Summary
| Direction in Asthma | ↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction |
|---|---|
| Category | Other |
| Compared against | obese asthmatic children with sufficient vitamin D |
| Associated symptoms | lower Forced Expiratory Volume in the first second, lower Functional Residual Capacity, lower Total Lung Capacity |
| Source | Lautenbacher et al. 2016 — doi:10.1002/ppul.23485 |
| Condition atlas | Asthma Biomarker Atlas |
Other conditions where 25-Hydroxyvitamin D is reported
- 25-Hydroxyvitamin D in Low Back Pain — ↓ reduced vs matched healthy controls
- 25-Hydroxyvitamin D in Major Depressive Disorder — ↓ reduced vs healthy controls
- 25-Hydroxyvitamin D in Migraine — ↓ reduced vs healthy controls
- 25-Hydroxyvitamin D in Multiple Sclerosis — ↓ reduced vs healthy controls
See the cross-condition hub: 25-Hydroxyvitamin D across conditions.
Related Other markers in Asthma
Full list: Asthma Biomarker Atlas.
Frequently asked questions
Is 25-Hydroxyvitamin D high or low in Asthma?
Mixed. Some studies report higher and others lower 25-Hydroxyvitamin D in Asthma compared with obese asthmatic children with sufficient vitamin D, so no single direction is established. Source: Lautenbacher et al. 2016.
What symptoms is 25-Hydroxyvitamin D associated with in Asthma?
The cited literature associates this marker with lower Forced Expiratory Volume in the first second, lower Functional Residual Capacity, lower Total Lung Capacity. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures 25-Hydroxyvitamin D?
The atlas record does not list a standardised clinical test code (LOINC) for 25-Hydroxyvitamin D, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal 25-Hydroxyvitamin D result diagnostic of Asthma?
No. No single biomarker is diagnostic of Asthma. 25-Hydroxyvitamin D findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is 25-Hydroxyvitamin D specific to Asthma?
No. The same marker is also reported in Low Back Pain, Major Depressive Disorder, Migraine, Multiple Sclerosis in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-10-08 · Page generated from asthma.json · Browse: Asthma atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.