Research Tracker›Biomarker Atlas›Major Depressive Disorder›Insulin-like Growth Factor-1 (IGF-1)

Insulin-like Growth Factor-1 (IGF-1) in Major Depressive Disorder

Insulin-like Growth Factor-1 (IGF-1) belongs to the other group of Major Depressive Disorder markers and is reported to be raised relative to healthy controls. The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Arinami et al. 2023 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedOther

Summary

Direction in Major Depressive Disorder↑ Elevated — higher than in the comparison group
CategoryOther
Compared againsthealthy controls
SourceArinami et al. 2023 — doi:10.1038/s41598-023-28449-8
Condition atlasMajor Depressive Disorder Biomarker Atlas

Related Other markers in Major Depressive Disorder

Full list: Major Depressive Disorder Biomarker Atlas.

Frequently asked questions

Is Insulin-like Growth Factor-1 (IGF-1) high or low in Major Depressive Disorder?

Elevated. Studies summarised in the OSMF atlas report higher Insulin-like Growth Factor-1 (IGF-1) in Major Depressive Disorder than in healthy controls. Source: Arinami et al. 2023.

Which test measures Insulin-like Growth Factor-1 (IGF-1)?

The atlas record does not list a standardised clinical test code (LOINC) for Insulin-like Growth Factor-1 (IGF-1), which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal Insulin-like Growth Factor-1 (IGF-1) result diagnostic of Major Depressive Disorder?

No. No single biomarker is diagnostic of Major Depressive Disorder. Insulin-like Growth Factor-1 (IGF-1) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Insulin-like Growth Factor-1 (IGF-1) in Major Depressive Disorder: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 8, 2026, from https://research.opensourcemed.info/biomarkers/major-depressive-disorder/insulin-like-growth-factor-1-igf-1.html
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Last reviewed: 2026-10-08 · Page generated from major-depressive-disorder.json · Browse: Major Depressive Disorder atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.