Summary
| Direction in PACVS | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Functional |
| Also described as | Enterosalivary NO pathway |
| Compared against | HC (healthy controls) |
| Associated symptoms | Reduced NO bioavailability |
| Test type | Clinical or physiological test |
| Source | Halma 2024 — doi:10.2196/preprints.70342 |
| Condition atlas | PACVS Biomarker Atlas |
Related Functional markers in PACVS
- Heart rate variability (HRV) ↓
- Orthostatic heart rate increment ↑
- 6-minute walk distance ↓
- Exertional SpO₂ nadir ↓
- Chester Step Test (VO₂ proxy) ↓
- PAC-19QoL score ↓
- Neurofilament light chain (NfL) ↑
Full list: PACVS Biomarker Atlas.
Frequently asked questions
Is Salivary nitric oxide high or low in PACVS?
Reduced. Studies summarised in the OSMF atlas report lower Salivary nitric oxide in PACVS than in healthy controls. Source: Halma 2024.
What symptoms is Salivary nitric oxide associated with in PACVS?
The cited literature associates this marker with Reduced NO bioavailability. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Salivary nitric oxide?
It is measured as a clinical or physiological test. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Salivary nitric oxide result diagnostic of PACVS?
No. No single biomarker is diagnostic of PACVS. Salivary nitric oxide findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-30 · Page generated from pacvs.json · Browse: PACVS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.