Research Tracker›Biomarker Atlas›Epilepsy›Neuron-Specific Enolase (NSE)

Neuron-Specific Enolase (NSE) in Epilepsy

Neuron-Specific Enolase (NSE), also described as NSE, belongs to the neurological group of Epilepsy markers and is reported to be raised relative to the reference group of the cited comparison (status epilepticus patients vs control patients). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The finding is drawn from Hanin et al. 2022; it describes group-level differences, not a threshold that classifies an individual.

↑ ElevatedNeurological

Summary

Direction in Epilepsy↑ Elevated — higher than in the comparison group
CategoryNeurological
Also described asNSE
Compared againststatus epilepticus patients vs control patients
SourceHanin et al. 2022 — doi:10.1007/s00415-022-11004-2
Condition atlasEpilepsy Biomarker Atlas

Related Neurological markers in Epilepsy

Full list: Epilepsy Biomarker Atlas.

Frequently asked questions

Is Neuron-Specific Enolase (NSE) high or low in Epilepsy?

Elevated. Studies summarised in the OSMF atlas report higher Neuron-Specific Enolase (NSE) in Epilepsy than in the reference group of the cited comparison (status epilepticus patients vs control patients). Source: Hanin et al. 2022.

Which test measures Neuron-Specific Enolase (NSE)?

The atlas record does not list a standardised clinical test code (LOINC) for Neuron-Specific Enolase (NSE), which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal Neuron-Specific Enolase (NSE) result diagnostic of Epilepsy?

No. No single biomarker is diagnostic of Epilepsy. Neuron-Specific Enolase (NSE) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Neuron-Specific Enolase (NSE) in Epilepsy: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/epilepsy/neuron-specific-enolase-nse.html
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Last reviewed: 2026-07-03 · Page generated from epilepsy.json · Browse: Epilepsy atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.