Summary
| Direction in PACVS | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Functional |
| Also described as | Submaximal fitness test |
| Compared against | HC (healthy controls) |
| Associated symptoms | Reduced aerobic capacity |
| Test type | Clinical or physiological test |
| Source | Halma 2024 — doi:10.2196/preprints.70342 |
| Condition atlas | PACVS Biomarker Atlas |
Related Functional markers in PACVS
- Exertional SpO₂ nadir ↓
- PAC-19QoL score ↓
- 6-minute walk distance ↓
- Neurofilament light chain (NfL) ↑
- Orthostatic heart rate increment ↑
- Salivary nitric oxide ↓
- Heart rate variability (HRV) ↓
Full list: PACVS Biomarker Atlas.
Frequently asked questions
Is Chester Step Test (VO₂ proxy) high or low in PACVS?
Reduced. Studies summarised in the OSMF atlas report lower Chester Step Test (VO₂ proxy) in PACVS than in healthy controls. Source: Halma 2024.
What symptoms is Chester Step Test (VO₂ proxy) associated with in PACVS?
The cited literature associates this marker with Reduced aerobic capacity. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Chester Step Test (VO₂ proxy)?
It is measured as a clinical or physiological test. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Chester Step Test (VO₂ proxy) result diagnostic of PACVS?
No. No single biomarker is diagnostic of PACVS. Chester Step Test (VO₂ proxy) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-30 · Page generated from pacvs.json · Browse: PACVS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.