5 November 2026 – 11 November 2026 · published 11 November 2026 · Subscribe
Between 5 November 2026 and 11 November 2026 the tracker indexed 30 new peer-reviewed studies and 13 clinical-trial updates across 8 post-viral and post-infectious conditions.
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-11-11); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
Full feed: Long COVID research tracker
Pancreatic adenosquamous carcinoma (PASC) is a rare 1-4% of all pancreatic cancers and an aggressive pancreatic malignancy characterized by mixed adenocarcinoma and squamous histologies. Even after surgical intervention, patients with PASC have a lower median overall survival (mOS) than those with the more prevalent pancreatic ductal adenocarcinoma (PDAC).
Long COVID (LC) affects millions of people worldwide, yet its driving mechanisms remain incompletely defined and no treatment has been approved. Persistence of SARS-CoV-2 and reactivation of herpesviruses have been implicated in LC, but direct detection of these viral antigens in blood and tissues has been challenging.
Long COVID is a heterogeneous post-infectious condition following acute severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. Ongoing uncertainty around its definition, burden, diagnosis and management complicates clinical recognition and care in Southeast Asia.
Long COVID and other infection-associated chronic conditions (IACC) present management challenges for primary care clinicians and often require patient access to multidisciplinary specialists. To strengthen primary care capacity, the Long COVID and Fatiguing Illnesses Recovery Program (LC&FIRP) implemented a multi-modal learning model combining Extension for Community Healthcare Outcomes (ECHO) case-based learning...
Post-exertional malaise (PEM) is a multidimensional exertion-response pattern involving diverse triggers, variable onset, and prolonged recovery. This study developed and content-validated the Vienna Post-Exertional Malaise (VPEM) Questionnaire, a patient-reported outcome measure assessing functional decline, recovery, crash-associated symptoms, and pacing adaptations in ME/CFS.
Infection-associated chronic conditions and illnesses (IACCI) encompass several debilitating syndromes with overlapping symptoms that have been identified and documented for decades, primarily following infectious disease outbreaks. Conditions following infection that are diagnosed with objective clinical tests have been relatively well characterized and accepted by the medical establishment, although the...
Sex differences in COVID-19 and its sequelae remain poorly understood, which hinders targeted therapies. We performed plasma proteomic analyses of 69 hospitalized patients with COVID-19 and 30 healthy controls from a prospective Chinese cohort.
Influenza virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and respiratory syncytial virus (RSV) are leading causes of acute respiratory infections (ARIs). New Zealand's coronavirus disease 2019 (COVID-19) public health measures disrupted the circulation of these viruses in 2020-2021, creating a rare opportunity to explore the impact of potential immunity gaps on age-specific infection risk.
No abstract available.
Neurological complications are among typical clinical manifestations, both during the acute phase of SARS-CoV-2 infection and long-term post-acute COVID-19 sequelae, i.e., Long COVID. A growing body of evidence connects SARS-CoV-2 infection to systemic inflammation, peripheral immune dysregulation, functional alteration of the blood-brain barrier (BBB), neuroinflammatory processes, mitochondrial dysfunction and...
Despite extensive studies, many questions remain regarding the pathology and mechanisms behind Coronavirus disease 2019 (COVID-19), and particularly on post-acute sequelae of COVID-19 (PASC). Because existing mouse models cannot recapitulate human immune responses, we developed a human immune system (HIS) mouse model with physiologic expression of hACE2.
We aimed to understand what factors have impeded and enhanced Long COVID recovery among Latinos in South Texas. Through community partners, 78 participants were part of seven focus groups.
Post-COVID condition (PCC) is characterized by the persistence of symptoms following acute SARS-CoV-2 infection. This scoping review aimed to identify and compile scientific evidence on biomarkers associated with PCC to elucidate its pathophysiology and support clinical diagnosis and management.
Little is known about the magnitude of deaths and which comorbidities may contribute to the occurrence of outcomes among individuals with post-COVID conditions. This study aimed to identify deaths due to post-COVID conditions in Brazil from 2020 to 2023 and describe the consequential and contributing causes.
No abstract available.
A 33-year-old woman who had undergone heart transplantation two years earlier for post-COVID-19 myocarditis was admitted with decompensated heart failure secondary to acute antibody-mediated rejection. During hospitalization, she developed sepsis, cytomegalovirus infection, acute kidney injury, and an incidental pulmonary miliary pattern on chest computed tomography, without microbiological confirmation.
Cystic fibrosis (CF) causes severely damaged pancreatic morphology and cystic fibrosis-related diabetes (CFRD), but the cellular drivers of CFRD in the pancreas are not understood. Here, we perform single-cell and spatial profiling of 2.04 M cells from 23 non-disease or CF pancreas donors.
This study aims to identify the risk factors associated with the development of post-COVID-19 syndrome in patients discharged from hospitalizations due to severe acute respiratory syndrome. A systematic review of observational studies published between 2020 and 2023 was carried out in six databases.
COVID-19 placed an unprecedented burden on health workers and disrupted rehabilitation services. Existing reviews have examined health-worker infection and mortality, vaccine hesitancy and telerehabilitation separately; few have considered these dimensions together from the perspective of rehabilitation professionals.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID.
We evaluated the relationship between metformin, one of the most commonly prescribed medications for individuals with diabetes, and COVID-19 sequelae. We evaluated a retrospective cohort of individuals in the National Clinical Cohort Collaborative with Type 2 diabetes mellitus and COVID-19 who were prescribed metformin or a dipeptidyl peptidase-4 inhibitor (DPP4i) at least 30 days before the onset of acute COVID-19...
Despite the application of surgery and antifungal therapy, rhino-orbital-cerebral mucormycosis is a severe and life-threatening fungal infection with high morbidity and mortality rates, particularly in immunocompromised patients. This review aimed to focus on the current evidence on perioperative anesthetic management of rhino-orbital-cerebral mucormycosis (ROCM), emphasizing the unique challenges posed by its...
Patients with Long COVID and other infection-associated chronic conditions (IACC) often face barriers to accessing specialist care, prompting the need to strengthen primary care capacity to manage these complex conditions. Our study evaluated the effectiveness of an ECHO case-based virtual community of practice model for improving clinician knowledge, confidence, and practice for Long COVID and other IACC in a...
Full feed: ME/CFS research tracker
Neuroinflammation is a known pathophysiologic mechanism in multiple sclerosis and a proposed mechanism in fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Positron Emission Tomography (PET) imaging of the translocator protein (TSPO) has been widely used to measure neuroinflammation, though second-generation ligands are highly sensitive to a single nucleotide polymorphism, rs6971...
Full feed: Lyme / PTLDS research tracker
Lyme disease is a tick-borne zoonosis caused by Borrelia burgdorferi that can involve multiple organ systems, including the cardiovascular (CV) system, noted in ~1-10% of untreated patients. This can produce atrioventricular (AV) or bundle branch block, atrial fibrillation, and myopericarditis in the acute phase, and dilated cardiomyopathy in the chronic phase.
Full feed: MCAS research tracker
Endometriosis (EMs) pain severely reduces patients' quality of life, but its underlying mechanisms are not fully understood. Mast cells and C-C motif chemokine ligand 2 (CCL2) are highly abundant in EMs lesions, yet their roles in neural sensitization remain unclear.
Chronic spontaneous urticaria is a mast cell-driven skin disorder in which basophils and eosinophils contribute to inflammation. Omalizumab is effective for many patients, yet a subset remains resistant.
Allergic Rhinitis (AR) is an allergen-driven, IgE-mediated inflammatory disease of the nasal mucosa. Established therapies are effective for many patients, but incomplete symptom control, suboptimal adherence, and treatment preference sustain interest in new locally acting agents.
Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K-AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this signaling axis.
This study evaluated the therapeutic effect of hesperidin (HES) on allergic rhinitis (AR) in a mouse model induced by ovalbumin (OVA). After inducing AR in BALB/c mice through OVA, the severity of allergic reactions was assessed through behavioral scoring.
No new studies this window for: PACVS, Gulf War Illness, POTS, Other post-viral.
ClinicalTrials.gov records whose registry entry was last updated between 5 November 2026 and 11 November 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|---|---|---|---|---|
| NCT07842302 | Fighting Fatigue in Multiple Sclerosis: TMS vs. tDCS Efficacy. Other post-viral | Enrolling By Invitation | Not applicable | Tms, Tdcs | 2026-11-10 |
| NCT07798570 | Observational Study With CICR-NAM as a Food for Special Medicinal Purposes in Post-COVID Syndrome (PCS) Long COVID | Recruiting | Not applicable | Cicr-Nam | 2026-11-10 |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Long COVID | Not Yet Recruiting | Phase 1 | Keytruda | 2026-11-10 |
| NCT07316127 | Immunoadsorption in Autoimmune Long COVID Long COVID | Recruiting | Phase 2 | Immunoadsorption | 2026-11-10 |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 Other post-viral | Enrolling By Invitation | Phase 2 | Iv Normal Saline, Iv Immunoglobulin | 2026-11-10 |
| NCT02725060 | Autoimmune Basis for Postural Tachycardia Syndrome POTS, Other post-viral | Active Not Recruiting | Not applicable | Phenylephrine, Isoproterenol, 25 Micro-Ci Of Radiation | 2026-11-10 |
| NCT07925944 | Subgrouping Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Linking the Powerhouses of Cells to the Autonomic Nervous System ME/CFS | Active Not Recruiting | Not applicable | Exercise Test, Active Standing Test | 2026-11-09 |
| NCT07526558 | Mast Cell Treatment in Post-tick Bite Illness (PTBI) MCAS, Other post-viral | Not Yet Recruiting | Phase 2 | Ketotifen, Fexofenadine, Cromolyn Sodium | 2026-11-09 |
| NCT07197905 | Restoring Iron Deficiency in POTS POTS, Other post-viral | Active Not Recruiting | Phase 2 | Intravenous Iron | 2026-11-09 |
| NCT07478172 | Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease POTS, Other post-viral | Active Not Recruiting | Not applicable | Whole-Body Electrical Muscle Stimulation Exercise | 2026-11-06 |
| NCT07874217 | Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Long COVID, ME/CFS | Recruiting | Not applicable | Cryotherapy | 2026-11-05 |
| NCT06404047 | RECOVER-ENERGIZE Platform Protocol Long COVID | Completed | Not applicable | Personalized Cardiopulmonary Rehabilitation, Structured Pacing | 2026-11-05 |
| NCT05130099 | A Complex Intervention for Chronically Fatigued Lymphoma Survivors ME/CFS | Completed | Not applicable | Interdisciplinary Complex Intervention | 2026-11-05 |
Browse all tracked trials: clinical trials tracker.
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