15 June 2026 – 21 June 2026 · published 21 June 2026 · Subscribe
Between 15 June 2026 and 21 June 2026 the tracker indexed 33 new peer-reviewed studies and 5 clinical-trial updates across 8 post-viral and post-infectious conditions.
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
Full feed: ME/CFS research tracker
Chronic fatigue syndrome (CFS) is a syndrome encompassing several systemic diseases. Sijunzi Decoction (SJZD) is a classic formula in traditional Chinese medicine (TCM) for the treatment of spleen deficiency syndrome.
Hormonal dysregulation is increasingly reported in ME/CFS and Long COVID, yet the broader role of neuroendocrine disruption in these conditions remains underexplored. While changes in steroid, peptide, and neuropeptide hormones have been identified, these findings are often considered in isolation and without attention to their timing or integration within broader physiological systems.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem illness marked by fatigue, cognitive impairment, and post-exertional malaise. Gastrointestinal (GI) symptoms are frequently reported, yet their relationship to central features of the illness and biological correlates remains poorly understood.
No abstract available.
Long COVID is a prevalent condition characterised by pain, fatigue, disability, and a multitude of health issues. There are various treatment options for managing long COVID symptoms, including non-pharmacological interventions like physiotherapy and rehabilitation, which can be effectively delivered either in institutional care settings or via telerehabilitation.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, disabling condition with limited evidence-based treatment options. Self-management support is recommended to improve people's coping and quality of life, yet little is known about whether the provided self-management support meet individuals with ME/CFS and their next of kins needs.
Emerging evidence suggests that fatigue caused by accumulated stress may serve as a prodromal symptom of psychiatric disorders, and gut microbiome dysbiosis has been reported in many such conditions. However, little is known about microbial and metabolic signatures associated with fatigue in otherwise healthy individuals.
Fatigue is one of the most common presenting complaints in primary care and poses a significant diagnostic challenge due to its multifactorial aetiology. While the majority of cases are benign and self-limiting, fatigue may also represent an early manifestation of serious underlying pathology.
Full feed: Gulf War Illness research tracker
U.S. military veterans deployed to the Persian Gulf to serve in the 1990-1991 Gulf War (GWVs) have expressed concerns about potential increased risk of experiencing adverse COVID-related health outcomes given broad near-unique exposure to multiple diverse toxic agents during deployment and ongoing ~30% prevalence of Gulf War Illness (GWI+), a chronic, medically unexplained multi-symptom disorder associated with...
Full feed: POTS research tracker
Superior mesenteric artery (SMA) syndrome is a rare cause of proximal intestinal obstruction resulting from compression of the third portion of the duodenum between the aorta and the SMA. It most commonly occurs in slender individuals or those experiencing rapid weight loss, but presentations can be atypical and diagnostically challenging.
Vaccination against high-risk HPV types is a key preventive measure. However, concerns regarding vaccine safety may hinder vaccination efforts.
The combination of neurological, cardiac, and pulmonary disease in patients with systemic sclerosis (SS) is rare. The aim of the study was to report a patient with SS who manifested with migraine without aura, Raynaud's phenomenon, pulmonary hypertension, and postural tachycardia syndrome (POTS), a combination which has not been previously reported.
The diagnosis and management of hypermobility spectrum disorders and hypermobile Ehlers-Danlos syndrome (HSD/hEDS) are a healthcare challenge because of the wide array of symptoms, lack of diagnostic biomarkers, and evolving management guidelines. This study aimed to describe patient experiences, disability, and self-perceived success managing HSD/hEDS, with or without comorbid postural orthostatic tachycardia...
Postural orthostatic tachycardia syndrome (POTS) is a disorder characterized by a sudden onset of orthostatic intolerance upon standing, which may be relieved when lying down. The most common complications associated with POTS are trauma or injury from falling or fainting.
One of the most common complaints in ENT clinics is dizziness. Although most cases are caused by vestibular neuritis and benign paroxysmal positional vertigo (BPPV), a significant number of patients experience non-vestibular dizziness.
Full feed: MCAS research tracker
Controlling bleeding is one of the most fundamental challenges in cardiac surgery. Bleeding is controlled by neutralising heparin with protamine.
Mastocytosis is a neoplasm characterised by clonal proliferation of mast cells (MCs) in the skin and other organs, including the heart, and symptoms produced by MC-derived mediators. MC activation syndrome (MCAS) relates to increased and inappropriate activation of MCs without clonal proliferation.
Historically, Elaeocarpus sylvestris has served as a traditional medicinal agent for inflammatory disorders across East Asia. Recent studies have reported its antioxidant and anti-inflammatory activities, supporting its potential as a natural therapeutic resource for inflammatory skin diseases such as atopic dermatitis (AD).
Intestinal fibrosis is a common and serious complication of chronic inflammatory bowel disease (IBD) associated with stricture and obstruction. Although oxidative stress has been associated with IBD, how Duox2, the major source of ROS in gut epithelium, promotes fibrosis remains unknown.
Most pathophysiologically oriented anaphylaxis reviews list a plethora of mediators purportedly involved in symptom development during severe anaphylaxis. However, how many mediators are responsible for life-threatening anaphylaxis symptoms?
Phthalates are endocrine disruptors that alter the homeostasis of hormone-dependent organs. Perinatal exposure to endocrine disruptors can program different organs and promote morphological and metabolic alterations, increasing susceptibility to diseases later in life, as proposed by the Developmental Origins of Health and Disease (DOHaD) hypothesis.
No abstract available.
No abstract available.
Systemic mastocytosis (SM) results from clonal proliferation of mast cells (MC) in extra-cutaneous organs. The major criterion is the presence of multifocal MC clusters in the bone marrow and/or extracutaneous organs.
Kounis syndrome (KS) is an allergy-mediated acute coronary syndrome that is frequently under-recognized and potentially life threatening. A 52-year-old man developed an inferior ST-segment elevation myocardial infarction following a bee swarm attack.
Irritable bowel syndrome is a common disorder associated with substantial impairment in quality of life and remains challenging to manage due to its heterogeneous and incompletely understood pathophysiology leading to high rates of treatment failure. Recent evidence supports the existence of distinct IBS endotypes, including an emerging atopic variant characterised by allergic comorbidities, type 2 inflammation, and...
Harnessing transition metal dichalcogenides (TMDCs) for memristors provides a promising pathway toward high-density data storage and neuromorphic functionalities. Yet the single operation mode and insufficient on/off ratio extremely restrict the ultimate device performance.
Chronic inducible urticarias (CIndUs), including symptomatic dermographism (SD), cholinergic urticaria (CholU) and cold urticaria (ColdU), are mast cell (MC)-driven conditions triggered by subtype-specific, definite and reproducible stimuli. Although often considered self-limiting, these diseases can persist for years and significantly impair quality of life.
Dialyzer-associated anaphylaxis is an uncommon but serious complication of hemodialysis. Although severe anaphylaxis is rare, milder hypersensitivity reactions are likely underrecognized and frequently misattributed to cardiopulmonary or volume-related causes.
Osteoarthritis (OA) is a prevalent degenerative joint disease influenced by both genetic susceptibility and environmental factors. Increasing evidence suggests that exposure to persistent environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), may contribute to OA progression; however, the molecular mechanisms underlying these effects remain unclear.
Pain is a debilitating feature of hemophilia A (HA), yet it remains understudied. We developed models of chronic and acute pain in factor VIII knock-out (FVIIIKO; B6;129S-FVIIItm1Kaz/J), demonstrating characteristic features of hemarthrosis pain and gait.
No new studies this window for: Long COVID, PACVS, Lyme / PTLDS.
ClinicalTrials.gov records whose registry entry was last updated between 15 June 2026 and 21 June 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|---|---|---|---|---|
| NCT06974084 | A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID Long COVID | Not Yet Recruiting | Phase 2 | Maraviroc, Atorvastatin, 10Mg, 20Mg, 40Mg | 2026-06-18 |
| NCT06142253 | Water-based Activity to Enhance Recovery in Long COVID-19 Long COVID | Recruiting | Not applicable | Water+Ct | 2026-06-18 |
| NCT06593600 | Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS) POTS, Other post-viral | Active Not Recruiting | Phase 2 | Regn7544 | 2026-06-17 |
| NCT05967052 | Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation ME/CFS | Terminated | Phase 2 | Pregabalin, Independent Walking Training, Gradual Movement Therapy In The Ward | 2026-06-17 |
| NCT07651371 | Effects of a Physical Rehabilitation Program on Long COVID Long COVID | Completed | Not applicable | Physical Rehabilitation, Treadmill Ergometer, Pulley | 2026-06-16 |
Browse all tracked trials: clinical trials tracker.
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