Research Tracker›Biomarker Atlas›Hypertension›Endothelin-1

Endothelin-1 in Hypertension

Endothelin-1 is a other marker reported as elevated in Hypertension when patients are compared with patients with moderate to severe hypertension vs. normotensive individuals. Symptom domains tied to this marker in the source include moderate to severe hypertension. The evidence summarised here comes from Iglarz et al. 2003 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedOtherLOINC 27940-8

Summary

Direction in Hypertension↑ Elevated — higher than in the comparison group
CategoryOther
Compared againstpatients with moderate to severe hypertension vs. normotensive individuals
Associated symptomsmoderate to severe hypertension
Test typeBlood test (serum / plasma / whole blood)
LOINC code27940-8
SourceIglarz et al. 2003 — doi:10.1007/s11906-003-0071-4
Condition atlasHypertension Biomarker Atlas

Other conditions where Endothelin-1 is reported

See the cross-condition hub: Endothelin-1 across conditions.

Related Other markers in Hypertension

Full list: Hypertension Biomarker Atlas.

Frequently asked questions

Is Endothelin-1 high or low in Hypertension?

Elevated. Studies summarised in the OSMF atlas report higher Endothelin-1 in Hypertension than in patients with moderate to severe hypertension vs. normotensive individuals. Source: Iglarz et al. 2003.

What symptoms is Endothelin-1 associated with in Hypertension?

The cited literature associates this marker with moderate to severe hypertension. These are population-level associations and do not mean the marker causes the symptoms.

Which test measures Endothelin-1?

It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 27940-8. Many of the cited studies used research-grade assays, so clinical availability may vary.

Is one abnormal Endothelin-1 result diagnostic of Hypertension?

No. No single biomarker is diagnostic of Hypertension. Endothelin-1 findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Is Endothelin-1 specific to Hypertension?

No. The same marker is also reported in Long COVID in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.

Cite this page

Open Source Medicine Foundation. (2026). Endothelin-1 in Hypertension: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 8, 2026, from https://research.opensourcemed.info/biomarkers/hypertension/endothelin-1.html
Get OSMF research updates. New biomarker, trial and treatment evidence summaries by email.
Subscribe on Substack

Last reviewed: 2026-10-08 · Page generated from hypertension.json · Browse: Hypertension atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.