Between 18 May 2026 and 24 May 2026 the tracker indexed 17 new peer-reviewed studies and 8 clinical-trial updates across 8 post-viral and post-infectious conditions.
By the numbers
17new studies this issue
8trial updates this issue
544studies currently in the feeds
620clinical trials tracked
546biomarkers catalogued
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
New studies by condition
ME/CFS 9 new
Full feed: ME/CFS research tracker
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic illness, commonly associated with dysregulation of the immune system including reduced cytotoxicity of natural killer (NK) cells and post-exertional neuroimmune exhaustion. Previously, transient receptor potential melastatin 3 (TRPM3) ion channel impairment associated with reduced Ca Fluorescence live-cell imaging was used to investigate...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem illness marked by post-exertional malaise (PEM), cognitive dysfunction, autonomic disturbance, and impaired physiological resilience. Historically, the absence of validated biomarkers, heterogeneous definitions, and limited investigative capacity have complicated mechanistic interpretation and contributed to the use of psychosocial...
Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide. This report describes a rare case of herpes infection, secondary to RA, that emerged after coronavirus disease 2019 (COVID-19) infection or vaccination.
The global coronavirus pandemic has led to a quiet wave of a chronic illness referred to as 'Long/Post Covid-19 syndrome' (LC) which bears a notable resemblance to functional-somatic or 'fibromyalgia-type' syndromes, and whose pathophysiology is undetermined. The lack of effective therapies for LC is straining healthcare systems worldwide and causing widespread public health and socioeconomic concerns.
Somatic symptoms of common persistent somatic symptom (PSS) syndromes like irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and fibromyalgia (FM) are not fully attributed to well-established biomedical pathological processes. These syndromes are often under-recognized and diagnosis is often delayed.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex neuroimmunological disorder characterized by disabling symptoms that are often difficult to manage. More recently, in the context of SARS-CoV-2 infection, potential pathophysiological overlaps and disease modulation have been hypothesized.
No abstract available.
This study aims to characterize the burden and distinct patterns of chronic overlapping pain conditions (COPCs) multimorbidity in adults with autoimmune rheumatic diseases (ARDs). We analyzed 2008 to 2021 data from the Merative MarketScan Commercial Claims and Encounters Database, identifying 149,742 patients with ARDs (ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, Sjögren disease, systemic...
Infection-associated chronic illnesses (IACIs) encompass a spectrum of poorly understood syndromes often marked by significant neurologic and multisystem symptoms following an infectious event. This review focuses on several diseases representative of the IACI spectrum.
Postural Orthostatic Tachycardia Syndrome (POTS) 4 new
Full feed: POTS research tracker
Tilt table testing is commonly used to evaluate orthostatic intolerance and syncope and is typically performed with three-lead electrocardiography (ECG) monitoring, which limits P-wave interpretation. A 21-year-old woman with congenitally corrected transposition of the great arteries presented with recurrent tachy-palpitations and near syncope and was presumed to have postural tachycardia syndrome (POTS) after...
Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS.
Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily affects female patients. There are scarce data evaluating the long-term outcomes in POTS.
Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder associated with debilitating symptoms. No medications have been approved for treatment, and patients commonly use off-label medications to treat symptoms.
Other post-viral and post-infectious syndromes 4 new
Full feed: Other post-viral research tracker
Chikungunya virus infection is typically a self limiting febrile illness; however, rare cases may trigger severe immune dysregulation. We report an elderly man who developed secondary hemophagocytic lymphohistiocytosis following confirmed chikungunya infection.
To analyse the spectrum of biopsy-proven glomerulonephritis and associated demographic and clinical characteristics in patients undergoing ultrasound-guided renal biopsy. The prospective, cross-sectional, descriptive study was conducted at the Department of Nephrology, Ayub Teaching Hospital, Abbottabad, Pakistan, from April 5, 2023, to December 30, 2024, and comprised adult patients with biopsy-proven...
Post-dengue fatigue syndrome is a debilitating long-term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post-dengue depression complicate differentiation.
Influenza virus A (H1N1) can lead to acute respiratory infection, while Guillain-Barré Syndrome (GBS) is an autoimmune peripheral neuropathy, which can work as a post-infectious disease. There are clinical observations showing the existence of a possible relationship between the presence of H1N1 infection and GBS disease, and therefore there could be common immunopathological pathways associated with H1N1 infection...
No new studies this window for: Long COVID, PACVS, Lyme / PTLDS, Gulf War Illness, MCAS.
Trial activity
ClinicalTrials.gov records whose registry entry was last updated between 18 May 2026 and 24 May 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.
| NCT | Trial | Status | Phase | Agents | Updated |
|---|
| NCT07317401 | Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment ME/CFS | Not Yet Recruiting | Not applicable | Intermittent Hypoxia-Hyperoxia Treatment | 2026-05-22 |
| NCT07076862 | Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC) Long COVID | Recruiting | Early phase 1 | A.1 - [¹⁸F]F-Arag Pet/Ct, A.2 - [¹⁸F]F-Arag Pet/Ct, B.1 - [¹⁸F]F-Arag Pet/Ct | 2026-05-22 |
| NCT05747534 | AT1001 for the Treatment of Long COVID Long COVID | Active Not Recruiting | Phase 2 | Larazotide Acetate | 2026-05-22 |
| NCT07600320 | Fareon Open Label Device Clinical Trial Other post-viral | Not Yet Recruiting | Not applicable | Fareon Device | 2026-05-20 |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction Long COVID | Not Yet Recruiting | Phase 2 | Valacyclovir, Celecoxib, Paxlovid (Nirmatrelvir/Ritonavir) | 2026-05-19 |
| NCT07224490 | Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease Long COVID | Recruiting | Phase 1 | Kisspeptin 112-121 | 2026-05-19 |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 Long COVID | Recruiting | Phase 3 | Sirolimus (low-dose) | 2026-05-18 |
| NCT05699538 | Fatigability in Long COVID-19 Long COVID | Completed | Not applicable | Minimal-Dose Home-Based Resistance Exercise | 2026-05-18 |
Browse all tracked trials: clinical trials tracker.
Cite this issue
Open Source Medicine Foundation. Post-viral research digest, week 21 2026: 17 new studies. Published 24 May 2026. https://research.opensourcemed.info/digest/2026-W21.html
Issues are regenerated from the live tracker data within their week and frozen afterwards; the snapshot behind this page is at data/2026-W21.json.
Disclaimer. This digest is an automated, unreviewed listing of newly indexed PubMed records and ClinicalTrials.gov registry updates compiled by the Open Source Medicine Foundation. Inclusion is not endorsement; abstracts are excerpted verbatim from PubMed and may contain errors. It is not medical advice. Discuss any treatment decision with a qualified clinician.