{ "id": "2026-W21", "year": 2026, "week": 21, "week_monday": "2026-05-18", "week_sunday": "2026-05-24", "asof": "2026-05-24", "window_start": "2026-05-18", "window_end": "2026-05-24", "window_days": 7, "widened": false, "strict_study_count": 17, "strict_trial_count": 8, "study_count": 17, "trial_count": 8, "studies": { "long-covid": [], "me-cfs": [ { "pmid": "42177403", "title": "Deficient TRPM3-linked mitochondrial Ca", "journal": "BMC immunology", "pub_date": "2026-05-24", "authors": "Magawa, Chandi Tabeth, Eaton-Fitch, Natalie, Muraki, Katsuhiko, Marshall-Gradisnik, Sonya", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic illness, commonly associated with dysregulation of the immune system including reduced cytotoxicity of natural killer (NK) cells and post-exertional neuroimmune exhaustion. Previously, transient receptor potential melastatin 3 (TRPM3) ion channel impairment associated with reduced Ca Fluorescence live-cell imaging was used to investigate...", "url": "https://pubmed.ncbi.nlm.nih.gov/42177403/", "also": [] }, { "pmid": "42174604", "title": "Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.", "journal": "Journal of translational medicine", "pub_date": "2026-05-23", "authors": "Watton, Paul, Prusty, Bhupesh K", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem illness marked by post-exertional malaise (PEM), cognitive dysfunction, autonomic disturbance, and impaired physiological resilience. Historically, the absence of validated biomarkers, heterogeneous definitions, and limited investigative capacity have complicated mechanistic interpretation and contributed to the use of psychosocial...", "url": "https://pubmed.ncbi.nlm.nih.gov/42174604/", "also": [] }, { "pmid": "42175450", "title": "Post COVID-19 treated with AstraZeneca vaccine exacerbates arthritis with susceptibility to herpes in an older woman: A case report.", "journal": "Medicine", "pub_date": "2026-05-23", "authors": "Guzman, David Calderon, Brizuela, Norma Osnaya, Herrera, Maribel Ortiz, Peraza, Armando Valenzuela et al.", "excerpt": "Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide. This report describes a rare case of herpes infection, secondary to RA, that emerged after coronavirus disease 2019 (COVID-19) infection or vaccination.", "url": "https://pubmed.ncbi.nlm.nih.gov/42175450/", "also": [] }, { "pmid": "42174645", "title": "A systematic scoping review and conceptual analysis of new-onset fibromyalgia manifestations after non-hospitalized COVID-19: empirics, definitions, methodologies, pathophysiology, mapping of literature, and knowledge gaps.", "journal": "Journal of translational medicine", "pub_date": "2026-05-23", "authors": "Plaut, Shiloh", "excerpt": "The global coronavirus pandemic has led to a quiet wave of a chronic illness referred to as 'Long/Post Covid-19 syndrome' (LC) which bears a notable resemblance to functional-somatic or 'fibromyalgia-type' syndromes, and whose pathophysiology is undetermined. The lack of effective therapies for LC is straining healthcare systems worldwide and causing widespread public health and socioeconomic concerns.", "url": "https://pubmed.ncbi.nlm.nih.gov/42174645/", "also": [] }, { "pmid": "42167072", "title": "Longitudinal association of mental-health problems with subsequent diagnosis of persistent somatic symptom disorders: A large-scale registry-based observational study in primary care.", "journal": "General hospital psychiatry", "pub_date": "2026-05-22", "authors": "Kitselaar, Willeke M, Hartmann, Lea, Evers, Andrea W M, Numans, Mattijs E", "excerpt": "Somatic symptoms of common persistent somatic symptom (PSS) syndromes like irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and fibromyalgia (FM) are not fully attributed to well-established biomedical pathological processes. These syndromes are often under-recognized and diagnosis is often delayed.", "url": "https://pubmed.ncbi.nlm.nih.gov/42167072/", "also": [] }, { "pmid": "42158223", "title": "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS-CoV-2 Infection-A Case Report.", "journal": "Clinical case reports", "pub_date": "2026-05-20", "authors": "Ciobanu, Georgiana, Arn, Norbert", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex neuroimmunological disorder characterized by disabling symptoms that are often difficult to manage. More recently, in the context of SARS-CoV-2 infection, potential pathophysiological overlaps and disease modulation have been hypothesized.", "url": "https://pubmed.ncbi.nlm.nih.gov/42158223/", "also": [] }, { "pmid": "42147023", "title": "Response: Commentary: Cognitive behavioural therapy for the treatment of chronic fatigue syndrome in adults: a short analysis of the meta-analysis.", "journal": "Frontiers in psychiatry", "pub_date": "2026-05-18", "authors": "Kolala, Vivek, La Rosa, Billie, Vangaveti, Venkat, Chen, Kai Yang", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42147023/", "also": [] }, { "pmid": "42148468", "title": "Phenotypes of Chronic Overlapping Pain Multimorbidity in Rheumatology: A Population-Based Claims Study.", "journal": "Arthritis care & research", "pub_date": "2026-05-18", "authors": "Lu, Di, Cunanan, Kristen, Cragun, James, Vuong, Lauren et al.", "excerpt": "This study aims to characterize the burden and distinct patterns of chronic overlapping pain conditions (COPCs) multimorbidity in adults with autoimmune rheumatic diseases (ARDs). We analyzed 2008 to 2021 data from the Merative MarketScan Commercial Claims and Encounters Database, identifying 149,742 patients with ARDs (ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, Sjögren disease, systemic...", "url": "https://pubmed.ncbi.nlm.nih.gov/42148468/", "also": [] }, { "pmid": "42148664", "title": "Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses.", "journal": "Brain : a journal of neurology", "pub_date": "2026-05-18", "authors": "Arnaboldi, Paul M, Becker, Jacqueline, Nath, Avindra, Coyle, Patricia K et al.", "excerpt": "Infection-associated chronic illnesses (IACIs) encompass a spectrum of poorly understood syndromes often marked by significant neurologic and multisystem symptoms following an infectious event. This review focuses on several diseases representative of the IACI spectrum.", "url": "https://pubmed.ncbi.nlm.nih.gov/42148664/", "also": [ "lyme" ] } ], "pacvs": [], "lyme": [], "gulf-war-illness": [], "pots": [ { "pmid": "42165488", "title": "Presumed Postural Tachycardia Syndrome: 12-Lead Electrocardiograms During Tilt Table Testing Unmask an Atrial Tachycardia.", "journal": "JACC. Case reports", "pub_date": "2026-05-21", "authors": "Ramonfaur, Diego, El-Assaad, Iqbal, Mayuga, Kenneth A", "excerpt": "Tilt table testing is commonly used to evaluate orthostatic intolerance and syncope and is typically performed with three-lead electrocardiography (ECG) monitoring, which limits P-wave interpretation. A 21-year-old woman with congenitally corrected transposition of the great arteries presented with recurrent tachy-palpitations and near syncope and was presumed to have postural tachycardia syndrome (POTS) after...", "url": "https://pubmed.ncbi.nlm.nih.gov/42165488/", "also": [] }, { "pmid": "42156945", "title": "Gut hormones in POTS and their relation to hemodynamic parameters and gastrointestinal symptoms.", "journal": "Scientific reports", "pub_date": "2026-05-20", "authors": "Tufvesson, Hanna, Roth, Bodil, Johansson, Madeleine, Hamrefors, Viktor et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS.", "url": "https://pubmed.ncbi.nlm.nih.gov/42156945/", "also": [] }, { "pmid": "42153984", "title": "Long-term outcomes in patients with postural orthostatic tachycardia syndrome with an average follow-up of over 20 years.", "journal": "Journal of internal medicine", "pub_date": "2026-05-19", "authors": "Bourne, Kate M, Gamboa, Alfredo, Black, Bonnie, Hall, Juliette et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily affects female patients. There are scarce data evaluating the long-term outcomes in POTS.", "url": "https://pubmed.ncbi.nlm.nih.gov/42153984/", "also": [] }, { "pmid": "42146286", "title": "Do Medications Actually Help in Patients with Postural Orthostatic Tachycardia Syndrome?: A Qualitative Study.", "journal": "CJC open", "pub_date": "2026-05-18", "authors": "Uppal, Jaiden, Deol, Paras, Giri, Priyanshu, Sheldon, Robert S et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder associated with debilitating symptoms. No medications have been approved for treatment, and patients commonly use off-label medications to treat symptoms.", "url": "https://pubmed.ncbi.nlm.nih.gov/42146286/", "also": [] } ], "mcas": [], "other-post-viral": [ { "pmid": "42162666", "title": "A case report of secondary haemophagocytic lymphohistiocytosis following chikungunya virus infection: Insights into post-viral immune dysregulation.", "journal": "Indian journal of medical microbiology", "pub_date": "2026-05-21", "authors": "Bandyopadhyay, Syamasis, Sahu, Arghya, Chandra, Sandip Kumar, Dastidar, Aheli Ghosh et al.", "excerpt": "Chikungunya virus infection is typically a self limiting febrile illness; however, rare cases may trigger severe immune dysregulation. We report an elderly man who developed secondary hemophagocytic lymphohistiocytosis following confirmed chikungunya infection.", "url": "https://pubmed.ncbi.nlm.nih.gov/42162666/", "also": [] }, { "pmid": "42160557", "title": "The spectrum of biopsy proven glomerular disease in a tertiary hospital.", "journal": "JPMA. The Journal of the Pakistan Medical Association", "pub_date": "2026-05-20", "authors": "Aziz, Ayesha, Wajid, Lubna", "excerpt": "To analyse the spectrum of biopsy-proven glomerulonephritis and associated demographic and clinical characteristics in patients undergoing ultrasound-guided renal biopsy. The prospective, cross-sectional, descriptive study was conducted at the Department of Nephrology, Ayub Teaching Hospital, Abbottabad, Pakistan, from April 5, 2023, to December 30, 2024, and comprised adult patients with biopsy-proven...", "url": "https://pubmed.ncbi.nlm.nih.gov/42160557/", "also": [] }, { "pmid": "42160632", "title": "Post-Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta-Analysis of Associated Factors.", "journal": "Reviews in medical virology", "pub_date": "2026-05-20", "authors": "Condé, Anna, Maillard, Olivier, Rodrigo, Chaturaka, Bertolotti, Antoine et al.", "excerpt": "Post-dengue fatigue syndrome is a debilitating long-term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post-dengue depression complicate differentiation.", "url": "https://pubmed.ncbi.nlm.nih.gov/42160632/", "also": [] }, { "pmid": "42160373", "title": "Computational biology exposed a common pathogenic mechanism in influenza A and Guillain-Barré syndrome.", "journal": "PloS one", "pub_date": "2026-05-20", "authors": "Deng, Ye, Tang, Zhongwen, Chen, Qiong, Hu, Xujuan et al.", "excerpt": "Influenza virus A (H1N1) can lead to acute respiratory infection, while Guillain-Barré Syndrome (GBS) is an autoimmune peripheral neuropathy, which can work as a post-infectious disease. There are clinical observations showing the existence of a possible relationship between the presence of H1N1 infection and GBS disease, and therefore there could be common immunopathological pathways associated with H1N1 infection...", "url": "https://pubmed.ncbi.nlm.nih.gov/42160373/", "also": [] } ] }, "trials": [ { "nct_id": "NCT07317401", "title": "Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-05-22", "start_date": "2026-06-01", "sponsor": "University of Aarhus", "sponsor_type": "OTHER", "agents": [ "Intermittent Hypoxia-Hyperoxia Treatment" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07317401" }, { "nct_id": "NCT07076862", "title": "Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)", "status": "RECRUITING", "phase": "EARLY_PHASE1", "last_updated": "2026-05-22", "start_date": "2025-12-04", "sponsor": "University of California, Davis", "sponsor_type": "OTHER", "agents": [ "A.1 - [¹⁸F]F-Arag Pet/Ct", "A.2 - [¹⁸F]F-Arag Pet/Ct", "B.1 - [¹⁸F]F-Arag Pet/Ct", "B.2 - [¹⁸F]F-Arag Pet/Ct" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07076862" }, { "nct_id": "NCT05747534", "title": "AT1001 for the Treatment of Long COVID", "status": "ACTIVE_NOT_RECRUITING", "phase": "PHASE2", "last_updated": "2026-05-22", "start_date": "2023-05-31", "sponsor": "Massachusetts General Hospital", "sponsor_type": "OTHER", "agents": [ "Larazotide Acetate" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05747534" }, { "nct_id": "NCT07600320", "title": "Fareon Open Label Device Clinical Trial", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-05-20", "start_date": "2026-05-01", "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_type": "OTHER", "agents": [ "Fareon Device" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07600320" }, { "nct_id": "NCT07597902", "title": "SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction", "status": "NOT_YET_RECRUITING", "phase": "PHASE2", "last_updated": "2026-05-19", "start_date": "2026-06-01", "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_type": "OTHER", "agents": [ "Valacyclovir", "Celecoxib", "Paxlovid (Nirmatrelvir/Ritonavir)" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07597902" }, { "nct_id": "NCT07224490", "title": "Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease", "status": "RECRUITING", "phase": "PHASE1", "last_updated": "2026-05-19", "start_date": "2026-03-10", "sponsor": "Stephanie B. Seminara, MD", "sponsor_type": "OTHER", "agents": [ "Kisspeptin 112-121" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07224490" }, { "nct_id": "NCT06960928", "title": "Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19", "status": "RECRUITING", "phase": "PHASE3", "last_updated": "2026-05-18", "start_date": "2025-04-18", "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_type": "OTHER", "agents": [ "Sirolimus (low-dose)" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06960928" }, { "nct_id": "NCT05699538", "title": "Fatigability in Long COVID-19", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-05-18", "start_date": "2023-07-31", "sponsor": "VA Office of Research and Development", "sponsor_type": "FED", "agents": [ "Minimal-Dose Home-Based Resistance Exercise" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05699538" } ], "feed_latest_pub_date": "2026-07-10", "numbers": { "studies_tracked": 544, "trials_tracked": 620, "biomarkers_catalogued": 546, "feeds": 8 }, "feed_updates": { "long-covid": "2026-07-07", "me-cfs": "2026-07-06", "pacvs": "2026-06-25", "lyme": "2026-07-08", "gulf-war-illness": "2026-07-09", "pots": "2026-07-10", "mcas": "2026-07-10", "other-post-viral": "2026-06-25" }, "trials_last_run": "2026-06-26", "generated_at": "2026-10-07T22:29:14+00:00" }