Disease × agent evidence record

Creatine for Long COVID / Post-Acute COVID Sequelae (PACVS): evidence, trials and status

Synthesis-level literature links Creatine to Long COVID / Post-Acute COVID Sequelae (PACVS), but no registered trial in this database tests the pair, so the evidence is observational, pooled from other indications, or pre-dates registry practice.

0 registered trials 0 recruiting 14 publications Evidence tier C · Preliminary Score 35.0
Research Tracker › Pairs › Long COVID / Post-Acute COVID Sequelae (PACVS) › Creatine
Research map, not treatment advice. This page aggregates registry and literature records. It does not evaluate efficacy, dosing or safety for any individual. Discuss any treatment decision with a qualified clinician.

Summary

Creatine has reached Preclinical as its most advanced recorded development stage across any indication, and the database holds no approval for Long COVID / Post-Acute COVID Sequelae (PACVS). No registered clinical trial in this database tests Creatine specifically in Long COVID / Post-Acute COVID Sequelae (PACVS). The evidence below comes from published literature only, so any clinical signal has not yet been tested prospectively against this condition in a registered study. The literature layer holds 14 publications for this pair: 5 Cochrane reviews, 3 meta-analyses, 1 systematic review and 5 clinical trial publications. Publication years run from 2021 to 2026. Because at least one synthesis-level source exists (systematic review, meta-analysis or Cochrane review), this pair has been assessed beyond single studies, although the synthesis may concern a different indication.

The RepurpOS disease-intelligence file for Post-Acute COVID/Vaccination Syndrome ranks 675 candidate therapeutics from Open Targets, ChEMBL, DGIdb and PubMed; only a minority carry direct clinical evidence, and this page covers one of those. Spontaneous remission context recorded for the condition: Spontaneous resolution at 12 months: ~50-70% of patients; persistent symptoms at 2 years in 30-50%; severely debilitating long COVID in 10-15% at 1 year without intervention.

Open in Repurposing ExplorerAgent page: CreatineLong COVID / Post-Acute COVID Sequelae (PACVS) hubLong COVID / Post-Acute COVID Sequelae (PACVS) biomarkers & interventionsOSMF ReviewCitation

Evidence table

Evidence tierC · Preliminary
Evidence score35.0 (trials 0.0, literature 30.0, tier 5, approved bonus 0.0)
Registered trials0 total: 0 recruiting, 0 active / not yet recruiting, 0 completed, 0 other
Linked publications14 (5 Cochrane reviews, 5 clinical trial publications, 3 meta-analyses, 1 systematic review)
Agent typeSupplement
Development stage (any indication)Preclinical
Mechanism / classMetabolic modulation as a therapeutic strategy for post-acute vaccination syndrome (PACVS) · Halma M, Varon J · 2025
Data sourcesOSMF Chronic Disease Review
How the evidence score is calculated
  • Each registered trial scores by status (recruiting / active / enrolling 3, completed 2.5, not yet recruiting 2, unknown 1, terminated / withdrawn / suspended 0.5) plus a phase bonus (phase 3-4 +2, phase 2 +1, phase 1 +0.5). The trial component is capped at 30.
  • Each literature item scores by design (Cochrane review 5, meta-analysis 4, systematic review 3, RCT 3, clinical trial publication 2, curated reference 1.5, other PubMed record 1). The literature component is capped at 30.
  • The existing evidence tier adds 15 (A / Strong), 10 (B / Moderate), 5 (C / Preliminary) or 0 (D / Anecdotal).
  • Agents approved for any indication (max clinical phase 4) add 5, because an approved agent has an established safety profile that lowers the barrier to repurposing trials.
  • The score ranks what has been studied, not what works. It does not read effect sizes or directions of effect.

Registered clinical trials

No registered trial links Creatine to Long COVID / Post-Acute COVID Sequelae (PACVS) in the current OSMF trial extract.

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Published literature

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Mechanism and notes

Recorded mechanism or class: Metabolic modulation as a therapeutic strategy for post-acute vaccination syndrome (PACVS) · Halma M, Varon J · 2025.

OSMF's existing evidence tier for this pair is C (Preliminary), derived from the strength of the disease association recorded in OSMF Chronic Disease Review. The tier describes how well the drug-disease link is documented, not how well the drug works.

Frequently asked questions

Is Creatine approved for Long COVID / Post-Acute COVID Sequelae (PACVS)?

Creatine has reached Preclinical as its most advanced recorded development stage across any indication, and the database holds no approval for Long COVID / Post-Acute COVID Sequelae (PACVS). Approval status for the specific indication should always be confirmed with the relevant regulator and prescribing information.

Is Creatine in clinical trials for Long COVID / Post-Acute COVID Sequelae (PACVS)?

No registered clinical trial in this database tests Creatine specifically in Long COVID / Post-Acute COVID Sequelae (PACVS). The evidence below comes from published literature only, so any clinical signal has not yet been tested prospectively against this condition in a registered study.

What does the evidence show for Creatine in Long COVID / Post-Acute COVID Sequelae (PACVS)?

Synthesis-level literature links Creatine to Long COVID / Post-Acute COVID Sequelae (PACVS), but no registered trial in this database tests the pair, so the evidence is observational, pooled from other indications, or pre-dates registry practice. OSMF's existing evidence tier for this pair is C (Preliminary), derived from the strength of the disease association recorded in OSMF Chronic Disease Review. The tier describes how well the drug-disease link is documented, not how well the drug works.

Cite this page

Open Source Medicine Foundation. Creatine for Long COVID / Post-Acute COVID Sequelae (PACVS): evidence, trials and status. OSMF Research Tracker. Updated 2026-07-05. https://research.opensourcemed.info/pairs/post-acute-covidvaccination-syndrome/creatine.html

Data: ClinicalTrials.gov, PubMed, Open Targets, ChEMBL, DGIdb and the OSMF therapeutic agent database. Last updated 2026-07-05. Page built 2026-10-07.

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This is a research map, not treatment advice. Evidence tiers and scores summarise what has been studied, not whether a treatment works or is safe for you.