75 studies
An automated collection of peer-reviewed publications on MCAS (Mast Cell Activation Syndrome) and related mast cell activation phenotypes. MCAS involves inappropriate release of mast cell mediators (histamine, tryptase, prostaglandins, and others), causing multisystem symptoms such as flushing, urticaria, gastrointestinal distress, tachycardia, brain fog, and anaphylactoid reactions. It is increasingly studied in Long COVID, PACVS, POTS, and ME/CFS overlap syndromes, with growing interest in antihistamines, mast cell stabilizers, and dietary interventions.
Latest research: this page tracks 75 studies on MCAS indexed in PubMed, published between Oct 19, 2026 and Nov 6, 2026. The 30 most recent are listed below; the search box filters the full list. Journals with the most studies in this set: Journal of inflammation research (3), Frontiers in allergy (3) and Frontiers in immunology (3). List refreshed Nov 7, 2026 from PubMed.
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Disclaimer: Automated PubMed feed. Not medical advice. Consult a qualified healthcare provider.
Mast Cell-Derived CCL2 Exacerbates Endometriosis Pain via Binding to CCR4.
Endometriosis (EMs) pain severely reduces patients' quality of life, but its underlying mechanisms are not fully understood. Mast cells and C-C motif chemokine ligand 2 (CCL2) are highly abundant in EMs lesions, yet their roles in neural sensitization remain unclear. Bioinformatics analysis of a public scRNA-seq dataset (GSE179640) was performed to define
Basophil and eosinophil dynamics as predictors of omalizumab resistance in chronic spontaneous urticaria.
Chronic spontaneous urticaria is a mast cell-driven skin disorder in which basophils and eosinophils contribute to inflammation. Omalizumab is effective for many patients, yet a subset remains resistant. Hematologic markers such as eosinophil and basophil counts have been proposed as predictors, but their utility is unclear. This study aimed to investigate whether baseline...
More common than we thought: Hypermobile Ehlers-Danlos Syndrome, comorbidity burden, and long COVID risk in a national cohort.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID. Using data from over 19 million patie...
Licoflavone B mitigates allergic rhinitis by restraining epithelial PI3K-AKT/NF-κB NLRP3 inflammasome signaling.
Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K-AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this s...
Hesperidin alleviates allergic rhinitis by inhibiting NF-κB activation and restoring nasal epithelial barrier function.
This study evaluated the therapeutic effect of hesperidin (HES) on allergic rhinitis (AR) in a mouse model induced by ovalbumin (OVA). After inducing AR in BALB/c mice through OVA, the severity of allergic reactions was assessed through behavioral scoring. The levels of OVA-specific IgE, histamine, and IL-6 were measured by ELISA. Pathological changes, mast cell infiltrati...
Plant-derived Alkaloids for Allergic Rhinitis: Evidence, Exposure, Safety and Translational Readiness.
Allergic Rhinitis (AR) is an allergen-driven, IgE-mediated inflammatory disease of the nasal mucosa. Established therapies are effective for many patients, but incomplete symptom control, suboptimal adherence, and treatment preference sustain interest in new locally acting agents. Plant-derived alkaloids are frequently proposed as anti-allergic candidates; however, the lit...
Development and evaluation of a microneedle-assisted transdermal delivery system for compound betamethasone in atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and immune dysregulation, which may influence topical drug penetration and therapeutic efficacy. This study evaluated a microneedle-assisted approach to enhance the cutaneous delivery of compound betamethasone in AD. Franz diffusion cell experiments demonstrated 3.29-fo...
Mast cell-derived SPP1 promotes colorectal cancer liver metastasis by suppressing BTG1-mediated JUN degradation.
The role of mast cells in colorectal cancer (CRC) liver metastasis remains controversial. This study aimed to explore the effect of mast cells on the CRC liver metastasis and the underlying mechanism. The bulk-seq, scRNA-seq datasets and clinical samples were integrated to identify the association of mast cells and the SPP1-CD44 signaling and BTG1 with CRC liver metastasis...
Activity-Guided Identification of Prot2633 as a Major Proteolytic Contributor to the Reduced Allergenicity of Lacticaseibacillus paracasei XJ-003-Fermented Milk.
Lactic acid bacterial fermentation offers a food-compatible strategy for reducing milk allergenicity, but the responsible proteolytic components remain poorly defined. We evaluated milk fermented with Lacticaseibacillus paracasei XJ-003 using pooled sera from milk-allergic donors and characterized its protease system. Activity-guided purification of cell pellet lysates yie...
Key Players and Pathways of Mast Cell Activation in Urticaria.
Mast cells (MCs) are the principal effector cells in urticaria, orchestrating the release of mediators that drive wheal formation, angioedema, and pruritus. Although activation of MCs via the immunoglobulin (Ig) E and its high-affinity receptor (FcεRI) axis, including autoimmune urticaria mediated by IgE and IgG autoantibodies, remains the best characterized pathway, incre...
Diet-stress interactions in gut barrier dysfunction and metabolic inflammation.
The intestinal barrier is a dynamic host-microbe interface that contributes to metabolic homeostasis. Chronic psychological stress and adverse dietary patterns can each disturb microbiota, mucus, junctional, and inflammatory processes. This review evaluates the evidence for convergence of diet- and stress-responsive pathways at the intestinal barrier and their possible rel...
Basophils inhibit early lung metastasis by suppressing regulatory T cells.
Basophils are rare cells best known for their role in allergy but their contribution to cancer remains poorly understood. Here, we found that basophils suppress early lung metastatic seeding in mice by enhancing antitumor CD8
A 16-colour spectral flow cytometry panel to characterise T cell immunophenotypes in canine oral melanoma.
Advances in immunophenotyping of tumour-infiltrating lymphocytes (TILs) have improved our understanding of prognostic biomarkers and immune targets in human melanoma. However, whether the tumour-immune landscape in canine oral malignant melanoma (COMM) is concordant with that of human melanoma has not been properly defined. To address this gap, we developed a 16-colour spe...
Outcome measures in long COVID clinical trials: a review.
Long COVID is a multisystem disease that affects approximately 10% of people after a SARS-CoV-2 infection. In the absence of curative treatment, high-quality clinical treatment trials are urgently needed for long COVID. There is significant overlap between long COVID and other infection-associated chronic conditions, in particular myalgic encephalomyelitis. As such, trial ...
Remibrutinib (Rhapsido
Remibrutinib (Rhapsido
Sanghuangporus vaninii Polysaccharide Hydrogel Attenuates DNFB-Induced Atopic Dermatitis in Mice via Immunomodulation.
Atopic dermatitis (AD), a prevalent chronic inflammatory skin disorder, highlights the need for advanced immunomodulatory therapies. We isolated three novel polysaccharides (SVP1-SVP3) from Sanghuangporus vaninii, characterized their physicochemical properties, and formulated them into hydrogels. These were applied to 2,4-dinitrofluorobenzene (DNFB)-induced AD mouse models...
Identification of a Novel
This work describes, to our knowledge, the first reported case of a patient with an MDS/MPN overlap syndrome harboring a novel
Factors influencing the professional identity of medical care assistants: a qualitative study.
This study aimed to explore the factors influencing the professional identity of medical care assistants (MCAs) and to interpret relevant findings through the lens of social identity theory, thereby informing strategies to support professional identity and workforce stability. A qualitative descriptive research design was adopted. Using purposive sampling, 15 MCAs from a t...
Highly tunable mid-infrared perfect absorber based on unpatterned α-MoO
No abstract available.
Cross-cultural care awareness and self-perceived skillfulness among medical students in Egypt: a national study.
Cross-cultural care (CCC) enables effective, patient-centered care for individuals from diverse backgrounds. Despite its importance in improving care quality and reducing health disparities, evidence on CCC among medical students in Egypt remains scarce. This study assessed medical students' cross-cultural self-perceived skillfulness and cultural awareness, examined their ...
MRGPRX2 in Allergic and Immune-Mediated Diseases: Mechanisms, Clinical Relevance, and Therapeutic Translation.
Mas-related G protein-coupled receptor X2 (MRGPRX2) is a mast-cell-enriched receptor that mediates immunoglobulin E-independent activation by structurally diverse neuropeptides, host-defense peptides, microbial products, and selected cationic drugs. Its biology links tissue stress and neuroimmune signaling to degranulation, vascular responses, pruritus, barrier dysfunction...
Age-related biomechanical and structural remodeling of human middle cerebral arteries.
Proper cerebral artery function is essential for maintaining the brain's microenvironment. The multilayered organization of cellular and extracellular matrix (ECM) constituents enables large cerebral arteries to accommodate pulse pressure and ensure both effective blood distribution and protection of the microcirculation. However, aging and disease induce compositional and...
Effect of a breathing mask on type 2 mediator responses to subzero exercise in individuals without asthma.
Current evidence suggests that heat and moisture-exchanging breathing masks (HME) protect against exercise-induced bronchoconstriction (EIB). We aimed to explore whether mast cell mediator release following exercise in subzero conditions is affected by the use of an HME. To this end, 23 healthy, recreational-competitive endurance athletes aged 18-53 years without asthma pe...
A pectic polysaccharide from Lonicera japonica alleviates DNCB-induced atopic dermatitis-like inflammation associated with gut microbial and metabolic alterations and reduced cutaneous JAK2/STAT3 activation and Th17 responses.
Lonicera japonica Thunb. (Jin Yin Hua) is a traditional medicinal herb widely used in East Asia for inflammatory disorders and is commonly included in herbal prescriptions for atopic dermatitis (AD). WLJP-025p, a homogeneous pectic polysaccharide isolated from Lonicera japonica, has shown anti-inflammatory and anti-AD potential, but its underlying mechanisms remain unclear...
The new revolution in the treatment of chronic urticaria, present and future of an effective and safe approach.
Chronic spontaneous urticaria (CSU) is a heterogeneous mast cell-driven disease associated with a substantial burden on patients' quality of life. Although most patients achieve disease control with guideline-recommended therapies, a relevant proportion remains refractory, highlighting important unmet needs. This narrative review summarizes current, emerging, and investiga...
Perioperative Management of Coexisting Mast Cell Activation Syndrome and Malignant Hyperthermia Susceptibility: A Case Report and Novel Approach to Local Analgesia.
The coexistence of mast cell activation syndrome (MCAS) and malignant hyperthermia (MH) presents a significant perioperative challenge due to combined risks of anaphylaxis and anaesthesia-related hypermetabolic crisis. We describe the successful anaesthetic management of a man in his 60 s with confirmed MCAS and a strong family history of MH who underwent excision of multi...
High Level of Component C1q Binding Protein (C1QBP) is Associated With Poor Prognosis and Dysfunction of Mast Cells in Lung Adenocarcinoma.
Component C1q binding protein (C1QBP) is known as an important regulator of mitochondrial plasticity and is involved in antitumor immune response in cancers. Nevertheless, its role in lung adenocarcinoma (LUAD) still remains largely unknown. C1QBP expression in LUAD and adjacent normal samples was compared by Wilcoxon test, and the corresponding receiver operating characte...
Adverse childhood experiences and allergic diseases: A scoping review.
No abstract available.
Learn from nature, surpass nature: Bionic immune cell engineering-A new paradigm for unlocking the dual "delivery-activation" code in cancer therapy.
No abstract available.
Deciphering isonicotinylation and mast cell-associated pathogenic patterns in Duchenne muscular dystrophy: evidence from ensemble learning-driven multi-omics and
Duchenne muscular dystrophy (DMD) is dystrophin-deficiency skeletal and cardiac muscle disease. Protein post-translational modification (PTM) and aberrant immune cell activation play a key role in its pathogenesis. Our study aims to investigate isonicotinylation (Kinic)-associated signature modulatory patterns in mast cells and DMD pathogenesis. We first performed integrat...
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