Summary
| Direction in PACVS | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Inflammatory |
| Also described as | Pro-inflammatory cytokine |
| Compared against | HC (healthy controls) |
| Associated symptoms | Elevated in >80% of PACVS registry cohort |
| Test type | Blood test (serum / plasma / whole blood) |
| LOINC code | 26998-9 |
| Source | Mundorf et al. 2024 — doi:10.3390/vaccines12070790 |
| Condition atlas | PACVS Biomarker Atlas |
Other conditions where Interleukin-8 (IL-8 / CXCL8) is reported
- Interleukin-8 (IL-8 / CXCL8) in Gulf War Illness — ↑ elevated vs HGV
- Interleukin-8 (IL-8) in Long COVID — ↑ elevated vs HC
- Interleukin-8 (IL-8 / CXCL8) in ME/CFS — ↕ inconsistent vs HC
See the cross-condition hub: Interleukin-8 (IL-8 / CXCL8) across conditions.
Related Inflammatory markers in PACVS
- IL-6 ↑
Full list: PACVS Biomarker Atlas.
Frequently asked questions
Is IL-8 high or low in PACVS?
Elevated. Studies summarised in the OSMF atlas report higher IL-8 in PACVS than in healthy controls. Source: Mundorf et al. 2024.
What symptoms is IL-8 associated with in PACVS?
The cited literature associates this marker with Elevated in >80% of PACVS registry cohort. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures IL-8?
It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 26998-9. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal IL-8 result diagnostic of PACVS?
No. No single biomarker is diagnostic of PACVS. IL-8 findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is IL-8 specific to PACVS?
No. The same marker is also reported in Gulf War Illness, Long COVID, ME/CFS in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-06-30 · Page generated from pacvs.json · Browse: PACVS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.