{ "id": "2026-W43", "year": 2026, "week": 43, "week_monday": "2026-10-19", "week_sunday": "2026-10-25", "asof": "2026-10-25", "window_start": "2026-10-19", "window_end": "2026-10-25", "window_days": 7, "widened": false, "strict_study_count": 51, "strict_trial_count": 8, "study_count": 51, "trial_count": 8, "studies": { "long-covid": [ { "pmid": "42922787", "title": "Syphilis in pregnancy detection rate: time series study associated with descriptive analysis by periods, Campo Grande, 2015-2023.", "journal": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil", "pub_date": "2026-10-25", "authors": "Reis, Caroliny Oviedo Fernandes, Borges, Luciana Aparecida da Cunha, Santos-Pinto, Cláudia Du Bocage et al.", "excerpt": "To analyze the time series and trend of the syphilis in pregnancy detection rate over nine years and the variations in clinical and epidemiological characteristics across four periods according to relevant public health events in Campo Grande, Mato Grosso do Sul. Time series study with descriptive analysis by periods, using data from the Notifiable Diseases Information System ( A total of 2,802 cases were analyzed.", "url": "https://pubmed.ncbi.nlm.nih.gov/42922787/", "also": [] }, { "pmid": "42922780", "title": "Strong Protein Responses to Acute Infection Control General Post-Viral Sequelae and SARS-CoV-2-specific Neurocognitive Sequelae.", "journal": "medRxiv : the preprint server for health sciences", "pub_date": "2026-10-25", "authors": "Liou, Theodore G, Andrews, Ryan J, Battey, Heather S, Bass, Brenda L et al.", "excerpt": "After serious infections, many survivors fully recover while others face persistent symptoms including neurocognitive dysfunction, cardiopulmonary instabilities and disabling fatigue, classified broadly as Post-Acute Infection Syndromes (PAIS). Post-Acute Sequelae of COVID19 (PASC) is one special case.", "url": "https://pubmed.ncbi.nlm.nih.gov/42922780/", "also": [] }, { "pmid": "42921630", "title": "Prevalence and Trends of Post-COVID-19 Sequelae Among U.S. Adults With Prior COVID-19 Infection, 2022-2024.", "journal": "Cureus", "pub_date": "2026-10-25", "authors": "Bhargava, Ashish, Szpunar, Susan", "excerpt": "Post-acute sequelae of SARS-CoV-2 infection (PASC) affect a substantial proportion of U.S. adults, involving multiple organ systems and resulting in significant disability and diminished quality of life. Population-level PASC estimates include individuals without prior COVID-19 infection and therefore do not accurately reflect postinfection risk required for effective risk stratification.", "url": "https://pubmed.ncbi.nlm.nih.gov/42921630/", "also": [] }, { "pmid": "42925328", "title": "Multifactorial biomarker profiles in fatigued and non-fatigued post-COVID-19 patients: insights from a one-year follow-up.", "journal": "European journal of applied physiology", "pub_date": "2026-10-25", "authors": "Barrero-Santiago, Laura, Gomes de Jesus Ferreira, Leandro, Salomão, Rebecca, da Silva Almeida, Isabella et al.", "excerpt": "To compare blood biomarkers across SARS-CoV-2 fatigue, non-fatigue, and control groups; assessed longitudinal biomarker changes; and identified genetic associations and biomarkers linked to post-COVID-19 fatigue. This longitudinal observational study followed individuals with confirmed SARS-CoV-2 infection over a one-year period, stratifying them into fatigue (n = 27) and non-fatigue (n = 13) groups based on the...", "url": "https://pubmed.ncbi.nlm.nih.gov/42925328/", "also": [] }, { "pmid": "42923631", "title": "Intrinsic capacity with COVID-19 infection and late complications in the older adult population.", "journal": "Caspian journal of internal medicine", "pub_date": "2026-10-25", "authors": "Nikbakht, Hossein-Ali, Bakhtiari, Afsaneh, Tamadoni, Negar, Sivan, Manoj et al.", "excerpt": "Intrinsic capacity (IC) decline, infection susceptibility, and post-COVID sequelae in older adults, intensified by the pandemic, demand probing IC domains' infection/outcome links and population-level strategies for sustaining functional health. This cross-sectional study enrolled 600 older adults.", "url": "https://pubmed.ncbi.nlm.nih.gov/42923631/", "also": [] }, { "pmid": "42921163", "title": "Editorial: Long COVID in the biomedical sciences.", "journal": "British journal of biomedical science", "pub_date": "2026-10-25", "authors": "Kunnath, Anil Philip, Kavanagh, Owen, Tan, Shing Cheng", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42921163/", "also": [] }, { "pmid": "42921560", "title": "Economic Burden of Post-COVID Syndrome in Germany Between 2021 and 2025: A Statutory Health Insurance Claims Data Analysis.", "journal": "Journal of health economics and outcomes research", "pub_date": "2026-10-25", "authors": "Gensorowsky, Daniel, Fröling, Emma, Braegelmann, Kylie, Diekmannshemke, Jana et al.", "excerpt": "Evidence on the economic burden of post-COVID syndrome in Germany remains limited. This study quantifies post-COVID-associated healthcare resource utilization (HCRU), sick leave, and costs.", "url": "https://pubmed.ncbi.nlm.nih.gov/42921560/", "also": [] }, { "pmid": "42916103", "title": "Scavenger Receptor Class B Type 1 Mediated Transport Enables Delivery Across Capillarized Liver Sinusoids in Metabolic Dysfunction-Associated Steatohepatitis.", "journal": "ACS nano", "pub_date": "2026-10-23", "authors": "Yuan, Ruyan, Zhang, Jiamin, Huang, Yamei, Meng, Yiyang et al.", "excerpt": "Liver fibrosis in metabolic dysfunction associated steatohepatitis (MASH) lacks effective therapies, in part because therapeutic agents poorly penetrate the capillarized sinusoidal endothelium. As fibrosis progresses, liver sinusoidal endothelial cells (LSECs) become defenestrated and restrict trans-sinusoidal exchange, thereby limiting drug access to hepatic stellate cells (HSCs) within the perisinusoidal space.", "url": "https://pubmed.ncbi.nlm.nih.gov/42916103/", "also": [] }, { "pmid": "42913519", "title": "Risk factors associated with prolonged work incapacity in patients with COVID-19.", "journal": "Cirugia y cirujanos", "pub_date": "2026-10-23", "authors": "Nava-Piñeiro, Rafaela B, Santiago-Santos, Amós A, Varela-Tapia, Clara L, Martínez-Barro, Daniel", "excerpt": "To determine the risk factors associated with prolonged temporary work disability (TWD) in patients with COVID-19 in a rehabilitation unit. A cross-sectional, descriptive, and analytical study was carried out.", "url": "https://pubmed.ncbi.nlm.nih.gov/42913519/", "also": [] }, { "pmid": "42914166", "title": "Reply to: Moving beyond symptom management in long COVID guidelines: incorporating reinfection history, biological characterisation and health inequalities.", "journal": "The European respiratory journal", "pub_date": "2026-10-23", "authors": "Gu, Xiaoying, Zhang, Hui, Cao, Bin", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42914166/", "also": [] }, { "pmid": "42911254", "title": "Prevalence of alpha-synuclein seeding activity in the Olfactory Mucosa following SARS-CoV-2 infection: results from a pilot study.", "journal": "Acta neuropathologica", "pub_date": "2026-10-23", "authors": "Heim, Beatrice, Seppi, Klaus, De Cleene, Nicolas, Bongianni, Matilde et al.", "excerpt": "Olfactory dysfunction (OD) is a hallmark of SARS-CoV-2-infection where it is believed to result from neuroinflammation induced by viral invasion via the olfactory mucosa (OM). Hyposmia also affects the majority of patients with Parkinson's disease (PD) where it is caused by α-synuclein (aSyn) pathology in the olfactory system, and aSyn-seeding-activity can be detected in the OM using...", "url": "https://pubmed.ncbi.nlm.nih.gov/42911254/", "also": [] }, { "pmid": "42912439", "title": "Post-COVID-19 Expansion of Streptococcus pyogenes Lineages Causing Toxic Shock Syndrome, Japan, 2023-2024.", "journal": "Emerging infectious diseases", "pub_date": "2026-10-23", "authors": "Ikebe, Tadayoshi, Otsuka, Hitoshi, Sasaki, Mari, Yamaguchi, Takahiro et al.", "excerpt": "We analyzed 919 Streptococcus pyogenes isolates from laboratory-confirmed streptococcal toxic shock syndrome cases in Japan during 2023-2024. Post-COVID-19 resurgence was driven by expansion of M1", "url": "https://pubmed.ncbi.nlm.nih.gov/42912439/", "also": [] }, { "pmid": "42919197", "title": "Post-COVID syndrome's impact on sex life - results from a cross-sectional study.", "journal": "BMC public health", "pub_date": "2026-10-23", "authors": "Schröder, Dominik, Schmachtenberg, Tim, Heinemann, Stephanie, Müllenmeister, Christina et al.", "excerpt": "Having a satisfying sexual life is important to many people and impairment of sexual function is often perceived as a burden. This study investigates the self-perceived impairments to sex life in adults with Post-COVID-19 syndrome (PCS) and factors that are associated with impaired sex life.", "url": "https://pubmed.ncbi.nlm.nih.gov/42919197/", "also": [] }, { "pmid": "42914164", "title": "Moving beyond symptom management in long COVID guidelines: incorporating reinfection history, biological characterisation and health inequalities.", "journal": "The European respiratory journal", "pub_date": "2026-10-23", "authors": "Yang, Chengliang, Espín, Estefanía, Tebbutt, Scott J", "excerpt": "Long COVID, or post-COVID-19 condition, has become a defining post-pandemic health challenge, affecting hundreds of millions of people worldwide and imposing major burdens on individuals, health systems and economies. The recent", "url": "https://pubmed.ncbi.nlm.nih.gov/42914164/", "also": [] }, { "pmid": "42909166", "title": "Long COVID is associated with lipoxygenase-catalyzed metabolism of essential polyunsaturated fatty acids.", "journal": "iScience", "pub_date": "2026-10-23", "authors": "Moss, M Elizabeth, Pons, Stephanie, Tavares, Luciana P, Tang, Yan et al.", "excerpt": "Long COVID (LC) represents a failure of healthy resolution mechanisms for inflammation after SARS-CoV-2 infection. Dietary essential polyunsaturated fatty acids (PUFAs) and their downstream metabolites can orchestrate inflammation resolution, suggesting these pathways may be altered in LC.", "url": "https://pubmed.ncbi.nlm.nih.gov/42909166/", "also": [] }, { "pmid": "42909567", "title": "From persistent biomarker signatures to vascular pathophysiology in post-COVID-19 syndrome.", "journal": "Angiogenesis", "pub_date": "2026-10-23", "authors": "Sarıoğlu, Güney, Kaya, Oğuz Kaan", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42909567/", "also": [] }, { "pmid": "42909847", "title": "Emergence of Novel Macrolide-Resistant Mycoplasma pneumoniae Sequence Type 3 Subclades in Children after COVID-19 Pandemic, Taiwan.", "journal": "Emerging infectious diseases", "pub_date": "2026-10-23", "authors": "Hsieh, Yu-Chia, Lin, Chen-Ching, Wu, Jia-Wen, Liu, Yi-Hsuan et al.", "excerpt": "Post-COVID-19 pandemic Mycoplasma pneumoniae resurgences have occurred globally and have been particularly severe in Taiwan. We conducted a multicenter study to assess M. pneumoniae trends in children.", "url": "https://pubmed.ncbi.nlm.nih.gov/42909847/", "also": [] }, { "pmid": "42912090", "title": "Central Nervous System Alterations in Individuals with Long COVID: A Systematic Review.", "journal": "Revista da Sociedade Brasileira de Medicina Tropical", "pub_date": "2026-10-23", "authors": "Moraes, Janaina Ferreira de, Souza, Paulo Henrique Leite, Andrade, Michele Lacerda de, Dias et al.", "excerpt": "Long COVID (post-COVID-19 condition) has been associated with persistent neurological and cognitive symptoms, suggesting possible central nervous system involvement beyond the acute phase of severe acute respiratory syndrome coronavirus 2 infection. A systematic review of articles published up to April 2026 was conducted following the PRISMA guidelines, and observational studies evaluating neurophysiological...", "url": "https://pubmed.ncbi.nlm.nih.gov/42912090/", "also": [] }, { "pmid": "42909317", "title": "A narrative review of stem cell-based therapy for fibrosing interstitial lung diseases: clinical evidence and translational perspectives.", "journal": "Frontiers in pharmacology", "pub_date": "2026-10-23", "authors": "Li, Zhengnan, Geng, Lei, Li, Wei, Wang, Xiujuan et al.", "excerpt": "Fibrosing interstitial lung diseases (F-ILD) are a heterogeneous group of disorders characterized by pulmonary interstitial fibrosis and inflammation. Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of F-ILD.", "url": "https://pubmed.ncbi.nlm.nih.gov/42909317/", "also": [] }, { "pmid": "42906877", "title": "Test-retest reliability and interpretability of Long COVID Burden Index: A prospective observational study.", "journal": "Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy", "pub_date": "2026-10-22", "authors": "Yamada, Gen, Iwamoto, Noriko, Miyamori, Daisuke, Suzuki, Michiyo et al.", "excerpt": "The Long COVID Burden Index (LCBI) is an 11-item patient-reported outcome measure developed to assess the burden of long COVID symptoms on daily life. Although its cross-sectional validity and internal consistency have been demonstrated, its test-retest reliability, measurement error, and minimal important change (MIC) have not yet been evaluated.", "url": "https://pubmed.ncbi.nlm.nih.gov/42906877/", "also": [] }, { "pmid": "42905886", "title": "Protective Effect of COVID-19 Vaccination on Post-Infection Visuospatial Deficits.", "journal": "Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)", "pub_date": "2026-10-22", "authors": "da Silva, Lucas Gomes, Fini, Bruna Carmeni Di, Oliveira, Jordano César Milagres, Rosa, Daniela Valadão et al.", "excerpt": "COVID-19 has been associated with persistent cognitive deficits months after SARS-CoV-2 infection. Vaccination reduces severe disease, but its effect on post-infection cognition remains uncertain.", "url": "https://pubmed.ncbi.nlm.nih.gov/42905886/", "also": [] }, { "pmid": "42902791", "title": "Parasartorial Compartments (PASC) Block Added to Periarticular Infiltration in Total Knee Arthroplasty: A Randomised Controlled Trial.", "journal": "Pain medicine (Malden, Mass.)", "pub_date": "2026-10-22", "authors": "Atalay, Yunus Oktay, Basak, Okkes, Gölboyu, Birzat Emre, Ciftci, Bahadir", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42902791/", "also": [] }, { "pmid": "42903049", "title": "No evidence of hypercoagulability, altered fibrinolysis, or increased fibrin(ogen) microaggregates in never-hospitalized long COVID.", "journal": "HemaSphere", "pub_date": "2026-10-22", "authors": "Fraser, Emily, Ng, Kher, Hasan, Neda, Dunstan, Isobel et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42903049/", "also": [] }, { "pmid": "42902825", "title": "Knowing Long COVID: Epistemic Barriers to Recognition and Care.", "journal": "Journal of primary care & community health", "pub_date": "2026-10-22", "authors": "Jamoulle, Marc, Spanoghe, Martin, Rolus, Bram, Thielemans, Paul et al.", "excerpt": "ObjectiveThis study explored the epistemic barriers affecting the recognition and care of Long COVID. It sought to understand how uncertainty is produced, distributed, and navigated among clinicians, researchers, and patients, and how these dynamics shape care pathways and patient experiences.MethodsWe conducted a qualitative analysis grounded in more than 400 accounts of clinical encounters, alongside more than 100...", "url": "https://pubmed.ncbi.nlm.nih.gov/42902825/", "also": [] }, { "pmid": "42905724", "title": "Blood biomarkers of long COVID: A cross-sectional evaluation of key cytokines and the coordination of inflammation.", "journal": "PloS one", "pub_date": "2026-10-22", "authors": "Thomas, Callum, Ashton, Ruth E, Pretorius, Etheresia, Owen, Rebecca et al.", "excerpt": "Long COVID is a complex pathophysiological condition linked to a heterogenous symptom profile. Dysregulation of 1) immunological and inflammatory responses, 2) endothelial/vascular function, and 3) metabolic and clotting processes have been identified; however, there remains a lack of clinically validated diagnostic biomarkers.", "url": "https://pubmed.ncbi.nlm.nih.gov/42905724/", "also": [] }, { "pmid": "42902491", "title": "Evaluating the Mental Fatigue Scale for long COVID: A content validity study.", "journal": "Neuropsychological rehabilitation", "pub_date": "2026-10-21", "authors": "Riis-Djernæs, Line M, Oestergaard, Lisa Gregersen, Nielsen, Trine Brøns, Sørensen, Lotte et al.", "excerpt": "This study aimed to evaluate the content validity of the Mental Fatigue Scale (MFS) in individuals with long COVID. Content validity was assessed using COSMIN methodology through cognitive interviews with individuals with long COVID (n = 10) and focus groups with healthcare professionals (n = 8).", "url": "https://pubmed.ncbi.nlm.nih.gov/42902491/", "also": [] }, { "pmid": "42899626", "title": "[Recognizing and managing post-exertional malaise in primary care].", "journal": "Revue medicale suisse", "pub_date": "2026-10-20", "authors": "Garcia, Sara, Tzartzas, Konstantinos, von Plessen, Christian, Favrat, Bernard et al.", "excerpt": "Post-exertional malaise (PEM) is a syndrome characterized by a worsening of symptoms after physical, cognitive, or emotional exertion. It presents as increased fatigue, usually accompanied by other clinical symptoms, such as muscle pain or cognitive impairment.", "url": "https://pubmed.ncbi.nlm.nih.gov/42899626/", "also": [ "me-cfs" ] }, { "pmid": "42901033", "title": "Resilience as social practice: Negotiating long COVID at the intersection of illness and ageing.", "journal": "Social science & medicine (1982)", "pub_date": "2026-10-20", "authors": "Fang, Chao, Comery, Alastair, Baz, Sarah Akhtar, Sheard, Laura et al.", "excerpt": "Resilience is often framed within neoliberal health discourses as an individual capacity for adaptation, obscuring how the ability to endure illness is socially organised. This article reconceptualises resilience as a biographically embedded social practice through a study of older and emerging older adults living with Long COVID, an uncertain chronic health condition that unsettles everyday life and expectations of...", "url": "https://pubmed.ncbi.nlm.nih.gov/42901033/", "also": [] }, { "pmid": "42900956", "title": "Protective Effect of COVID-19 Vaccination on Post-Infection Visuospatial Deficits.", "journal": "Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)", "pub_date": "2026-10-20", "authors": "da Silva, Lucas Gomes, Fini, Bruna Carmeni Di, Oliveira, Jordano César Milagres, Rosa, Daniela Valadão et al.", "excerpt": "COVID-19 has been associated with persistent cognitive deficits months after SARS-CoV-2 infection. Vaccination reduces severe disease, but its effect on post-infection cognition remains uncertain.", "url": "https://pubmed.ncbi.nlm.nih.gov/42900956/", "also": [] }, { "pmid": "42897639", "title": "Post-translational modifications in the insoluble fraction of platelet-poor plasma distinguish pre-COVID-19 Postural Orthostatic Tachycardia Syndrome, Long COVID, and Long COVID-POTS: a preliminary study.", "journal": "Cardiovascular diabetology", "pub_date": "2026-10-20", "authors": "Booyens, Renata M, Vlok, Mare, Bester, Cecile, Hira, Rashmin et al.", "excerpt": "Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS), Long COVID with initial orthostatic hypotension (LC-IOH), and Long COVID-POTS (LC-POTS) are primarily chronic post-viral conditions with debilitating symptoms, despite routine laboratory findings often being normal. We previously identified amyloidogenic fibrinaloid microclot complexes (FMCs) in the insoluble fraction of platelet-poor plasma (PPP-IF)...", "url": "https://pubmed.ncbi.nlm.nih.gov/42897639/", "also": [ "pots" ] }, { "pmid": "42899016", "title": "Post-COVID-19 Condition has High Prevalence in Patients with Immune-mediated Inflammatory Diseases and Negatively Impacts Quality of Life.", "journal": "Journal of global infectious diseases", "pub_date": "2026-10-20", "authors": "Schlosser, Tobias, Krasselt, Marco, Hecker, Martin, Holler, Babett et al.", "excerpt": "Pandemic situation by severe acute respiratory syndrome coronavirus 2 and the associated disease (coronavirus disease 2019 [COVID-19]) presents broad challenges. Post-COVID-19 condition represents a continuum of persistent symptoms following the acute course.", "url": "https://pubmed.ncbi.nlm.nih.gov/42899016/", "also": [] }, { "pmid": "42897409", "title": "Obstructive sleep apnea is frequent in patients with Long COVID fatigue but is not significantly associated with alterations of quality of life and cognition.", "journal": "GeroScience", "pub_date": "2026-10-20", "authors": "Bawa, Aasheeta P, Lopez, Melissa, Miller, Janet, Sala, Marc A et al.", "excerpt": "Neurologic manifestations of Long COVID, also called post-acute sequelae of SARS-CoV-2 infection (PASC), include fatigue, cognitive dysfunction, sleep disturbances, and headaches, which can be debilitating. Since these symptoms overlap with those of obstructive sleep apnea (OSA), we sought to determine the prevalence of OSA in the population of a Neuro-COVID-19 clinic.", "url": "https://pubmed.ncbi.nlm.nih.gov/42897409/", "also": [] }, { "pmid": "42899434", "title": "Flow cytometry of bronchoalveolar lavage fluid in the diagnostic evaluation of fibrotic nonspecific interstitial pneumonia-like interstitial lung abnormalities in a former smoker with suspected post-COVID-19 syndrome.", "journal": "Polish archives of internal medicine", "pub_date": "2026-10-20", "authors": "Dolna-Michno, Justyna, Rudnicka-Sosin, Lucyna, Senderek, Tomasz, Wędrowska, Ewelina et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42899434/", "also": [] }, { "pmid": "42901242", "title": "Effects of prolonged SARS-CoV2 spike protein exposure in long COVID and a mouse model of the disease.", "journal": "The American journal of pathology", "pub_date": "2026-10-20", "authors": "Nuovo, Gerard, Laurence, Jeffrey, Tili, Esmerina, Li, Xing et al.", "excerpt": "We addressed the question: can the SARS-CoV2 spike protein persist in ACE2+ endothelia in the CNS/other sites and induce a prolonged microvasculature injury syndrome? People who died from COVID-19, with age-matched controls, and people with long COVID with symptoms persisting from 1-5 years, with controls of people who had recovered from COVID-19, were studied.", "url": "https://pubmed.ncbi.nlm.nih.gov/42901242/", "also": [] }, { "pmid": "42896573", "title": "[Not Available].", "journal": "Psychiatrische Praxis", "pub_date": "2026-10-19", "authors": "Schilling, Claudia", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42896573/", "also": [ "me-cfs" ] }, { "pmid": "42896570", "title": "[Not Available].", "journal": "Psychiatrische Praxis", "pub_date": "2026-10-19", "authors": "Henningsen, Peter", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42896570/", "also": [ "me-cfs" ] }, { "pmid": "42896728", "title": "Randomized controlled trial of pirfenidone XR for patients with COVID-19 and exploration of effects on long-COVID incidence.", "journal": "International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases", "pub_date": "2026-10-19", "authors": "M, Tamez-Torres Karla, Karina, Aguilar Laura, Alejandro, Díaz-Mejía Bruno, Maria de la Luz et al.", "excerpt": "Evaluate safety and efficacy of extended-release pirfenidone (pirfenidone-XR), an anti-inflammatory and anti-fibrotic agent, as an early treatment for acute and long-term effects of COVID-19. This double-blinded, placebo-controlled trial randomized hospitalized and ambulatory COVID-19 patients in Mexico City 2:1 to pirfenidone-XR or placebo.", "url": "https://pubmed.ncbi.nlm.nih.gov/42896728/", "also": [] }, { "pmid": "42895160", "title": "Persistent Cognitive Vulnerability After COVID-19 in Older Adults: Longitudinal Clinical Trajectories and Multi-Cohort Transcriptomic Evidence.", "journal": "Current aging science", "pub_date": "2026-10-19", "authors": "Lara, Maximiliano Correa, Hernandez, Erika Martinez", "excerpt": "Older adults frequently experience persistent cognitive impairment after COVID-19, yet the mechanisms underlying impaired recovery and resilience remain poorly understood. Integrating longitudinal clinical trajectories with molecular signatures may clarify why cognitive function fails to recover in this population.", "url": "https://pubmed.ncbi.nlm.nih.gov/42895160/", "also": [] }, { "pmid": "42896671", "title": "Mid-Term Outcomes for Lung Transplantation in for COVID-19 Respiratory Failure: An Analysis of the United Network for Organ Sharing Database.", "journal": "The Journal of thoracic and cardiovascular surgery", "pub_date": "2026-10-19", "authors": "Hassaballa, Aly Sherif, O'Neill, John W, Gregorio, Paulo H P, Mazur, Michael Zane et al.", "excerpt": "Lung transplantation is a feasible therapeutic option for irreversible lung injury caused by COVID-19, but comprehensive mid-term outcome data remain limited. This study evaluated outcomes after lung transplantation for COVID-19 acute respiratory distress syndrome (CARDS) and post-COVID pulmonary fibrosis (CPF) using a national registry.", "url": "https://pubmed.ncbi.nlm.nih.gov/42896671/", "also": [] }, { "pmid": "42895975", "title": "Long COVID and financial hardships among workers: Evidence from the California Health Interview Survey, 2022-2023.", "journal": "Journal of occupational and environmental medicine", "pub_date": "2026-10-19", "authors": "Garvey, Kathleen, Wambui, David, Vergara, Ximena", "excerpt": "We used California Health Interview Survey (CHIS) data to examine relationships between long COVID and financial hardship among California workers. We analyzed cross-sectional 2022-2023 CHIS adult survey data.", "url": "https://pubmed.ncbi.nlm.nih.gov/42895975/", "also": [] }, { "pmid": "42895360", "title": "Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.", "journal": "Journal of rehabilitation medicine", "pub_date": "2026-10-19", "authors": "Negm, Akram, Stolz, Maike, Krauth, Christian", "excerpt": "To evaluate supervised physical, psycho-logical, and alternative non-pharmacological interventions for improving patient-reported and objective functional outcomes in adults with post-COVID-19 condition. Systematic review of randomized controlled trials.", "url": "https://pubmed.ncbi.nlm.nih.gov/42895360/", "also": [] } ], "me-cfs": [ { "pmid": "42919747", "title": "Construction and verification of an immune signature model for chronic fatigue syndrome: Leveraging TCM syndromes and elements for enhanced assessment.", "journal": "Journal of integrative medicine", "pub_date": "2026-10-23", "authors": "Qin, Le-le, Zhang, Zhen-Xian, Wang, Jing-Han, Shi, Jia-Ning et al.", "excerpt": "The purpose of this study is to establish an immune function assessment model that considers clinical symptoms and laboratory tests by combining traditional Chinese medicine (TCM) syndromes and syndrome elements with lymphocyte cell counts for evaluating immune function in patients with chronic fatigue syndrome (CFS). A survey was conducted involving 473 CFS patients who were categorized based on immune function and...", "url": "https://pubmed.ncbi.nlm.nih.gov/42919747/", "also": [] }, { "pmid": "42901254", "title": "Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.", "journal": "Autoimmunity reviews", "pub_date": "2026-10-20", "authors": "Zheng, Sai-Hua, Gao, Shao-Jun, Cai, Jing-Jing, Shen, Zong-Xiang et al.", "excerpt": "Endometriosis has traditionally been defined as a disease localized to the pelvis. However, its clinical presentation is often accompanied by systemic comorbidities that extend far beyond the pelvic cavity, a phenomenon that challenges the traditional disease paradigm.", "url": "https://pubmed.ncbi.nlm.nih.gov/42901254/", "also": [] } ], "pacvs": [], "lyme": [], "gulf-war-illness": [], "pots": [ { "pmid": "42900975", "title": "Exogenous testosterone use in cisgender heterosexual females with postural orthostatic tachycardia syndrome: A dual case report.", "journal": "Autonomic neuroscience : basic & clinical", "pub_date": "2026-10-20", "authors": "Boris, Jeffrey R", "excerpt": "Exogenous testosterone has been previously reported to have given clinical improvement in symptoms of postural orthostatic tachycardia syndrome (POTS) in reported cases of transgender patients during their transition from female to male. Herein is presented two case reports of cisgender heterosexual female patients with POTS who have used testosterone for the management of concurrent gynecologic problems, but who...", "url": "https://pubmed.ncbi.nlm.nih.gov/42900975/", "also": [] } ], "mcas": [ { "pmid": "42894756", "title": "Topical Remibrutinib Attenuates LL37-Induced Rosacea-Like Dermatitis by Inhibiting BTK Activation, NF-κB Signaling and Mast Cell Activation.", "journal": "Journal of inflammation research", "pub_date": "2026-10-19", "authors": "Li, Wangchao, Fan, Huiping, Liu, Hua, Ma, Qingsong et al.", "excerpt": "Rosacea is a chronic inflammatory skin disorder in which LL37-driven mast cell activation contributes to cutaneous inflammation. Bruton's tyrosine kinase (BTK) is a key regulator of canonical IgE-dependent mast cell responses; however, its role in LL37-induced, IgE-independent mast cell activation remains unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42894756/", "also": [] }, { "pmid": "42895944", "title": "Thiophene-Benzimidazole Conjugates Attenuate IL-33-induced Inflammation in Human Mast Cell Line and in ex vivo Human Skin Organ Cultures.", "journal": "Skin pharmacology and physiology", "pub_date": "2026-10-19", "authors": "Gvirtz, Raanan, Kahremany, Shirin, Trifonov, Lena, Weintraub, Sagiv et al.", "excerpt": "Aberrant Interleukin-33 (IL-33) activation is associated with numerous dermatological inflammatory and autoimmune diseases, such as atopic dermatitis, lupus, vitiligo and psoriasis. Thus, the inhibition of this pathway may provide therapeutic options in multiple pathologies.", "url": "https://pubmed.ncbi.nlm.nih.gov/42895944/", "also": [] }, { "pmid": "42894375", "title": "Phenotyping Interstitial Cystitis/Bladder Pain Syndrome: Clinical and Mechanistic Evidence, Candidate Biomarkers, and Implications for Management.", "journal": "Lower urinary tract symptoms", "pub_date": "2026-10-19", "authors": "Qiao, Pengfei, Tian, Zhentao, He, Zhen", "excerpt": "Interstitial cystitis and bladder pain syndrome are clinically overlapping conditions that should be distinguished according to Hunner lesion status. IC with Hunner lesions is a distinct inflammatory bladder disease characterized by urothelial denudation, lymphoplasmacytic infiltration, adaptive immune activation, and progressive structural impairment.", "url": "https://pubmed.ncbi.nlm.nih.gov/42894375/", "also": [] }, { "pmid": "42894018", "title": "Noninvasive urinary biomarkers 3-bromotyrosine and leukotriene E4 in assessing asthma control and flare-up in children: a case-control study.", "journal": "European journal of pediatrics", "pub_date": "2026-10-19", "authors": "Yadav, Krishna Kumar, Gupta, Nitesh R, Yadav, Sunita, Kulshrestha, Manish Raj et al.", "excerpt": "To assess urinary biomarkers 3-bromotyrosine and leukotriene E4 (LTE4) levels in children with asthma and their association with asthma control and flare-up. This was a prospective study which applied a case-control design with 2:1 ratio.", "url": "https://pubmed.ncbi.nlm.nih.gov/42894018/", "also": [] }, { "pmid": "42896419", "title": "Genetically engineering mast cells as effectors for targeted cancer cell cytotoxicity.", "journal": "Biomaterials", "pub_date": "2026-10-19", "authors": "Han, Xiao, Wen, Di, Fu, Ruxing, Soto, Jennifer et al.", "excerpt": "Type-I hypersensitivity is a mast cell-mediated degranulation process induced by IgE-antigen recognition. Inspired by this highly specific mechanism, we developed a new cell therapy platform by genetically engineering mouse mast cell line MC/9 to overexpress the cytotoxic proteins perforin and granzyme B (PG-MCs) via lentiviral transduction.", "url": "https://pubmed.ncbi.nlm.nih.gov/42896419/", "also": [] }, { "pmid": "42896755", "title": "CD300f acts as an inducible inhibitory checkpoint that limits mast cell activation by suppressing MITF-dependent activation.", "journal": "The Journal of investigative dermatology", "pub_date": "2026-10-19", "authors": "Song, Lihong, Ollé, Laia, Zhang, Zeng, Lago, Natalia et al.", "excerpt": "Mast cells (MCs) are key regulators of cutaneous immune responses and play a central role in allergic and non-IgE-mediated skin inflammation by activating the Mas-related G protein-coupled receptor X2 (MRGPRX2). The inhibitory receptor CD300f has been shown to modulate MC activation, but its role in regulating MRGPRX2-dependent signaling remains unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42896755/", "also": [] }, { "pmid": "42894084", "title": "A Review: Mast Cells as Targets for Glucocorticoid Action.", "journal": "Current allergy and asthma reports", "pub_date": "2026-10-19", "authors": "Atum, Daniel, Ogwal, Jimmy Odongo, Obeny, Abel", "excerpt": "This review aims to summarize the established and potential targets of glucocorticoids (GCs) on mast cells, which are implicated in the pathophysiology of various allergic and inflammatory diseases including asthma, allergic rhinitis, and atopic dermatitis. We sought to answer the following questions: (1) How do glucocorticoids inhibit the release of mediators from mast cells?", "url": "https://pubmed.ncbi.nlm.nih.gov/42894084/", "also": [] } ], "other-post-viral": [] }, "trials": [ { "nct_id": "NCT07388550", "title": "Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)", "status": "NOT_YET_RECRUITING", "phase": "PHASE1", "last_updated": "2026-10-23", "start_date": "2026-10-28", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Keytruda" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07388550" }, { "nct_id": "NCT05764538", "title": "DAOIB for the Treatment of Brain Fog", "status": "RECRUITING", "phase": "PHASE2", "last_updated": "2026-10-23", "start_date": "2023-02-27", "sponsor": "Chang Gung Memorial Hospital", "sponsor_type": "OTHER", "agents": [ "Daoib" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05764538" }, { "nct_id": "NCT07888673", "title": "Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic Diseases", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-10-22", "start_date": "2025-10-01", "sponsor": "Hospital Donostia", "sponsor_type": "OTHER", "agents": [ "Transcraneal Magnetic Stimulation" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07888673" }, { "nct_id": "NCT07888543", "title": "Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-10-22", "start_date": "2026-09-10", "sponsor": "Centre Hospitalier Universitaire, Amiens", "sponsor_type": "OTHER", "agents": [ "Mri Scan", "Electrocardiogram" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07888543" }, { "nct_id": "NCT06928506", "title": "Effect of Hi-OxSR for the Treatment of Post COVID Condition", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-10-22", "start_date": "2025-08-01", "sponsor": "University Health Network, Toronto", "sponsor_type": "OTHER", "agents": [ "Hi-Oxsr Device", "Hi-Ox Device" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06928506" }, { "nct_id": "NCT05092516", "title": "Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC)", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-10-21", "start_date": "2022-06-07", "sponsor": "Massachusetts General Hospital", "sponsor_type": "OTHER", "agents": [ "Active Tdcs" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05092516" }, { "nct_id": "NCT07881302", "title": "Effect of Ivabradine on Adolescent Dysautonomia", "status": "NOT_YET_RECRUITING", "phase": "PHASE2", "last_updated": "2026-10-20", "start_date": "2026-11", "sponsor": "Kathryn Armstrong", "sponsor_type": "OTHER", "agents": [ "Ivabradine" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07881302" }, { "nct_id": "NCT07880171", "title": "Intensive Home-based Transcranial Direct Current Stimulation for Long COVID", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-10-19", "start_date": "2025-09-02", "sponsor": "Hospital de Basurto", "sponsor_type": "OTHER", "agents": [ "Transcranial Direct Current Stimulation" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07880171" } ], "feed_latest_pub_date": "2026-10-25", "numbers": { "studies_tracked": 539, "trials_tracked": 632, "biomarkers_catalogued": 603, "feeds": 8 }, "feed_updates": { "long-covid": "2026-10-25", "me-cfs": "2026-10-24", "pacvs": "2026-10-23", "lyme": "2026-10-18", "gulf-war-illness": "2026-10-11", "pots": "2026-10-21", "mcas": "2026-10-22", "other-post-viral": "2026-10-20" }, "trials_last_run": "2026-10-25", "generated_at": "2026-10-25T09:11:14+00:00" }