Summary
Elasomeran has reached the approved stage (maximum clinical phase 4) for at least one indication, so its use in Long COVID / Post-Acute COVID Sequelae (PACVS) would be drug repurposing rather than first-in-human development. This does not mean it is approved for Long COVID / Post-Acute COVID Sequelae (PACVS). ClinicalTrials.gov lists 1 registered trial linking Elasomeran to Long COVID / Post-Acute COVID Sequelae (PACVS): 1 has completed. The most advanced is Phase 2 (NCT05077254). It plans or enrolled 48 participants. Registered activity dates to 2021. No published literature item is linked to Elasomeran and Long COVID / Post-Acute COVID Sequelae (PACVS) in the OSMF database yet, so the record rests on registry entries alone. Registry entries describe intent to study, not outcomes.
The RepurpOS disease-intelligence file for Post-Acute COVID/Vaccination Syndrome ranks 675 candidate therapeutics from Open Targets, ChEMBL, DGIdb and PubMed; only a minority carry direct clinical evidence, and this page covers one of those. Spontaneous remission context recorded for the condition: Spontaneous resolution at 12 months: ~50-70% of patients; persistent symptoms at 2 years in 30-50%; severely debilitating long COVID in 10-15% at 1 year without intervention.
Evidence table
| Evidence tier | A · Strong |
|---|---|
| Evidence score | 23.5 (trials 3.5, literature 0.0, tier 15, approved bonus 5.0) |
| Registered trials | 1 total: 0 recruiting, 0 active / not yet recruiting, 1 completed, 0 other |
| Linked publications | 0 |
| Agent type | Drug (Small molecule) |
| Development stage (any indication) | Approved |
| Mechanism / class | Not recorded |
| Data sources | Open Targets, ChEMBL |
How the evidence score is calculated
- Each registered trial scores by status (recruiting / active / enrolling 3, completed 2.5, not yet recruiting 2, unknown 1, terminated / withdrawn / suspended 0.5) plus a phase bonus (phase 3-4 +2, phase 2 +1, phase 1 +0.5). The trial component is capped at 30.
- Each literature item scores by design (Cochrane review 5, meta-analysis 4, systematic review 3, RCT 3, clinical trial publication 2, curated reference 1.5, other PubMed record 1). The literature component is capped at 30.
- The existing evidence tier adds 15 (A / Strong), 10 (B / Moderate), 5 (C / Preliminary) or 0 (D / Anecdotal).
- Agents approved for any indication (max clinical phase 4) add 5, because an approved agent has an established safety profile that lowers the barrier to repurposing trials.
- The score ranks what has been studied, not what works. It does not read effect sizes or directions of effect.
Registered clinical trials
| NCT ID | Title | Status | Phase | Enrolment |
|---|---|---|---|---|
| NCT05077254 | COVID Protection After Transplant-Immunosuppression Reduction 2021 | completed | Phase 2 | 48 |
Published literature
No publication is linked to this pair yet.
Mechanism and notes
No mechanism of action is recorded for this pair in the source databases.
OSMF's existing evidence tier for this pair is A (Strong), derived from the strength of the disease association recorded in Open Targets and ChEMBL. The tier describes how well the drug-disease link is documented, not how well the drug works.
Frequently asked questions
Is Elasomeran approved for Long COVID / Post-Acute COVID Sequelae (PACVS)?
Elasomeran has reached the approved stage (maximum clinical phase 4) for at least one indication, so its use in Long COVID / Post-Acute COVID Sequelae (PACVS) would be drug repurposing rather than first-in-human development. This does not mean it is approved for Long COVID / Post-Acute COVID Sequelae (PACVS). Approval status for the specific indication should always be confirmed with the relevant regulator and prescribing information.
Is Elasomeran in clinical trials for Long COVID / Post-Acute COVID Sequelae (PACVS)?
ClinicalTrials.gov lists 1 registered trial linking Elasomeran to Long COVID / Post-Acute COVID Sequelae (PACVS): 1 has completed. The most advanced is Phase 2 (NCT05077254). It plans or enrolled 48 participants. Registered activity dates to 2021.
What does the evidence show for Elasomeran in Long COVID / Post-Acute COVID Sequelae (PACVS)?
Elasomeran has 1 completed registered trial for Long COVID / Post-Acute COVID Sequelae (PACVS) but no linked publication, which usually means results are unpublished, pending, or not yet matched to this record. OSMF's existing evidence tier for this pair is A (Strong), derived from the strength of the disease association recorded in Open Targets and ChEMBL. The tier describes how well the drug-disease link is documented, not how well the drug works.
Cite this page
Data: ClinicalTrials.gov, PubMed, Open Targets, ChEMBL, DGIdb and the OSMF therapeutic agent database. Last updated 2026-07-05. Page built 2026-10-07.