{ "id": "2026-W45", "year": 2026, "week": 45, "week_monday": "2026-11-02", "week_sunday": "2026-11-08", "asof": "2026-11-08", "window_start": "2026-11-02", "window_end": "2026-11-08", "window_days": 7, "widened": false, "strict_study_count": 22, "strict_trial_count": 8, "study_count": 22, "trial_count": 8, "studies": { "long-covid": [ { "pmid": "42968424", "title": "Research Landscape of Chronic Pain and Neuropsychiatric Symptoms (1983-2025): A Comprehensive Bibliometric Analysis.", "journal": "Pain research & management", "pub_date": "2026-11-02", "authors": "Quan, Xingpu, Fu, Xinrui, Lu, Tao, Lai, Jiandong et al.", "excerpt": "Chronic pain affects a substantial proportion of the global adult population and is closely associated with neuropsychiatric symptoms, such as depression and anxiety, which may further worsen pain outcomes and increase mortality risk. However, development trends and research hotspots in this field remain insufficiently clarified.", "url": "https://pubmed.ncbi.nlm.nih.gov/42968424/", "also": [] }, { "pmid": "42968174", "title": "Measuring infectious disease stigma in the German population: Psychometric properties of stigma scales related to COVID-19, Long Covid and non-vaccination in a representative population sample.", "journal": "Archives of public health = Archives belges de sante publique", "pub_date": "2026-11-02", "authors": "Menzinger, Jule, Alpers, Carlotta, McLaren, Thomas, Danqa, Dafina et al.", "excerpt": "The COVID-19 pandemic was widely accompanied by stigma towards certain groups of people, which can diminish efforts of disease control and exacerbate negative impacts of the disease itself. Research on COVID-19-related stigma in the German population is scarce and, internationally, is lacking validated and standardized measurement instruments.", "url": "https://pubmed.ncbi.nlm.nih.gov/42968174/", "also": [] }, { "pmid": "42969024", "title": "Hepatic Stellate Cells: Fibrogenic Effectors to Central Regulators of Metabolism, Liver Disease Signaling, and Systemic Crosstalk.", "journal": "Gut and liver", "pub_date": "2026-11-02", "authors": "Li, Xiang, Chen, Hao, Fu, Wenguang", "excerpt": "Hepatic stellate cells (HSCs) have long been regarded as the core effector cells in liver fibrosis. The advent of single-cell omics and metabolomics has led to a paradigm shift in our understanding of these cells.", "url": "https://pubmed.ncbi.nlm.nih.gov/42969024/", "also": [] } ], "me-cfs": [], "pacvs": [], "lyme": [], "gulf-war-illness": [], "pots": [ { "pmid": "42986813", "title": "More common than we thought: Hypermobile Ehlers-Danlos Syndrome, comorbidity burden, and long COVID risk in a national cohort.", "journal": "PLOS digital health", "pub_date": "2026-11-05", "authors": "Pearson, Megan L, Laraway, Bryan J, Elias, Ellen R, Bilousova, Ganna et al.", "excerpt": "Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID.", "url": "https://pubmed.ncbi.nlm.nih.gov/42986813/", "also": [ "mcas" ] }, { "pmid": "42981266", "title": "Experiences of individually tailored physical exercise in COVID-19-induced postural orthostatic tachycardia syndrome: A qualitative content analysis.", "journal": "PloS one", "pub_date": "2026-11-04", "authors": "Svensson, Annie, Sönnerfors, Pernilla, Holmström, Linda, Nygren-Bonnier, Malin et al.", "excerpt": "Postural Orthostatic Tachycardia Syndrome (POTS) is a phenotype of post-COVID-19 Condition (PCC), characterised by orthostatic intolerance and a range of debilitating symptoms. Exercise is a frequently implemented intervention in the treatment of POTS and PCC.", "url": "https://pubmed.ncbi.nlm.nih.gov/42981266/", "also": [] }, { "pmid": "42969784", "title": "Gender Diversity in Pediatric Chronic Orthostatic Intolerance: Mental Health and Quality-of-Life Outcomes.", "journal": "Clinical pediatrics", "pub_date": "2026-11-02", "authors": "Frye, William S, Mauriello, Daniel, Mitchell, Brooke, Greenberg, Brooke et al.", "excerpt": "This retrospective medical record review examined the proportion of transgender and gender-diverse (TGD) youth within a multidisciplinary pediatric autonomic dysfunction clinic specializing in chronic orthostatic intolerance, compared quality-of-life (QoL) scores between TGD and cisgender youth, and identified opportunities to improve health equity in nonpharmacological recommendations. Data on gender identity...", "url": "https://pubmed.ncbi.nlm.nih.gov/42969784/", "also": [] } ], "mcas": [ { "pmid": "42992652", "title": "Mast Cell-Derived CCL2 Exacerbates Endometriosis Pain via Binding to CCR4.", "journal": "Omics : a journal of integrative biology", "pub_date": "2026-11-06", "authors": "Deng, Ya, Chen, Ping, Ding, Haigang", "excerpt": "Endometriosis (EMs) pain severely reduces patients' quality of life, but its underlying mechanisms are not fully understood. Mast cells and C-C motif chemokine ligand 2 (CCL2) are highly abundant in EMs lesions, yet their roles in neural sensitization remain unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42992652/", "also": [] }, { "pmid": "42992522", "title": "Basophil and eosinophil dynamics as predictors of omalizumab resistance in chronic spontaneous urticaria.", "journal": "Cutaneous and ocular toxicology", "pub_date": "2026-11-06", "authors": "Oraloğlu, Göktürk, Süne, Ceren, Duman, Nilay, Demirel, Boratay Erin et al.", "excerpt": "Chronic spontaneous urticaria is a mast cell-driven skin disorder in which basophils and eosinophils contribute to inflammation. Omalizumab is effective for many patients, yet a subset remains resistant.", "url": "https://pubmed.ncbi.nlm.nih.gov/42992522/", "also": [] }, { "pmid": "42983188", "title": "Plant-derived Alkaloids for Allergic Rhinitis: Evidence, Exposure, Safety and Translational Readiness.", "journal": "Current pharmaceutical biotechnology", "pub_date": "2026-11-05", "authors": "Yang, Yaodong, Ma, Xuemei, Liu, Yuxin, Ma, Long et al.", "excerpt": "Allergic Rhinitis (AR) is an allergen-driven, IgE-mediated inflammatory disease of the nasal mucosa. Established therapies are effective for many patients, but incomplete symptom control, suboptimal adherence, and treatment preference sustain interest in new locally acting agents.", "url": "https://pubmed.ncbi.nlm.nih.gov/42983188/", "also": [] }, { "pmid": "42986481", "title": "Licoflavone B mitigates allergic rhinitis by restraining epithelial PI3K-AKT/NF-κB NLRP3 inflammasome signaling.", "journal": "Human cell", "pub_date": "2026-11-05", "authors": "Shen, Qi, Ma, Xiaoyao, Liu, Hui, Li, Xuemin et al.", "excerpt": "Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K-AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this signaling axis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42986481/", "also": [] }, { "pmid": "42986406", "title": "Hesperidin alleviates allergic rhinitis by inhibiting NF-κB activation and restoring nasal epithelial barrier function.", "journal": "Medical molecular morphology", "pub_date": "2026-11-05", "authors": "Zhou, Kai, Wu, Qian, Han, Jiajia, Muratov, Muzaffar et al.", "excerpt": "This study evaluated the therapeutic effect of hesperidin (HES) on allergic rhinitis (AR) in a mouse model induced by ovalbumin (OVA). After inducing AR in BALB/c mice through OVA, the severity of allergic reactions was assessed through behavioral scoring.", "url": "https://pubmed.ncbi.nlm.nih.gov/42986406/", "also": [] }, { "pmid": "42980805", "title": "Mast cell-derived SPP1 promotes colorectal cancer liver metastasis by suppressing BTG1-mediated JUN degradation.", "journal": "Cellular and molecular life sciences : CMLS", "pub_date": "2026-11-04", "authors": "Wei, Zhao-Yi, Lv, Feng, Hao, Liang, Li, Jian-Wen et al.", "excerpt": "The role of mast cells in colorectal cancer (CRC) liver metastasis remains controversial. This study aimed to explore the effect of mast cells on the CRC liver metastasis and the underlying mechanism.", "url": "https://pubmed.ncbi.nlm.nih.gov/42980805/", "also": [] }, { "pmid": "42979487", "title": "Key Players and Pathways of Mast Cell Activation in Urticaria.", "journal": "Journal of inflammation research", "pub_date": "2026-11-04", "authors": "Jahn, Carolin, Gialama, Dimitra, Pashuk, Margarita, Xiang, Yi-Kui et al.", "excerpt": "Mast cells (MCs) are the principal effector cells in urticaria, orchestrating the release of mediators that drive wheal formation, angioedema, and pruritus. Although activation of MCs via the immunoglobulin (Ig) E and its high-affinity receptor (FcεRI) axis, including autoimmune urticaria mediated by IgE and IgG autoantibodies, remains the best characterized pathway, increasing evidence indicates that additional...", "url": "https://pubmed.ncbi.nlm.nih.gov/42979487/", "also": [] }, { "pmid": "42977922", "title": "Diet-stress interactions in gut barrier dysfunction and metabolic inflammation.", "journal": "Molecular medicine (Cambridge, Mass.)", "pub_date": "2026-11-04", "authors": "Tičinović Kurir, Tina, Pavlović, Nikola, Šantić, Roko, Lerotić, Ivana Irma et al.", "excerpt": "The intestinal barrier is a dynamic host-microbe interface that contributes to metabolic homeostasis. Chronic psychological stress and adverse dietary patterns can each disturb microbiota, mucus, junctional, and inflammatory processes.", "url": "https://pubmed.ncbi.nlm.nih.gov/42977922/", "also": [] }, { "pmid": "42981018", "title": "Development and evaluation of a microneedle-assisted transdermal delivery system for compound betamethasone in atopic dermatitis.", "journal": "Drug delivery and translational research", "pub_date": "2026-11-04", "authors": "Wang, Si-Ning, Qiao, Xiaojing, Du, Fangzhi, Chen, Jing et al.", "excerpt": "Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunctio​n and immune dysregulation, which may influence topical drug penetration and therapeutic efficacy. This study evaluated a microneedle-assisted approach to enhance the cutaneous delivery of compound betamethasone in AD.", "url": "https://pubmed.ncbi.nlm.nih.gov/42981018/", "also": [] }, { "pmid": "42977840", "title": "Basophils inhibit early lung metastasis by suppressing regulatory T cells.", "journal": "Nature cancer", "pub_date": "2026-11-04", "authors": "Torchia, Bruno, Fournier, Nadine, Yücel, Simge, Fournier, Morgane et al.", "excerpt": "Basophils are rare cells best known for their role in allergy but their contribution to cancer remains poorly understood. Here, we found that basophils suppress early lung metastatic seeding in mice by enhancing antitumor CD8", "url": "https://pubmed.ncbi.nlm.nih.gov/42977840/", "also": [] }, { "pmid": "42980418", "title": "Activity-Guided Identification of Prot2633 as a Major Proteolytic Contributor to the Reduced Allergenicity of Lacticaseibacillus paracasei XJ-003-Fermented Milk.", "journal": "Journal of agricultural and food chemistry", "pub_date": "2026-11-04", "authors": "Ma, Ruida, Xu, Yunpeng, Guo, Zihao, Zhang, Haiyun et al.", "excerpt": "Lactic acid bacterial fermentation offers a food-compatible strategy for reducing milk allergenicity, but the responsible proteolytic components remain poorly defined. We evaluated milk fermented with Lacticaseibacillus paracasei XJ-003 using pooled sera from milk-allergic donors and characterized its protease system.", "url": "https://pubmed.ncbi.nlm.nih.gov/42980418/", "also": [] }, { "pmid": "42973774", "title": "Outcome measures in long COVID clinical trials: a review.", "journal": "Frontiers in public health", "pub_date": "2026-11-03", "authors": "van Rhijn-Brouwer, Femke C C, de Canson, Chloé, VanDerNagel, Joanneke E L, Westerhuis, Xandra et al.", "excerpt": "Long COVID is a multisystem disease that affects approximately 10% of people after a SARS-CoV-2 infection. In the absence of curative treatment, high-quality clinical treatment trials are urgently needed for long COVID.", "url": "https://pubmed.ncbi.nlm.nih.gov/42973774/", "also": [] }, { "pmid": "42977135", "title": "A 16-colour spectral flow cytometry panel to characterise T cell immunophenotypes in canine oral melanoma.", "journal": "Developmental and comparative immunology", "pub_date": "2026-11-03", "authors": "Hindriks, E, Lozano-Andrés, E, Roos, A, Zandvliet, M M J M et al.", "excerpt": "Advances in immunophenotyping of tumour-infiltrating lymphocytes (TILs) have improved our understanding of prognostic biomarkers and immune targets in human melanoma. However, whether the tumour-immune landscape in canine oral malignant melanoma (COMM) is concordant with that of human melanoma has not been properly defined.", "url": "https://pubmed.ncbi.nlm.nih.gov/42977135/", "also": [] }, { "pmid": "42969038", "title": "Sanghuangporus vaninii Polysaccharide Hydrogel Attenuates DNFB-Induced Atopic Dermatitis in Mice via Immunomodulation.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "pub_date": "2026-11-02", "authors": "Li, Wei, Guo, Chunhe, Jin, Yudi, Wang, Wenzhe et al.", "excerpt": "Atopic dermatitis (AD), a prevalent chronic inflammatory skin disorder, highlights the need for advanced immunomodulatory therapies. We isolated three novel polysaccharides (SVP1-SVP3) from Sanghuangporus vaninii, characterized their physicochemical properties, and formulated them into hydrogels.", "url": "https://pubmed.ncbi.nlm.nih.gov/42969038/", "also": [] }, { "pmid": "42970053", "title": "Remibrutinib (Rhapsido", "journal": "Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents", "pub_date": "2026-11-02", "authors": "Abduweli, Abdusemi, Hu, Longqin", "excerpt": "Remibrutinib (Rhapsido", "url": "https://pubmed.ncbi.nlm.nih.gov/42970053/", "also": [] }, { "pmid": "42968844", "title": "Identification of a Novel", "journal": "EJHaem", "pub_date": "2026-11-02", "authors": "Caledec, Marianne, Labussière-Wallet, Hélène, Fontaine, Juliette, Larcher, Marie et al.", "excerpt": "This work describes, to our knowledge, the first reported case of a patient with an MDS/MPN overlap syndrome harboring a novel", "url": "https://pubmed.ncbi.nlm.nih.gov/42968844/", "also": [] } ], "other-post-viral": [] }, "trials": [ { "nct_id": "NCT07478172", "title": "Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-11-06", "start_date": "2026-03-10", "sponsor": "University of Missouri-Columbia", "sponsor_type": "OTHER", "agents": [ "Whole-Body Electrical Muscle Stimulation Exercise" ], "conditions": [ "pots", "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07478172" }, { "nct_id": "NCT07388550", "title": "Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)", "status": "NOT_YET_RECRUITING", "phase": "PHASE1", "last_updated": "2026-11-06", "start_date": "2026-11-11", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Keytruda" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07388550" }, { "nct_id": "NCT07874217", "title": "Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-11-05", "start_date": "2026-10-05", "sponsor": "Oxford Brookes University", "sponsor_type": "OTHER", "agents": [ "Cryotherapy" ], "conditions": [ "long-covid", "me-cfs" ], "mapped_conditions": [ "Long COVID / PASC", "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07874217" }, { "nct_id": "NCT06404047", "title": "RECOVER-ENERGIZE Platform Protocol", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-11-05", "start_date": "2024-07-17", "sponsor": "Duke University", "sponsor_type": "OTHER", "agents": [ "Personalized Cardiopulmonary Rehabilitation", "Structured Pacing" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06404047" }, { "nct_id": "NCT05130099", "title": "A Complex Intervention for Chronically Fatigued Lymphoma Survivors", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-11-05", "start_date": "2021-11-20", "sponsor": "Oslo University Hospital", "sponsor_type": "OTHER", "agents": [ "Interdisciplinary Complex Intervention" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT05130099" }, { "nct_id": "NCT07916259", "title": "The Study of Brave-LC LDN Treatment Trial", "status": "NOT_YET_RECRUITING", "phase": "PHASE3", "last_updated": "2026-11-04", "start_date": "2026-11-16", "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_type": "NIH", "agents": [ "Naltrexone" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07916259" }, { "nct_id": "NCT04435002", "title": "The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-11-04", "start_date": "2020-05-09", "sponsor": "Istanbul Medipol University Hospital", "sponsor_type": "OTHER", "agents": [ "Acupressure" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT04435002" }, { "nct_id": "NCT05350774", "title": "Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2", "status": "ENROLLING_BY_INVITATION", "phase": "PHASE2", "last_updated": "2026-11-03", "start_date": "2023-07-10", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Iv Normal Saline", "Iv Immunoglobulin" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT05350774" } ], "feed_latest_pub_date": "2026-11-06", "numbers": { "studies_tracked": 538, "trials_tracked": 634, "biomarkers_catalogued": 603, "feeds": 8 }, "feed_updates": { "long-covid": "2026-11-02", "me-cfs": "2026-11-01", "pacvs": "2026-11-08", "lyme": "2026-11-03", "gulf-war-illness": "2026-11-04", "pots": "2026-11-06", "mcas": "2026-11-07", "other-post-viral": "2026-10-28" }, "trials_last_run": "2026-11-08", "generated_at": "2026-11-08T11:18:49+00:00" }