Summary
| Direction in Migraine | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Pulmonary |
| Compared against | healthy controls |
| Associated symptoms | headache-free period |
| Source | Ciancarelli et al. 2003 — doi:10.1046/j.1468-2982.2003.00447.x |
| Condition atlas | Migraine Biomarker Atlas |
Related Pulmonary markers in Migraine
- Neurofilament Light Chain (NfL) ↕
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) ↕
- Interleukin-6 ↑
- Serotonin ↓
- Homocysteine ↑
- Serum Ferritin ↓
- High-Sensitivity CRP ↕
- Serum Magnesium ↓
Full list: Migraine Biomarker Atlas.
Frequently asked questions
Is Nitric Oxide Metabolites high or low in Migraine?
Elevated. Studies summarised in the OSMF atlas report higher Nitric Oxide Metabolites in Migraine than in healthy controls. Source: Ciancarelli et al. 2003.
What symptoms is Nitric Oxide Metabolites associated with in Migraine?
The cited literature associates this marker with headache-free period. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Nitric Oxide Metabolites?
The atlas record does not list a standardised clinical test code (LOINC) for Nitric Oxide Metabolites, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal Nitric Oxide Metabolites result diagnostic of Migraine?
No. No single biomarker is diagnostic of Migraine. Nitric Oxide Metabolites findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Cite this page
Subscribe on Substack
Last reviewed: 2026-10-08 · Page generated from migraine.json · Browse: Migraine atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.