Summary
| Direction in PACVS | ↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction |
|---|---|
| Category | Autoimmune |
| Also described as | GPCR autoantibody |
| Compared against | HC (healthy controls) |
| Associated symptoms | Autonomic, GI symptoms |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Mantovani et al. 2024 — doi:10.3390/biomedicines12122852 |
| Condition atlas | PACVS Biomarker Atlas |
Trials, interventions and tests
Commercial test availability
Anti-CHRM3 (Muscarinic M3) Autoantibodies — specialty laboratory test.
Links are for reference only; availability, specimen requirements and coverage vary by location.
Related Autoimmune markers in PACVS
- Anti-ADRA2A (α2B adrenergic receptor) ↓
- Anti-idiotype antibodies (ACE2 ↔ Anti-S) ↕
- Anti-STAB1 autoantibodies ↑
- Anti-GPCR autoantibodies (panel) ↑
- Anti-MAS1 receptor autoantibodies ↑
- Anti-AT1R (angiotensin II type 1 receptor) ↑
- Anti-ACE2 autoantibodies ↑
Full list: PACVS Biomarker Atlas.
Frequently asked questions
Is Anti-CHRM3 (muscarinic M3) high or low in PACVS?
Mixed. Some studies report higher and others lower Anti-CHRM3 (muscarinic M3) in PACVS compared with healthy controls, so no single direction is established. Source: Mantovani et al. 2024.
What symptoms is Anti-CHRM3 (muscarinic M3) associated with in PACVS?
The cited literature associates this marker with Autonomic, GI symptoms. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Anti-CHRM3 (muscarinic M3)?
It is measured as a blood test (serum / plasma / whole blood). Commercial laboratories such as CellTrend (specialty) list an orderable assay.
Is one abnormal Anti-CHRM3 (muscarinic M3) result diagnostic of PACVS?
No. No single biomarker is diagnostic of PACVS. Anti-CHRM3 (muscarinic M3) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Cite this page
Subscribe on Substack
Last reviewed: 2026-06-30 · Page generated from pacvs.json · Browse: PACVS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.