Summary
| Direction in PACVS | ↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction |
|---|---|
| Category | Proteomic |
| Also described as | Immunocapture + mass spectrometry |
| Compared against | HC (healthy controls) |
| Associated symptoms | Quantitative vaccine-encoded spike detection |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Sutton et al. 2023 — doi:10.1016/j.vaccine.2023.04.044 |
| Condition atlas | PACVS Biomarker Atlas |
Related Proteomic markers in PACVS
- IL-8 ↑
- Heart rate variability (HRV) ↓
- IL-6 ↑
- Salivary nitric oxide ↓
- Blood lactate (exercise) ↑
- Orthostatic heart rate increment ↑
- Transferrin saturation ↓
- 6-minute walk distance ↓
Full list: PACVS Biomarker Atlas.
Frequently asked questions
Is Spike (LC-MS/MS quantification) high or low in PACVS?
Mixed. Some studies report higher and others lower Spike (LC-MS/MS quantification) in PACVS compared with healthy controls, so no single direction is established. Source: Sutton et al. 2023.
What symptoms is Spike (LC-MS/MS quantification) associated with in PACVS?
The cited literature associates this marker with Quantitative vaccine-encoded spike detection. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Spike (LC-MS/MS quantification)?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Spike (LC-MS/MS quantification) result diagnostic of PACVS?
No. No single biomarker is diagnostic of PACVS. Spike (LC-MS/MS quantification) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-30 · Page generated from pacvs.json · Browse: PACVS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.