Summary
| Direction in Low Back Pain | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Other |
| Compared against | matched healthy controls |
| Associated symptoms | chronic low back pain |
| Source | Lotfi et al. 2007 — doi:10.1007/s10067-007-0603-4 |
| Condition atlas | Low Back Pain Biomarker Atlas |
Other conditions where 25-Hydroxyvitamin D is reported
- 25-Hydroxyvitamin D in Asthma — ↕ inconsistent vs obese asthmatic children with sufficient vitamin D
- 25-Hydroxyvitamin D in Major Depressive Disorder — ↓ reduced vs healthy controls
- 25-Hydroxyvitamin D in Migraine — ↓ reduced vs healthy controls
- 25-Hydroxyvitamin D in Multiple Sclerosis — ↓ reduced vs healthy controls
See the cross-condition hub: 25-Hydroxyvitamin D across conditions.
Related Other markers in Low Back Pain
Full list: Low Back Pain Biomarker Atlas.
Frequently asked questions
Is 25-Hydroxyvitamin D high or low in Low Back Pain?
Reduced. Studies summarised in the OSMF atlas report lower 25-Hydroxyvitamin D in Low Back Pain than in matched healthy controls. Source: Lotfi et al. 2007.
What symptoms is 25-Hydroxyvitamin D associated with in Low Back Pain?
The cited literature associates this marker with chronic low back pain. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures 25-Hydroxyvitamin D?
The atlas record does not list a standardised clinical test code (LOINC) for 25-Hydroxyvitamin D, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal 25-Hydroxyvitamin D result diagnostic of Low Back Pain?
No. No single biomarker is diagnostic of Low Back Pain. 25-Hydroxyvitamin D findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is 25-Hydroxyvitamin D specific to Low Back Pain?
No. The same marker is also reported in Asthma, Major Depressive Disorder, Migraine, Multiple Sclerosis in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-10-08 · Page generated from low-back-pain.json · Browse: Low Back Pain atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.