{ "id": "2026-W22", "year": 2026, "week": 22, "week_monday": "2026-05-25", "week_sunday": "2026-05-31", "asof": "2026-05-31", "window_start": "2026-05-25", "window_end": "2026-05-31", "window_days": 7, "widened": false, "strict_study_count": 11, "strict_trial_count": 5, "study_count": 11, "trial_count": 5, "studies": { "long-covid": [], "me-cfs": [ { "pmid": "42212259", "title": "Cardiopulmonary exercise test results do not change over two sequential days in patients with chronic fatigue syndrome.", "journal": "Frontiers in physiology", "pub_date": "2026-05-29", "authors": "Mancini, Donna M, Cook, Dane B, Brunjes, Danielle L, Soto, Tiffany et al.", "excerpt": "Two consecutive cardiopulmonary exercise tests (CPETs) performed 24 hours apart are increasingly used to determine post-exertional malaise (PEM) and disability in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Declines in functional capacity on Day 2 reflect impaired recovery and PEM.", "url": "https://pubmed.ncbi.nlm.nih.gov/42212259/", "also": [] }, { "pmid": "42205163", "title": "Central noradrenergic deficiency in post-infectious chronic fatigue: neurobehavioral correlates.", "journal": "Brain communications", "pub_date": "2026-05-28", "authors": "Aregawi, Lillian, Walitt, Brian, Sullivan, Patti, Norato, Gina et al.", "excerpt": "Fatigue, brain fog and post-exertional malaise are major features of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of severe acute respiratory syndrome coronavirus 2. To date, no specific neurotransmitter abnormalities have been found in either condition.", "url": "https://pubmed.ncbi.nlm.nih.gov/42205163/", "also": [] }, { "pmid": "42196410", "title": "Toward a Molecular Reclassification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Integrating Multi-Omics, Machine Learning, and Precision Medicine.", "journal": "International journal of molecular sciences", "pub_date": "2026-05-27", "authors": "Frank, Joshua, Nesterovitch, Nicole, Movva, Chetana, Klimas, Nancy G et al.", "excerpt": "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease characterized by a multitude of symptoms across various organ systems. Diagnosis has relied heavily on heterogeneous clinical symptom presentation and evolving case definitions, with treatment focused on addressing presenting symptoms due to the paucity of validated biomarkers.", "url": "https://pubmed.ncbi.nlm.nih.gov/42196410/", "also": [] }, { "pmid": "42190845", "title": "Shared genetic risk between functional somatic syndromes, internalizing disorders, and immune-mediated diseases: a twin-sibling study.", "journal": "Brain, behavior, and immunity", "pub_date": "2026-05-27", "authors": "Steen, Olivier D, Ohlsson, Henrik, van Ockenburg, Sonja L, Kendler, Kenneth S et al.", "excerpt": "Functional somatic syndromes frequently co-occur with internalizing disorders such as anxiety disorders and major depressive disorder. Both show familial associations with immune-mediated diseases.", "url": "https://pubmed.ncbi.nlm.nih.gov/42190845/", "also": [] }, { "pmid": "42196290", "title": "Human Endogenous Retroviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Emerging Roles in Pathogenesis, Immunity, Biomarkers and Therapeutics.", "journal": "International journal of molecular sciences", "pub_date": "2026-05-27", "authors": "Perera, Krishani Dinali, Oltra, Elisa, Carding, Simon R", "excerpt": "Human endogenous retroviruses (HERVs) are potential driving forces of the pathophysiology of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), linking post-infectious immune dysfunction to chronic inflammation and immune and neurocognitive dysfunction that are hallmark features of ME/CFS. Accumulating evidence from related autoimmune diseases and cancers has shown that reactivated HERVs can contribute to...", "url": "https://pubmed.ncbi.nlm.nih.gov/42196290/", "also": [ "other-post-viral" ] }, { "pmid": "42196466", "title": "Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in Chronic Fatigue Syndrome and Long COVID.", "journal": "International journal of molecular sciences", "pub_date": "2026-05-27", "authors": "Petrov, Steliyan, Bozhkova, Martina, Ivanovska, Mariya, Kalfova, Teodora et al.", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long Coronavirus Disease 2019 (long COVID) are complex chronic conditions that often follow infectious triggers with overlapping clinical features but poorly defined pathophysiological relationships. This study aimed to identify disease-specific immune signatures through multiparameter immunophenotyping of monocytes, dendritic cells, and T cell subsets.", "url": "https://pubmed.ncbi.nlm.nih.gov/42196466/", "also": [] } ], "pacvs": [], "lyme": [], "gulf-war-illness": [], "pots": [ { "pmid": "42191437", "title": "[Post-COVID postural orthostatic tachycardia syndrome: Documentation of a hyperadrenergic phenotype by comprehensive autonomic testing].", "journal": "Annales de cardiologie et d'angeiologie", "pub_date": "2026-05-27", "authors": "Rahali, Z, El Boussaadani, B, Raissuni, Z", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia characterized by an excessive increase in heart rate upon standing, in the absence of orthostatic hypotension. Post-infectious forms, particularly following SARS-CoV-2 infection, have been increasingly reported.", "url": "https://pubmed.ncbi.nlm.nih.gov/42191437/", "also": [] }, { "pmid": "42191429", "title": "Physiological and clinical comparison of active stand and head-up tilt tests in Postural Orthostatic Tachycardia Syndrome (POTS).", "journal": "Autonomic neuroscience : basic & clinical", "pub_date": "2026-05-27", "authors": "Robbins, N M", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42191429/", "also": [] }, { "pmid": "42183595", "title": "Eye pain and ocular surface characteristics in Postural Orthostatic Tachycardia Syndrome (POTS): The role of autonomic dysfunction.", "journal": "The ocular surface", "pub_date": "2026-05-25", "authors": "Karakus, Sezen, Huang, Jane Jin, Yashar, Meltem, Haile, Meron et al.", "excerpt": "Postural Orthostatic Tachycardia Syndrome (POTS), an autonomic nervous system dysfunction, is frequently associated with ocular symptoms including pain and dryness. This study aimed to characterize ocular surface findings in POTS patients to clarify whether these symptoms reflect classic dry eye disease or altered sensory processing related to autonomic dysfunction.", "url": "https://pubmed.ncbi.nlm.nih.gov/42183595/", "also": [] }, { "pmid": "42179241", "title": "Comparative Analysis of Circulating Cytokines and Adrenergic Autoantibodies in Postural Orthostatic Tachycardia Syndrome, Postacute Sequelae of SARS-CoV-2, and Healthy Controls.", "journal": "Journal of the American Heart Association", "pub_date": "2026-05-25", "authors": "Seeley, Marie-Claire, Gallagher, Celine, Wilson, Gemma, Bailey, Danielle et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is increasingly recognized after SARS-CoV-2 infection. We compared autonomic phenotype, functional impact, and circulating immune markers in POTS, postacute sequelae of COVID-19 (PASC), and healthy controls.", "url": "https://pubmed.ncbi.nlm.nih.gov/42179241/", "also": [] } ], "mcas": [], "other-post-viral": [ { "pmid": "42178759", "title": "Hemi-Chorea in Anti-GQ1b Syndrome: Expanding the Movement Disorder Spectrum.", "journal": "Movement disorders clinical practice", "pub_date": "2026-05-25", "authors": "Gupta, Ashutosh", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42178759/", "also": [] } ] }, "trials": [ { "nct_id": "NCT06847191", "title": "NE3107 in Adults With Neurological Symptoms of Long COVID", "status": "ACTIVE_NOT_RECRUITING", "phase": "PHASE2", "last_updated": "2026-05-29", "start_date": "2025-04-29", "sponsor": "BioVie Inc.", "sponsor_type": "INDUSTRY", "agents": [ "Ne3107" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06847191" }, { "nct_id": "NCT05676008", "title": "A Study of Positive Emotions With Long COVID-19", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-05-29", "start_date": "2023-01-12", "sponsor": "University of California, Davis", "sponsor_type": "OTHER", "agents": [ "Microdosing Of Mindfulness" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05676008" }, { "nct_id": "NCT07559994", "title": "Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-05-28", "start_date": "2021-09-02", "sponsor": "Fundacion Investigacion Interhospitalaria Cardiovascular", "sponsor_type": "OTHER", "agents": [ "Coronary Functional Test" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07559994" }, { "nct_id": "NCT06721949", "title": "Taurine Supplementation in Long COVID", "status": "RECRUITING", "phase": "PHASE2", "last_updated": "2026-05-27", "start_date": "2025-11-18", "sponsor": "University of Alberta", "sponsor_type": "OTHER", "agents": [ "Taurine" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06721949" }, { "nct_id": "NCT05705193", "title": "Brain-Training Treatment for Long COVID in Older Adults", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-05-26", "start_date": "2023-04-07", "sponsor": "UConn Health", "sponsor_type": "OTHER", "agents": [ "Neuroflex" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05705193" } ], "feed_latest_pub_date": "2026-07-10", "numbers": { "studies_tracked": 544, "trials_tracked": 620, "biomarkers_catalogued": 546, "feeds": 8 }, "feed_updates": { "long-covid": "2026-07-07", "me-cfs": "2026-07-06", "pacvs": "2026-06-25", "lyme": "2026-07-08", "gulf-war-illness": "2026-07-09", "pots": "2026-07-10", "mcas": "2026-07-10", "other-post-viral": "2026-06-25" }, "trials_last_run": "2026-06-26", "generated_at": "2026-10-07T22:29:14+00:00" }