RepurpOS

POTS (Postural Orthostatic Tachycardia Syndrome)

Disease intelligence for Postural Orthostatic Tachycardia Syndrome: 124 alterations and 117 ranked therapeutics from curated public databases.

Disease overview

Alterations
124
Molecular (A)
100
Clinical (B–E)
0
Trial outcome measures (T)
24
Direct drugs
0
Via biomarker
137
Natural agents
0
Natural products
0
Merged ranked
137
With trial/literature evidence
25

Sources: Open Targets, HPO, ClinicalTrials.gov, DGIdb, ChEMBL, PubMed Literature · Pipeline phase 6 · Updated 2026-10-15

Related: Fitness landscape

Identifiers: MONDO: MONDO:0001315 · MESH: D054972

Alterations

124 total · Types A (molecular) through E (functional). Molecular rows are Open Targets gene–disease associations (evidence column = OT association score), not measured levels; phenotypes are HPO terms annotated directly to this disease (Monarch); type T rows are outcome measures used in completed ClinicalTrials.gov studies, not alterations of the disease.

NameTypeSubtypeDirection FrequencyEvidenceSourcesLinks
SLC6A2
solute carrier family 6 member 2
 Molecular Gene — — OT score 0.51 Open Targets UniProt Ensembl Open Targets
HCN4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
 Molecular Gene — — OT score 0.29 Open Targets UniProt Ensembl Open Targets
SLC6A4
solute carrier family 6 member 4
 Molecular Gene — — OT score 0.27 Open Targets UniProt Ensembl Open Targets
NR3C1
nuclear receptor subfamily 3 group C member 1
 Molecular Gene — — OT score 0.18 Open Targets UniProt Ensembl Open Targets
ADRB1
adrenoceptor beta 1
 Molecular Gene — — OT score 0.11 Open Targets UniProt Ensembl Open Targets
ADRB2
adrenoceptor beta 2
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRB3
adrenoceptor beta 3
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRA1A
adrenoceptor alpha 1A
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRA1B
adrenoceptor alpha 1B
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRA1D
adrenoceptor alpha 1D
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRA2C
adrenoceptor alpha 2C
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRA2A
adrenoceptor alpha 2A
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
ADRA2B
adrenoceptor alpha 2B
 Molecular Gene — — OT score 0.10 Open Targets UniProt Ensembl Open Targets
AGT
angiotensinogen
 Molecular Gene — — OT score 0.09 Open Targets UniProt Ensembl Open Targets
AGTR1
angiotensin II receptor type 1
 Molecular Gene — — OT score 0.09 Open Targets UniProt Ensembl Open Targets
GH1
growth hormone 1
 Molecular Gene — — OT score 0.08 Open Targets UniProt Ensembl Open Targets
FCGRT
Fc gamma receptor and transporter
 Molecular Gene — — OT score 0.08 Open Targets UniProt Ensembl Open Targets
ACHE
acetylcholinesterase (Yt blood group)
 Molecular Gene — — OT score 0.08 Open Targets UniProt Ensembl Open Targets
CYP3A4
cytochrome P450 family 3 subfamily A member 4
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
CYP3A43
cytochrome P450 family 3 subfamily A member 43
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
CYP3A5
cytochrome P450 family 3 subfamily A member 5
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
CYP3A7
cytochrome P450 family 3 subfamily A member 7
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
GNRHR
gonadotropin releasing hormone receptor
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
OPRD1
opioid receptor delta 1
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
OPRK1
opioid receptor kappa 1
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
OPRM1
opioid receptor mu 1
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
PGR
progesterone receptor
 Molecular Gene — — OT score 0.07 Open Targets UniProt Ensembl Open Targets
CHRNA3
cholinergic receptor nicotinic alpha 3 subunit
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CHRNB4
cholinergic receptor nicotinic beta 4 subunit
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CHGA
chromogranin A
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SLC7A9
solute carrier family 7 member 9
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
COMT
catechol-O-methyltransferase
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CLCN5
Cl-/H+ antiporter 5
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
UMOD
uromodulin
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CA1
carbonic anhydrase 1
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CA12
carbonic anhydrase 12
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CA2
carbonic anhydrase 2
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
CA4
carbonic anhydrase 4
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN2A
glutamate ionotropic receptor NMDA type subunit 2A
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN2B
glutamate ionotropic receptor NMDA type subunit 2B
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN2C
glutamate ionotropic receptor NMDA type subunit 2C
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN2D
glutamate ionotropic receptor NMDA type subunit 2D
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN3A
glutamate ionotropic receptor NMDA type subunit 3A
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GRIN3B
glutamate ionotropic receptor NMDA type subunit 3B
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
PTGS1
prostaglandin-endoperoxide synthase 1
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
PTGS2
prostaglandin-endoperoxide synthase 2
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SLC6A3
solute carrier family 6 member 3
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SSTR1
somatostatin receptor 1
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SSTR2
somatostatin receptor 2
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SSTR3
somatostatin receptor 3
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SSTR4
somatostatin receptor 4
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
SSTR5
somatostatin receptor 5
 Molecular Gene — — OT score 0.06 Open Targets UniProt Ensembl Open Targets
ACE2
angiotensin converting enzyme 2
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
REN
renin
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
SLC22A12
solute carrier family 22 member 12
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
SLC16A10
solute carrier family 16 member 10
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
AGXT
alanine--glyoxylate aminotransferase
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
STUB1
STIP1 homology and U-box containing protein 1
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
OTC
ornithine transcarbamylase
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
SLC13A2
solute carrier family 13 member 2
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
CLDN2
claudin 2
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
SGK1
serum/glucocorticoid regulated kinase 1
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
RET
ret proto-oncogene
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
AQP7
aquaporin 7
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
AQP7B
aquaporin 7B
 Molecular Gene — — OT score 0.05 Open Targets UniProt Ensembl Open Targets
AQP7P3
aquaporin 7 pseudogene 3
 Molecular Gene — — OT score 0.05 Open Targets Ensembl Open Targets
HAL
histidine ammonia-lyase
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
SLC26A4
solute carrier family 26 member 4
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
GRHPR
glyoxylate and hydroxypyruvate reductase
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
WHAMM
WASP homolog associated with actin, golgi membranes and microtubules
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
AVP
arginine vasopressin
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
SLC2A9
solute carrier family 2 member 9
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
WNK4
WNK lysine deficient protein kinase 4
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
NOS3
nitric oxide synthase 3
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
SLC3A1
solute carrier family 3 member 1
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
CALCA
calcitonin related polypeptide alpha
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
NOS1
nitric oxide synthase 1
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
CEBPD
CCAAT enhancer binding protein delta
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
MOCS1
molybdenum cofactor synthesis 1
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
NOS2
nitric oxide synthase 2
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
PTGDR2
prostaglandin D2 receptor 2
 Molecular Gene — — OT score 0.04 Open Targets UniProt Ensembl Open Targets
NPPA
natriuretic peptide A
 Molecular Gene — — OT score 0.03 Open Targets UniProt Ensembl Open Targets
ADM
adrenomedullin
 Molecular Gene — — OT score 0.03 Open Targets UniProt Ensembl Open Targets
AR
androgen receptor
 Molecular Gene — — OT score 0.03 Open Targets UniProt Ensembl Open Targets
GSTM1
glutathione S-transferase mu 1
 Molecular Gene — — OT score 0.03 Open Targets UniProt Ensembl Open Targets
GIP
gastric inhibitory polypeptide
 Molecular Gene — — OT score 0.03 Open Targets UniProt Ensembl Open Targets
POMC
proopiomelanocortin
 Molecular Gene — — OT score 0.03 Open Targets UniProt Ensembl Open Targets
EDNRA
endothelin receptor type A
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
DBH
dopamine beta-hydroxylase
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
IL1B
interleukin 1 beta
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
NPPC
natriuretic peptide C
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
RETN
resistin
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
OPRL1
opioid related nociceptin receptor 1
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
S100A6
S100 calcium binding protein A6
 Molecular Gene — — OT score 0.02 Open Targets UniProt Ensembl Open Targets
MB
myoglobin
 Molecular Gene — — OT score 0.01 Open Targets UniProt Ensembl Open Targets
24 Hour Urinary Catecholamine (DOPA) Excretion During Treatment Normalized to Creatinine Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov LOINC
Blood pressure Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Change from baseline in quality of life over time Trial outcome measure Clinical scale — — Trial outcome measure ClinicalTrials.gov —
Composite Dysautonomia Symptom Score (COMPASS 31) Trial outcome measure Clinical scale — — Trial outcome measure ClinicalTrials.gov —
EQ-5D-5L Quality of Life Score Trial outcome measure Clinical scale — — Trial outcome measure ClinicalTrials.gov —
End-tidal CO2 levels Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Fatigue Severity Scale (FSS) Trial outcome measure Clinical scale — — Trial outcome measure ClinicalTrials.gov —
Heart Rate Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Medical Research Council (MRC) Dyspnoea Scale Trial outcome measure Clinical scale — — Trial outcome measure ClinicalTrials.gov —
Morning salivary cortisol levels Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Neuro Quality of Life Score Trial outcome measure Clinical scale — — Trial outcome measure ClinicalTrials.gov —
Plasma Catecholamines (Norepinephrine) After the Last Dose of Placebo or Carbidopa Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Plasma Dopamine Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Plasma HS-CRP levels Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov LOINC
Plasma IL-1 levels Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Plasma IL-10 levels Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Plasma IL-6 levels Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Plasma Norepinephrine Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Plasma Volume Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Post-Exertional Malaise (PEM) Screener Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Urinary Dopa Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Urinary Dopamine Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Urinary Norepinephrine Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —
Urinary Sodium Trial outcome measure Lab value — — Trial outcome measure ClinicalTrials.gov —

Therapeutics

Direct disease associations, biomarker-linked drugs, OSMF narrative-review natural agents, and merged ranking. Only agents with registry trials or published clinical literature are shown by default.

DrugTypePhaseEvidence ScorePrice (UK / US)Trials & literatureSourcesLinks
ACETAZOLAMIDE Repurposing Small molecule Approved Strong 95 UK £3–£8 / 28–56 tabs · US $8–$15 / 30 tabs — ChEMBL ChEMBL Open Targets
ACETYLCYSTEINE Repurposing Small molecule Approved Strong 95 UK £5–£12 / 30 tabs or effervescent · US $8–$15 / 30-60 tabs (NAC)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ALLOPURINOL Repurposing Small molecule Approved Strong 95 UK £1–£3 / 28 tabs · US $4–$10 / 30-90 tabs
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
AMPHETAMINE Repurposing Small molecule Approved Strong 95 UK Controlled — specialist pricing · US Varies (branded higher) — ChEMBL ChEMBL Open Targets
ARGIPRESSIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ASPARAGINASE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ATENOLOL Repurposing Small molecule Approved Strong 95 UK £1–£3 / 28 tabs · US $3–$8 / 30 tabs — DGIdb —
BICALUTAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BICALUTAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
BOSUTINIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CAMPTOTHECIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CANNABIDIOL Repurposing Small molecule Approved Strong 95 UK Varies (specialist) · US $30–$80 / 30-day (varies by product)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CARBACHOL Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CARBOPLATIN Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CARVEDILOL Repurposing Small molecule Approved Strong 95 UK £2–£5 / 28 tabs · US $5–$10 / 30 tabs — DGIdb —
CETUXIMAB Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
CHORIOGONADOTROPIN ALFA Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CIPROFLOXACIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CIPROFLOXACIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CISPLATIN Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CLOMIPRAMINE Repurposing Small molecule Approved Strong 95 UK £5–£12 / 28 tabs · US $8–$20 / 30 tabs — ChEMBL ChEMBL Open Targets
CURCUMIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CYCLOPHOSPHAMIDE ANHYDROUS Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
DACARBAZINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DASATINIB ANHYDROUS Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
DAUNORUBICIN LIPOSOMAL Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DIAZEPAM Repurposing Small molecule Approved Strong 95 UK £1–£3 / 28 tabs · US $3–$8 / 30 tabs — ChEMBL ChEMBL Open Targets
DICHLORPHENAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DIETHYLSTILBESTROL Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DOCETAXEL ANHYDROUS Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
DOXORUBICIN HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ENZALUTAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
EPIRUBICIN Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — ChEMBL ChEMBL Open Targets
ERYTHROMYCIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ESTRAMUSTINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ETHOXZOLAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ETOPOSIDE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
FLOXURIDINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
FLUDARABINE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
FLUMAZENIL Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FLUOROURACIL Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
GEMCITABINE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
GLYBURIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
IMIPRAMINE Repurposing Small molecule Approved Strong 95 UK Low cost · US Low cost — ChEMBL ChEMBL Open Targets
INDAPAMIDE Repurposing Small molecule Approved Strong 95 UK £2–£4 / 28 tabs · US $5–$10 / 30 tabs — ChEMBL ChEMBL Open Targets
INDOMETHACIN Repurposing Small molecule Approved Strong 95 UK £3–£8 / 28–56 tabs · US $6–$15 / 30–60 tabs — ChEMBL ChEMBL Open Targets
INTERFERON ALFA-2B Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
IRINOTECAN HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ISOSORBIDE DINITRATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
LEUCOVORIN CALCIUM Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
LEVODOPA Repurposing Small molecule Approved Strong 95 UK Varies (often combo) · US Varies — DGIdb —
MAFENIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MECAMYLAMINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MEDROXYPROGESTERONE ACETATE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
METHAZOLAMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
METHOTREXATE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
METHOXSALEN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
METOPROLOL Repurposing Small molecule Approved Strong 95 UK £2–£4 / 28 tabs · US $4–$9 / 30 tabs — ChEMBL ChEMBL Open Targets
MIANSERIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MITOXANTRONE HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
NALIDIXIC ACID Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
NALTREXONE HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 UK £15–£30 / 28–50 tabs (low-dose) · US $20–$40 / 30 tabs — DGIdb —
NEVIRAPINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
NICOTINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
NICOTINE POLACRILEX Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
NIRAPARIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
NORFLOXACIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
OFLOXACIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
OLAPARIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
OXALIPLATIN Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
PEGASPARGASE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
PHENOBARBITAL Repurposing Small molecule Approved Strong 95 UK £3–£10 / supply · US $5–$15 / 30 tabs — DGIdb —
PHENYLEPHRINE HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 UK Low cost generic · US Very low cost — DGIdb —
PHENYTOIN Repurposing Small molecule Approved Strong 95 UK £3–£8 / supply · US $6–$15 / 30 tabs — ChEMBL ChEMBL Open Targets
PRASTERONE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
PRAVASTATIN SODIUM Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
PRAZOSIN Repurposing Small molecule Approved Strong 95 UK £2–£6 / 28–60 tabs · US $5–$12 / 30–60 tabs — ChEMBL ChEMBL Open Targets
PREDNISOLONE Repurposing Small molecule Approved Strong 95 UK £2–£5 / 28 tabs · US $5–$10 / 30 tabs — DGIdb —
PREDNISONE Repurposing Small molecule Approved Strong 95 UK £2–£5 / 28–30 tabs · US $4–$8 / 30 tabs
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
PROCARBAZINE HYDROCHLORIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ROFECOXIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
RUCAPARIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
SACITUZUMAB GOVITECAN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
SILDENAFIL Repurposing Small molecule Approved Strong 95 UK £2–£8 / 4–8 tabs (generic) · US $5–$15 / 10-30 tabs
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
SIROLIMUS Repurposing Small molecule Approved Strong 95 UK Specialty — £100s per pack · US $50–$200+ / supply (varies) — DGIdb —
SIROLIMUS Repurposing Small molecule Approved Strong 95 UK Specialty — £100s per pack · US $50–$200+ / supply (varies) — ChEMBL ChEMBL Open Targets
SODIUM CHLORIDE Repurposing Small molecule Approved Strong 95 UK Very low (tablets or solution) · US Very low — DGIdb —
SULBACTAM Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
TACROLIMUS ANHYDROUS Repurposing Small molecule Approved Strong 95 UK Specialty · US $30–$100+ / supply — ChEMBL ChEMBL Open Targets
TALAZOPARIB Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
TAZOBACTAM Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
TEMOZOLOMIDE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
TESTOSTERONE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
TRETINOIN Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
TROGLITAZONE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
VERAPAMIL Repurposing Small molecule Approved Strong 95 UK £2–£5 / 28 tabs · US $4–$10 / 30–60 tabs — DGIdb —
VINORELBINE Repurposing Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
ZIDOVUDINE Repurposing Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DARAPLADIB Repurposing Small molecule Phase III Moderate 70 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FENRETINIDE Repurposing Small molecule Phase III Moderate 70 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
COMPOUND 2 [PMID: 22380603] Repurposing Small molecule Phase II Emerging 50 Research / experimental compound — pricing not applicable for routine clinical use — DGIdb —
RETINOIC ACID AGENT Repurposing Small molecule Phase II Emerging 50 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ALPRENOLOL Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
AMIFLOXACIN Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
BROLAMFETAMINE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CARZENIDE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DIFLOXACIN Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DIMECAMINE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ELLAGIC ACID Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ENISOPROST Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FENCAMFAMIN Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FLEROXACIN Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
IDOXIFENE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
LYSERGIDE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MERAFLOXACIN Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
TENAMFETAMINE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ZIDAPAMIDE Repurposing Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
Midodrine Repurposing Small molecule Approved Strong 90 UK £55–£75 / 100 tabs (2.5-5mg) · US $18 / 90 tabs (2.5mg, Cost Plus) — —
Pyridostigmine Repurposing Small molecule Approved Strong 90 UK £15–£25 / 60 tabs · US $20–$35 / 30–60 tabs — —
Fludrocortisone Repurposing Small molecule Approved Strong 90 UK £6–£10 / 30 tabs (0.1mg) · US $6 / 30 tabs (0.1mg, Cost Plus) — —
Sildenafil Repurposing Small molecule Active trials Strong 90 UK £2–£8 / 4–8 tabs (generic) · US $5–$15 / 10-30 tabs — —
Propranolol Repurposing Small molecule Approved Strong 90 UK £2–£5 / 28–56 tabs · US $4–$10 / 30–60 tabs — —
Atenolol Repurposing Small molecule Approved Strong 90 UK £1–£3 / 28 tabs · US $3–$8 / 30 tabs — —
Carvedilol Repurposing Small molecule Approved Strong 90 UK £2–£5 / 28 tabs · US $5–$10 / 30 tabs — —
Metoprolol Repurposing Small molecule Approved Strong 90 UK £2–£4 / 28 tabs · US $4–$9 / 30 tabs — —
Verapamil Repurposing Small molecule Approved Strong 90 UK £2–£5 / 28 tabs · US $4–$10 / 30–60 tabs — —
Ivabradine Repurposing Small molecule Approved Strong 90 UK £28–£40 / 56 tabs (5mg) · US $28 / 60 tabs (5mg, Cost Plus) — —
Atomoxetine Repurposing Small molecule Clinical trials Strong 90 UK £20–£40 / 28 tabs · US $30–$70 / 30 tabs — —
Ephedrine Repurposing Small molecule Approved Strong 90 UK £5–£15 / supply (hospital/OTC limits) · US $10–$25 / supply — —
Apixaban Repurposing Small molecule Clinical trials Strong 90 UK £20–£50 / 28-60 tabs · US $30–$70 / 30-60 tabs — —
Rivaroxaban Repurposing Small molecule Clinical trials Strong 90 UK £20–£50 / 28 tabs (varies by dose) · US $30–$80 / 30 tabs — —
Gabapentin Repurposing Small molecule Clinical trials Strong 90 UK £2–£5 / 28–100 tabs · US $5–$12 / 30–90 tabs — —
Amitriptyline Repurposing Small molecule Clinical trials Strong 90 UK £1–£3 / 28 tabs · US $4–$10 / 30 tabs — —
Sertraline Repurposing Small molecule Clinical trials Strong 90 UK £1–£3 / 28 tabs · US $4–$9 / 30 tabs — —
Paroxetine Repurposing Small molecule Clinical trials Strong 90 UK £2–£4 / 28 tabs · US $5–$10 / 30 tabs — —
IVIG Repurposing Small molecule Clinical trials Strong 90 Research / experimental compound — pricing not applicable for routine clinical use — —
Methylphenidate Repurposing Small molecule Clinical trials Strong 90 UK £10–£25 / 28–30 tabs (generic) · US $15–$40 / 30 tabs — —

No therapeutics in this section.

DrugTypePhaseEvidence ScorePrice (UK / US)Trials & literatureSourcesLinks
ACETAZOLAMIDE Repurposing via AARS1 Small molecule Approved Strong 95 UK £3–£8 / 28–56 tabs · US $8–$15 / 30 tabs — ChEMBL ChEMBL Open Targets
ACETYLCYSTEINE Repurposing via ACO1 Small molecule Approved Strong 95 UK £5–£12 / 30 tabs or effervescent · US $8–$15 / 30-60 tabs (NAC)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ALLOPURINOL Repurposing via CCHCR1 Small molecule Approved Strong 95 UK £1–£3 / 28 tabs · US $4–$10 / 30-90 tabs
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
AMPHETAMINE Repurposing via AARS1 Small molecule Approved Strong 95 UK Controlled — specialist pricing · US Varies (branded higher) — ChEMBL ChEMBL Open Targets
ARGIPRESSIN Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ASPARAGINASE Repurposing via CCHCR1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ATENOLOL Repurposing via BAX Small molecule Approved Strong 95 UK £1–£3 / 28 tabs · US $3–$8 / 30 tabs — DGIdb —
BICALUTAMIDE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
BICALUTAMIDE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
BOSUTINIB Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CAMPTOTHECIN Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CANNABIDIOL Repurposing via ABCC5 Small molecule Approved Strong 95 UK Varies (specialist) · US $30–$80 / 30-day (varies by product)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CARBACHOL Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CARBOPLATIN Repurposing via BRCA2 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CARVEDILOL Repurposing via BAX Small molecule Approved Strong 95 UK £2–£5 / 28 tabs · US $5–$10 / 30 tabs — DGIdb —
CETUXIMAB Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
CHORIOGONADOTROPIN ALFA Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CIPROFLOXACIN Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
CIPROFLOXACIN Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CISPLATIN Repurposing via BRCA2 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CLOMIPRAMINE Repurposing via AARS1 Small molecule Approved Strong 95 UK £5–£12 / 28 tabs · US $8–$20 / 30 tabs — ChEMBL ChEMBL Open Targets
CURCUMIN Repurposing via CAMK2A Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
CYCLOPHOSPHAMIDE ANHYDROUS Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
DACARBAZINE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DASATINIB ANHYDROUS Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
DAUNORUBICIN LIPOSOMAL Repurposing via ABCC5 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DIAZEPAM Repurposing via AARS1 Small molecule Approved Strong 95 UK £1–£3 / 28 tabs · US $3–$8 / 30 tabs — ChEMBL ChEMBL Open Targets
DICHLORPHENAMIDE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DIETHYLSTILBESTROL Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DOCETAXEL ANHYDROUS Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
DOXORUBICIN HYDROCHLORIDE Repurposing via ABCC5 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ENZALUTAMIDE Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
EPIRUBICIN Repurposing via AARS1 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — ChEMBL ChEMBL Open Targets
ERYTHROMYCIN Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ESTRAMUSTINE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ETHOXZOLAMIDE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ETOPOSIDE Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
FLOXURIDINE Repurposing via ABCC5 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
FLUDARABINE Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
FLUMAZENIL Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FLUOROURACIL Repurposing via ABCC5 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
GEMCITABINE Repurposing via BRCA2 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
GLYBURIDE Repurposing via ABCC5 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
IMIPRAMINE Repurposing via AARS1 Small molecule Approved Strong 95 UK Low cost · US Low cost — ChEMBL ChEMBL Open Targets
INDAPAMIDE Repurposing via AARS1 Small molecule Approved Strong 95 UK £2–£4 / 28 tabs · US $5–$10 / 30 tabs — ChEMBL ChEMBL Open Targets
INDOMETHACIN Repurposing via AARS1 Small molecule Approved Strong 95 UK £3–£8 / 28–56 tabs · US $6–$15 / 30–60 tabs — ChEMBL ChEMBL Open Targets
INTERFERON ALFA-2B Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
IRINOTECAN HYDROCHLORIDE Repurposing via ABCC5 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
ISOSORBIDE DINITRATE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
LEUCOVORIN CALCIUM Repurposing via ABCC5 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
LEVODOPA Repurposing via BAX Small molecule Approved Strong 95 UK Varies (often combo) · US Varies — DGIdb —
MAFENIDE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MECAMYLAMINE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MEDROXYPROGESTERONE ACETATE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
METHAZOLAMIDE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
METHOTREXATE Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
METHOXSALEN Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
METOPROLOL Repurposing via AARS1 Small molecule Approved Strong 95 UK £2–£4 / 28 tabs · US $4–$9 / 30 tabs — ChEMBL ChEMBL Open Targets
MIANSERIN Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MITOXANTRONE HYDROCHLORIDE Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
NALIDIXIC ACID Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
NALTREXONE HYDROCHLORIDE Repurposing via BAX Small molecule Approved Strong 95 UK £15–£30 / 28–50 tabs (low-dose) · US $20–$40 / 30 tabs — DGIdb —
NEVIRAPINE Repurposing via CCHCR1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
NICOTINE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
NICOTINE POLACRILEX Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
NIRAPARIB Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
NORFLOXACIN Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
OFLOXACIN Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
OLAPARIB Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
OXALIPLATIN Repurposing via ABCC5 Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
PEGASPARGASE Repurposing via CCHCR1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
PHENOBARBITAL Repurposing via BAX Small molecule Approved Strong 95 UK £3–£10 / supply · US $5–$15 / 30 tabs — DGIdb —
PHENYLEPHRINE HYDROCHLORIDE Repurposing via BAX Small molecule Approved Strong 95 UK Low cost generic · US Very low cost — DGIdb —
PHENYTOIN Repurposing via AARS1 Small molecule Approved Strong 95 UK £3–£8 / supply · US $6–$15 / 30 tabs — ChEMBL ChEMBL Open Targets
PRASTERONE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
PRAVASTATIN SODIUM Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
PRAZOSIN Repurposing via AARS1 Small molecule Approved Strong 95 UK £2–£6 / 28–60 tabs · US $5–$12 / 30–60 tabs — ChEMBL ChEMBL Open Targets
PREDNISOLONE Repurposing via BAX Small molecule Approved Strong 95 UK £2–£5 / 28 tabs · US $5–$10 / 30 tabs — DGIdb —
PREDNISONE Repurposing via CCHCR1 Small molecule Approved Strong 95 UK £2–£5 / 28–30 tabs · US $4–$8 / 30 tabs
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
PROCARBAZINE HYDROCHLORIDE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ROFECOXIB Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
RUCAPARIB Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
SACITUZUMAB GOVITECAN Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
SILDENAFIL Repurposing via ABCC5 Small molecule Approved Strong 95 UK £2–£8 / 4–8 tabs (generic) · US $5–$15 / 10-30 tabs
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
SIROLIMUS Repurposing via BAX Small molecule Approved Strong 95 UK Specialty — £100s per pack · US $50–$200+ / supply (varies) — DGIdb —
SIROLIMUS Repurposing via AARS1 Small molecule Approved Strong 95 UK Specialty — £100s per pack · US $50–$200+ / supply (varies) — ChEMBL ChEMBL Open Targets
SODIUM CHLORIDE Repurposing via BAX Small molecule Approved Strong 95 UK Very low (tablets or solution) · US Very low — DGIdb —
SULBACTAM Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
TACROLIMUS ANHYDROUS Repurposing via AARS1 Small molecule Approved Strong 95 UK Specialty · US $30–$100+ / supply — ChEMBL ChEMBL Open Targets
TALAZOPARIB Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
TAZOBACTAM Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
TEMOZOLOMIDE Repurposing via BRCA2 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)
No indexed hits
View evidence

CT.gov search · Cochrane · PubMed

 DGIdb —
TESTOSTERONE Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
TRETINOIN Repurposing via BAX Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
TROGLITAZONE Repurposing via AARS1 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
VERAPAMIL Repurposing via BAX Small molecule Approved Strong 95 UK £2–£5 / 28 tabs · US $4–$10 / 30–60 tabs — DGIdb —
VINORELBINE Repurposing via BAX Small molecule Approved Strong 95 Hospital / IV specialty — prices per vial or dose (often hundreds–thousands USD/GBP) — DGIdb —
ZIDOVUDINE Repurposing via ABCC5 Small molecule Approved Strong 95 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
DARAPLADIB Repurposing via AARS1 Small molecule Phase III Moderate 70 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FENRETINIDE Repurposing via AARS1 Small molecule Phase III Moderate 70 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
COMPOUND 2 [PMID: 22380603] Repurposing via ABCC5 Small molecule Phase II Emerging 50 Research / experimental compound — pricing not applicable for routine clinical use — DGIdb —
RETINOIC ACID AGENT Repurposing via APOD Small molecule Phase II Emerging 50 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — DGIdb —
ALPRENOLOL Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
AMIFLOXACIN Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
BROLAMFETAMINE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
CARZENIDE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DIFLOXACIN Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
DIMECAMINE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ELLAGIC ACID Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ENISOPROST Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FENCAMFAMIN Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
FLEROXACIN Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
IDOXIFENE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
LYSERGIDE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
MERAFLOXACIN Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
TENAMFETAMINE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
ZIDAPAMIDE Repurposing via AARS1 Small molecule Phase II Emerging 45 Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US) — ChEMBL ChEMBL Open Targets
Midodrine Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £55–£75 / 100 tabs (2.5-5mg) · US $18 / 90 tabs (2.5mg, Cost Plus) — —
Pyridostigmine Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £15–£25 / 60 tabs · US $20–$35 / 30–60 tabs — —
Fludrocortisone Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £6–£10 / 30 tabs (0.1mg) · US $6 / 30 tabs (0.1mg, Cost Plus) — —
Sildenafil Repurposing via Clinical Trial Small molecule Active trials Strong 90 UK £2–£8 / 4–8 tabs (generic) · US $5–$15 / 10-30 tabs — —
Propranolol Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £2–£5 / 28–56 tabs · US $4–$10 / 30–60 tabs — —
Atenolol Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £1–£3 / 28 tabs · US $3–$8 / 30 tabs — —
Carvedilol Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £2–£5 / 28 tabs · US $5–$10 / 30 tabs — —
Metoprolol Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £2–£4 / 28 tabs · US $4–$9 / 30 tabs — —
Verapamil Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £2–£5 / 28 tabs · US $4–$10 / 30–60 tabs — —
Ivabradine Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £28–£40 / 56 tabs (5mg) · US $28 / 60 tabs (5mg, Cost Plus) — —
Atomoxetine Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £20–£40 / 28 tabs · US $30–$70 / 30 tabs — —
Ephedrine Repurposing via Clinical Trial Small molecule Approved Strong 90 UK £5–£15 / supply (hospital/OTC limits) · US $10–$25 / supply — —
Apixaban Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £20–£50 / 28-60 tabs · US $30–$70 / 30-60 tabs — —
Rivaroxaban Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £20–£50 / 28 tabs (varies by dose) · US $30–$80 / 30 tabs — —
Gabapentin Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £2–£5 / 28–100 tabs · US $5–$12 / 30–90 tabs — —
Amitriptyline Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £1–£3 / 28 tabs · US $4–$10 / 30 tabs — —
Sertraline Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £1–£3 / 28 tabs · US $4–$9 / 30 tabs — —
Paroxetine Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £2–£4 / 28 tabs · US $5–$10 / 30 tabs — —
IVIG Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 Research / experimental compound — pricing not applicable for routine clinical use — —
Methylphenidate Repurposing via Clinical Trial Small molecule Clinical trials Strong 90 UK £10–£25 / 28–30 tabs (generic) · US $15–$40 / 30 tabs — —

Alterations and therapeutics are aggregated from public databases (Open Targets, HPO, ChEMBL, DGIdb, and others). Natural agents are candidates from OSMF narrative reviews on opensourcemed.info/chronic-disease.html — not approved treatments. This page is for research orientation only — not medical advice.

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