Summary
| Direction in Migraine | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Other |
| Compared against | controls |
| Test type | Blood test (serum / plasma / whole blood) |
| LOINC code | 13965-9 |
| Source | Lippi et al. 2014 — doi:10.1016/j.cca.2014.02.028 |
| Condition atlas | Migraine Biomarker Atlas |
Other conditions where Homocysteine is reported
- Homocysteine in Alzheimer's Disease and Other Dementias — ↑ elevated vs healthy individuals
- Homocysteine in Gulf War Illness — ↑ elevated vs HGV
- Homocysteine in Major Depressive Disorder — ↑ elevated vs normal reference range
See the cross-condition hub: Homocysteine across conditions.
Related Other markers in Migraine
- Interleukin-6 ↑
- Glutamate ↑
- 25-Hydroxyvitamin D ↓
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) ↕
- Serotonin ↓
- Serum Ferritin ↓
Full list: Migraine Biomarker Atlas.
Frequently asked questions
Is Homocysteine high or low in Migraine?
Elevated. Studies summarised in the OSMF atlas report higher Homocysteine in Migraine than in controls. Source: Lippi et al. 2014.
Which test measures Homocysteine?
It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 13965-9. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Homocysteine result diagnostic of Migraine?
No. No single biomarker is diagnostic of Migraine. Homocysteine findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is Homocysteine specific to Migraine?
No. The same marker is also reported in Alzheimer's Disease and Other Dementias, Gulf War Illness, Major Depressive Disorder in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-10-08 · Page generated from migraine.json · Browse: Migraine atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.