{
  "slug": "major-depressive-disorder",
  "id": "major-depressive-disorder-biomarkers",
  "condition": {
    "name": "Major Depressive Disorder",
    "shortName": "Major Depressive Disorder",
    "alternateNames": []
  },
  "page": {
    "title": "Major Depressive Disorder Biomarker Atlas | Blood Tests & Molecular Alterations",
    "breadcrumbName": "Major Depressive Disorder Biomarkers",
    "description": "Searchable atlas of Major Depressive Disorder biomarkers, from peer-reviewed literature comparing patient levels vs. healthy controls.",
    "keywords": [
      "Major Depressive Disorder biomarkers",
      "Major Depressive Disorder blood tests",
      "biomarker atlas",
      "biomarker database"
    ],
    "canonical": "https://research.opensourcemed.info/major-depressive-disorder-biomarkers.html",
    "hero": "Molecular alterations reported in Major Depressive Disorder compared to healthy controls, from peer-reviewed literature.",
    "dateModified": "2026-07-03"
  },
  "categories": {
    "endocrine": "Endocrine",
    "inflammatory": "Inflammatory",
    "neurological": "Neurological"
  },
  "filters": [
    "endocrine",
    "inflammatory",
    "neurological"
  ],
  "markers": [
    {
      "name": "BDNF",
      "alternateName": "BDNF",
      "direction": "down",
      "category": "neurological",
      "comparison": "MDD patients vs healthy controls",
      "symptoms": "",
      "reference": {
        "citation": "Nobis et al. 2020",
        "doi": "10.3390/jcm9123793"
      }
    },
    {
      "name": "Cortisol",
      "alternateName": "Cortisol",
      "direction": "up",
      "category": "endocrine",
      "comparison": "MDD patients vs healthy controls (HPA axis dysregulation)",
      "symptoms": "",
      "reference": {
        "citation": "Nobis et al. 2020",
        "doi": "10.3390/jcm9123793"
      },
      "testType": "BloodTest",
      "loinc": "2143-6"
    },
    {
      "name": "CRP",
      "alternateName": "CRP",
      "direction": "up",
      "category": "inflammatory",
      "comparison": "females with depression vs healthy female controls",
      "symptoms": "",
      "reference": {
        "citation": "Jarkas et al. 2024",
        "doi": "10.1016/j.bbi.2024.07.037"
      },
      "testType": "BloodTest",
      "loinc": "1988-5"
    },
    {
      "name": "IL-6",
      "alternateName": "IL-6",
      "direction": "up",
      "category": "inflammatory",
      "comparison": "females with depression vs healthy female controls",
      "symptoms": "",
      "reference": {
        "citation": "Jarkas et al. 2024",
        "doi": "10.1016/j.bbi.2024.07.037"
      },
      "testType": "BloodTest",
      "loinc": "26881-5"
    }
  ]
}