Summary
| Direction in Long COVID | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Vascular |
| Also described as | Cardiac injury marker |
| Compared against | HC (healthy controls) |
| Associated symptoms | Cardiac involvement |
| Test type | Blood test (serum / plasma / whole blood) |
| LOINC code | 10839-9 |
| Source | Thomas et al. 2024 — doi:10.1007/s40291-024-00731-z |
| Condition atlas | Long COVID Biomarker Atlas |
Trials, interventions and tests
In clinical-trial registrations this marker maps to the outcome term Assessment of Change in Troponin Laboratory Testing Results (3 registered trials use a matching outcome measure).
Clinical trials using Troponin as an outcome
- NCT06597682: Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (Not Yet Recruiting)
Outcome measure: Inflammatory Cardiac Involvement symptom cluster: Change in cTNT Levels - NCT04482595: BIO 300 Oral Suspension in Previously Hospitalized Long COVID Patients (Unknown)
Outcome measure: Change in Clinical Laboratory Values - NCT05669261: Treatment of Long COVID Symptoms Utilizing Autologous Stem Cells Following COVID-19 Infection (Unknown)
Outcome measure: Assessment of Change in Troponin Laboratory Testing Results
Interventions studied alongside this marker
Hypothesis-generating links from trial outcome usage and literature co-occurrence. Not treatment recommendations.
- Coenzyme Q10 — 1 trial, 6 PubMed co-citations
e.g. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac…
Commercial test availability
Troponin — commercial laboratory test.
Links are for reference only; availability, specimen requirements and coverage vary by location.
Related Vascular markers in Long COVID
- NT-proBNP ↑
- Asymmetric dimethylarginine (ADMA) ↑
- Endothelin-1 ↑
- Resistin ↑
- VCAM-1 ↑
- ICAM-1 ↑
- von Willebrand Factor (vWF) ↑
Full list: Long COVID Biomarker Atlas.
Frequently asked questions
Is Troponin high or low in Long COVID?
Elevated. Studies summarised in the OSMF atlas report higher Troponin in Long COVID than in healthy controls. Source: Thomas et al. 2024.
What symptoms is Troponin associated with in Long COVID?
The cited literature associates this marker with Cardiac involvement. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Troponin?
It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 10839-9. Commercial laboratories such as Quest Diagnostics, LabCorp list an orderable assay.
Is one abnormal Troponin result diagnostic of Long COVID?
No. No single biomarker is diagnostic of Long COVID. Troponin findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from long-covid.json · Browse: Long COVID atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.