[Not Available].
No abstract available.
- Research Tracker
- Weekly Digest
- Week 42 2026
Between 6 October 2026 and 12 October 2026 the tracker indexed 28 new peer-reviewed studies and 11 clinical-trial updates across 8 post-viral and post-infectious conditions.
By the numbers
28new studies this issue
11trial updates this issue
539studies currently in the feeds
629clinical trials tracked
603biomarkers catalogued
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-10-12); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
In this issue:
New studies by condition
Long COVID (PASC) 24 new
Full feed: Long COVID research tracker
SARS-CoV-2 seeds IAPP aggregation and β-cell failure.
The global diabetes incidence has surged post-COVID-19, yet how SARS-CoV-2 drives long-term beta cell (β-cell) failure remains incompletely elucidated. We identified a mechanism whereby SARS-CoV-2 structural proteins directly hijack islet amyloid polypeptide (IAPP) to induce pathogenic amyloid deposition, disrupting insulin granule maturation, trafficking, and secretion in an age-susceptible islet microenvironment.
Trends in long COVID and post-viral fatigue in children in primary care in England.
Post-viral sequelae following the COVID-19 pandemic attention to post-viral fatigue and long COVID, but the impact on children and young people's (CYP) primary care use is unknown. To examine temporal, seasonal, and sociodemographic patterns in primary care consultations for long COVID and PVFS in We conducted a retrospective, population-based dynamic cohort study using Clinical Practice Research Datalink Aurum data...
Supporting the psychosocial well-being of patients with Long COVID: patient-informed strategies from a qualitative study.
Long COVID, an illness characterized by long-lasting symptoms following SARS-CoV-2 infection, exacts a substantial toll on psychosocial well-being and overall health. Persistent physiological symptoms and associated experiences can negatively impact employment, daily functioning, identity, and social relationships.
Persistent Immune Thrombocytopenia as a Post-Acute Sequelae of COVID-19: A Case Report.
Immune thrombocytopenia (ITP) is a recognized hematologic complication associated with coronavirus disease 2019 (COVID-19), but its persistence years after acute infection remains uncommon. We present a case of a 52-year-old male who was diagnosed with COVID-19 in June 2020.
Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID.
Long COVID (LC) - a chronic condition characterized by persistent, debilitating symptoms following SARS-CoV-2 infection - has emerged as a major public health challenge. Although many interrelated mechanisms have been proposed as drivers of LC, the root causes have yet to be identified, posing significant challenges for therapeutic development.
Microtesla magnetic therapy for cognitive impairment in long COVID: a randomized pilot study.
Cognitive impairment is common in post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection (long COVID) and substantially affects function and quality of life. Evidence suggests that sustained neuroinflammation, cerebrovascular dysfunction and mitochondrial impairment contribute to cognitive symptoms.
Incidence and Determinants of Post-Coronavirus Disease Syndrome by Disease Severity: An Ambispective Cohort Study from a Tertiary Care Hospital in Puducherry.
Post-coronavirus disease 2019 (COVID-19) condition, or long COVID, persists beyond the acute phase, impacting quality of life. This study estimated the incidence and determinants of post-COVID syndrome (PCS) in Puducherry, India.
Health Care Expenditures and Cost-Sharing Before and After Long COVID: Three-Year Evidence From a Statewide Multi-Payer Cohort.
The objective of this study was to quantify expenditures for long COVID (LC) before/after diagnosis and compare 3-year trajectories with similar patients without LC in claims. A retrospective cohort study was conducted using Colorado All Payer Claims Database multi-payer claims (October 1, 2020-August 1, 2024).
Exercise effectiveness on fatigue in Long-COVID: systematic review and meta-analysis.
Patients with Long COVID commonly experience fatigue-related distress, often leading to low energy, reduced activity endurance, and exertional dyspnea, all of which negatively impact quality of life. Although studies have increasingly explored the effects of exercise on Long COVID-related fatigue, a comprehensive synthesis of the evidence is lacking.
Depleted before the dose: the mitochondrial vulnerability threshold hypothesis for fluoroquinolone-associated multisystem toxicity.
Fluoroquinolone (FQ) antibiotics have an established capacity for mitochondrial injury, yet only a subset of exposed patients develop severe or persistent toxicity. We propose the Mitochondrial Vulnerability Threshold (MVT) hypothesis: that whether a standard therapeutic FQ dose produces clinically significant toxicity may depend substantially on the patient's pre-existing mitochondrial reserve capacity rather than...
Could persistent extravascular fibrin deposition link microvascular and interstitial pathology in long COVID?
Long COVID is associated with persistent endothelial dysfunction, microvascular impairment, coagulation abnormalities, impaired fibrinolysis, and tissue hypoxia. Although these intravascular abnormalities are increasingly documented, less attention has been paid to whether vascular injury may also generate persistent pathology in the extravascular interstitial compartment.
Bridging the gap in Long COVID care: identifying core competencies for primary care curriculum development and evaluation.
There is an unmet need for Long COVID care within our healthcare system. Primary care clinicians (PCPs) face challenges in providing effective care due to limited relevant Long COVID training and lack of standardized clinical resources.
A cognitive architecture for Long COVID: the interplay of brain fog, fatigue, attention and memory.
The cognitive mechanisms underlying post-acute COVID-19 sequelae ('Long COVID') remain poorly defined. While deficits in memory and executive function are well-documented, it is unclear whether these arise from primary neural dysfunction or are secondary consequences of fatigue-related factors.
Reply to letter "Inflammatory Biomarkers in Long COVID: From Cross-Sectional Association to Claims of Prediction".
No abstract available.
Pulmonary Function, Functional Capacity, Voice, and Sleep in Post-COVID-19 Individuals With and Without Inspiratory Muscle Weakness.
To compare pulmonary function, functional capacity, voice, and sleep in post-COVID-19 individuals with and without inspiratory muscle weakness, as well as to investigate the association between vocal deviations, respiratory muscle strength, pulmonary function, functional capacity, and sleep parameters. Cross-sectional study with 28 post-COVID-19 adults, distributed into groups with (n = 14) and without (n = 14)...
Prior COVID-19 vaccination and cognitive outcomes after SARS-CoV-2 infection: a mini-review.
COVID-19 infection has been frequently associated with cognitive deficits that persist for months after the acute phase, but the impact of vaccination on preventing these deficits remains uncertain. Evidence suggests that immunization reduces the incidence and severity of post-COVID symptoms, yet few studies have evaluated its influence on cognition using objective measures.
Mechanisms of Accelerated Biological Aging and Premature Cardiovascular Events in Young and Middle-Aged Post-COVID-19 Survivors.
This review evaluates the impact of Post-Acute Sequelae of SARS-CoV-2 on adults aged 25 to 55, focusing on the potential for accelerated biological aging and an increased incidence of acute cardiovascular events. By synthesizing evidence from 110 epidemiological and mechanistic studies, we examine the interplay between viral-induced immune dysregulation, endothelial injury, and systemic physiological decline in a...
Exploratory clinical and immunological changes following Tixagevimab/Cilgavimab administration in immunodeficient patients with SARS-CoV-2-associated ME/CFS and persistent circulating spike protein.also ME/CFS
Persistent circulating SARS-CoV-2 spike protein has been proposed as a potential contributor to long-COVID pathophysiology. Whether administration of spike-targeting monoclonal antibodies is followed by changes in spike protein concentrations, autonomic receptor autoantibodies, or clinical outcomes remains uncertain.
Effectiveness of tailored individual follow-up vs. standard one-day group course on health-related quality of life in patients with post COVID-19 condition: a randomized controlled trial.
Post COVID-19 condition (PCC), is characterized by a wide range of symptoms, including fatigue and cognitive problems. Symptoms may lead to disability in everyday life and reduced health-related quality of life (HRQoL).
Correction: The Current and Future Burden of Long COVID in the United States.
No abstract available.
Lived Experiences of Long COVID in Iranian Immigrants in Canada: Implications for Post-Infection Care and Global Health Equity.
This study aimed to explore the lived experiences of Iranian immigrants in Canada with Long COVID (LC) and to examine how these experiences can inform culturally responsive healthcare approaches. This qualitative study employed an interpretive description (ID) methodology and was conducted in Canada in 2024.
Invasive Haemophilus Influenzae Infection in Children: Clinical Characteristics, Serotypes and Outcome: A Multicenter Study in Oman.
Haemophilus influenzae remains an important cause of invasive bacterial infections in children despite widespread vaccination against H. influenzae type b (Hib). In recent years, changes in epidemiology and the emergence of non-Hib serotypes have been increasingly reported worldwide.
Altered gut microbial functional landscape in children with pediatric inflammatory multisystem syndrome following SARS-CoV-2 infection: an exploratory metagenomic study.
Pediatric Inflammatory Multisystem Syndrome (PIMS), also known as MIS-C (Multisystem inflammatory syndrome in children), is a severe post-infectious inflammatory condition associated with SARS-CoV-2 in children. While coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, primarily affects the respiratory system, growing evidence highlights gastrointestinal involvement and the relevance of the gut-lung axis in...
ME/CFS 1 new
Full feed: ME/CFS research tracker
Characterizing Pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Symptom Burden, Functional Impairment, and Comparison With Adults in the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study.
To characterize the clinical, functional, and educational characteristics of adolescents with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and compare selected illness domains with adults in the Multi-Site Clinical Assessment of ME/CFS (MCAM) study. Baseline cross-sectional data from adolescents aged 10-17 years enrolled in MCAM were analyzed.
Chronic Lyme / Post-Treatment Lyme Disease Syndrome 1 new
Full feed: Lyme / PTLDS research tracker
Tick-borne diseases in French Guiana: A comprehensive review pinpointing differences from mainland France.
French Guiana (FG), an Amazonian French territory, represents a unique ecological and epidemiological setting for tick-borne diseases (TBDs). In contrast to mainland France, where TBDs are well-documented, data from FG remain scarce.
Gulf War Illness 1 new
Full feed: Gulf War Illness research tracker
Deposition, Retention, and Clearance of Depleted Uranium and Tungsten Following Inhalation Exposure: Biokinetic Analysis and Implications for Long-term Health Effects.
This study evaluates respiratory deposition and subsequent biokinetic behavior of DU and W aerosols using computational modeling informed by reported military exposure conditions. Particle deposition fractions in the respiratory tract were calculated using REDCALdep, which implements the ICRP Publication 66 respiratory tract deposition model with relevant updates from ICRP Publication 130.
No new studies this window for: PACVS, POTS, MCAS.
Trial activity
ClinicalTrials.gov records whose registry entry was last updated between 6 October 2026 and 12 October 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|---|---|---|---|---|
| NCT07757555 | Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial POTS, Other post-viral | Not Yet Recruiting | Early phase 1 | Guanfacine, Cromolyn Sodium | 2026-10-09 |
| NCT07468604 | Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition Other post-viral | Recruiting | Phase 4 | 5 Ml Of 0.25% Bupivacaine With Epinephrine | 2026-10-09 |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Long COVID | Not Yet Recruiting | Phase 1 | Keytruda | 2026-10-09 |
| NCT07546539 | Photobiomodulation in Chronic Fatigue Syndrome ME/CFS | Recruiting | Not applicable | Photobiomodulation | 2026-10-08 |
| NCT07285473 | Low-Dose Naltrexone For ME/CFS: Dose-Finding ME/CFS | Not Yet Recruiting | Phase 2 | Low-Dose Naltrexone (LDN) | 2026-10-08 |
| NCT06822179 | Effectiveness of a Personalized In-home Telerehabilitation Program on Self-Care in Patients With Long COVID Long COVID | Completed | Phase 2 | Personalised Exercise Program | 2026-10-08 |
| NCT06766825 | Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) Long COVID | Completed | Phase 2 | Plitidepsin 1.5 Mg/Day | 2026-10-08 |
| NCT05874037 | Fluvoxamine for Long COVID-19 Long COVID | Completed | Phase 2 | Fluvoxamine | 2026-10-07 |
| NCT07661862 | PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID Long COVID | Recruiting | Not applicable | Perceive-Outreach Disease Management Program | 2026-10-06 |
| NCT06928272 | Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study Long COVID | Recruiting | Phase 3 | Pirfenidone, Upadacitinib | 2026-10-06 |
| NCT06404073 | RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM)) Long COVID | Completed | Not applicable | Structured Pacing | 2026-10-06 |
Browse all tracked trials: clinical trials tracker.
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Open Source Medicine Foundation. Post-viral research digest, week 42 2026: 28 new studies. Published 12 October 2026. https://research.opensourcemed.info/digest/2026-W42.html
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Disclaimer. This digest is an automated, unreviewed listing of newly indexed PubMed records and ClinicalTrials.gov registry updates compiled by the Open Source Medicine Foundation. Inclusion is not endorsement; abstracts are excerpted verbatim from PubMed and may contain errors. It is not medical advice. Discuss any treatment decision with a qualified clinician.