Peer-Reviewed Literature Synthesis

Migraine Biomarker Atlas

Molecular alterations reported in Migraine compared to healthy controls, from peer-reviewed literature.

NIH funding$43MFY2025 · RCDC estimate

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Migraine patients relative to a named comparison population — not inferred.

12
Curated markers
4
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Liampas et al. 2020

DOI: 10.1016/j.neurol.2019.12.008 →
Peer-Reviewed Literature

Caronna et al. 2024

DOI: 10.1016/B978-0-12-823357-3.00024-0 →
Peer-Reviewed Literature

D'Andrea et al. 2010

DOI: 10.1007/s10072-010-0267-8 →
Peer-Reviewed Literature

Gudmundsson et al. 2009

DOI: 10.1111/j.1468-2982.2009.01865.x →
Peer-Reviewed Literature

Lippi et al. 2014

DOI: 10.1016/j.cca.2014.02.028 →
Peer-Reviewed Literature

Empl et al. 2003

DOI: 10.1046/j.1468-2982.2003.00453.x →
Peer-Reviewed Literature

Carta et al. 2025

DOI: 10.1007/s12026-025-09674-x →
Peer-Reviewed Literature

Ciancarelli et al. 2003

DOI: 10.1046/j.1468-2982.2003.00447.x →
Peer-Reviewed Literature

Riesco et al. 2017

DOI: 10.1007/s11916-017-0618-8 →
Peer-Reviewed Literature

Villalón et al. 2003

DOI: 10.2174/1570161033386826 →
Peer-Reviewed Literature

Turan et al. 2019

DOI: 10.1016/j.reuma.2017.12.012 →
Peer-Reviewed Literature

Bhurat et al. 2022

DOI: 10.1007/s13312-022-2576-4 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Individual Migraine biomarker pages

Each Migraine marker has its own page with direction, comparison group, symptoms, test details, citation and FAQ. Browse all marker pages.

Inflammatory

Neurological

Other

Pulmonary

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Migraine Biomarkers: 12 Blood Tests & Lab Markers. Research Tracker. https://research.opensourcemed.info/migraine-biomarkers.html (accessed )

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