Peer-Reviewed Literature Synthesis

Asthma Biomarker Atlas

Molecular alterations reported in Asthma compared to healthy controls, from peer-reviewed literature.

US DALYs1.44MWHO GHE 2021 · all ages
Global DALYs21.99MWHO GHE 2021 · worldwide
US mortality3,646 deaths/yrWHO GHE 2021
Global mortality425.7K deaths/yrWHO GHE 2021 · worldwide
NIH funding$242MFY2025 · RCDC estimate
Funding levelUnderfunded
Spontaneous remission26% of childhood-onset asthma in clinical remission by adulthood; <20% adult-onset achieves sustained remission; 65%…
Best-intervention remissionBiologics (anti-IL-5, anti-IL-4/13, anti-IgE) achieve near-zero exacerbation rates in eligible severe patients…
Gap sizeModerate; highly severity-dependent; large practice gap for AIT
Primary barrierbiological (severe phenotype) + practice (AIT underutilized)
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Asthma patients relative to a named comparison population — not inferred.

9
Curated markers
2
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Lautenbacher et al. 2016

DOI: 10.1002/ppul.23485 →
Peer-Reviewed Literature

Bacharier et al. 2024

DOI: 10.1016/j.jaci.2023.09.044 →
Peer-Reviewed Literature

Whittle et al. 2019

DOI: 10.1038/s41598-019-45257-1 →
Peer-Reviewed Literature

Loewenthal et al. 2022

DOI: 10.1055/s-0042-1743290 →
Peer-Reviewed Literature

Okuyama et al. 2014

DOI: 10.1159/000360577 →
Peer-Reviewed Literature

Lucas et al. 2020

DOI: 10.1038/s41586-020-2588-y →
Peer-Reviewed Literature

Sonnenberg-Riethmacher et al. 2021

DOI: 10.3389/fimmu.2021.722170 →
Peer-Reviewed Literature

Schatz et al. 2014

DOI: 10.1016/j.jaip.2014.09.004 →
Peer-Reviewed Literature

Suzuki et al. 2000

DOI: 10.1016/s0090-6980(00)00091-5 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Individual Asthma biomarker pages

Each Asthma marker has its own page with direction, comparison group, symptoms, test details, citation and FAQ. Browse all marker pages.

Other

Pulmonary

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Asthma Biomarkers: 9 Blood Tests & Lab Markers. Research Tracker. https://research.opensourcemed.info/asthma-biomarkers.html (accessed )

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