Summary
| Direction in Migraine | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Other |
| Compared against | healthy controls |
| Source | Liampas et al. 2020 — doi:10.1016/j.neurol.2019.12.008 |
| Condition atlas | Migraine Biomarker Atlas |
Other conditions where 25-Hydroxyvitamin D is reported
- 25-Hydroxyvitamin D in Asthma — ↕ inconsistent vs obese asthmatic children with sufficient vitamin D
- 25-Hydroxyvitamin D in Low Back Pain — ↓ reduced vs matched healthy controls
- 25-Hydroxyvitamin D in Major Depressive Disorder — ↓ reduced vs healthy controls
- 25-Hydroxyvitamin D in Multiple Sclerosis — ↓ reduced vs healthy controls
See the cross-condition hub: 25-Hydroxyvitamin D across conditions.
Related Other markers in Migraine
- Glutamate ↑
- Homocysteine ↑
- Interleukin-6 ↑
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) ↕
- Serotonin ↓
- Serum Ferritin ↓
Full list: Migraine Biomarker Atlas.
Frequently asked questions
Is 25-Hydroxyvitamin D high or low in Migraine?
Reduced. Studies summarised in the OSMF atlas report lower 25-Hydroxyvitamin D in Migraine than in healthy controls. Source: Liampas et al. 2020.
Which test measures 25-Hydroxyvitamin D?
The atlas record does not list a standardised clinical test code (LOINC) for 25-Hydroxyvitamin D, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal 25-Hydroxyvitamin D result diagnostic of Migraine?
No. No single biomarker is diagnostic of Migraine. 25-Hydroxyvitamin D findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is 25-Hydroxyvitamin D specific to Migraine?
No. The same marker is also reported in Asthma, Low Back Pain, Major Depressive Disorder, Multiple Sclerosis in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
Cite this page
Subscribe on Substack
Last reviewed: 2026-10-08 · Page generated from migraine.json · Browse: Migraine atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.