Summary
| Direction in Long COVID | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Vascular |
| Also described as | Natriuretic peptide |
| Compared against | HC (healthy controls) |
| Associated symptoms | Cardiovascular LC |
| Test type | Blood test (serum / plasma / whole blood) |
| LOINC code | 33762-6 |
| Source | Thomas et al. 2024 — doi:10.1007/s40291-024-00731-z |
| Condition atlas | Long COVID Biomarker Atlas |
Other conditions where NT-proBNP is reported
- NT-proBNP in Atrial Fibrillation — ↑ elevated vs cardiac stress/AF vs healthy
- NT-proBNP in Hypertension — ↑ elevated vs hypertensive (asymptomatic, at-risk) vs normal
See the cross-condition hub: NT-proBNP across conditions.
Trials, interventions and tests
In clinical-trial registrations this marker maps to the outcome term Factors of inflamatory and prothrombotic processes: D-Dimer, N-terminal prohormone of brain natriuretic peptide (NT Pro-BNP), C-reactive protenin and Antinuclear antibodies (ANA) (5 registered trials use a matching outcome measure).
Clinical trials using NT-proBNP as an outcome
- NCT06597682: Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (Not Yet Recruiting)
Outcome measure: Change in proBNP Levels - NCT04695704: Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: (Terminated)
Outcome measure: Factors of inflamatory and prothrombotic processes: D-Dimer, N-terminal prohormone of brain natriuretic peptide (NT Pro-BNP), C-reactive protenin and Antinuclear antibodies (ANA) - NCT05823896: ImPROving Quality of LIFe in the Long COVID Patient (Completed)
Outcome measure: Change from baseline in plasma biomarkers over time - NCT06065033: Exercise Interventions in Post-acute Sequelae of Covid-19 (Withdrawn)
Outcome measure: NTproBNP - NCT05128292: Effect of CoQ10 Plus Selenium Supplementation on Clinical Outcomes and Biochemical Markers in ME/CFS (CoSeME Study) (Completed)
Outcome measure: Measurement of biomarkers of cardiovascular risk.
Interventions studied alongside this marker
Hypothesis-generating links from trial outcome usage and literature co-occurrence. Not treatment recommendations.
- Coenzyme Q10 — 2 trials, 6 PubMed co-citations
e.g. Idebenone protects against doxorubicin-induced cardiac injury by inhibiting ferroptosis in cardiomyocytes. - Exercise therapy — 1 trial, 6 PubMed co-citations
e.g. Time-Course of Physiological Adaptations to High-Intensity Interval Training-Based Cardiac Rehabilitation…
Commercial test availability
NT-proBNP — commercial laboratory test.
Links are for reference only; availability, specimen requirements and coverage vary by location.
Related Vascular markers in Long COVID
- Troponin ↑
- Asymmetric dimethylarginine (ADMA) ↑
- Endothelin-1 ↑
- Resistin ↑
- VCAM-1 ↑
- ICAM-1 ↑
- von Willebrand Factor (vWF) ↑
Full list: Long COVID Biomarker Atlas.
Frequently asked questions
Is NT-proBNP high or low in Long COVID?
Elevated. Studies summarised in the OSMF atlas report higher NT-proBNP in Long COVID than in healthy controls. Source: Thomas et al. 2024.
What symptoms is NT-proBNP associated with in Long COVID?
The cited literature associates this marker with Cardiovascular LC. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures NT-proBNP?
It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 33762-6. Commercial laboratories such as Quest Diagnostics, LabCorp list an orderable assay.
Is one abnormal NT-proBNP result diagnostic of Long COVID?
No. No single biomarker is diagnostic of Long COVID. NT-proBNP findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is NT-proBNP specific to Long COVID?
No. The same marker is also reported in Atrial Fibrillation, Hypertension in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-06-29 · Page generated from long-covid.json · Browse: Long COVID atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.