Disease × agent pairs

ME/CFS: candidate agents with evidence

191 agents linked to Myalgic Encephalomyelitis / Chronic Fatigue Syndrome by at least one registered trial or two publications, ranked by the OSMF evidence score. Not treatment advice.

Research Tracker › Pairs › ME/CFS

Conventional Exercise

Behavioural · tier C · 1 trials (0 recruiting) · 45 publications · score 38.0

Mindful And Conscious Movement-Based Exercise

Behavioural · tier C · 1 trials (0 recruiting) · 45 publications · score 38.0

Physical Training Program

Behavioural · tier C · 1 trials (1 recruiting) · 45 publications · score 38.0

Amygdala Retraining Program

Other · tier C · 1 trials (0 recruiting) · 45 publications · score 37.5

Integrative Rehabilitation Program

Behavioural · tier C · 1 trials (0 recruiting) · 45 publications · score 37.5

Resilience Building Exercises

Behavioural · tier C · 1 trials (0 recruiting) · 45 publications · score 37.5

Telerehabilitation Program Based On Cardiorespiratory Principles

Behavioural · tier C · 1 trials (0 recruiting) · 45 publications · score 37.5

Acupuncture.

Behavioural · tier C · 1 trials (0 recruiting) · 24 publications · score 31.0

N-Acetylcysteine (NAC)

Behavioural · tier B · 3 trials (0 recruiting) · 8 publications · score 28.0

Rituximab

Behavioural · tier B · 5 trials (1 recruiting) · 0 publications · score 27.0

Active Transcutaneous Vns

Behavioural · tier C · 1 trials (1 recruiting) · 17 publications · score 25.0

Transcutaneous Vagus Nerve Stimulation

Device · tier C · 1 trials (0 recruiting) · 17 publications · score 25.0

Transcutaneous Non-Invasive Vagus Nerve Stimulation

Device · tier C · 1 trials (0 recruiting) · 17 publications · score 24.5

Processing Speed Training

Behavioural · tier C · 1 trials (1 recruiting) · 15 publications · score 23.0

Reaction Time Training

Behavioural · tier C · 1 trials (1 recruiting) · 15 publications · score 23.0

Intravenous Immunoglobulin (IVIG)

Behavioural · tier B · 0 trials (0 recruiting) · 8 publications · score 22.0

Fluvoxamine

Drug · tier B · 1 trials (0 recruiting) · 6 publications · score 20.5

Coenzyme Q10 (CoQ10)

Behavioural · tier C · 3 trials (0 recruiting) · 4 publications · score 19.5

Sodium Oxybate

Other · tier B · 3 trials (0 recruiting) · 0 publications · score 19.5

Clonidine

Behavioural · tier C · 2 trials (0 recruiting) · 8 publications · score 19.0

Metformin

Drug · tier B · 1 trials (0 recruiting) · 3 publications · score 19.0

Low-Dose Naltrexone (LDN)

Drug · tier C · 2 trials (1 recruiting) · 3 publications · score 16.5

Hyperbaric Oxygen Therapy (HBOT)

Behavioural · tier B · 1 trials (1 recruiting) · 2 publications · score 16.0

Ampligen

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Anakinra

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 14.5

Cognitive Behavioural Therapy

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Compound Ciwujia Granules, Guipi Granules

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Gcjbp Laennec Inj.

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Lisdexamfetamine Dimesylate

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Pyridostigmine

Other · tier C · 1 trials (1 recruiting) · 5 publications · score 14.5

Sildenafil

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Solriamfetol Oral Tablet [Sunosi]

Other · tier B · 1 trials (0 recruiting) · 0 publications · score 14.5

Conventional Physiotherapy

Behavioural · tier C · 1 trials (1 recruiting) · 6 publications · score 14.0

Home-Based Transcranial Direct Current Stimulation

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 14.0

Photobiomodulation

Other · tier C · 1 trials (1 recruiting) · 6 publications · score 14.0

Wearable Device

Behavioural · tier C · 1 trials (1 recruiting) · 6 publications · score 14.0

Inspiratory Muscle Training

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 13.5

Manual Therapy

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 13.5

Mental Training

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 13.5

Recovery Factors

Other · tier C · 2 trials (0 recruiting) · 3 publications · score 13.0

Dietary Supplements

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 12.5

Pyridostigmine Bromide

Behavioural · tier C · 1 trials (0 recruiting) · 4 publications · score 12.5

Photobiomodulation Therapy

Other · tier C · 1 trials (0 recruiting) · 6 publications · score 12.0

Lactose Capsula

Behavioural · tier C · 1 trials (0 recruiting) · 3 publications · score 11.5

In-Session Instrumental Activities Of Daily Living Training

Behavioural · tier C · 1 trials (1 recruiting) · 3 publications · score 11.0

Acceptance And Commitment Therapy

Other · tier C · 1 trials (0 recruiting) · 3 publications · score 10.5

Fermented Velvet Antler Extract

Behavioural · tier C · 1 trials (0 recruiting) · 3 publications · score 10.5

Hydrogen Water

Other · tier C · 3 trials (0 recruiting) · 0 publications · score 10.0

Lumbrokinase

Other · tier C · 1 trials (1 recruiting) · 1 publications · score 10.0

Floradapt Intensive Gi

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 9.0

Lingzhi Capsule

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 9.0

Vericiguat Oral Tablet

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 9.0

Cyclophosphamide

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Dpa-714 Pet/Mri

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.5

Duloxetine

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Melatonin Plus Zinc

Supplement · tier C · 2 trials (0 recruiting) · 0 publications · score 8.5

Nortriptyline

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Pacing

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Physical Effort Stimulation

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.5

Preprocessed Thawed Autologous Fmt

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Preprocessed Thawed Donor Fmt

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Relaxation Therapy

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Self-Administered Acupressure

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.5

Thermal Pain Stimulation

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.5

A 3-Day Course

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Acceptance Commitment Therapy For Chronic Fatigue

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Apa Program

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Autonomic Function Testing

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Bupivacaine Injection

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Cognitive Behavioral Therapy

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Creatine

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Ct38

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Dynamic Neural Retraining System

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

E-Cograt

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Exercise Test On Ergocycle

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Extension For Community Healthcare Outcomes

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Follow Up Phone Calls

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Hydrogen Water Which Is Prepared From An Otc Supplement.

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

In-Session Brain Health Training

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Inebilizumab

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Ketamine

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

L-Nmma Trimethaphan

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Methyldopa

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Micro Breaks In Everyday Life For Chronic Fatigue

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Midazolam

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Molecular Hydrogen Produced By A Metallic Magnesium Tablet, Consumed 3X A Day Dissolved In Water. Treatment Duration Is 16 Weeks.

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Multicomponent Treatment

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Near Infrared Spectroscopy

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Nesa X-Signal

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Online Visit

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Probiotics

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Saline Infusions

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Trans-Auricular Vagus Nerve Stimulation: High Intensity

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Trans-Auricular Vagus Nerve Stimulation: Low Intensity

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Transcutaneous Vagus Nerve Stimulator

Device · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Transfer Package

Behavioural · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Valganciclovir

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 8.0

Waiting List

Other · tier C · 1 trials (1 recruiting) · 0 publications · score 8.0

Active

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Acupressure

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Acupressure Treatment.

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Asarm

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Biopsychological Intervention

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Bright Light Therapy

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Cardiopulmonary Exercise Test

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Cbt

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Cognitive-Behavioral Self-Management

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Experimental: Nutrilite® High Dose

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Experimental: Nutrilite® Low Dose

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Faecal Transplantation

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Fitnet Treatment

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Fmg

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Graded Dobutamine Infusions

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Graded Phenylephrine Injections

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Guanidinoacetic Acid

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Gutmagnific™ H.

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Gutmagnific™ L.

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Hg

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Immunoadsorption

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Intervention Group

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Journaling

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Medical Food - Anhydrous Enol-Oxaloacetate

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Mental Stress Test

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Movement To Rhythm

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Nasal Cpap Treatment During Sleep

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Patient-Partner Videotelephone-Delivered Cognitive Behavioral Stress Management Intervention

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Patient-Partner Videotelephone-Delivered Health Information

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Phosphoserine Plus Vitamin C

Supplement · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Posture Study, Autonomic Function Tests, And A Stress Test

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Psychosocial Challenge Involving Socioevaluative Public Speaking

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Reiki

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Ribose

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Saline Infusion

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Seasonal Influenza Vaccination

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Submaximal Bicycle Exercise Stress Test On Days 1 And 2

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Symptom Monitoring

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Two-Day Cardiopulmonary Exercise Test

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.5

Intermittent Hypoxia-Hyperoxia Treatment

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.0

Methyl-P Plus Nutrient Formula

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 7.0

Moxibustion

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 7.0

Applied Relaxation

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Clinical Yoga

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Combined Treatment: Heart Rhythm Biofeedback Plus Hydrogen Water

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Comprehensive Theocentric Psychological Assessment

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Decompartmentalization Framework

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Droxidopa

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Etanercept

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Gradual Movement Therapy In The Ward

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Heart Rhythm Biofeedback

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Independent Walking Training

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Iodocarb

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Liquid Herbal Tinctures

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Mental Imagery

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Normal Saline

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Nutraceutical Supplements

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Oral Rehydration Solution

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Pain Relaxation Techniques

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Pg2

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Pregabalin

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Psychotherapy

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

Telerehabilitation

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.5

[Zr-89]Oxine-Labeled Leukocytes Pet/Mri

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Actigraphy

Other · tier C · 2 trials (0 recruiting) · 0 publications · score 6.0

Active Kinetic Oscillation Stimulation

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Bioarginina C

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Blood Test

Other · tier C · 2 trials (0 recruiting) · 0 publications · score 6.0

Case Formulation With Web-Program

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Citalopram

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Common Moxa-Stick Moxibustion

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Delayed Cbt

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Immediate Cbt

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Interdisciplinary Complex Intervention

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Isomaltose And Magnesium Stearate

Supplement · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Maximal Effort Test

Other · tier C · 2 trials (0 recruiting) · 0 publications · score 6.0

Neuromuscular Evaluation

Other · tier C · 2 trials (0 recruiting) · 0 publications · score 6.0

Red Ginseng Powder Capsule

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Tau + Multicomponent Treatment Virtual Sfcamina

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

The Multi-Domain Tai Chi Digital Therapy Software Application

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Thunder-Fire Moxibustion Therapy

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Treatment As Usual

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Yan Nian Jiu Zhuan Fa

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 6.0

Cycling

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Food Diary

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Health Promoting Dialogue

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Naltrexone Hcl

Drug · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Standard Treatment / Treatment As Usual

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Stool Analysis

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Swimming

Other · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Transcraneal Direct Current Electric Stimulation

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Transcranial Direct Current Electric Stimulation

Behavioural · tier C · 1 trials (0 recruiting) · 0 publications · score 5.5

Hyperbaric

Behavioural · tier D · 0 trials (0 recruiting) · 2 publications · score 3.0

Research map, not treatment advice. Built 2026-10-07.