{ "id": "2026-W44", "year": 2026, "week": 44, "week_monday": "2026-10-26", "week_sunday": "2026-11-01", "asof": "2026-11-01", "window_start": "2026-10-26", "window_end": "2026-11-01", "window_days": 7, "widened": false, "strict_study_count": 37, "strict_trial_count": 9, "study_count": 37, "trial_count": 9, "studies": { "long-covid": [], "me-cfs": [ { "pmid": "42962653", "title": "More pronounced diurnal cortisol rhythms are longitudinally associated with less fatigue in colorectal cancer survivors: A 12-month prospective cohort study.", "journal": "Psychoneuroendocrinology", "pub_date": "2026-10-30", "authors": "Frenken, Koen G, Scheer, Frank A J L, Qian, Jingyi, Bours, Martijn J L et al.", "excerpt": "Fatigue is amongst the most debilitating cancer-related symptoms, affecting up to one-third of colorectal cancer (CRC) survivors. Accumulating evidence implicates dysregulation of HPA axis as a potential mechanism contributing to chronic fatigue syndrome.", "url": "https://pubmed.ncbi.nlm.nih.gov/42962653/", "also": [] }, { "pmid": "42962334", "title": "Interpreting exercise effects in ME/CFS: trial independence, safety ascertainment, and exploratory moderator analyses.", "journal": "Journal of psychosomatic research", "pub_date": "2026-10-30", "authors": "Liang, Jiachen, Li, Huanan", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42962334/", "also": [] }, { "pmid": "42946587", "title": "Communicating uncertainty without reinforcing mind-body dualism: lessons from the revision of the French national health insurance ME/CFS webpage.", "journal": "Journal of psychosomatic research", "pub_date": "2026-10-28", "authors": "Lemogne, Cédric, Pitron, Victor, Mhanna, Elsa, Gouraud, Clément et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42946587/", "also": [] }, { "pmid": "42942118", "title": "The Glymphatic-Meningeal Lymphatic System and Autophagy in ME/CFS and Long COVID: A Mechanistic Perspective.", "journal": "International journal of molecular sciences", "pub_date": "2026-10-27", "authors": "Nemat-Gorgani, Mohsen, Jensen, Michael Anthony, Davis, Ronald Wayne", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of SARS-CoV-2 infection (Long COVID) are complex multisystem disorders affecting 60-400 million individuals globally. They are considered post-infectious illnesses and share similar biological mechanisms, including immune dysregulation, orthostatic intolerance and cognitive dysfunction, highlighting a substantial overlap between the...", "url": "https://pubmed.ncbi.nlm.nih.gov/42942118/", "also": [] }, { "pmid": "42945241", "title": "Stress-inducible WASF3 regulates brain metabolism and cognitive function.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "pub_date": "2026-10-27", "authors": "Syed, Abu M, Ma, Jin, Wang, Ping-Yuan, Son, Youlim et al.", "excerpt": "Wiskott-Aldrich syndrome protein family member 3 (WASF3) disrupts mitochondrial respiration and is induced in association with endoplasmic reticulum stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Because cognitive impairment is a hallmark of ME/CFS, we investigated the role of WASF3 in brain metabolism and function using WASF3 transgenic and knockout mouse models.", "url": "https://pubmed.ncbi.nlm.nih.gov/42945241/", "also": [] }, { "pmid": "42934697", "title": "ME/CFS and the thalamus as a precision gate: what reversible thalamocortical connectivity reveals about central gain in post-infectious fatigue.", "journal": "Journal of translational medicine", "pub_date": "2026-10-27", "authors": "Strube, Andreas", "excerpt": "Kim and colleagues report a finding that is easy to understate: thalamic hyperconnectivity with sensorimotor and visuo-occipital cortices, present in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) at baseline, shifts back toward the pattern seen in healthy controls after hyperbaric oxygen therapy and does so most in the patients who improve clinically. To my knowledge, this is the first...", "url": "https://pubmed.ncbi.nlm.nih.gov/42934697/", "also": [] }, { "pmid": "42941838", "title": "CATCH-EVseq, an Ultra-Sensitive Capture Assay to Monitor Human Enterovirus RNA.", "journal": "International journal of molecular sciences", "pub_date": "2026-10-27", "authors": "Germain, Arnaud, Hanson, Maureen R", "excerpt": "The detection of low-abundance viral RNA in chronic or persistent infections remains a major challenge in virology, constrained by the sensitivity and specificity of traditional methods. One such infection, chronic enterovirus (EV) infection, has been proposed as a potential underlying factor in Myalgic Encephalomyelitis (ME), although this hypothesis remains debated.", "url": "https://pubmed.ncbi.nlm.nih.gov/42941838/", "also": [] } ], "pacvs": [], "lyme": [ { "pmid": "42928119", "title": "\"The clock is ticking\": high prevalence of tick-borne zoonoses in healthy adults with varying tick-bite exposure in Northwestern Italy.", "journal": "BMC infectious diseases", "pub_date": "2026-10-26", "authors": "Vada, Rachele, Zanet, Stefania, Ferroglio, Ezio, Trisciuoglio, Anna et al.", "excerpt": "Tick-borne zoonoses are among the main vector-borne and emerging diseases in Europe. Individuals with chronic high-frequency tick exposure represent sentinel populations for pathogen circulation.", "url": "https://pubmed.ncbi.nlm.nih.gov/42928119/", "also": [] } ], "gulf-war-illness": [ { "pmid": "42929460", "title": "The impact of depressive symptoms on supraspinal pain neuromodulatory functional connectivity and therapeutic implication.", "journal": "Molecular pain", "pub_date": "2026-10-26", "authors": "Leung, Albert, Lopez, Caleb, Le, Valerie, Ho, Michael et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42929460/", "also": [] } ], "pots": [ { "pmid": "42951440", "title": "Evaluation and Management of Syncope in Pregnancy and Postpartum.", "journal": "Obstetrics and gynecology clinics of North America", "pub_date": "2026-10-28", "authors": "Azeem, Nabila, Nunez-Pellot, Cristina, Crousillat, Daniela, Cain, M Ashley", "excerpt": "Syncope and presyncope symptoms occur commonly in pregnancy. Evaluation of syncope should include careful history and physical examination to determine underlying etiology.", "url": "https://pubmed.ncbi.nlm.nih.gov/42951440/", "also": [] }, { "pmid": "42932937", "title": "Orthostatic and exercise intolerance in post-acute sequelae of COVID-19 occur with intact sympathetic neural control and preserved cardiac reserve.", "journal": "American journal of physiology. Heart and circulatory physiology", "pub_date": "2026-10-26", "authors": "Howden, Erin J, Sesa-Ashton, Gianni, Foulkes, Stephen J, Wallace, Imogen et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42932937/", "also": [] } ], "mcas": [ { "pmid": "42958574", "title": "Effect of a breathing mask on type 2 mediator responses to subzero exercise in individuals without asthma.", "journal": "BMC research notes", "pub_date": "2026-10-30", "authors": "Hanstock, Helen, Ainegren, Mats, Andersson, Erik P, Bäckebjörk, Ella et al.", "excerpt": "Current evidence suggests that heat and moisture-exchanging breathing masks (HME) protect against exercise-induced bronchoconstriction (EIB). We aimed to explore whether mast cell mediator release following exercise in subzero conditions is affected by the use of an HME.", "url": "https://pubmed.ncbi.nlm.nih.gov/42958574/", "also": [] }, { "pmid": "42955719", "title": "The new revolution in the treatment of chronic urticaria, present and future of an effective and safe approach.", "journal": "Italian journal of dermatology and venereology", "pub_date": "2026-10-29", "authors": "Giménez-Arnau, Ana M, Barei, Francesca, Salman, Andaç", "excerpt": "Chronic spontaneous urticaria (CSU) is a heterogeneous mast cell-driven disease associated with a substantial burden on patients' quality of life. Although most patients achieve disease control with guideline-recommended therapies, a relevant proportion remains refractory, highlighting important unmet needs.", "url": "https://pubmed.ncbi.nlm.nih.gov/42955719/", "also": [] }, { "pmid": "42953382", "title": "Perioperative Management of Coexisting Mast Cell Activation Syndrome and Malignant Hyperthermia Susceptibility: A Case Report and Novel Approach to Local Analgesia.", "journal": "Case reports in anesthesiology", "pub_date": "2026-10-29", "authors": "Gearing, Peter Francis, Nack, Thomas, Liyanage, Dinuk, Martis, Walston Reginald et al.", "excerpt": "The coexistence of mast cell activation syndrome (MCAS) and malignant hyperthermia (MH) presents a significant perioperative challenge due to combined risks of anaphylaxis and anaesthesia-related hypermetabolic crisis. We describe the successful anaesthetic management of a man in his 60 s with confirmed MCAS and a strong family history of MH who underwent excision of multiple malignant cutaneous lesions.", "url": "https://pubmed.ncbi.nlm.nih.gov/42953382/", "also": [] }, { "pmid": "42952304", "title": "High Level of Component C1q Binding Protein (C1QBP) is Associated With Poor Prognosis and Dysfunction of Mast Cells in Lung Adenocarcinoma.", "journal": "Cancer medicine", "pub_date": "2026-10-29", "authors": "Li, Wei, Huang, Guangnan, Zeng, Lizhong, Dang, Wenhui et al.", "excerpt": "Component C1q binding protein (C1QBP) is known as an important regulator of mitochondrial plasticity and is involved in antitumor immune response in cancers. Nevertheless, its role in lung adenocarcinoma (LUAD) still remains largely unknown.", "url": "https://pubmed.ncbi.nlm.nih.gov/42952304/", "also": [] }, { "pmid": "42952037", "title": "Adverse childhood experiences and allergic diseases: A scoping review.", "journal": "Allergy and asthma proceedings", "pub_date": "2026-10-29", "authors": "Verdi, Marylee, White, Andrew A, Sun, Michael, Chapman, Natalie et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42952037/", "also": [] }, { "pmid": "42957112", "title": "A pectic polysaccharide from Lonicera japonica alleviates DNCB-induced atopic dermatitis-like inflammation associated with gut microbial and metabolic alterations and reduced cutaneous JAK2/STAT3 activation and Th17 responses.", "journal": "Journal of ethnopharmacology", "pub_date": "2026-10-29", "authors": "Jin, Mingzhu, Hu, Yue, Ding, Mengmeng, Cheng, Jiayue et al.", "excerpt": "Lonicera japonica Thunb. (Jin Yin Hua) is a traditional medicinal herb widely used in East Asia for inflammatory disorders and is commonly included in herbal prescriptions for atopic dermatitis (AD).", "url": "https://pubmed.ncbi.nlm.nih.gov/42957112/", "also": [] }, { "pmid": "42947516", "title": "Vanadium Oxide/MXene Composite Fiber Cathodes With Superior Spinnability Enabling High Electrochemical Performance for Fiber-Shaped Zinc-Ion Batteries.", "journal": "Small (Weinheim an der Bergstrasse, Germany)", "pub_date": "2026-10-28", "authors": "Xu, Jiayi, Zhu, Zhen, Liang, Penghua, Kong, Zhihan et al.", "excerpt": "Fiber-shaped zinc-ion batteries are highly deformable and can store energy in irregular spaces. Fiber cathodes with carbon fiber cores can be continuously prepared via wet spinning.", "url": "https://pubmed.ncbi.nlm.nih.gov/42947516/", "also": [] }, { "pmid": "42948700", "title": "Learn from nature, surpass nature: Bionic immune cell engineering-A new paradigm for unlocking the dual \"delivery-activation\" code in cancer therapy.", "journal": "Acta pharmaceutica Sinica. B", "pub_date": "2026-10-28", "authors": "Chen, Guanyi, Li, Baohu, Gao, Shenghua, Yang, Jinfei et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42948700/", "also": [] }, { "pmid": "42947810", "title": "Deciphering isonicotinylation and mast cell-associated pathogenic patterns in Duchenne muscular dystrophy: evidence from ensemble learning-driven multi-omics and", "journal": "Frontiers in molecular biosciences", "pub_date": "2026-10-28", "authors": "Yu, Sunrui, Xu, Duojia, Hua, Yuting, Mo, Hangfeng et al.", "excerpt": "Duchenne muscular dystrophy (DMD) is dystrophin-deficiency skeletal and cardiac muscle disease. Protein post-translational modification (PTM) and aberrant immune cell activation play a key role in its pathogenesis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42947810/", "also": [] }, { "pmid": "42938342", "title": "Somatic Blood Mosaicism and Psychiatric Disease: Current Evidence and Causal Limits.", "journal": "Genes", "pub_date": "2026-10-27", "authors": "Belbe, Andrada-Adelaida, Pîrlog, Lorin-Manuel, Pilatec, Alissia-Nicoleta, Militaru, Mariela-Sanda et al.", "excerpt": "Somatic blood mosaicism is an established feature of ageing and a heterogeneous marker of haematologic cancer and inflammatory and vascular risk, but its psychiatric evidence base remains small. This structured critical narrative review evaluates mutation-defined clonal haematopoiesis, clonal haematopoiesis of indeterminate potential (CHIP), autosomal mosaic chromosomal alterations (mCAs), and sex-chromosome loss...", "url": "https://pubmed.ncbi.nlm.nih.gov/42938342/", "also": [] }, { "pmid": "42935749", "title": "Shared mediators, divergent networks: a tissue-response hypothesis for discordant phenotypes in chronic spontaneous urticaria and atopic dermatitis.", "journal": "Frontiers in allergy", "pub_date": "2026-10-27", "authors": "Ye, Young-Min, Hide, Michihiro", "excerpt": "Chronic spontaneous urticaria (CSU) and atopic dermatitis (AD) are pruritic inflammatory skin diseases that share partly overlapping mast-cell-related pathways, including IgE/FcεRI signaling, type 2 inflammation, neuroimmune signaling, and lipid mediator pathways. Yet they usually produce distinct phenotypes: transient wheals and angioedema in CSU and persistent eczematous lesions with inflammation in AD.", "url": "https://pubmed.ncbi.nlm.nih.gov/42935749/", "also": [] }, { "pmid": "42943834", "title": "Petasin at the Membrane: Fine-Tuning Lipid Organization and Interfacial Electrostatics in Mast Cell Plasma Membrane Models.", "journal": "Molecules (Basel, Switzerland)", "pub_date": "2026-10-27", "authors": "Yordanova, Vesela, Angelova, Ralitsa, Hazarosova, Rusina, Nesheva, Aleksandrina et al.", "excerpt": "Petasin, a lipophilic sesquiterpene ester isolated from", "url": "https://pubmed.ncbi.nlm.nih.gov/42943834/", "also": [] }, { "pmid": "42941478", "title": "Olopatadine in Seasonal Allergic Conjunctivitis: Efficacy, Ocular Surface Safety, and Practical Considerations for Preservative-Free Multidose Therapy.", "journal": "Journal of clinical medicine", "pub_date": "2026-10-27", "authors": "Ciprandi, Giorgio", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42941478/", "also": [] }, { "pmid": "42938206", "title": "Lower Serum SCCA2 Detectability in Chronic Spontaneous Compared with Chronic Inducible Urticaria: A Prospective Observational Study.", "journal": "Diagnostics (Basel, Switzerland)", "pub_date": "2026-10-27", "authors": "Gökdeniz, Osman, Çetinkaya, Elif, Ünlü, Burak, Yıldız, Burak et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42938206/", "also": [] }, { "pmid": "42935742", "title": "IL-33/ST2 signalling in pediatric food allergy and eosinophilic gastrointestinal disorders: a systematic review of human and preclinical evidence.", "journal": "Frontiers in immunology", "pub_date": "2026-10-27", "authors": "Grama, Monica, Săsăran, Maria Oana, Stan Muntean, Ana, Coman, Delia et al.", "excerpt": "Interleukin-33 (IL-33) is an epithelial-derived member of the IL-1 cytokine family that functions as an alarmin and signals through the ST2 receptor, upstream of type 2 inflammation. Together with thymic stromal lymphopoietin (TSLP) and IL-25, it constitutes an epithelial alarmin triad that orchestrates barrier-related immune responses.", "url": "https://pubmed.ncbi.nlm.nih.gov/42935742/", "also": [] }, { "pmid": "42935123", "title": "Cutaneous Mast Cells Contribute to the Analgesic Effect of Manual Therapy on CCD Rats.", "journal": "Pain research & management", "pub_date": "2026-10-27", "authors": "Yu, Jiayang, Sun, Pingping, Xie, Dong, Zeng, Xinyu et al.", "excerpt": "Lumbar disc herniation (LDH) commonly induces low back and leg pain. Manual therapy (MT) is effective in relieving such pain clinically, but its mechanism remains unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42935123/", "also": [] }, { "pmid": "42936909", "title": "Colonic Mast Cell Density and Diarrhoea: Evidence Against a Threshold Effect in Biopsies From 3508 Patients.", "journal": "Alimentary pharmacology & therapeutics", "pub_date": "2026-10-27", "authors": "Langreiter, Marlena, Genta, Robert M, Schreiner, Philipp", "excerpt": "Elevated mast cell (MC) counts in colonic biopsies are frequently observed in patients with chronic diarrhoea or unspecific abdominal symptoms, potentially leading to a diagnosis of mast cell activation syndrome. However, the clinical relevance of MC quantification in this setting remains controversial.", "url": "https://pubmed.ncbi.nlm.nih.gov/42936909/", "also": [] }, { "pmid": "42942991", "title": "Beyond Neuroinflammation: Targeting the Microbe-Barrier-Brain Axis Through Precision Nutrition in Neurological Long COVID (Neuro-PASC).", "journal": "Nutrients", "pub_date": "2026-10-27", "authors": "Velázquez De Castro-Bono, Amador, Castro-Luna, Gracia, Guil-Guerrero, José Luis", "excerpt": "Post-acute Neurological Sequelae of SARS-CoV-2 infection (Neuro-PASC) contribute substantially to Long COVID-related disability, with cognitive impairment, chronic fatigue, dysautonomia, and neuropsychiatric symptoms among its most debilitating manifestations. Although its pathogenesis remains incompletely understood, evidence implicates persistent immune activation, intestinal barrier dysfunction, microbiota...", "url": "https://pubmed.ncbi.nlm.nih.gov/42942991/", "also": [] }, { "pmid": "42929870", "title": "Triterpenoid Exposure and HO-1 Blockade Sensitize Neoplastic Mast Cells Against Midostaurin and Avapritinib.", "journal": "Cells", "pub_date": "2026-10-26", "authors": "John, Max Vincent, Filik Schüppler, Yüksel, Witzeneder, Nadine, Schneeweiss-Gleixner, Mathias et al.", "excerpt": "Advanced systemic mastocytosis (advSM), including aggressive SM (ASM), SM with an associated hematologic neoplasm (SM-AHN) and mast cell leukemia (MCL), are rare, mostly KIT D816V-driven malignancies with a poor prognosis. KIT D816V-targeting drugs, such as midostaurin or avapritinib, can induce hematologic responses in most patients with advSM.", "url": "https://pubmed.ncbi.nlm.nih.gov/42929870/", "also": [] }, { "pmid": "42928090", "title": "Microbial serotonin signalling axes in irritable bowel syndrome: integrative molecular crosstalk among enterochromaffin cells, gut microbiota, neuroimmune circuits, and precision therapeutic engineering.", "journal": "Archives of microbiology", "pub_date": "2026-10-26", "authors": "Mehra, Ravinder Kumar, Singh, Bhanu Pratap, Siddiqui, Shakir, Aldawsari, Mohammed F et al.", "excerpt": "Irritable bowel syndrome (IBS) is a common, often disabling disorder of gut-brain interaction whose molecular basis remains incompletely defined, leaving diagnosis largely symptom-based and treatment largely non-mechanistic. We argue that the serotonin (5-hydroxytryptamine; hereafter 5-HT, the primary term used throughout, with \"serotonin\" retained in less technical contexts) signalling axis-positioned at the...", "url": "https://pubmed.ncbi.nlm.nih.gov/42928090/", "also": [] }, { "pmid": "42933572", "title": "Inositol hexakisphosphate kinase 1 regulates polyphosphate synthesis by maintaining V-ATPase-dependent secretory granule acidification.", "journal": "The Journal of biological chemistry", "pub_date": "2026-10-26", "authors": "Mallick, Manisha, Bhandari, Rashna", "excerpt": "Polyphosphate (polyP), a linear polymer of orthophosphate residues, is enriched in secretory granules in specialised mammalian cell types including platelets and mast cells. Although polyP released during activation and degranulation of these cells has been shown to promote blood clotting and inflammation, little is known about the mechanisms governing polyP synthesis in these granules.", "url": "https://pubmed.ncbi.nlm.nih.gov/42933572/", "also": [] }, { "pmid": "42929821", "title": "Fibroblast-Derived PLA2G12A Amplifies Mast Cell Activation Through Extracellular Phospholipid Remodeling.", "journal": "Cells", "pub_date": "2026-10-26", "authors": "Taketomi, Yoshitaka, Miki, Yoshimi, Higashi, Takayoshi, Nagasaki, Yuki et al.", "excerpt": "Extracellular vesicles (EVs) mediate intercellular communication, yet whether extracellular phospholipid metabolism on EV membranes regulates immune activation remains incompletely understood. Through comparative phenotypic analyses of multiple secreted phospholipase A", "url": "https://pubmed.ncbi.nlm.nih.gov/42929821/", "also": [] }, { "pmid": "42928058", "title": "Enhancing Surface Icephobic Performance via Spontaneous Fracture Characteristics of Ice Crystals Regulated by Structural Scale Under Shear Flow Conditions.", "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)", "pub_date": "2026-10-26", "authors": "Jiang, Jiawei, Shen, Yizhou, Xu, Yangjiangshan, Xiang, Junxian et al.", "excerpt": "Icephobic surfaces are conventionally designed by minimizing ice adhesion; however, whether this strategy remains valid under aerodynamic shear remains poorly understood. Here, we reveal that an external flow field fundamentally alters ice adhesion dynamics by inducing the spontaneous fracture and detachment of ice crystals through aerodynamic shear forces.", "url": "https://pubmed.ncbi.nlm.nih.gov/42928058/", "also": [] } ], "other-post-viral": [ { "pmid": "42941392", "title": "The Influence of Neurotic Disorders and Neurobiological Basis on Eating Behavior in a 21-Year-Old Patient: A Case Study-Diagnostic Difficulties: Is It PANDAS/PANS in Relation to an Elevated ASO Level and the Diagnosis of OCD?", "journal": "Journal of clinical medicine", "pub_date": "2026-10-27", "authors": "Zygo, Agnieszka, Regin, Kamila J, Purkiewicz, Aleksandra", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42941392/", "also": [] }, { "pmid": "42942383", "title": "Association of Epithelial Alarmins and Th2 Cytokines with Disease Severity in Non-Cystic Fibrosis Bronchiectasis.", "journal": "Medicina (Kaunas, Lithuania)", "pub_date": "2026-10-27", "authors": "Gurbuz, Okan, Baydar Toprak, Oya, Daglioglu, Gulcin, Guzel, Efraim et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42942383/", "also": [] }, { "pmid": "42928892", "title": "One trigger, two systems: post-infectious severe Guillain-Barre syndrome with concurrent central nervous system demyelination\": a case report.", "journal": "Oxford medical case reports", "pub_date": "2026-10-26", "authors": "Numan, Mohammad, Alhatou, Mohammad, Hussain, Zaeem, Hussain, Maidah et al.", "excerpt": "Combined central and peripheral demyelination is a rare but serious neurological condition that is associated with poor outcomes. We report a 31-year-old male presenting with rapidly progressive Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) variant of Guillain-Barré syndrome following an upper respiratory tract infection.", "url": "https://pubmed.ncbi.nlm.nih.gov/42928892/", "also": [] } ] }, "trials": [ { "nct_id": "NCT07388550", "title": "Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)", "status": "NOT_YET_RECRUITING", "phase": "PHASE1", "last_updated": "2026-10-30", "start_date": "2026-11-04", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Keytruda" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07388550" }, { "nct_id": "NCT06907251", "title": "Dapagliflozin for Long COVID Syndrome", "status": "NOT_YET_RECRUITING", "phase": "PHASE3", "last_updated": "2026-10-30", "start_date": "2026-12-01", "sponsor": "Ottawa Heart Institute Research Corporation", "sponsor_type": "OTHER", "agents": [ "Dapagliflozin" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06907251" }, { "nct_id": "NCT07523113", "title": "ME/CFS Brain Fog: Cognitive Rehabilitation Trial", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-10-29", "start_date": "2026-06-23", "sponsor": "University of Alabama at Birmingham", "sponsor_type": "OTHER", "agents": [ "Processing Speed Training", "In-Session Instrumental Activities Of Daily Living Training", "Transfer Package", "Follow Up Phone Calls", "Trans-Auricular Vagus Nerve Stimulation: High Intensity", "In-Session Brain Health Training", "Reaction Time Training", "Trans-Auricular Vagus Nerve Stimulation: Low Intensity" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07523113" }, { "nct_id": "NCT06095297", "title": "Long COVID Brain Fog: Cognitive Rehabilitation Trial", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-10-29", "start_date": "2024-04-25", "sponsor": "University of Alabama at Birmingham", "sponsor_type": "OTHER", "agents": [ "Processing Speed Training", "In-Lab Instrumental Activities Of Daily Living Training", "In-Lab Brain Health Training", "Transfer Package", "Follow Up Phone Calls", "Vocational Rehabilitation", "Peer Mentoring", "Reaction Time Training", "Trans-Auricular Vagus Nerve Stimulation: High Intensity", "Trans-Auricular Vagus Nerve Stimulation: Low Intensity" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06095297" }, { "nct_id": "NCT07600320", "title": "Fareon Open Label Device Clinical Trial", "status": "ENROLLING_BY_INVITATION", "phase": "NA", "last_updated": "2026-10-28", "start_date": "2026-05-11", "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_type": "OTHER", "agents": [ "Fareon Device" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07600320" }, { "nct_id": "NCT07597902", "title": "SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction", "status": "RECRUITING", "phase": "PHASE2", "last_updated": "2026-10-28", "start_date": "2026-10-20", "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_type": "OTHER", "agents": [ "Valacyclovir", "Celecoxib", "Paxlovid (Nirmatrelvir/Ritonavir)" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07597902" }, { "nct_id": "NCT06953661", "title": "Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-10-28", "start_date": "2025-10-16", "sponsor": "Stanford University", "sponsor_type": "OTHER", "agents": [ "Stellate Ganglion Block", "Ropivacaine", "Normal Saline" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT06953661" }, { "nct_id": "NCT07899346", "title": "Study of VYD2311 for the Treatment of Adults With Long-COVID or Post-Vaccination Syndrome", "status": "NOT_YET_RECRUITING", "phase": "PHASE2", "last_updated": "2026-10-27", "start_date": "2026-10", "sponsor": "Invivyd, Inc.", "sponsor_type": "INDUSTRY", "agents": [ "Vyd2311" ], "conditions": [ "long-covid", "pacvs" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07899346" }, { "nct_id": "NCT05350774", "title": "Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2", "status": "ENROLLING_BY_INVITATION", "phase": "PHASE2", "last_updated": "2026-10-26", "start_date": "2023-07-10", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Iv Normal Saline", "Iv Immunoglobulin" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT05350774" } ], "feed_latest_pub_date": "2026-10-30", "numbers": { "studies_tracked": 539, "trials_tracked": 634, "biomarkers_catalogued": 603, "feeds": 8 }, "feed_updates": { "long-covid": "2026-10-25", "me-cfs": "2026-11-01", "pacvs": "2026-10-31", "lyme": "2026-10-26", "gulf-war-illness": "2026-10-27", "pots": "2026-10-29", "mcas": "2026-10-30", "other-post-viral": "2026-10-28" }, "trials_last_run": "2026-11-01", "generated_at": "2026-11-01T11:17:53+00:00" }