinical improvement in symptoms of postural orthostatic tachycardia syndrome (POTS) in reported cases of transgender patients during their transition from female to male. Herein is presented two case reports of cisgender heterosexual female patients with POTS who have used testosterone for the management of...
Post-translational modifications in the insoluble fraction of platelet-poor plasma distinguish pre-COVID-19 Postural Orthostatic Tachycardia Syndrome, Long COVID, and Long COVID-POTS: a preliminary study.
Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS), Long COVID with initial orthostatic hypotension (LC-IOH), and Long COVID-POTS (LC-POTS) are primarily chronic post-viral conditions with debilitating symptoms, despite routine laboratory findings often being normal. We previously identified amyloidogenic fibrinaloid microclot complexes (FMCs) in the insolubl...
Are we treating the wrong POTS in RECOVER-AUTONOMIC? A call for phenotype subtyping.
No abstract available.
Evidence of autoimmune etiology in children with small fiber neuropathy.
Small fiber neuropathy (SFN) is becoming increasingly recognized as a cause of autonomic dysfunction, sensory disturbances, and neuropathic pain. While SFN was previously considered predominantly idiopathic, cases of autoimmune SFN are now well described in adults but remain underexplored in children. In this retrospective chart review, we identified pediatric patients dia...
[An insight into the long/post COVID care situation in Germany-a rapid scoping review].
Long/post COVID and related conditions such as myalgic encephalomyelitis/chronic fatigue syndrome, postural orthostatic tachycardia syndrome and post-vaccination syndrome are associated with persistent functional impairments and are met with care structures in Germany that are difficult to navigate. The rapid scoping review offers an insight into care structures, capacitie...
Effect of transcutaneous auricular vagus nerve stimulation on perioperative psychological symptoms in patients undergoing elective thoracoscopic lung resection: A randomized controlled trial.
Perioperative anxiety is highly prevalent in patients undergoing thoracoscopic lung resection, adversely affecting postoperative recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising noninvasive neuromodulatory intervention with demonstrated efficacy in various psychiatric and stress-related conditions. This study aimed to evaluate t...
Effectiveness of Individualized Physical Exercise in COVID-19-Induced Postural Orthostatic Tachycardia Syndrome.
Postural orthostatic tachycardia syndrome (POTS) is common in post-COVID-19 condition and is associated with high symptom burden and reduced quality of life. Although physical exercise is recommended for POTS, evidence of its effectiveness remains limited. The objectives of the study was to evaluate the effectiveness of tailored exercise on health-related quality of life (...
The link between inflammation and autonomic dysfunction in alpha-synucleinopathies - narrative review.
Alpha-synucleinopathies are a group of disorders characterized by the accumulation of the pathological form of alpha-synuclein. This group comprises Parkinson's disease, Parkinson's disease dementia, multiple system atrophy, dementia with Lewy bodies, pure autonomic failure, and idiopathic REM sleep behavior disorder. Despite sharing a similar molecular basis, these disord...
Targeting Brain-Body Processes in Postural Tachycardia Syndrome: A Pilot Trial of POts Reprocessing Therapy.
Postural tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by orthostatic intolerance and frequently accompanied by a broad constellation of debilitating symptoms. Emerging evidence suggests that dysregulation within central-autonomic regulatory networks may contribute to symptom persistence. We developed POts Reprocessing Therapy (PORT), a neuropla...
Pediatric Abdominal Vascular Compression Syndromes: Clinical Presentation, Comorbidities, asnd Outcomes Following Surgical Correction.
The goal of this case series was to characterize the clinical presentation, comorbidities, and postoperative outcomes of pediatric patients who underwent surgical repair for median arcuate ligament syndrome (MALS) and/or nutcracker syndrome (NCS). We conducted a retrospective chart review of 17 pediatric patients who underwent open surgical repair for MALS and/or NCS at a ...
Association between symptoms of pediatric postural orthostatic tachycardia syndrome and joint hypermobility syndromes.
No abstract available.
Multimorbidity, functional impairment and health-related quality of life in postural orthostatic tachycardia syndrome: findings from an Australian observational cohort study.
To characterise the symptom, comorbidity and diagnostic journey of adult and older adolescent patients with postural orthostatic tachycardia syndrome (POTS). Cross-sectional observational cohort study. Participants ≥16 years old with physician-confirmed POTS who enrolled in the Australian POTS registry between 1 May 2021 and 30 April 2024 were included. 500 participants en...
In reply to: "Spontaneous intracranial hypotension and autonomic dysfunction association highlights POTS as a central nervous system disorder".
No abstract available.
Coexisting Postural Orthostatic Tachycardia Syndrome on Autonomic Reflex Testing in Functional Neurologic Disorder.
BACKGROUND Functional neurological disorder (FND) is characterized by neurological symptoms identified through positive clinical signs that are incongruent with recognized structural neurological disease. Postural orthostatic tachycardia syndrome (POTS), in contrast, is defined by excessive orthostatic tachycardia and is associated with a range of multisystem autonomic sym...
Cardiovascular autonomic dysfunction in late-stage Lyme disease: a comprehensive autonomic assessment.
Lyme disease, caused by
Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome.
No abstract available.
Orthostatic Intolerance in Patients With Disorders of Gut-Brain Interaction: A Systematic Review and Meta-Analysis.
Patients with severe manifestations of disorders of gut-brain interaction (DGBI) have higher rates of concomitant Orthostatic Intolerance (OI) and Postural Orthostatic Tachycardia Syndrome (POTS). These conditions diminish quality of life and increase health care use. We conducted a systematic review to assess OI and POTS prevalence in patients with DGBI. Databases were se...
The Expanding Multisystem Research Landscape of Hypermobile Ehlers-Danlos Syndrome: An Analysis of Orthopedic, Autonomic, Immunologic, and Neuropsychiatric Comorbidities.
Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorder (HSD) are increasingly recognized among orthopedic physicians to cause joint instability, frequent dislocation, and chronic musculoskeletal pain. Yet, patients with these disorders frequently have coexisting conditions, such as postural tachycardia syndrome (POTS), mast cell activation syndrome (...
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