Summary
| Direction in Multiple Sclerosis | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Other |
| Compared against | healthy controls |
| Source | Clarke et al. 2020 — doi:10.4049/jimmunol.2000129 |
| Condition atlas | Multiple Sclerosis Biomarker Atlas |
Other conditions where 25-Hydroxyvitamin D is reported
- 25-Hydroxyvitamin D in Asthma — ↕ inconsistent vs obese asthmatic children with sufficient vitamin D
- 25-Hydroxyvitamin D in Low Back Pain — ↓ reduced vs matched healthy controls
- 25-Hydroxyvitamin D in Major Depressive Disorder — ↓ reduced vs healthy controls
- 25-Hydroxyvitamin D in Migraine — ↓ reduced vs healthy controls
See the cross-condition hub: 25-Hydroxyvitamin D across conditions.
Related Other markers in Multiple Sclerosis
Full list: Multiple Sclerosis Biomarker Atlas.
Frequently asked questions
Is 25-Hydroxyvitamin D high or low in Multiple Sclerosis?
Reduced. Studies summarised in the OSMF atlas report lower 25-Hydroxyvitamin D in Multiple Sclerosis than in healthy controls. Source: Clarke et al. 2020.
Which test measures 25-Hydroxyvitamin D?
The atlas record does not list a standardised clinical test code (LOINC) for 25-Hydroxyvitamin D, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal 25-Hydroxyvitamin D result diagnostic of Multiple Sclerosis?
No. No single biomarker is diagnostic of Multiple Sclerosis. 25-Hydroxyvitamin D findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is 25-Hydroxyvitamin D specific to Multiple Sclerosis?
No. The same marker is also reported in Asthma, Low Back Pain, Major Depressive Disorder, Migraine in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-10-08 · Page generated from multiple-sclerosis.json · Browse: Multiple Sclerosis atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.