RepurpOS

Polycythaemia Vera / Myeloproliferative Neoplasms

Disease intelligence for Polycythemia Vera: 80 alterations and 277 ranked therapeutics from curated public databases.

US DALYs606.6KWHO GHE 2021 · all ages
Global DALYs11.04MWHO GHE 2021 · worldwide
US mortality26.9K deaths/yrWHO GHE 2021
Global mortality311.3K deaths/yrWHO GHE 2021 · worldwide
Spontaneous remissionPV/ET/MF: no spontaneous remission; progressive disorders with risk of transformation to MF (PV/ET) and blast phase…
Best-intervention remissionJAK2 inhibitor (ruxolitinib) for MF/PV: 35-42% spleen volume reduction, significant symptom improvement…
Gap sizeModerate — ruxolitinib is established but HSCT underused in eligible MF patients; ropeginterferon is superior in PV…
Primary barrieraccess/practice
Full remission profile →

Disease overview

Alterations
80
Molecular (A)
36
Clinical (B–E)
44
Trial outcome measures (T)
0
Direct drugs
53
Via biomarker
224
Natural agents
0
Natural products
0
Merged ranked
277
With trial/literature evidence
25

Sources: Open Targets, HPO, ClinicalTrials.gov, DGIdb, ChEMBL, PubMed Literature, Seeds, Examine.com · Pipeline phase 7 · Updated 2026-10-15

Remission & chronicity

Spontaneous remission
PV/ET/MF: no spontaneous remission; progressive disorders with risk of transformation to MF (PV/ET) and blast phase (all); median survival PV >20 years, MF 5-7 years
Best-intervention remission
JAK2 inhibitor (ruxolitinib) for MF/PV: 35-42% spleen volume reduction, significant symptom improvement; ropeginterferon alfa-2b: superior complete haematological response vs hydroxyurea (PROUD-PV); allogeneic HSCT (MF): curative in 30-60% of transplant-eligible patients
Drug-free remission
—
Relapse after remission
—
Chronicity
—
Gap size
Moderate — ruxolitinib is established but HSCT underused in eligible MF patients; ropeginterferon is superior in PV but access varies
Primary barrier
access/practice
Barrier detail: Hydroxyurea remains the most common cytoreductive agent for PV/ET despite ropeginterferon demonstrating superior molecular response; HSCT for MF is underutilised in patients who could benefit; JAK2 mutation molecular monitoring not performed systematically

Last SoC change: 2022 — ropeginterferon alfa-2b (Besremi) FDA approved for PV; 2019 fedratinib (JAK2/FLT3) for MF; pacritinib 2022 for thrombocytopenic MF; ruxolitinib 2011 for MF, 2014 for PV; hydroxyurea standard since 1960s

Remission data layers: disease_db_100 · source-locked manual data · confidence: high

Related: Fitness landscape

Identifiers: MONDO: MONDO:0009891 · ORPHA: ORPHA:729

Alterations

80 total · Types A (molecular) through E (functional). Molecular rows are Open Targets gene–disease associations (evidence column = OT association score), not measured levels; phenotypes are HPO terms annotated directly to this disease (Monarch); type T rows are outcome measures used in completed ClinicalTrials.gov studies, not alterations of the disease.

NameTypeSubtypeDirection FrequencyEvidenceSourcesLinks
FLT3
fms related receptor tyrosine kinase 3
 Molecular Gene — — OT score 0.55 Open Targets UniProt Ensembl Open Targets
CHEK2
checkpoint kinase 2
 Molecular Gene — — OT score 0.45 Open Targets UniProt Ensembl Open Targets
ACVR1
activin A receptor type 1
 Molecular Gene — — OT score 0.40 Open Targets UniProt Ensembl Open Targets
DNMT3A
DNA methyltransferase 3 alpha
 Molecular Gene — — OT score 0.38 Open Targets UniProt Ensembl Open Targets
ASXL1
ASXL transcriptional regulator 1
 Molecular Gene — — OT score 0.31 Open Targets UniProt Ensembl Open Targets
CELF2
CUGBP Elav-like family member 2
 Molecular Gene — — OT score 0.31 Open Targets UniProt Ensembl Open Targets
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
 Molecular Gene — — OT score 0.31 Open Targets UniProt Ensembl Open Targets
BCR
BCR activator of RhoGEF and GTPase
 Molecular Gene — — OT score 0.31 Open Targets UniProt Ensembl Open Targets
HDAC1
histone deacetylase 1
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
HDAC10
histone deacetylase 10
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
HDAC11
histone deacetylase 11
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
EPAS1
endothelial PAS domain protein 1
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
CALR
calreticulin
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
CBL
Cbl proto-oncogene
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
EZH2
enhancer of zeste 2 polycomb repressive complex 2 subunit
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
BCOR
BCL6 corepressor
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
GATA2
GATA binding protein 2
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
APC
APC regulator of Wnt signaling pathway
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
ALK
ALK receptor tyrosine kinase
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
FAT4
FAT atypical cadherin 4
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
GNAS
GNAS complex locus
 Molecular Gene — — OT score 0.28 Open Targets UniProt Ensembl Open Targets
CLMB
calcimembrin
 Molecular Gene — — OT score 0.25 Open Targets UniProt Ensembl Open Targets
DPT
dermatopontin
 Molecular Gene — — OT score 0.23 Open Targets UniProt Ensembl Open Targets
DPP8
dipeptidyl peptidase 8
 Molecular Gene — — OT score 0.20 Open Targets UniProt Ensembl Open Targets
BRAF
B-Raf proto-oncogene, serine/threonine kinase
 Molecular Gene — — OT score 0.19 Open Targets UniProt Ensembl Open Targets
FGFR2
fibroblast growth factor receptor 2
 Molecular Gene — — OT score 0.19 Open Targets UniProt Ensembl Open Targets
EP300
EP300 lysine acetyltransferase
 Molecular Gene — — OT score 0.19 Open Targets UniProt Ensembl Open Targets
ATM
ATM serine/threonine kinase
 Molecular Gene — — OT score 0.19 Open Targets UniProt Ensembl Open Targets
GATA3
GATA binding protein 3
 Molecular Gene — — OT score 0.18 Open Targets UniProt Ensembl Open Targets
AFG1L
AFG1 like ATPase
 Molecular Gene — — OT score 0.17 Open Targets UniProt Ensembl Open Targets
COL19A1
collagen type XIX alpha 1 chain
 Molecular Gene — — OT score 0.16 Open Targets UniProt Ensembl Open Targets
GYPA
glycophorin A (MNS blood group)
 Molecular Gene — — OT score 0.16 Open Targets UniProt Ensembl Open Targets
ABHD6
abhydrolase domain containing 6, acylglycerol lipase
 Molecular Gene — — OT score 0.14 Open Targets UniProt Ensembl Open Targets
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 Molecular Gene — — OT score 0.14 Open Targets UniProt Ensembl Open Targets
ATG10
autophagy related 10
 Molecular Gene — — OT score 0.12 Open Targets UniProt Ensembl Open Targets
GFI1B
growth factor independent 1B transcriptional repressor
 Molecular Gene — — OT score 0.12 Open Targets UniProt Ensembl Open Targets
Abdominal pain Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Abnormal thrombosis Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Abnormality of vision Pathology Pathological finding — frequent HPO annotation HPO, Monarch HPO
Acute leukemia Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Angina pectoris Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Arterial thrombosis Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Arthralgia Pathology Pathological finding — frequent HPO annotation HPO, Monarch HPO
Bruising susceptibility Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Budd-Chiari syndrome Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Cerebral hemorrhage Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Cerebral ischemia Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Early satiety Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Epistaxis Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Erythromelalgia Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Fatigue Functional Functional test — frequent HPO annotation HPO, Monarch HPO
Gastrointestinal hemorrhage Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Gingival bleeding Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Headache Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Hepatomegaly Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Hypertension Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Increased circulating hemoglobin concentration Lab / Clinical Lab value — — HPO annotation HPO, Monarch HPO
Increased hematocrit Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Increased megakaryocyte count Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Increased red blood cell mass Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Increased total leukocyte count Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Intermittent claudication Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Myelodysplasia Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Myelofibrosis Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Paresthesia Pathology Pathological finding — frequent HPO annotation HPO, Monarch HPO
Polycythemia Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Portal hypertension Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Portal vein thrombosis Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Pruritus Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Pulmonary embolism Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Respiratory insufficiency Pathology Pathological finding — frequent HPO annotation HPO, Monarch HPO
Splenomegaly Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Stroke Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Thrombocytopenia Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Thrombocytosis Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Thromboembolism Pathology Pathological finding — — HPO annotation HPO, Monarch HPO
Tinnitus Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Venous thrombosis Pathology Pathological finding — occasional HPO annotation HPO, Monarch HPO
Vertigo Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO
Weight loss Pathology Pathological finding — very_frequent HPO annotation HPO, Monarch HPO

Therapeutics

Direct disease associations, biomarker-linked drugs, OSMF narrative-review natural agents, and merged ranking. Only agents with registry trials or published clinical literature are shown by default.

DrugTypePhaseEvidence ScorePrice (UK / US)Trials & literatureSourcesLinks
ABEMACICLIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ABIRATERONE ACETATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ACETAZOLAMIDE Repurposing Small molecule Approved Strong 95 UK £3–£8 / 28–56 tabs · US $8–$15 / 30 tabs — ChEMBL ChEMBL Open Targets
ACYCLOVIR Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ADENOSINE TRIPHOSPHATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AFATINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ALECTINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ALECTINIB HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb ChEMBL Open Targets
ALPELISIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AMPHETAMINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ASCIMINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ASCIMINIB HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb ChEMBL Open Targets
ATEZOLIZUMAB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AVAPRITINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AVELUMAB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AXITINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AZACITIDINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BENDAMUSTINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BEVACIZUMAB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BICALUTAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
BINIMETINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
BLINATUMOMAB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BOSUTINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
BOSUTINIB MONOHYDRATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb ChEMBL Open Targets
BRENTUXIMAB VEDOTIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BRIGATINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BUSULFAN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CABOZANTINIB S-MALATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CAMPTOTHECIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CAPECITABINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CAPMATINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CARBACHOL Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CARBAMAZEPINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CELECOXIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CEMIPLIMAB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CERITINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CETUXIMAB Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
CHLOROQUINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CIPROFLOXACIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CISPLATIN Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
CLOMIPRAMINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
COBIMETINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CRIZOTINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CYCLOPHOSPHAMIDE ANHYDROUS Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
CYTARABINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DABRAFENIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DABRAFENIB MESYLATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb ChEMBL Open Targets
DASATINIB ANHYDROUS Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
DECITABINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
DENOSUMAB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DrugTypePhaseEvidence ScorePrice (UK / US)SourcesLinks
ANAGRELIDE Small molecule Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
GIVINOSTAT Small molecule Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
HYDROXYUREA Small molecule Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
INTERFERON Biologic Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
INTERFERON ALFA Biologic Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
INTERFERON ALFA-2A Biologic Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
INTERFERON ALFA-2B Biologic Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
NOVAFERON Small molecule Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
PEGINTERFERON ALFA-2B Biologic Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
PIPOBROMAN Small molecule Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
RUSFERTIDE Biologic Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
SAPABLURSEN Small molecule Phase III Moderate 80 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
ASPIRIN Small molecule Phase II Emerging 60 UK Very low cost · US Very low cost Open Targets ChEMBL Open Targets
BOMEDEMSTAT Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
CLOPIDOGREL Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
CYCLOPHOSPHAMIDE Small molecule Phase II Emerging 60 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) Open Targets ChEMBL Open Targets
CYCLOSPORINE Biologic Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
DASATINIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
DASATINIB ANHYDROUS Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
DOXORUBICIN Small molecule Phase II Emerging 60 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) Open Targets ChEMBL Open Targets
ERLOTINIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
ETOPOSIDE Small molecule Phase II Emerging 60 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) Open Targets ChEMBL Open Targets
FLUDARABINE Small molecule Phase II Emerging 60 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) Open Targets ChEMBL Open Targets
GANDOTINIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
IDASANUTLIN Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
IMATINIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
IMATINIB MESYLATE Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
IMETELSTAT Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
LESTAURTINIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
LUMINESPIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
METHOTREXATE Small molecule Phase II Emerging 60 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) Open Targets ChEMBL Open Targets
MIRABEGRON Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
MOMELOTINIB Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
NAVTEMADLIN Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
PREDNISONE Small molecule Phase II Emerging 60 UK £2–£5 / 28–30 tabs · US $4–$8 / 30 tabs Open Targets ChEMBL Open Targets
RITUXIMAB Biologic Phase II Emerging 60 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) Open Targets ChEMBL Open Targets
VINCRISTINE Small molecule Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
ZINPENTRAXIN ALFA Biologic Phase II Emerging 60 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
ACETYLCYSTEINE Small molecule Phase I Emerging 35 UK £5–£12 / 30 tabs or effervescent · US $8–$15 / 30-60 tabs (NAC) Open Targets ChEMBL Open Targets
POMALIDOMIDE Small molecule Phase I Emerging 35 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) Open Targets ChEMBL Open Targets
DrugTypePhaseEvidence ScorePrice (UK / US)Trials & literatureSourcesLinks
ABEMACICLIB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ABIRATERONE ACETATE Repurposing via APC Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ACETAZOLAMIDE Repurposing via ABHD6 Small molecule Approved Strong 95 UK £3–£8 / 28–56 tabs · US $8–$15 / 30 tabs — ChEMBL ChEMBL Open Targets
ACYCLOVIR Repurposing via ABL1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ADENOSINE TRIPHOSPHATE Repurposing via ABL1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AFATINIB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ALECTINIB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ALECTINIB HYDROCHLORIDE Repurposing via ALK Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb ChEMBL Open Targets
ALPELISIB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AMPHETAMINE Repurposing via ABHD6 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ASCIMINIB Repurposing via BCR Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ASCIMINIB HYDROCHLORIDE Repurposing via BCR Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb ChEMBL Open Targets
ATEZOLIZUMAB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AVAPRITINIB Repurposing via CBL Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AVELUMAB Repurposing via ATM Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AXITINIB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
AZACITIDINE Repurposing via ABL1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BENDAMUSTINE Repurposing via ATM Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BEVACIZUMAB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BICALUTAMIDE Repurposing via ABHD6 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
BINIMETINIB Repurposing via APC Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
BLINATUMOMAB Repurposing via BCR Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BOSUTINIB Repurposing via BCR Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
BOSUTINIB MONOHYDRATE Repurposing via BCR Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb ChEMBL Open Targets
BRENTUXIMAB VEDOTIN Repurposing via ALK Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BRIGATINIB Repurposing via ALK Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BUSULFAN Repurposing via BCR Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CABOZANTINIB S-MALATE Repurposing via ABL1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CAMPTOTHECIN Repurposing via ATM Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CAPECITABINE Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CAPMATINIB Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CARBACHOL Repurposing via ABHD6 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CARBAMAZEPINE Repurposing via ALK Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CELECOXIB Repurposing via APC Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CEMIPLIMAB Repurposing via ALK Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CERITINIB Repurposing via ALK Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CETUXIMAB Repurposing via BRAF Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
CHLOROQUINE Repurposing via BRAF Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CIPROFLOXACIN Repurposing via ABHD6 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CISPLATIN Repurposing via ALK Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —

Alterations and therapeutics are aggregated from public databases (Open Targets, HPO, ChEMBL, DGIdb, and others). Natural agents are candidates from OSMF narrative reviews on opensourcemed.info/chronic-disease.html — not approved treatments. This page is for research orientation only — not medical advice.

Generated by OSMF Disease Intelligence Pipeline · Schema 1.1.0