Peer-Reviewed Literature Synthesis

Epilepsy Biomarker Atlas

Molecular alterations reported in Epilepsy compared to healthy controls, from peer-reviewed literature.

US DALYs429.3KWHO GHE 2021 · all ages
Global DALYs14.37MWHO GHE 2021 · worldwide
US mortality3,951 deaths/yrWHO GHE 2021
Global mortality143.7K deaths/yrWHO GHE 2021 · worldwide
NIH funding$216MFY2025 · RCDC estimate
Funding levelModerate
Spontaneous remission60-85% achieve seizure freedom on medication; of those, 50-75% remain seizure-free after withdrawal (varies by…
Best-intervention remissionNot clearly higher than on-medication rates -- the real gap is behavioral/practice
Gap sizeSmall biological gap; large practice gap
Primary barrierpractice
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Epilepsy patients relative to a named comparison population — not inferred.

10
Curated markers
2
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Vakrinou et al. 2022

DOI: 10.1007/s00415-022-11304-7 →
Peer-Reviewed Literature

Paltrinieri et al. 2017

DOI: 10.1111/vcp.12443 →
Peer-Reviewed Literature

Runtz et al. 2018

DOI: 10.1111/epi.13942 →
Peer-Reviewed Literature

Walker et al. 2022

DOI: 10.1111/epi.17116 →
Peer-Reviewed Literature

Tsuji et al. 2011

DOI: 10.1055/s-0031-1279725 →
Peer-Reviewed Literature

Chatzikonstantinou et al. 2015

DOI: 10.1684/epd.2015.0779 →
Peer-Reviewed Literature

Sung et al. 2024

DOI: 10.1111/jvim.17110 →
Peer-Reviewed Literature

Hanin et al. 2022

DOI: 10.1007/s00415-022-11004-2 →
Peer-Reviewed Literature

Bauer 1996

DOI: 10.1016/0920-1211(96)00009-5 →
Peer-Reviewed Literature

Simani et al. 2020

DOI: 10.1021/acschemneuro.0c00492 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Individual Epilepsy biomarker pages

Each Epilepsy marker has its own page with direction, comparison group, symptoms, test details, citation and FAQ. Browse all marker pages.

Neurological

Other

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Epilepsy Biomarkers: 10 Blood Tests & Lab Markers. Research Tracker. https://research.opensourcemed.info/epilepsy-biomarkers.html (accessed )

Weekly post-viral research digest

New peer-reviewed studies and trial activity across Long COVID, ME/CFS, PACVS, Lyme and Gulf War Illness, every week. Free, no spam.

Subscribe on Substack   Browse the digest archive · RSS