Summary
| Direction in PACVS | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Autoimmune |
| Also described as | GPCR autoantibody |
| Compared against | HC (inverse with symptoms) (healthy controls (inverse with symptoms)) |
| Associated symptoms | Negatively associated with brain fog |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Mantovani et al. 2024 — doi:10.3390/biomedicines12122852 |
| Condition atlas | PACVS Biomarker Atlas |
Related Autoimmune markers in PACVS
- Anti-STAB1 autoantibodies ↑
- Anti-CHRM3 (muscarinic M3) ↕
- Anti-MAS1 receptor autoantibodies ↑
- Anti-idiotype antibodies (ACE2 ↔ Anti-S) ↕
- Anti-AT1R (angiotensin II type 1 receptor) ↑
- Anti-GPCR autoantibodies (panel) ↑
- Anti-ACE2 autoantibodies ↑
Full list: PACVS Biomarker Atlas.
Frequently asked questions
Is Anti-ADRA2A (α2B adrenergic receptor) high or low in PACVS?
Reduced. Studies summarised in the OSMF atlas report lower Anti-ADRA2A (α2B adrenergic receptor) in PACVS than in healthy controls (inverse with symptoms). Source: Mantovani et al. 2024.
What symptoms is Anti-ADRA2A (α2B adrenergic receptor) associated with in PACVS?
The cited literature associates this marker with Negatively associated with brain fog. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Anti-ADRA2A (α2B adrenergic receptor)?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Anti-ADRA2A (α2B adrenergic receptor) result diagnostic of PACVS?
No. No single biomarker is diagnostic of PACVS. Anti-ADRA2A (α2B adrenergic receptor) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-30 · Page generated from pacvs.json · Browse: PACVS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.