Peer-Reviewed Literature Synthesis

Type 2 Diabetes Biomarker Atlas

Molecular alterations reported in Type 2 Diabetes compared to healthy controls, from peer-reviewed literature.

Spontaneous remission1.6-1.7% at 7 years on standard care (population-level cohorts UK and US)
Best-intervention remission46-58% at 5 years post-bariatric surgery; up to 86% at 1 year with >15% total weight loss via intensive dietary…
Gap sizeVery large
Primary barrierpractice/access
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Type 2 Diabetes patients relative to a named comparison population — not inferred.

6
Curated markers
2
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Fantuzzi et al. 2008

DOI: 10.1016/j.jaci.2007.10.018 →
Peer-Reviewed Literature

Sevilla-Gonzalez et al. 2025

DOI: 10.1038/s41467-025-57452-y →
Peer-Reviewed Literature

Smushkin et al. 2010

DOI: 10.1016/j.mpmed.2010.08.008 →
Peer-Reviewed Literature

Arif et al. 2024

DOI: 10.6026/973206300200202 →
Peer-Reviewed Literature

Pellegrini et al. 2024

DOI: 10.3390/cells13191662 →
Peer-Reviewed Literature

Nelson et al. 2018

DOI: 10.1016/j.ccl.2017.12.005 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Part of the Open Source Medicine Foundation Network

Open Source Medicine Foundation The OSMF hub — advancing open-source biomedical research infrastructure, tools, and evidence synthesis.
SpikeProtein.site Database and research resource on SARS-CoV-2 spike protein biology, persistence, and clinical implications.
Vaccine Data Navigator Open-access navigation tool for vaccine adverse event reporting and surveillance data.
PACVS Research Summit Annual summit convening researchers, clinicians, and patients on PACVS science.