Research Tracker›Biomarker Atlas›Long COVID›Endothelin-1

Endothelin-1 in Long COVID

Endothelin-1, also described as Vasoactive peptide, is a vascular marker reported as elevated in Long COVID (PASC, Post-Acute Sequelae of COVID-19) when patients are compared with healthy controls. Clinically, it has been associated with vasoconstriction, POTS. The finding is drawn from Thomas et al. 2024; it describes group-level differences, not a threshold that classifies an individual.

↑ ElevatedVascularLOINC 27940-8

Summary

Direction in Long COVID↑ Elevated — higher than in the comparison group
CategoryVascular
Also described asVasoactive peptide
Compared againstHC (healthy controls)
Associated symptomsVasoconstriction, POTS
Test typeBlood test (serum / plasma / whole blood)
LOINC code27940-8
SourceThomas et al. 2024 — doi:10.1007/s40291-024-00731-z
Condition atlasLong COVID Biomarker Atlas

Trials, interventions and tests

Commercial test availability

Endothelin-1 — specialty laboratory test.

Links are for reference only; availability, specimen requirements and coverage vary by location.

Related Vascular markers in Long COVID

Full list: Long COVID Biomarker Atlas.

Frequently asked questions

Is Endothelin-1 high or low in Long COVID?

Elevated. Studies summarised in the OSMF atlas report higher Endothelin-1 in Long COVID than in healthy controls. Source: Thomas et al. 2024.

What symptoms is Endothelin-1 associated with in Long COVID?

The cited literature associates this marker with Vasoconstriction, POTS. These are population-level associations and do not mean the marker causes the symptoms.

Which test measures Endothelin-1?

It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 27940-8. Commercial laboratories such as ARUP Laboratories list an orderable assay.

Is one abnormal Endothelin-1 result diagnostic of Long COVID?

No. No single biomarker is diagnostic of Long COVID. Endothelin-1 findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Endothelin-1 in Long COVID: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/long-covid/endothelin-1.html
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Last reviewed: 2026-06-29 · Page generated from long-covid.json · Browse: Long COVID atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.