Between 2 November 2026 and 8 November 2026 the tracker indexed 22 new peer-reviewed studies and 8 clinical-trial updates across 8 post-viral and post-infectious conditions.
By the numbers
22new studies this issue
8trial updates this issue
538studies currently in the feeds
634clinical trials tracked
603biomarkers catalogued
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-11-08); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
New studies by condition
Long COVID (PASC) 3 new
Full feed: Long COVID research tracker
Chronic pain affects a substantial proportion of the global adult population and is closely associated with neuropsychiatric symptoms, such as depression and anxiety, which may further worsen pain outcomes and increase mortality risk. However, development trends and research hotspots in this field remain insufficiently clarified.
The COVID-19 pandemic was widely accompanied by stigma towards certain groups of people, which can diminish efforts of disease control and exacerbate negative impacts of the disease itself. Research on COVID-19-related stigma in the German population is scarce and, internationally, is lacking validated and standardized measurement instruments.
Hepatic stellate cells (HSCs) have long been regarded as the core effector cells in liver fibrosis. The advent of single-cell omics and metabolomics has led to a paradigm shift in our understanding of these cells.
Postural Orthostatic Tachycardia Syndrome (POTS) 3 new
Full feed: POTS research tracker
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID.
Postural Orthostatic Tachycardia Syndrome (POTS) is a phenotype of post-COVID-19 Condition (PCC), characterised by orthostatic intolerance and a range of debilitating symptoms. Exercise is a frequently implemented intervention in the treatment of POTS and PCC.
This retrospective medical record review examined the proportion of transgender and gender-diverse (TGD) youth within a multidisciplinary pediatric autonomic dysfunction clinic specializing in chronic orthostatic intolerance, compared quality-of-life (QoL) scores between TGD and cisgender youth, and identified opportunities to improve health equity in nonpharmacological recommendations. Data on gender identity...
Mast Cell Activation Syndrome (MCAS) 16 new
Full feed: MCAS research tracker
Endometriosis (EMs) pain severely reduces patients' quality of life, but its underlying mechanisms are not fully understood. Mast cells and C-C motif chemokine ligand 2 (CCL2) are highly abundant in EMs lesions, yet their roles in neural sensitization remain unclear.
Chronic spontaneous urticaria is a mast cell-driven skin disorder in which basophils and eosinophils contribute to inflammation. Omalizumab is effective for many patients, yet a subset remains resistant.
Allergic Rhinitis (AR) is an allergen-driven, IgE-mediated inflammatory disease of the nasal mucosa. Established therapies are effective for many patients, but incomplete symptom control, suboptimal adherence, and treatment preference sustain interest in new locally acting agents.
Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K-AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this signaling axis.
This study evaluated the therapeutic effect of hesperidin (HES) on allergic rhinitis (AR) in a mouse model induced by ovalbumin (OVA). After inducing AR in BALB/c mice through OVA, the severity of allergic reactions was assessed through behavioral scoring.
The role of mast cells in colorectal cancer (CRC) liver metastasis remains controversial. This study aimed to explore the effect of mast cells on the CRC liver metastasis and the underlying mechanism.
Mast cells (MCs) are the principal effector cells in urticaria, orchestrating the release of mediators that drive wheal formation, angioedema, and pruritus. Although activation of MCs via the immunoglobulin (Ig) E and its high-affinity receptor (FcεRI) axis, including autoimmune urticaria mediated by IgE and IgG autoantibodies, remains the best characterized pathway, increasing evidence indicates that additional...
The intestinal barrier is a dynamic host-microbe interface that contributes to metabolic homeostasis. Chronic psychological stress and adverse dietary patterns can each disturb microbiota, mucus, junctional, and inflammatory processes.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and immune dysregulation, which may influence topical drug penetration and therapeutic efficacy. This study evaluated a microneedle-assisted approach to enhance the cutaneous delivery of compound betamethasone in AD.
Basophils are rare cells best known for their role in allergy but their contribution to cancer remains poorly understood. Here, we found that basophils suppress early lung metastatic seeding in mice by enhancing antitumor CD8
Lactic acid bacterial fermentation offers a food-compatible strategy for reducing milk allergenicity, but the responsible proteolytic components remain poorly defined. We evaluated milk fermented with Lacticaseibacillus paracasei XJ-003 using pooled sera from milk-allergic donors and characterized its protease system.
Long COVID is a multisystem disease that affects approximately 10% of people after a SARS-CoV-2 infection. In the absence of curative treatment, high-quality clinical treatment trials are urgently needed for long COVID.
Advances in immunophenotyping of tumour-infiltrating lymphocytes (TILs) have improved our understanding of prognostic biomarkers and immune targets in human melanoma. However, whether the tumour-immune landscape in canine oral malignant melanoma (COMM) is concordant with that of human melanoma has not been properly defined.
Atopic dermatitis (AD), a prevalent chronic inflammatory skin disorder, highlights the need for advanced immunomodulatory therapies. We isolated three novel polysaccharides (SVP1-SVP3) from Sanghuangporus vaninii, characterized their physicochemical properties, and formulated them into hydrogels.
Remibrutinib (Rhapsido
This work describes, to our knowledge, the first reported case of a patient with an MDS/MPN overlap syndrome harboring a novel
No new studies this window for: ME/CFS, PACVS, Lyme / PTLDS, Gulf War Illness, Other post-viral.
Trial activity
ClinicalTrials.gov records whose registry entry was last updated between 2 November 2026 and 8 November 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|
| NCT07478172 | Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease POTS, Other post-viral | Active Not Recruiting | Not applicable | Whole-Body Electrical Muscle Stimulation Exercise | 2026-11-06 |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Long COVID | Not Yet Recruiting | Phase 1 | Keytruda | 2026-11-06 |
| NCT07874217 | Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Long COVID, ME/CFS | Recruiting | Not applicable | Cryotherapy | 2026-11-05 |
| NCT06404047 | RECOVER-ENERGIZE Platform Protocol Long COVID | Completed | Not applicable | Personalized Cardiopulmonary Rehabilitation, Structured Pacing | 2026-11-05 |
| NCT05130099 | A Complex Intervention for Chronically Fatigued Lymphoma Survivors ME/CFS | Completed | Not applicable | Interdisciplinary Complex Intervention | 2026-11-05 |
| NCT07916259 | The Study of Brave-LC LDN Treatment Trial Long COVID | Not Yet Recruiting | Phase 3 | Naltrexone | 2026-11-04 |
| NCT04435002 | The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome ME/CFS | Completed | Not applicable | Acupressure | 2026-11-04 |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 Other post-viral | Enrolling By Invitation | Phase 2 | Iv Normal Saline, Iv Immunoglobulin | 2026-11-03 |
Browse all tracked trials: clinical trials tracker.
Cite this issue
Open Source Medicine Foundation. Post-viral research digest, week 45 2026: 22 new studies. Published 8 November 2026. https://research.opensourcemed.info/digest/2026-W45.html
Issues are regenerated from the live tracker data within their week and frozen afterwards; the snapshot behind this page is at data/2026-W45.json.
Disclaimer. This digest is an automated, unreviewed listing of newly indexed PubMed records and ClinicalTrials.gov registry updates compiled by the Open Source Medicine Foundation. Inclusion is not endorsement; abstracts are excerpted verbatim from PubMed and may contain errors. It is not medical advice. Discuss any treatment decision with a qualified clinician.