Weekly digest · ISO week 45

Post-viral research digest, week 45 2026: 22 new studies

2 November 2026 – 8 November 2026 · published 8 November 2026 · Subscribe

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  3. Week 45 2026

Between 2 November 2026 and 8 November 2026 the tracker indexed 22 new peer-reviewed studies and 8 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

22new studies this issue
8trial updates this issue
538studies currently in the feeds
634clinical trials tracked
603biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-11-08); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

In this issue:

New studies by condition

Long COVID (PASC) 3 new

Full feed: Long COVID research tracker

Research Landscape of Chronic Pain and Neuropsychiatric Symptoms (1983-2025): A Comprehensive Bibliometric Analysis.

Pain research & management · 2 November 2026 · Quan, Xingpu, Fu, Xinrui, Lu, Tao, Lai, Jiandong et al. PubMed 42968424

Chronic pain affects a substantial proportion of the global adult population and is closely associated with neuropsychiatric symptoms, such as depression and anxiety, which may further worsen pain outcomes and increase mortality risk. However, development trends and research hotspots in this field remain insufficiently clarified.

Measuring infectious disease stigma in the German population: Psychometric properties of stigma scales related to COVID-19, Long Covid and non-vaccination in a representative population sample.

Archives of public health = Archives belges de sante publique · 2 November 2026 · Menzinger, Jule, Alpers, Carlotta, McLaren, Thomas, Danqa, Dafina et al. PubMed 42968174

The COVID-19 pandemic was widely accompanied by stigma towards certain groups of people, which can diminish efforts of disease control and exacerbate negative impacts of the disease itself. Research on COVID-19-related stigma in the German population is scarce and, internationally, is lacking validated and standardized measurement instruments.

Postural Orthostatic Tachycardia Syndrome (POTS) 3 new

Full feed: POTS research tracker

More common than we thought: Hypermobile Ehlers-Danlos Syndrome, comorbidity burden, and long COVID risk in a national cohort.also MCAS

PLOS digital health · 5 November 2026 · Pearson, Megan L, Laraway, Bryan J, Elias, Ellen R, Bilousova, Ganna et al. PubMed 42986813

Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID.

Experiences of individually tailored physical exercise in COVID-19-induced postural orthostatic tachycardia syndrome: A qualitative content analysis.

PloS one · 4 November 2026 · Svensson, Annie, Sönnerfors, Pernilla, Holmström, Linda, Nygren-Bonnier, Malin et al. PubMed 42981266

Postural Orthostatic Tachycardia Syndrome (POTS) is a phenotype of post-COVID-19 Condition (PCC), characterised by orthostatic intolerance and a range of debilitating symptoms. Exercise is a frequently implemented intervention in the treatment of POTS and PCC.

Gender Diversity in Pediatric Chronic Orthostatic Intolerance: Mental Health and Quality-of-Life Outcomes.

Clinical pediatrics · 2 November 2026 · Frye, William S, Mauriello, Daniel, Mitchell, Brooke, Greenberg, Brooke et al. PubMed 42969784

This retrospective medical record review examined the proportion of transgender and gender-diverse (TGD) youth within a multidisciplinary pediatric autonomic dysfunction clinic specializing in chronic orthostatic intolerance, compared quality-of-life (QoL) scores between TGD and cisgender youth, and identified opportunities to improve health equity in nonpharmacological recommendations. Data on gender identity...

Mast Cell Activation Syndrome (MCAS) 16 new

Full feed: MCAS research tracker

Mast Cell-Derived CCL2 Exacerbates Endometriosis Pain via Binding to CCR4.

Omics : a journal of integrative biology · 6 November 2026 · Deng, Ya, Chen, Ping, Ding, Haigang PubMed 42992652

Endometriosis (EMs) pain severely reduces patients' quality of life, but its underlying mechanisms are not fully understood. Mast cells and C-C motif chemokine ligand 2 (CCL2) are highly abundant in EMs lesions, yet their roles in neural sensitization remain unclear.

Plant-derived Alkaloids for Allergic Rhinitis: Evidence, Exposure, Safety and Translational Readiness.

Current pharmaceutical biotechnology · 5 November 2026 · Yang, Yaodong, Ma, Xuemei, Liu, Yuxin, Ma, Long et al. PubMed 42983188

Allergic Rhinitis (AR) is an allergen-driven, IgE-mediated inflammatory disease of the nasal mucosa. Established therapies are effective for many patients, but incomplete symptom control, suboptimal adherence, and treatment preference sustain interest in new locally acting agents.

Licoflavone B mitigates allergic rhinitis by restraining epithelial PI3K-AKT/NF-κB NLRP3 inflammasome signaling.

Human cell · 5 November 2026 · Shen, Qi, Ma, Xiaoyao, Liu, Hui, Li, Xuemin et al. PubMed 42986481

Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K-AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this signaling axis.

Hesperidin alleviates allergic rhinitis by inhibiting NF-κB activation and restoring nasal epithelial barrier function.

Medical molecular morphology · 5 November 2026 · Zhou, Kai, Wu, Qian, Han, Jiajia, Muratov, Muzaffar et al. PubMed 42986406

This study evaluated the therapeutic effect of hesperidin (HES) on allergic rhinitis (AR) in a mouse model induced by ovalbumin (OVA). After inducing AR in BALB/c mice through OVA, the severity of allergic reactions was assessed through behavioral scoring.

Key Players and Pathways of Mast Cell Activation in Urticaria.

Journal of inflammation research · 4 November 2026 · Jahn, Carolin, Gialama, Dimitra, Pashuk, Margarita, Xiang, Yi-Kui et al. PubMed 42979487

Mast cells (MCs) are the principal effector cells in urticaria, orchestrating the release of mediators that drive wheal formation, angioedema, and pruritus. Although activation of MCs via the immunoglobulin (Ig) E and its high-affinity receptor (FcεRI) axis, including autoimmune urticaria mediated by IgE and IgG autoantibodies, remains the best characterized pathway, increasing evidence indicates that additional...

Diet-stress interactions in gut barrier dysfunction and metabolic inflammation.

Molecular medicine (Cambridge, Mass.) · 4 November 2026 · Tičinović Kurir, Tina, Pavlović, Nikola, Šantić, Roko, Lerotić, Ivana Irma et al. PubMed 42977922

The intestinal barrier is a dynamic host-microbe interface that contributes to metabolic homeostasis. Chronic psychological stress and adverse dietary patterns can each disturb microbiota, mucus, junctional, and inflammatory processes.

Development and evaluation of a microneedle-assisted transdermal delivery system for compound betamethasone in atopic dermatitis.

Drug delivery and translational research · 4 November 2026 · Wang, Si-Ning, Qiao, Xiaojing, Du, Fangzhi, Chen, Jing et al. PubMed 42981018

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunctio​n and immune dysregulation, which may influence topical drug penetration and therapeutic efficacy. This study evaluated a microneedle-assisted approach to enhance the cutaneous delivery of compound betamethasone in AD.

Activity-Guided Identification of Prot2633 as a Major Proteolytic Contributor to the Reduced Allergenicity of Lacticaseibacillus paracasei XJ-003-Fermented Milk.

Journal of agricultural and food chemistry · 4 November 2026 · Ma, Ruida, Xu, Yunpeng, Guo, Zihao, Zhang, Haiyun et al. PubMed 42980418

Lactic acid bacterial fermentation offers a food-compatible strategy for reducing milk allergenicity, but the responsible proteolytic components remain poorly defined. We evaluated milk fermented with Lacticaseibacillus paracasei XJ-003 using pooled sera from milk-allergic donors and characterized its protease system.

Outcome measures in long COVID clinical trials: a review.

Frontiers in public health · 3 November 2026 · van Rhijn-Brouwer, Femke C C, de Canson, Chloé, VanDerNagel, Joanneke E L, Westerhuis, Xandra et al. PubMed 42973774

Long COVID is a multisystem disease that affects approximately 10% of people after a SARS-CoV-2 infection. In the absence of curative treatment, high-quality clinical treatment trials are urgently needed for long COVID.

A 16-colour spectral flow cytometry panel to characterise T cell immunophenotypes in canine oral melanoma.

Developmental and comparative immunology · 3 November 2026 · Hindriks, E, Lozano-Andrés, E, Roos, A, Zandvliet, M M J M et al. PubMed 42977135

Advances in immunophenotyping of tumour-infiltrating lymphocytes (TILs) have improved our understanding of prognostic biomarkers and immune targets in human melanoma. However, whether the tumour-immune landscape in canine oral malignant melanoma (COMM) is concordant with that of human melanoma has not been properly defined.

Sanghuangporus vaninii Polysaccharide Hydrogel Attenuates DNFB-Induced Atopic Dermatitis in Mice via Immunomodulation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2 November 2026 · Li, Wei, Guo, Chunhe, Jin, Yudi, Wang, Wenzhe et al. PubMed 42969038

Atopic dermatitis (AD), a prevalent chronic inflammatory skin disorder, highlights the need for advanced immunomodulatory therapies. We isolated three novel polysaccharides (SVP1-SVP3) from Sanghuangporus vaninii, characterized their physicochemical properties, and formulated them into hydrogels.

Remibrutinib (Rhapsido

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2 November 2026 · Abduweli, Abdusemi, Hu, Longqin PubMed 42970053

Remibrutinib (Rhapsido

Identification of a Novel

EJHaem · 2 November 2026 · Caledec, Marianne, Labussière-Wallet, Hélène, Fontaine, Juliette, Larcher, Marie et al. PubMed 42968844

This work describes, to our knowledge, the first reported case of a patient with an MDS/MPN overlap syndrome harboring a novel

No new studies this window for: ME/CFS, PACVS, Lyme / PTLDS, Gulf War Illness, Other post-viral.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 2 November 2026 and 8 November 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCTTrialStatusPhaseAgentsUpdated
NCT07478172Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
POTS, Other post-viral
Active Not RecruitingNot applicableWhole-Body Electrical Muscle Stimulation Exercise2026-11-06
NCT07388550Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Long COVID
Not Yet RecruitingPhase 1Keytruda2026-11-06
NCT07874217Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study
Long COVID, ME/CFS
RecruitingNot applicableCryotherapy2026-11-05
NCT06404047RECOVER-ENERGIZE Platform Protocol
Long COVID
CompletedNot applicablePersonalized Cardiopulmonary Rehabilitation, Structured Pacing2026-11-05
NCT05130099A Complex Intervention for Chronically Fatigued Lymphoma Survivors
ME/CFS
CompletedNot applicableInterdisciplinary Complex Intervention2026-11-05
NCT07916259The Study of Brave-LC LDN Treatment Trial
Long COVID
Not Yet RecruitingPhase 3Naltrexone2026-11-04
NCT04435002The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome
ME/CFS
CompletedNot applicableAcupressure2026-11-04
NCT05350774Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Other post-viral
Enrolling By InvitationPhase 2Iv Normal Saline, Iv Immunoglobulin2026-11-03

Browse all tracked trials: clinical trials tracker.

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Cite this issue

Open Source Medicine Foundation. Post-viral research digest, week 45 2026: 22 new studies. Published 8 November 2026. https://research.opensourcemed.info/digest/2026-W45.html

Issues are regenerated from the live tracker data within their week and frozen afterwards; the snapshot behind this page is at data/2026-W45.json.

Disclaimer. This digest is an automated, unreviewed listing of newly indexed PubMed records and ClinicalTrials.gov registry updates compiled by the Open Source Medicine Foundation. Inclusion is not endorsement; abstracts are excerpted verbatim from PubMed and may contain errors. It is not medical advice. Discuss any treatment decision with a qualified clinician.