Summary
| Direction in Epilepsy | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Other |
| Compared against | patients without acute inflammatory or infectious CNS diseases |
| Associated symptoms | focal seizures with impaired consciousness, status epilepticus, EEG abnormalities, epileptogenic lesions |
| Test type | Blood test (serum / plasma / whole blood) |
| LOINC code | 2524-7 |
| Source | Chatzikonstantinou et al. 2015 — doi:10.1684/epd.2015.0779 |
| Condition atlas | Epilepsy Biomarker Atlas |
Other conditions where Lactate is reported
- Lactate in Gulf War Illness — ↑ elevated vs HGV
- Lactate in Long COVID — ↑ elevated vs HC
- Lactate (blood) in ME/CFS — ↑ elevated vs HC
See the cross-condition hub: Lactate across conditions.
Related Other markers in Epilepsy
Full list: Epilepsy Biomarker Atlas.
Frequently asked questions
Is Lactate high or low in Epilepsy?
Elevated. Studies summarised in the OSMF atlas report higher Lactate in Epilepsy than in patients without acute inflammatory or infectious CNS diseases. Source: Chatzikonstantinou et al. 2015.
What symptoms is Lactate associated with in Epilepsy?
The cited literature associates this marker with focal seizures with impaired consciousness, status epilepticus, EEG abnormalities, epileptogenic lesions. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Lactate?
It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 2524-7. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Lactate result diagnostic of Epilepsy?
No. No single biomarker is diagnostic of Epilepsy. Lactate findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is Lactate specific to Epilepsy?
No. The same marker is also reported in Gulf War Illness, Long COVID, ME/CFS in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
Cite this page
Subscribe on Substack
Last reviewed: 2026-10-08 · Page generated from epilepsy.json · Browse: Epilepsy atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.