Research Tracker›Biomarker Atlas›Multiple Sclerosis›YKL-40

YKL-40 in Multiple Sclerosis

YKL-40 is a other marker reported as elevated in Multiple Sclerosis when patients are compared with healthy individuals. The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Dönder et al. 2021 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedOther

Summary

Direction in Multiple Sclerosis↑ Elevated — higher than in the comparison group
CategoryOther
Compared againsthealthy individuals
SourceDönder et al. 2021 — doi:10.1590/0004-282X-ANP-2020-0326
Condition atlasMultiple Sclerosis Biomarker Atlas

Related Other markers in Multiple Sclerosis

Full list: Multiple Sclerosis Biomarker Atlas.

Frequently asked questions

Is YKL-40 high or low in Multiple Sclerosis?

Elevated. Studies summarised in the OSMF atlas report higher YKL-40 in Multiple Sclerosis than in healthy individuals. Source: Dönder et al. 2021.

Which test measures YKL-40?

The atlas record does not list a standardised clinical test code (LOINC) for YKL-40, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal YKL-40 result diagnostic of Multiple Sclerosis?

No. No single biomarker is diagnostic of Multiple Sclerosis. YKL-40 findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). YKL-40 in Multiple Sclerosis: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 8, 2026, from https://research.opensourcemed.info/biomarkers/multiple-sclerosis/ykl-40.html
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Last reviewed: 2026-10-08 · Page generated from multiple-sclerosis.json · Browse: Multiple Sclerosis atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.