25 May 2026 – 31 May 2026 · published 31 May 2026 · Subscribe
Between 25 May 2026 and 31 May 2026 the tracker indexed 11 new peer-reviewed studies and 5 clinical-trial updates across 8 post-viral and post-infectious conditions.
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
Full feed: ME/CFS research tracker
Two consecutive cardiopulmonary exercise tests (CPETs) performed 24 hours apart are increasingly used to determine post-exertional malaise (PEM) and disability in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Declines in functional capacity on Day 2 reflect impaired recovery and PEM.
Fatigue, brain fog and post-exertional malaise are major features of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of severe acute respiratory syndrome coronavirus 2. To date, no specific neurotransmitter abnormalities have been found in either condition.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease characterized by a multitude of symptoms across various organ systems. Diagnosis has relied heavily on heterogeneous clinical symptom presentation and evolving case definitions, with treatment focused on addressing presenting symptoms due to the paucity of validated biomarkers.
Functional somatic syndromes frequently co-occur with internalizing disorders such as anxiety disorders and major depressive disorder. Both show familial associations with immune-mediated diseases.
Human endogenous retroviruses (HERVs) are potential driving forces of the pathophysiology of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), linking post-infectious immune dysfunction to chronic inflammation and immune and neurocognitive dysfunction that are hallmark features of ME/CFS. Accumulating evidence from related autoimmune diseases and cancers has shown that reactivated HERVs can contribute to...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long Coronavirus Disease 2019 (long COVID) are complex chronic conditions that often follow infectious triggers with overlapping clinical features but poorly defined pathophysiological relationships. This study aimed to identify disease-specific immune signatures through multiparameter immunophenotyping of monocytes, dendritic cells, and T cell subsets.
Full feed: POTS research tracker
Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia characterized by an excessive increase in heart rate upon standing, in the absence of orthostatic hypotension. Post-infectious forms, particularly following SARS-CoV-2 infection, have been increasingly reported.
No abstract available.
Postural Orthostatic Tachycardia Syndrome (POTS), an autonomic nervous system dysfunction, is frequently associated with ocular symptoms including pain and dryness. This study aimed to characterize ocular surface findings in POTS patients to clarify whether these symptoms reflect classic dry eye disease or altered sensory processing related to autonomic dysfunction.
Postural orthostatic tachycardia syndrome (POTS) is increasingly recognized after SARS-CoV-2 infection. We compared autonomic phenotype, functional impact, and circulating immune markers in POTS, postacute sequelae of COVID-19 (PASC), and healthy controls.
No new studies this window for: Long COVID, PACVS, Lyme / PTLDS, Gulf War Illness, MCAS.
ClinicalTrials.gov records whose registry entry was last updated between 25 May 2026 and 31 May 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|---|---|---|---|---|
| NCT06847191 | NE3107 in Adults With Neurological Symptoms of Long COVID Long COVID | Active Not Recruiting | Phase 2 | Ne3107 | 2026-05-29 |
| NCT05676008 | A Study of Positive Emotions With Long COVID-19 Long COVID | Active Not Recruiting | Not applicable | Microdosing Of Mindfulness | 2026-05-29 |
| NCT07559994 | Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain Long COVID | Active Not Recruiting | Not applicable | Coronary Functional Test | 2026-05-28 |
| NCT06721949 | Taurine Supplementation in Long COVID Long COVID | Recruiting | Phase 2 | Taurine | 2026-05-27 |
| NCT05705193 | Brain-Training Treatment for Long COVID in Older Adults Long COVID | Active Not Recruiting | Not applicable | Neuroflex | 2026-05-26 |
Browse all tracked trials: clinical trials tracker.
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