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Calcitonin Gene-Related Peptide (CGRP) in Migraine

Calcitonin Gene-Related Peptide (CGRP), also described as CGRP, belongs to the neurological group of Migraine markers and is reported to be raised relative to the reference group of the cited comparison (migraine attack and interictal vs healthy controls). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Caronna et al. 2024 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedNeurological

Summary

Direction in Migraine↑ Elevated — higher than in the comparison group
CategoryNeurological
Also described asCGRP
Compared againstmigraine attack and interictal vs healthy controls
SourceCaronna et al. 2024 — doi:10.1016/B978-0-12-823357-3.00024-0
Condition atlasMigraine Biomarker Atlas

Related Neurological markers in Migraine

Full list: Migraine Biomarker Atlas.

Frequently asked questions

Is Calcitonin Gene-Related Peptide (CGRP) high or low in Migraine?

Elevated. Studies summarised in the OSMF atlas report higher Calcitonin Gene-Related Peptide (CGRP) in Migraine than in the reference group of the cited comparison (migraine attack and interictal vs healthy controls). Source: Caronna et al. 2024.

Which test measures Calcitonin Gene-Related Peptide (CGRP)?

The atlas record does not list a standardised clinical test code (LOINC) for Calcitonin Gene-Related Peptide (CGRP), which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal Calcitonin Gene-Related Peptide (CGRP) result diagnostic of Migraine?

No. No single biomarker is diagnostic of Migraine. Calcitonin Gene-Related Peptide (CGRP) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Calcitonin Gene-Related Peptide (CGRP) in Migraine: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/migraine/calcitonin-gene-related-peptide-cgrp.html
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Last reviewed: 2026-07-03 · Page generated from migraine.json · Browse: Migraine atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.