Long COVID (PASC) 41 new
Full feed: Long COVID research tracker
To analyze the time series and trend of the syphilis in pregnancy detection rate over nine years and the variations in clinical and epidemiological characteristics across four periods according to relevant public health events in Campo Grande, Mato Grosso do Sul. Time series study with descriptive analysis by periods, using data from the Notifiable Diseases Information System ( A total of 2,802 cases were analyzed.
After serious infections, many survivors fully recover while others face persistent symptoms including neurocognitive dysfunction, cardiopulmonary instabilities and disabling fatigue, classified broadly as Post-Acute Infection Syndromes (PAIS). Post-Acute Sequelae of COVID19 (PASC) is one special case.
Post-acute sequelae of SARS-CoV-2 infection (PASC) affect a substantial proportion of U.S. adults, involving multiple organ systems and resulting in significant disability and diminished quality of life. Population-level PASC estimates include individuals without prior COVID-19 infection and therefore do not accurately reflect postinfection risk required for effective risk stratification.
To compare blood biomarkers across SARS-CoV-2 fatigue, non-fatigue, and control groups; assessed longitudinal biomarker changes; and identified genetic associations and biomarkers linked to post-COVID-19 fatigue. This longitudinal observational study followed individuals with confirmed SARS-CoV-2 infection over a one-year period, stratifying them into fatigue (n = 27) and non-fatigue (n = 13) groups based on the...
Intrinsic capacity (IC) decline, infection susceptibility, and post-COVID sequelae in older adults, intensified by the pandemic, demand probing IC domains' infection/outcome links and population-level strategies for sustaining functional health. This cross-sectional study enrolled 600 older adults.
No abstract available.
Evidence on the economic burden of post-COVID syndrome in Germany remains limited. This study quantifies post-COVID-associated healthcare resource utilization (HCRU), sick leave, and costs.
Liver fibrosis in metabolic dysfunction associated steatohepatitis (MASH) lacks effective therapies, in part because therapeutic agents poorly penetrate the capillarized sinusoidal endothelium. As fibrosis progresses, liver sinusoidal endothelial cells (LSECs) become defenestrated and restrict trans-sinusoidal exchange, thereby limiting drug access to hepatic stellate cells (HSCs) within the perisinusoidal space.
To determine the risk factors associated with prolonged temporary work disability (TWD) in patients with COVID-19 in a rehabilitation unit. A cross-sectional, descriptive, and analytical study was carried out.
No abstract available.
Olfactory dysfunction (OD) is a hallmark of SARS-CoV-2-infection where it is believed to result from neuroinflammation induced by viral invasion via the olfactory mucosa (OM). Hyposmia also affects the majority of patients with Parkinson's disease (PD) where it is caused by α-synuclein (aSyn) pathology in the olfactory system, and aSyn-seeding-activity can be detected in the OM using...
We analyzed 919 Streptococcus pyogenes isolates from laboratory-confirmed streptococcal toxic shock syndrome cases in Japan during 2023-2024. Post-COVID-19 resurgence was driven by expansion of M1
Having a satisfying sexual life is important to many people and impairment of sexual function is often perceived as a burden. This study investigates the self-perceived impairments to sex life in adults with Post-COVID-19 syndrome (PCS) and factors that are associated with impaired sex life.
Long COVID, or post-COVID-19 condition, has become a defining post-pandemic health challenge, affecting hundreds of millions of people worldwide and imposing major burdens on individuals, health systems and economies. The recent
Long COVID (LC) represents a failure of healthy resolution mechanisms for inflammation after SARS-CoV-2 infection. Dietary essential polyunsaturated fatty acids (PUFAs) and their downstream metabolites can orchestrate inflammation resolution, suggesting these pathways may be altered in LC.
No abstract available.
Post-COVID-19 pandemic Mycoplasma pneumoniae resurgences have occurred globally and have been particularly severe in Taiwan. We conducted a multicenter study to assess M. pneumoniae trends in children.
Long COVID (post-COVID-19 condition) has been associated with persistent neurological and cognitive symptoms, suggesting possible central nervous system involvement beyond the acute phase of severe acute respiratory syndrome coronavirus 2 infection. A systematic review of articles published up to April 2026 was conducted following the PRISMA guidelines, and observational studies evaluating neurophysiological...
Fibrosing interstitial lung diseases (F-ILD) are a heterogeneous group of disorders characterized by pulmonary interstitial fibrosis and inflammation. Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of F-ILD.
The Long COVID Burden Index (LCBI) is an 11-item patient-reported outcome measure developed to assess the burden of long COVID symptoms on daily life. Although its cross-sectional validity and internal consistency have been demonstrated, its test-retest reliability, measurement error, and minimal important change (MIC) have not yet been evaluated.
COVID-19 has been associated with persistent cognitive deficits months after SARS-CoV-2 infection. Vaccination reduces severe disease, but its effect on post-infection cognition remains uncertain.
No abstract available.
No abstract available.
ObjectiveThis study explored the epistemic barriers affecting the recognition and care of Long COVID. It sought to understand how uncertainty is produced, distributed, and navigated among clinicians, researchers, and patients, and how these dynamics shape care pathways and patient experiences.MethodsWe conducted a qualitative analysis grounded in more than 400 accounts of clinical encounters, alongside more than 100...
Long COVID is a complex pathophysiological condition linked to a heterogenous symptom profile. Dysregulation of 1) immunological and inflammatory responses, 2) endothelial/vascular function, and 3) metabolic and clotting processes have been identified; however, there remains a lack of clinically validated diagnostic biomarkers.
This study aimed to evaluate the content validity of the Mental Fatigue Scale (MFS) in individuals with long COVID. Content validity was assessed using COSMIN methodology through cognitive interviews with individuals with long COVID (n = 10) and focus groups with healthcare professionals (n = 8).
Post-exertional malaise (PEM) is a syndrome characterized by a worsening of symptoms after physical, cognitive, or emotional exertion. It presents as increased fatigue, usually accompanied by other clinical symptoms, such as muscle pain or cognitive impairment.
Resilience is often framed within neoliberal health discourses as an individual capacity for adaptation, obscuring how the ability to endure illness is socially organised. This article reconceptualises resilience as a biographically embedded social practice through a study of older and emerging older adults living with Long COVID, an uncertain chronic health condition that unsettles everyday life and expectations of...
COVID-19 has been associated with persistent cognitive deficits months after SARS-CoV-2 infection. Vaccination reduces severe disease, but its effect on post-infection cognition remains uncertain.
Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS), Long COVID with initial orthostatic hypotension (LC-IOH), and Long COVID-POTS (LC-POTS) are primarily chronic post-viral conditions with debilitating symptoms, despite routine laboratory findings often being normal. We previously identified amyloidogenic fibrinaloid microclot complexes (FMCs) in the insoluble fraction of platelet-poor plasma (PPP-IF)...
Pandemic situation by severe acute respiratory syndrome coronavirus 2 and the associated disease (coronavirus disease 2019 [COVID-19]) presents broad challenges. Post-COVID-19 condition represents a continuum of persistent symptoms following the acute course.
Neurologic manifestations of Long COVID, also called post-acute sequelae of SARS-CoV-2 infection (PASC), include fatigue, cognitive dysfunction, sleep disturbances, and headaches, which can be debilitating. Since these symptoms overlap with those of obstructive sleep apnea (OSA), we sought to determine the prevalence of OSA in the population of a Neuro-COVID-19 clinic.
No abstract available.
We addressed the question: can the SARS-CoV2 spike protein persist in ACE2+ endothelia in the CNS/other sites and induce a prolonged microvasculature injury syndrome? People who died from COVID-19, with age-matched controls, and people with long COVID with symptoms persisting from 1-5 years, with controls of people who had recovered from COVID-19, were studied.
No abstract available.
No abstract available.
Evaluate safety and efficacy of extended-release pirfenidone (pirfenidone-XR), an anti-inflammatory and anti-fibrotic agent, as an early treatment for acute and long-term effects of COVID-19. This double-blinded, placebo-controlled trial randomized hospitalized and ambulatory COVID-19 patients in Mexico City 2:1 to pirfenidone-XR or placebo.
Older adults frequently experience persistent cognitive impairment after COVID-19, yet the mechanisms underlying impaired recovery and resilience remain poorly understood. Integrating longitudinal clinical trajectories with molecular signatures may clarify why cognitive function fails to recover in this population.
Lung transplantation is a feasible therapeutic option for irreversible lung injury caused by COVID-19, but comprehensive mid-term outcome data remain limited. This study evaluated outcomes after lung transplantation for COVID-19 acute respiratory distress syndrome (CARDS) and post-COVID pulmonary fibrosis (CPF) using a national registry.
We used California Health Interview Survey (CHIS) data to examine relationships between long COVID and financial hardship among California workers. We analyzed cross-sectional 2022-2023 CHIS adult survey data.
To evaluate supervised physical, psycho-logical, and alternative non-pharmacological interventions for improving patient-reported and objective functional outcomes in adults with post-COVID-19 condition. Systematic review of randomized controlled trials.
Mast Cell Activation Syndrome (MCAS) 7 new
Full feed: MCAS research tracker
Rosacea is a chronic inflammatory skin disorder in which LL37-driven mast cell activation contributes to cutaneous inflammation. Bruton's tyrosine kinase (BTK) is a key regulator of canonical IgE-dependent mast cell responses; however, its role in LL37-induced, IgE-independent mast cell activation remains unclear.
Aberrant Interleukin-33 (IL-33) activation is associated with numerous dermatological inflammatory and autoimmune diseases, such as atopic dermatitis, lupus, vitiligo and psoriasis. Thus, the inhibition of this pathway may provide therapeutic options in multiple pathologies.
Interstitial cystitis and bladder pain syndrome are clinically overlapping conditions that should be distinguished according to Hunner lesion status. IC with Hunner lesions is a distinct inflammatory bladder disease characterized by urothelial denudation, lymphoplasmacytic infiltration, adaptive immune activation, and progressive structural impairment.
To assess urinary biomarkers 3-bromotyrosine and leukotriene E4 (LTE4) levels in children with asthma and their association with asthma control and flare-up. This was a prospective study which applied a case-control design with 2:1 ratio.
Type-I hypersensitivity is a mast cell-mediated degranulation process induced by IgE-antigen recognition. Inspired by this highly specific mechanism, we developed a new cell therapy platform by genetically engineering mouse mast cell line MC/9 to overexpress the cytotoxic proteins perforin and granzyme B (PG-MCs) via lentiviral transduction.
Mast cells (MCs) are key regulators of cutaneous immune responses and play a central role in allergic and non-IgE-mediated skin inflammation by activating the Mas-related G protein-coupled receptor X2 (MRGPRX2). The inhibitory receptor CD300f has been shown to modulate MC activation, but its role in regulating MRGPRX2-dependent signaling remains unclear.
This review aims to summarize the established and potential targets of glucocorticoids (GCs) on mast cells, which are implicated in the pathophysiology of various allergic and inflammatory diseases including asthma, allergic rhinitis, and atopic dermatitis. We sought to answer the following questions: (1) How do glucocorticoids inhibit the release of mediators from mast cells?
ClinicalTrials.gov records whose registry entry was last updated between 19 October 2026 and 25 October 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.