Summary
| Direction in Major Depressive Disorder | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Other |
| Compared against | healthy controls |
| Source | Lorkiewicz et al. 2021 — doi:10.3390/jcm10184142 |
| Condition atlas | Major Depressive Disorder Biomarker Atlas |
Other conditions where Interleukin-1 beta is reported
- Interleukin-1 beta in Low Back Pain — ↑ elevated vs control discs
See the cross-condition hub: Interleukin-1 beta across conditions.
Related Other markers in Major Depressive Disorder
- Insulin-like Growth Factor-1 (IGF-1) ↑
- Homocysteine ↑
- Dehydroepiandrosterone Sulfate (DHEA-S) ↕
- 25-Hydroxyvitamin D ↓
Full list: Major Depressive Disorder Biomarker Atlas.
Frequently asked questions
Is Interleukin-1 beta high or low in Major Depressive Disorder?
Elevated. Studies summarised in the OSMF atlas report higher Interleukin-1 beta in Major Depressive Disorder than in healthy controls. Source: Lorkiewicz et al. 2021.
Which test measures Interleukin-1 beta?
The atlas record does not list a standardised clinical test code (LOINC) for Interleukin-1 beta, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal Interleukin-1 beta result diagnostic of Major Depressive Disorder?
No. No single biomarker is diagnostic of Major Depressive Disorder. Interleukin-1 beta findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is Interleukin-1 beta specific to Major Depressive Disorder?
No. The same marker is also reported in Low Back Pain in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-10-08 · Page generated from major-depressive-disorder.json · Browse: Major Depressive Disorder atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.