Weekly digest · ISO week 21

Post-viral research digest, week 21 2026: 17 new studies

18 May 2026 – 24 May 2026 · published 24 May 2026 · Subscribe

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Between 18 May 2026 and 24 May 2026 the tracker indexed 17 new peer-reviewed studies and 8 clinical-trial updates across 8 post-viral and post-infectious conditions.

By the numbers

17new studies this issue
8trial updates this issue
544studies currently in the feeds
620clinical trials tracked
546biomarkers catalogued

Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.

In this issue:

New studies by condition

ME/CFS 9 new

Full feed: ME/CFS research tracker

Deficient TRPM3-linked mitochondrial Ca

BMC immunology · 24 May 2026 · Magawa, Chandi Tabeth, Eaton-Fitch, Natalie, Muraki, Katsuhiko, Marshall-Gradisnik, Sonya PubMed 42177403

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic illness, commonly associated with dysregulation of the immune system including reduced cytotoxicity of natural killer (NK) cells and post-exertional neuroimmune exhaustion. Previously, transient receptor potential melastatin 3 (TRPM3) ion channel impairment associated with reduced Ca Fluorescence live-cell imaging was used to investigate...

Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.

Journal of translational medicine · 23 May 2026 · Watton, Paul, Prusty, Bhupesh K PubMed 42174604

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem illness marked by post-exertional malaise (PEM), cognitive dysfunction, autonomic disturbance, and impaired physiological resilience. Historically, the absence of validated biomarkers, heterogeneous definitions, and limited investigative capacity have complicated mechanistic interpretation and contributed to the use of psychosocial...

Post COVID-19 treated with AstraZeneca vaccine exacerbates arthritis with susceptibility to herpes in an older woman: A case report.

Medicine · 23 May 2026 · Guzman, David Calderon, Brizuela, Norma Osnaya, Herrera, Maribel Ortiz, Peraza, Armando Valenzuela et al. PubMed 42175450

Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide. This report describes a rare case of herpes infection, secondary to RA, that emerged after coronavirus disease 2019 (COVID-19) infection or vaccination.

A systematic scoping review and conceptual analysis of new-onset fibromyalgia manifestations after non-hospitalized COVID-19: empirics, definitions, methodologies, pathophysiology, mapping of literature, and knowledge gaps.

Journal of translational medicine · 23 May 2026 · Plaut, Shiloh PubMed 42174645

The global coronavirus pandemic has led to a quiet wave of a chronic illness referred to as 'Long/Post Covid-19 syndrome' (LC) which bears a notable resemblance to functional-somatic or 'fibromyalgia-type' syndromes, and whose pathophysiology is undetermined. The lack of effective therapies for LC is straining healthcare systems worldwide and causing widespread public health and socioeconomic concerns.

Longitudinal association of mental-health problems with subsequent diagnosis of persistent somatic symptom disorders: A large-scale registry-based observational study in primary care.

General hospital psychiatry · 22 May 2026 · Kitselaar, Willeke M, Hartmann, Lea, Evers, Andrea W M, Numans, Mattijs E PubMed 42167072

Somatic symptoms of common persistent somatic symptom (PSS) syndromes like irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and fibromyalgia (FM) are not fully attributed to well-established biomedical pathological processes. These syndromes are often under-recognized and diagnosis is often delayed.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS-CoV-2 Infection-A Case Report.

Clinical case reports · 20 May 2026 · Ciobanu, Georgiana, Arn, Norbert PubMed 42158223

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex neuroimmunological disorder characterized by disabling symptoms that are often difficult to manage. More recently, in the context of SARS-CoV-2 infection, potential pathophysiological overlaps and disease modulation have been hypothesized.

Phenotypes of Chronic Overlapping Pain Multimorbidity in Rheumatology: A Population-Based Claims Study.

Arthritis care & research · 18 May 2026 · Lu, Di, Cunanan, Kristen, Cragun, James, Vuong, Lauren et al. PubMed 42148468

This study aims to characterize the burden and distinct patterns of chronic overlapping pain conditions (COPCs) multimorbidity in adults with autoimmune rheumatic diseases (ARDs). We analyzed 2008 to 2021 data from the Merative MarketScan Commercial Claims and Encounters Database, identifying 149,742 patients with ARDs (ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, Sjögren disease, systemic...

Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses.also Lyme / PTLDS

Brain : a journal of neurology · 18 May 2026 · Arnaboldi, Paul M, Becker, Jacqueline, Nath, Avindra, Coyle, Patricia K et al. PubMed 42148664

Infection-associated chronic illnesses (IACIs) encompass a spectrum of poorly understood syndromes often marked by significant neurologic and multisystem symptoms following an infectious event. This review focuses on several diseases representative of the IACI spectrum.

Postural Orthostatic Tachycardia Syndrome (POTS) 4 new

Full feed: POTS research tracker

Presumed Postural Tachycardia Syndrome: 12-Lead Electrocardiograms During Tilt Table Testing Unmask an Atrial Tachycardia.

JACC. Case reports · 21 May 2026 · Ramonfaur, Diego, El-Assaad, Iqbal, Mayuga, Kenneth A PubMed 42165488

Tilt table testing is commonly used to evaluate orthostatic intolerance and syncope and is typically performed with three-lead electrocardiography (ECG) monitoring, which limits P-wave interpretation. A 21-year-old woman with congenitally corrected transposition of the great arteries presented with recurrent tachy-palpitations and near syncope and was presumed to have postural tachycardia syndrome (POTS) after...

Gut hormones in POTS and their relation to hemodynamic parameters and gastrointestinal symptoms.

Scientific reports · 20 May 2026 · Tufvesson, Hanna, Roth, Bodil, Johansson, Madeleine, Hamrefors, Viktor et al. PubMed 42156945

Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS.

Other post-viral and post-infectious syndromes 4 new

Full feed: Other post-viral research tracker

A case report of secondary haemophagocytic lymphohistiocytosis following chikungunya virus infection: Insights into post-viral immune dysregulation.

Indian journal of medical microbiology · 21 May 2026 · Bandyopadhyay, Syamasis, Sahu, Arghya, Chandra, Sandip Kumar, Dastidar, Aheli Ghosh et al. PubMed 42162666

Chikungunya virus infection is typically a self limiting febrile illness; however, rare cases may trigger severe immune dysregulation. We report an elderly man who developed secondary hemophagocytic lymphohistiocytosis following confirmed chikungunya infection.

The spectrum of biopsy proven glomerular disease in a tertiary hospital.

JPMA. The Journal of the Pakistan Medical Association · 20 May 2026 · Aziz, Ayesha, Wajid, Lubna PubMed 42160557

To analyse the spectrum of biopsy-proven glomerulonephritis and associated demographic and clinical characteristics in patients undergoing ultrasound-guided renal biopsy. The prospective, cross-sectional, descriptive study was conducted at the Department of Nephrology, Ayub Teaching Hospital, Abbottabad, Pakistan, from April 5, 2023, to December 30, 2024, and comprised adult patients with biopsy-proven...

Post-Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta-Analysis of Associated Factors.

Reviews in medical virology · 20 May 2026 · Condé, Anna, Maillard, Olivier, Rodrigo, Chaturaka, Bertolotti, Antoine et al. PubMed 42160632

Post-dengue fatigue syndrome is a debilitating long-term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post-dengue depression complicate differentiation.

Computational biology exposed a common pathogenic mechanism in influenza A and Guillain-Barré syndrome.

PloS one · 20 May 2026 · Deng, Ye, Tang, Zhongwen, Chen, Qiong, Hu, Xujuan et al. PubMed 42160373

Influenza virus A (H1N1) can lead to acute respiratory infection, while Guillain-Barré Syndrome (GBS) is an autoimmune peripheral neuropathy, which can work as a post-infectious disease. There are clinical observations showing the existence of a possible relationship between the presence of H1N1 infection and GBS disease, and therefore there could be common immunopathological pathways associated with H1N1 infection...

No new studies this window for: Long COVID, PACVS, Lyme / PTLDS, Gulf War Illness, MCAS.

Trial activity

ClinicalTrials.gov records whose registry entry was last updated between 18 May 2026 and 24 May 2026. A registry update can be anything from a status change to an edited contact field; status shown is as of the tracker snapshot.

NCTTrialStatusPhaseAgentsUpdated
NCT07317401Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment
ME/CFS
Not Yet RecruitingNot applicableIntermittent Hypoxia-Hyperoxia Treatment2026-05-22
NCT07076862Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)
Long COVID
RecruitingEarly phase 1A.1 - [¹⁸F]F-Arag Pet/Ct, A.2 - [¹⁸F]F-Arag Pet/Ct, B.1 - [¹⁸F]F-Arag Pet/Ct2026-05-22
NCT05747534AT1001 for the Treatment of Long COVID
Long COVID
Active Not RecruitingPhase 2Larazotide Acetate2026-05-22
NCT07600320Fareon Open Label Device Clinical Trial
Other post-viral
Not Yet RecruitingNot applicableFareon Device2026-05-20
NCT07597902SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
Long COVID
Not Yet RecruitingPhase 2Valacyclovir, Celecoxib, Paxlovid (Nirmatrelvir/Ritonavir)2026-05-19
NCT07224490Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Long COVID
RecruitingPhase 1Kisspeptin 112-1212026-05-19
NCT06960928Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19
Long COVID
RecruitingPhase 3Sirolimus (low-dose)2026-05-18
NCT05699538Fatigability in Long COVID-19
Long COVID
CompletedNot applicableMinimal-Dose Home-Based Resistance Exercise2026-05-18

Browse all tracked trials: clinical trials tracker.

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Cite this issue

Open Source Medicine Foundation. Post-viral research digest, week 21 2026: 17 new studies. Published 24 May 2026. https://research.opensourcemed.info/digest/2026-W21.html

Issues are regenerated from the live tracker data within their week and frozen afterwards; the snapshot behind this page is at data/2026-W21.json.

Disclaimer. This digest is an automated, unreviewed listing of newly indexed PubMed records and ClinicalTrials.gov registry updates compiled by the Open Source Medicine Foundation. Inclusion is not endorsement; abstracts are excerpted verbatim from PubMed and may contain errors. It is not medical advice. Discuss any treatment decision with a qualified clinician.