26 October 2026 – 1 November 2026 · published 1 November 2026 · Subscribe
Between 26 October 2026 and 1 November 2026 the tracker indexed 37 new peer-reviewed studies and 9 clinical-trial updates across 8 post-viral and post-infectious conditions.
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-11-01); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
Full feed: ME/CFS research tracker
Fatigue is amongst the most debilitating cancer-related symptoms, affecting up to one-third of colorectal cancer (CRC) survivors. Accumulating evidence implicates dysregulation of HPA axis as a potential mechanism contributing to chronic fatigue syndrome.
No abstract available.
No abstract available.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of SARS-CoV-2 infection (Long COVID) are complex multisystem disorders affecting 60-400 million individuals globally. They are considered post-infectious illnesses and share similar biological mechanisms, including immune dysregulation, orthostatic intolerance and cognitive dysfunction, highlighting a substantial overlap between the...
Wiskott-Aldrich syndrome protein family member 3 (WASF3) disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Because cognitive impairment is a hallmark of ME/CFS, we investigated the role of WASF3 in brain metabolism and function using WASF3 transgenic and knockout mouse models.
Kim and colleagues report a finding that is easy to understate: thalamic hyperconnectivity with sensorimotor and visuo-occipital cortices, present in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) at baseline, shifts back toward the pattern seen in healthy controls after hyperbaric oxygen therapy and does so most in the patients who improve clinically. To my knowledge, this is the first...
The detection of low-abundance viral RNA in chronic or persistent infections remains a major challenge in virology, constrained by the sensitivity and specificity of traditional methods. One such infection, chronic enterovirus (EV) infection, has been proposed as a potential underlying factor in Myalgic Encephalomyelitis (ME), although this hypothesis remains debated.
Full feed: Lyme / PTLDS research tracker
Tick-borne zoonoses are among the main vector-borne and emerging diseases in Europe. Individuals with chronic high-frequency tick exposure represent sentinel populations for pathogen circulation.
Full feed: Gulf War Illness research tracker
No abstract available.
Full feed: POTS research tracker
Syncope and presyncope symptoms occur commonly in pregnancy. Evaluation of syncope should include careful history and physical examination to determine underlying etiology.
No abstract available.
Full feed: MCAS research tracker
Current evidence suggests that heat and moisture-exchanging breathing masks (HME) protect against exercise-induced bronchoconstriction (EIB). We aimed to explore whether mast cell mediator release following exercise in subzero conditions is affected by the use of an HME.
Chronic spontaneous urticaria (CSU) is a heterogeneous mast cell-driven disease associated with a substantial burden on patients' quality of life. Although most patients achieve disease control with guideline-recommended therapies, a relevant proportion remains refractory, highlighting important unmet needs.
The coexistence of mast cell activation syndrome (MCAS) and malignant hyperthermia (MH) presents a significant perioperative challenge due to combined risks of anaphylaxis and anaesthesia-related hypermetabolic crisis. We describe the successful anaesthetic management of a man in his 60 s with confirmed MCAS and a strong family history of MH who underwent excision of multiple malignant cutaneous lesions.
Component C1q binding protein (C1QBP) is known as an important regulator of mitochondrial plasticity and is involved in antitumor immune response in cancers. Nevertheless, its role in lung adenocarcinoma (LUAD) still remains largely unknown.
No abstract available.
Lonicera japonica Thunb. (Jin Yin Hua) is a traditional medicinal herb widely used in East Asia for inflammatory disorders and is commonly included in herbal prescriptions for atopic dermatitis (AD).
Fiber-shaped zinc-ion batteries are highly deformable and can store energy in irregular spaces. Fiber cathodes with carbon fiber cores can be continuously prepared via wet spinning.
No abstract available.
Duchenne muscular dystrophy (DMD) is dystrophin-deficiency skeletal and cardiac muscle disease. Protein post-translational modification (PTM) and aberrant immune cell activation play a key role in its pathogenesis.
Somatic blood mosaicism is an established feature of ageing and a heterogeneous marker of haematologic cancer and inflammatory and vascular risk, but its psychiatric evidence base remains small. This structured critical narrative review evaluates mutation-defined clonal haematopoiesis, clonal haematopoiesis of indeterminate potential (CHIP), autosomal mosaic chromosomal alterations (mCAs), and sex-chromosome loss...
Chronic spontaneous urticaria (CSU) and atopic dermatitis (AD) are pruritic inflammatory skin diseases that share partly overlapping mast-cell-related pathways, including IgE/FcεRI signaling, type 2 inflammation, neuroimmune signaling, and lipid mediator pathways. Yet they usually produce distinct phenotypes: transient wheals and angioedema in CSU and persistent eczematous lesions with inflammation in AD.
Petasin, a lipophilic sesquiterpene ester isolated from
No abstract available.
No abstract available.
Interleukin-33 (IL-33) is an epithelial-derived member of the IL-1 cytokine family that functions as an alarmin and signals through the ST2 receptor, upstream of type 2 inflammation. Together with thymic stromal lymphopoietin (TSLP) and IL-25, it constitutes an epithelial alarmin triad that orchestrates barrier-related immune responses.
Lumbar disc herniation (LDH) commonly induces low back and leg pain. Manual therapy (MT) is effective in relieving such pain clinically, but its mechanism remains unclear.
Elevated mast cell (MC) counts in colonic biopsies are frequently observed in patients with chronic diarrhoea or unspecific abdominal symptoms, potentially leading to a diagnosis of mast cell activation syndrome. However, the clinical relevance of MC quantification in this setting remains controversial.
Post-acute Neurological Sequelae of SARS-CoV-2 infection (Neuro-PASC) contribute substantially to Long COVID-related disability, with cognitive impairment, chronic fatigue, dysautonomia, and neuropsychiatric symptoms among its most debilitating manifestations. Although its pathogenesis remains incompletely understood, evidence implicates persistent immune activation, intestinal barrier dysfunction, microbiota...
Advanced systemic mastocytosis (advSM), including aggressive SM (ASM), SM with an associated hematologic neoplasm (SM-AHN) and mast cell leukemia (MCL), are rare, mostly KIT D816V-driven malignancies with a poor prognosis. KIT D816V-targeting drugs, such as midostaurin or avapritinib, can induce hematologic responses in most patients with advSM.
Irritable bowel syndrome (IBS) is a common, often disabling disorder of gut-brain interaction whose molecular basis remains incompletely defined, leaving diagnosis largely symptom-based and treatment largely non-mechanistic. We argue that the serotonin (5-hydroxytryptamine; hereafter 5-HT, the primary term used throughout, with "serotonin" retained in less technical contexts) signalling axis-positioned at the...
Polyphosphate (polyP), a linear polymer of orthophosphate residues, is enriched in secretory granules in specialised mammalian cell types including platelets and mast cells. Although polyP released during activation and degranulation of these cells has been shown to promote blood clotting and inflammation, little is known about the mechanisms governing polyP synthesis in these granules.
Extracellular vesicles (EVs) mediate intercellular communication, yet whether extracellular phospholipid metabolism on EV membranes regulates immune activation remains incompletely understood. Through comparative phenotypic analyses of multiple secreted phospholipase A
Icephobic surfaces are conventionally designed by minimizing ice adhesion; however, whether this strategy remains valid under aerodynamic shear remains poorly understood. Here, we reveal that an external flow field fundamentally alters ice adhesion dynamics by inducing the spontaneous fracture and detachment of ice crystals through aerodynamic shear forces.
No new studies this window for: Long COVID, PACVS.
ClinicalTrials.gov records whose registry entry was last updated between 26 October 2026 and 1 November 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|---|---|---|---|---|
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Long COVID | Not Yet Recruiting | Phase 1 | Keytruda | 2026-10-30 |
| NCT06907251 | Dapagliflozin for Long COVID Syndrome Long COVID | Not Yet Recruiting | Phase 3 | Dapagliflozin | 2026-10-30 |
| NCT07523113 | ME/CFS Brain Fog: Cognitive Rehabilitation Trial ME/CFS | Recruiting | Not applicable | Processing Speed Training, In-Session Instrumental Activities Of Daily Living Training, Transfer Package | 2026-10-29 |
| NCT06095297 | Long COVID Brain Fog: Cognitive Rehabilitation Trial Long COVID | Active Not Recruiting | Not applicable | Processing Speed Training, In-Lab Instrumental Activities Of Daily Living Training, In-Lab Brain Health Training | 2026-10-29 |
| NCT07600320 | Fareon Open Label Device Clinical Trial Other post-viral | Enrolling By Invitation | Not applicable | Fareon Device | 2026-10-28 |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction Long COVID | Recruiting | Phase 2 | Valacyclovir, Celecoxib, Paxlovid (Nirmatrelvir/Ritonavir) | 2026-10-28 |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome Other post-viral | Recruiting | Not applicable | Stellate Ganglion Block, Ropivacaine, Normal Saline | 2026-10-28 |
| NCT07899346 | Study of VYD2311 for the Treatment of Adults With Long-COVID or Post-Vaccination Syndrome Long COVID, PACVS | Not Yet Recruiting | Phase 2 | Vyd2311 | 2026-10-27 |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 Other post-viral | Enrolling By Invitation | Phase 2 | Iv Normal Saline, Iv Immunoglobulin | 2026-10-26 |
Browse all tracked trials: clinical trials tracker.
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